Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications
Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition o...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hoang, Ngoc Ha [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag Berlin Heidelberg 2016 |
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| Übergeordnetes Werk: |
Enthalten in: Polymer bulletin - Berlin : Springer, 1978, 74(2016), 5 vom: 31. Aug., Seite 1595-1609 |
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| Übergeordnetes Werk: |
volume:74 ; year:2016 ; number:5 ; day:31 ; month:08 ; pages:1595-1609 |
| Links: |
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| DOI / URN: |
10.1007/s00289-016-1791-3 |
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| Katalog-ID: |
SPR003763404 |
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| 100 | 1 | |a Hoang, Ngoc Ha |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
| 264 | 1 | |c 2016 | |
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| 520 | |a Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. | ||
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| 650 | 4 | |a Drug delivery system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Nano |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Micelle |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lim, Chaemin |4 aut | |
| 700 | 1 | |a Sim, Taehoon |4 aut | |
| 700 | 1 | |a Lee, Eun Seong |4 aut | |
| 700 | 1 | |a Youn, Yu Seok |4 aut | |
| 700 | 1 | |a Kim, Dongin |4 aut | |
| 700 | 1 | |a Oh, Kyung Taek |4 aut | |
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10.1007/s00289-016-1791-3 doi (DE-627)SPR003763404 (SPR)s00289-016-1791-3-e DE-627 ger DE-627 rakwb eng Hoang, Ngoc Ha verfasserin aut Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 Lim, Chaemin aut Sim, Taehoon aut Lee, Eun Seong aut Youn, Yu Seok aut Kim, Dongin aut Oh, Kyung Taek aut Enthalten in Polymer bulletin Berlin : Springer, 1978 74(2016), 5 vom: 31. Aug., Seite 1595-1609 (DE-627)268761833 (DE-600)1473175-7 1436-2449 nnns volume:74 year:2016 number:5 day:31 month:08 pages:1595-1609 https://dx.doi.org/10.1007/s00289-016-1791-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 74 2016 5 31 08 1595-1609 |
| spelling |
10.1007/s00289-016-1791-3 doi (DE-627)SPR003763404 (SPR)s00289-016-1791-3-e DE-627 ger DE-627 rakwb eng Hoang, Ngoc Ha verfasserin aut Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 Lim, Chaemin aut Sim, Taehoon aut Lee, Eun Seong aut Youn, Yu Seok aut Kim, Dongin aut Oh, Kyung Taek aut Enthalten in Polymer bulletin Berlin : Springer, 1978 74(2016), 5 vom: 31. Aug., Seite 1595-1609 (DE-627)268761833 (DE-600)1473175-7 1436-2449 nnns volume:74 year:2016 number:5 day:31 month:08 pages:1595-1609 https://dx.doi.org/10.1007/s00289-016-1791-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 74 2016 5 31 08 1595-1609 |
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10.1007/s00289-016-1791-3 doi (DE-627)SPR003763404 (SPR)s00289-016-1791-3-e DE-627 ger DE-627 rakwb eng Hoang, Ngoc Ha verfasserin aut Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 Lim, Chaemin aut Sim, Taehoon aut Lee, Eun Seong aut Youn, Yu Seok aut Kim, Dongin aut Oh, Kyung Taek aut Enthalten in Polymer bulletin Berlin : Springer, 1978 74(2016), 5 vom: 31. Aug., Seite 1595-1609 (DE-627)268761833 (DE-600)1473175-7 1436-2449 nnns volume:74 year:2016 number:5 day:31 month:08 pages:1595-1609 https://dx.doi.org/10.1007/s00289-016-1791-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 74 2016 5 31 08 1595-1609 |
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10.1007/s00289-016-1791-3 doi (DE-627)SPR003763404 (SPR)s00289-016-1791-3-e DE-627 ger DE-627 rakwb eng Hoang, Ngoc Ha verfasserin aut Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 Lim, Chaemin aut Sim, Taehoon aut Lee, Eun Seong aut Youn, Yu Seok aut Kim, Dongin aut Oh, Kyung Taek aut Enthalten in Polymer bulletin Berlin : Springer, 1978 74(2016), 5 vom: 31. Aug., Seite 1595-1609 (DE-627)268761833 (DE-600)1473175-7 1436-2449 nnns volume:74 year:2016 number:5 day:31 month:08 pages:1595-1609 https://dx.doi.org/10.1007/s00289-016-1791-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 74 2016 5 31 08 1595-1609 |
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10.1007/s00289-016-1791-3 doi (DE-627)SPR003763404 (SPR)s00289-016-1791-3-e DE-627 ger DE-627 rakwb eng Hoang, Ngoc Ha verfasserin aut Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 Lim, Chaemin aut Sim, Taehoon aut Lee, Eun Seong aut Youn, Yu Seok aut Kim, Dongin aut Oh, Kyung Taek aut Enthalten in Polymer bulletin Berlin : Springer, 1978 74(2016), 5 vom: 31. Aug., Seite 1595-1609 (DE-627)268761833 (DE-600)1473175-7 1436-2449 nnns volume:74 year:2016 number:5 day:31 month:08 pages:1595-1609 https://dx.doi.org/10.1007/s00289-016-1791-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2411 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 74 2016 5 31 08 1595-1609 |
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Hoang, Ngoc Ha @@aut@@ Lim, Chaemin @@aut@@ Sim, Taehoon @@aut@@ Lee, Eun Seong @@aut@@ Youn, Yu Seok @@aut@@ Kim, Dongin @@aut@@ Oh, Kyung Taek @@aut@@ |
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To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. 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Hoang, Ngoc Ha |
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Hoang, Ngoc Ha misc Anticancer misc Block copolymer misc Drug delivery system misc Nano misc Micelle Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications Anticancer (dpeaa)DE-He213 Block copolymer (dpeaa)DE-He213 Drug delivery system (dpeaa)DE-He213 Nano (dpeaa)DE-He213 Micelle (dpeaa)DE-He213 |
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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
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Hoang, Ngoc Ha Lim, Chaemin Sim, Taehoon Lee, Eun Seong Youn, Yu Seok Kim, Dongin Oh, Kyung Taek |
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characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
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Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
| abstract |
Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. © Springer-Verlag Berlin Heidelberg 2016 |
| abstractGer |
Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. © Springer-Verlag Berlin Heidelberg 2016 |
| abstract_unstemmed |
Abstract Formulation optimization from the early steps plays an important role in the success of drug delivery system development. To optimize nano-sized micelles based on poly(ethylene glycol)-b-poly(lactide)-b-poly(ethylene glycol) (PEG-PLA-PEG) triblock copolymers, the effect of PLA composition on the physicochemical properties of micelles was studied. Doxorubicin (DOX) was used to be encapsulated into micelles. In vitro studies on the safety of triblock copolymers and cytotoxicity of DOX-loaded micelles compared to free DOX were done, using MDA-MB-231 cells. Critical micelle concentration and micelle size were found to be linearly dependent on the PLA molecular weight (MW). In addition, it was shown that long PLA-containing micelles had low stability. The sizes of DOX-loaded micelles were bigger than those of empty micelles. The loading amount of DOX into micelles as well as the release rate of DOX from micelles depended on the PLA MW. Triblock copolymers themselves did not show any toxicity over a wide range of concentration. DOX-loaded micelles killed more tumor cells than free DOX. In summary, difference in hydrophobicity can be a critical factor to determine the physicochemical properties of micelles composed of PEG-PLA-PEG, and thus, it can affect the drug delivery efficacy of micelles. After considering all related factors, PEG-PLA-PEG 2 kDa-6 kDa-2 kDa seemed to be the best polymer for further studies. © Springer-Verlag Berlin Heidelberg 2016 |
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5 |
| title_short |
Characterization of a triblock copolymer, poly(ethylene glycol)-polylactide-poly(ethylene glycol), with different structures for anticancer drug delivery applications |
| url |
https://dx.doi.org/10.1007/s00289-016-1791-3 |
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Lim, Chaemin Sim, Taehoon Lee, Eun Seong Youn, Yu Seok Kim, Dongin Oh, Kyung Taek |
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Lim, Chaemin Sim, Taehoon Lee, Eun Seong Youn, Yu Seok Kim, Dongin Oh, Kyung Taek |
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10.1007/s00289-016-1791-3 |
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| score |
7.400571 |