High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma

Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM...
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Autor*in:	Aurer, Igor [verfasserIn] Nemet, Damir Mitrović, Zdravko Dujmović, Dino Bašić-Kinda, Sandra Radman, Ivo Sertić, Dubravka Šantek, Fedor Kralik, Marko Dotlić, Snježana Mazić, Sanja Labar, Boris

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Hodgkin’s lymphoma Antineoplastic combined chemotherapy protocols Ifosfamide Mitoxantrone Autologous stem cell transplantation

Anmerkung:	© Springer-Verlag Berlin Heidelberg 2016

Übergeordnetes Werk:	Enthalten in: Annals of hematology - Berlin : Springer, 1955, 95(2016), 7 vom: 22. Apr., Seite 1129-1136
Übergeordnetes Werk:	volume:95 ; year:2016 ; number:7 ; day:22 ; month:04 ; pages:1129-1136

Links:	Volltext

DOI / URN:	10.1007/s00277-016-2676-0

Katalog-ID:	SPR003921808

Internformat


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100	1		\|a Aurer, Igor \|e verfasserin \|4 aut
245	1	0	\|a High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
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520			\|a Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options.
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650		4	\|a Antineoplastic combined chemotherapy protocols \|7 (dpeaa)DE-He213
650		4	\|a Ifosfamide \|7 (dpeaa)DE-He213
650		4	\|a Mitoxantrone \|7 (dpeaa)DE-He213
650		4	\|a Autologous stem cell transplantation \|7 (dpeaa)DE-He213
700	1		\|a Nemet, Damir \|4 aut
700	1		\|a Mitrović, Zdravko \|4 aut
700	1		\|a Dujmović, Dino \|4 aut
700	1		\|a Bašić-Kinda, Sandra \|4 aut
700	1		\|a Radman, Ivo \|4 aut
700	1		\|a Sertić, Dubravka \|4 aut
700	1		\|a Šantek, Fedor \|4 aut
700	1		\|a Kralik, Marko \|4 aut
700	1		\|a Dotlić, Snježana \|4 aut
700	1		\|a Mazić, Sanja \|4 aut
700	1		\|a Labar, Boris \|4 aut
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856	4	0	\|u https://dx.doi.org/10.1007/s00277-016-2676-0 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
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912			\|a GBV_ILN_711
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
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912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
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912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_2116
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912			\|a GBV_ILN_2119
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912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2424
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
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912			\|a GBV_ILN_4242
912			\|a GBV_ILN_4246
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912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
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951			\|a AR
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Indexfelder

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matchkey_str	article:14320584:2016----::ihoefsaienmtxnrnhiiptetwtrlpeor
hierarchy_sort_str	2016
publishDate	2016
allfields	10.1007/s00277-016-2676-0 doi (DE-627)SPR003921808 (SPR)s00277-016-2676-0-e DE-627 ger DE-627 rakwb eng Aurer, Igor verfasserin aut High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Nemet, Damir aut Mitrović, Zdravko aut Dujmović, Dino aut Bašić-Kinda, Sandra aut Radman, Ivo aut Sertić, Dubravka aut Šantek, Fedor aut Kralik, Marko aut Dotlić, Snježana aut Mazić, Sanja aut Labar, Boris aut Enthalten in Annals of hematology Berlin : Springer, 1955 95(2016), 7 vom: 22. Apr., Seite 1129-1136 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136 https://dx.doi.org/10.1007/s00277-016-2676-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 95 2016 7 22 04 1129-1136
spelling	10.1007/s00277-016-2676-0 doi (DE-627)SPR003921808 (SPR)s00277-016-2676-0-e DE-627 ger DE-627 rakwb eng Aurer, Igor verfasserin aut High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Nemet, Damir aut Mitrović, Zdravko aut Dujmović, Dino aut Bašić-Kinda, Sandra aut Radman, Ivo aut Sertić, Dubravka aut Šantek, Fedor aut Kralik, Marko aut Dotlić, Snježana aut Mazić, Sanja aut Labar, Boris aut Enthalten in Annals of hematology Berlin : Springer, 1955 95(2016), 7 vom: 22. Apr., Seite 1129-1136 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136 https://dx.doi.org/10.1007/s00277-016-2676-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 95 2016 7 22 04 1129-1136
allfields_unstemmed	10.1007/s00277-016-2676-0 doi (DE-627)SPR003921808 (SPR)s00277-016-2676-0-e DE-627 ger DE-627 rakwb eng Aurer, Igor verfasserin aut High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Nemet, Damir aut Mitrović, Zdravko aut Dujmović, Dino aut Bašić-Kinda, Sandra aut Radman, Ivo aut Sertić, Dubravka aut Šantek, Fedor aut Kralik, Marko aut Dotlić, Snježana aut Mazić, Sanja aut Labar, Boris aut Enthalten in Annals of hematology Berlin : Springer, 1955 95(2016), 7 vom: 22. Apr., Seite 1129-1136 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136 https://dx.doi.org/10.1007/s00277-016-2676-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 95 2016 7 22 04 1129-1136
allfieldsGer	10.1007/s00277-016-2676-0 doi (DE-627)SPR003921808 (SPR)s00277-016-2676-0-e DE-627 ger DE-627 rakwb eng Aurer, Igor verfasserin aut High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Nemet, Damir aut Mitrović, Zdravko aut Dujmović, Dino aut Bašić-Kinda, Sandra aut Radman, Ivo aut Sertić, Dubravka aut Šantek, Fedor aut Kralik, Marko aut Dotlić, Snježana aut Mazić, Sanja aut Labar, Boris aut Enthalten in Annals of hematology Berlin : Springer, 1955 95(2016), 7 vom: 22. Apr., Seite 1129-1136 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136 https://dx.doi.org/10.1007/s00277-016-2676-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 95 2016 7 22 04 1129-1136
allfieldsSound	10.1007/s00277-016-2676-0 doi (DE-627)SPR003921808 (SPR)s00277-016-2676-0-e DE-627 ger DE-627 rakwb eng Aurer, Igor verfasserin aut High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2016 Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213 Nemet, Damir aut Mitrović, Zdravko aut Dujmović, Dino aut Bašić-Kinda, Sandra aut Radman, Ivo aut Sertić, Dubravka aut Šantek, Fedor aut Kralik, Marko aut Dotlić, Snježana aut Mazić, Sanja aut Labar, Boris aut Enthalten in Annals of hematology Berlin : Springer, 1955 95(2016), 7 vom: 22. Apr., Seite 1129-1136 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136 https://dx.doi.org/10.1007/s00277-016-2676-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2424 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 95 2016 7 22 04 1129-1136
language	English
source	Enthalten in Annals of hematology 95(2016), 7 vom: 22. Apr., Seite 1129-1136 volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136
sourceStr	Enthalten in Annals of hematology 95(2016), 7 vom: 22. Apr., Seite 1129-1136 volume:95 year:2016 number:7 day:22 month:04 pages:1129-1136
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Hodgkin’s lymphoma Antineoplastic combined chemotherapy protocols Ifosfamide Mitoxantrone Autologous stem cell transplantation
isfreeaccess_bool	false
container_title	Annals of hematology
authorswithroles_txt_mv	Aurer, Igor @@aut@@ Nemet, Damir @@aut@@ Mitrović, Zdravko @@aut@@ Dujmović, Dino @@aut@@ Bašić-Kinda, Sandra @@aut@@ Radman, Ivo @@aut@@ Sertić, Dubravka @@aut@@ Šantek, Fedor @@aut@@ Kralik, Marko @@aut@@ Dotlić, Snježana @@aut@@ Mazić, Sanja @@aut@@ Labar, Boris @@aut@@
publishDateDaySort_date	2016-04-22T00:00:00Z
hierarchy_top_id	253389852
id	SPR003921808
language_de	englisch
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author	Aurer, Igor
spellingShingle	Aurer, Igor misc Hodgkin’s lymphoma misc Antineoplastic combined chemotherapy protocols misc Ifosfamide misc Mitoxantrone misc Autologous stem cell transplantation High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
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topic_title	High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma Hodgkin’s lymphoma (dpeaa)DE-He213 Antineoplastic combined chemotherapy protocols (dpeaa)DE-He213 Ifosfamide (dpeaa)DE-He213 Mitoxantrone (dpeaa)DE-He213 Autologous stem cell transplantation (dpeaa)DE-He213
topic	misc Hodgkin’s lymphoma misc Antineoplastic combined chemotherapy protocols misc Ifosfamide misc Mitoxantrone misc Autologous stem cell transplantation
topic_unstemmed	misc Hodgkin’s lymphoma misc Antineoplastic combined chemotherapy protocols misc Ifosfamide misc Mitoxantrone misc Autologous stem cell transplantation
topic_browse	misc Hodgkin’s lymphoma misc Antineoplastic combined chemotherapy protocols misc Ifosfamide misc Mitoxantrone misc Autologous stem cell transplantation
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title	High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
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title_full	High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
author_sort	Aurer, Igor
journal	Annals of hematology
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author_browse	Aurer, Igor Nemet, Damir Mitrović, Zdravko Dujmović, Dino Bašić-Kinda, Sandra Radman, Ivo Sertić, Dubravka Šantek, Fedor Kralik, Marko Dotlić, Snježana Mazić, Sanja Labar, Boris
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author-letter	Aurer, Igor
doi_str_mv	10.1007/s00277-016-2676-0
title_sort	high-dose ifosfamide and mitoxantrone (hdim) in patients with relapsed or refractory hodgkin’s lymphoma
title_auth	High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
abstract	Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. © Springer-Verlag Berlin Heidelberg 2016
abstractGer	Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. © Springer-Verlag Berlin Heidelberg 2016
abstract_unstemmed	Abstract Relapsed/refractory Hodgkin’s lymphoma (HL) is treated with salvage chemotherapy and autologous stem cell transplantation (ASCT). Optimal chemotherapy is unknown. We retrospectively analyzed outcomes of 58 patients treated with 2 cycles of high-dose ifosfamide and mitoxantrone (HDIM). HDIM consisted of ifosfamide 5 g/$ m^{2} $/day and MESNA 5 g/$ m^{2} $/day in continuous 24-h infusion (days 1 and 2), MESNA 2.5 g/$ m^{2} $ over 12 h (day 3), and mitoxantrone 20 mg/$ m^{2} $ (day 1) administered every 2 weeks. Stem cells were collected after the first cycle. Responding patients proceeded to ASCT. Toxicity was acceptable. Stem cell mobilization was successful in 96 % of patients. Overall response rate was 74 % (89 % in relapsing and 45 % in refractory patients) with 31 % complete remissions. After a median follow-up of 54 months, 5-year event-free survival was 56 % (69 % for relapsing and 35 % for refractory patients), and 5-year overall survival was 67 % (73 % for relapsing and 55 % for refractory patients). Significant adverse prognostic factors were refractoriness to previous therapy and HDIM failure. No differences in outcomes were noted between patients with early and late relapses or between complete and partial responders. HDIM is a well-tolerated and effective regimen for relapsed and refractory HL with excellent stem cell mobilizing properties. Patients failing HDIM may still benefit from other salvage options. © Springer-Verlag Berlin Heidelberg 2016
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container_issue	7
title_short	High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma
url	https://dx.doi.org/10.1007/s00277-016-2676-0
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author2	Nemet, Damir Mitrović, Zdravko Dujmović, Dino Bašić-Kinda, Sandra Radman, Ivo Sertić, Dubravka Šantek, Fedor Kralik, Marko Dotlić, Snježana Mazić, Sanja Labar, Boris
author2Str	Nemet, Damir Mitrović, Zdravko Dujmović, Dino Bašić-Kinda, Sandra Radman, Ivo Sertić, Dubravka Šantek, Fedor Kralik, Marko Dotlić, Snježana Mazić, Sanja Labar, Boris
ppnlink	253389852
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hochschulschrift_bool	false
doi_str	10.1007/s00277-016-2676-0
up_date	2024-07-03T22:32:32.803Z
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High-dose ifosfamide and mitoxantrone (HDIM) in patients with relapsed or refractory Hodgkin’s lymphoma

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