Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment
Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood take...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lee, Sung-Eun [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2018 |
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| Übergeordnetes Werk: |
Enthalten in: Annals of hematology - Berlin : Springer, 1955, 97(2018), 11 vom: 25. Juni, Seite 2163-2171 |
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| Übergeordnetes Werk: |
volume:97 ; year:2018 ; number:11 ; day:25 ; month:06 ; pages:2163-2171 |
| Links: |
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| DOI / URN: |
10.1007/s00277-018-3401-y |
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| Katalog-ID: |
SPR003956512 |
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| 024 | 7 | |a 10.1007/s00277-018-3401-y |2 doi | |
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| 041 | |a eng | ||
| 100 | 1 | |a Lee, Sung-Eun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © Springer-Verlag GmbH Germany, part of Springer Nature 2018 | ||
| 520 | |a Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. | ||
| 650 | 4 | |a Multiple myeloma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lenalidomide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Low-dose dexamethasone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Infection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD4 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD161 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T cells |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lim, Ji-Young |4 aut | |
| 700 | 1 | |a Ryu, Da-Bin |4 aut | |
| 700 | 1 | |a Kim, Tae Woo |4 aut | |
| 700 | 1 | |a Park, Sung Soo |4 aut | |
| 700 | 1 | |a Jeon, Young-Woo |4 aut | |
| 700 | 1 | |a Yoon, Jae-Ho |4 aut | |
| 700 | 1 | |a Cho, Byung-Sik |4 aut | |
| 700 | 1 | |a Eom, Ki-Seong |4 aut | |
| 700 | 1 | |a Kim, Yoo-Jin |4 aut | |
| 700 | 1 | |a Kim, Hee-Je |4 aut | |
| 700 | 1 | |a Lee, Seok |4 aut | |
| 700 | 1 | |a Cho, Seok-Goo |4 aut | |
| 700 | 1 | |a Kim, Dong-Wook |4 aut | |
| 700 | 1 | |a Lee, Jong Wook |4 aut | |
| 700 | 1 | |a Min, Chang-Ki |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of hematology |d Berlin : Springer, 1955 |g 97(2018), 11 vom: 25. Juni, Seite 2163-2171 |w (DE-627)253389852 |w (DE-600)1458429-3 |x 1432-0584 |7 nnns |
| 773 | 1 | 8 | |g volume:97 |g year:2018 |g number:11 |g day:25 |g month:06 |g pages:2163-2171 |
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| 912 | |a GBV_ILN_2064 | ||
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| 912 | |a GBV_ILN_2070 | ||
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10.1007/s00277-018-3401-y doi (DE-627)SPR003956512 (SPR)s00277-018-3401-y-e DE-627 ger DE-627 rakwb eng Lee, Sung-Eun verfasserin aut Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Lim, Ji-Young aut Ryu, Da-Bin aut Kim, Tae Woo aut Park, Sung Soo aut Jeon, Young-Woo aut Yoon, Jae-Ho aut Cho, Byung-Sik aut Eom, Ki-Seong aut Kim, Yoo-Jin aut Kim, Hee-Je aut Lee, Seok aut Cho, Seok-Goo aut Kim, Dong-Wook aut Lee, Jong Wook aut Min, Chang-Ki aut Enthalten in Annals of hematology Berlin : Springer, 1955 97(2018), 11 vom: 25. Juni, Seite 2163-2171 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:97 year:2018 number:11 day:25 month:06 pages:2163-2171 https://dx.doi.org/10.1007/s00277-018-3401-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 97 2018 11 25 06 2163-2171 |
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10.1007/s00277-018-3401-y doi (DE-627)SPR003956512 (SPR)s00277-018-3401-y-e DE-627 ger DE-627 rakwb eng Lee, Sung-Eun verfasserin aut Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Lim, Ji-Young aut Ryu, Da-Bin aut Kim, Tae Woo aut Park, Sung Soo aut Jeon, Young-Woo aut Yoon, Jae-Ho aut Cho, Byung-Sik aut Eom, Ki-Seong aut Kim, Yoo-Jin aut Kim, Hee-Je aut Lee, Seok aut Cho, Seok-Goo aut Kim, Dong-Wook aut Lee, Jong Wook aut Min, Chang-Ki aut Enthalten in Annals of hematology Berlin : Springer, 1955 97(2018), 11 vom: 25. Juni, Seite 2163-2171 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:97 year:2018 number:11 day:25 month:06 pages:2163-2171 https://dx.doi.org/10.1007/s00277-018-3401-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 97 2018 11 25 06 2163-2171 |
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10.1007/s00277-018-3401-y doi (DE-627)SPR003956512 (SPR)s00277-018-3401-y-e DE-627 ger DE-627 rakwb eng Lee, Sung-Eun verfasserin aut Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Lim, Ji-Young aut Ryu, Da-Bin aut Kim, Tae Woo aut Park, Sung Soo aut Jeon, Young-Woo aut Yoon, Jae-Ho aut Cho, Byung-Sik aut Eom, Ki-Seong aut Kim, Yoo-Jin aut Kim, Hee-Je aut Lee, Seok aut Cho, Seok-Goo aut Kim, Dong-Wook aut Lee, Jong Wook aut Min, Chang-Ki aut Enthalten in Annals of hematology Berlin : Springer, 1955 97(2018), 11 vom: 25. Juni, Seite 2163-2171 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:97 year:2018 number:11 day:25 month:06 pages:2163-2171 https://dx.doi.org/10.1007/s00277-018-3401-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 97 2018 11 25 06 2163-2171 |
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10.1007/s00277-018-3401-y doi (DE-627)SPR003956512 (SPR)s00277-018-3401-y-e DE-627 ger DE-627 rakwb eng Lee, Sung-Eun verfasserin aut Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Lim, Ji-Young aut Ryu, Da-Bin aut Kim, Tae Woo aut Park, Sung Soo aut Jeon, Young-Woo aut Yoon, Jae-Ho aut Cho, Byung-Sik aut Eom, Ki-Seong aut Kim, Yoo-Jin aut Kim, Hee-Je aut Lee, Seok aut Cho, Seok-Goo aut Kim, Dong-Wook aut Lee, Jong Wook aut Min, Chang-Ki aut Enthalten in Annals of hematology Berlin : Springer, 1955 97(2018), 11 vom: 25. Juni, Seite 2163-2171 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:97 year:2018 number:11 day:25 month:06 pages:2163-2171 https://dx.doi.org/10.1007/s00277-018-3401-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 97 2018 11 25 06 2163-2171 |
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10.1007/s00277-018-3401-y doi (DE-627)SPR003956512 (SPR)s00277-018-3401-y-e DE-627 ger DE-627 rakwb eng Lee, Sung-Eun verfasserin aut Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag GmbH Germany, part of Springer Nature 2018 Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 Lim, Ji-Young aut Ryu, Da-Bin aut Kim, Tae Woo aut Park, Sung Soo aut Jeon, Young-Woo aut Yoon, Jae-Ho aut Cho, Byung-Sik aut Eom, Ki-Seong aut Kim, Yoo-Jin aut Kim, Hee-Je aut Lee, Seok aut Cho, Seok-Goo aut Kim, Dong-Wook aut Lee, Jong Wook aut Min, Chang-Ki aut Enthalten in Annals of hematology Berlin : Springer, 1955 97(2018), 11 vom: 25. Juni, Seite 2163-2171 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:97 year:2018 number:11 day:25 month:06 pages:2163-2171 https://dx.doi.org/10.1007/s00277-018-3401-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 97 2018 11 25 06 2163-2171 |
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Lee, Sung-Eun @@aut@@ Lim, Ji-Young @@aut@@ Ryu, Da-Bin @@aut@@ Kim, Tae Woo @@aut@@ Park, Sung Soo @@aut@@ Jeon, Young-Woo @@aut@@ Yoon, Jae-Ho @@aut@@ Cho, Byung-Sik @@aut@@ Eom, Ki-Seong @@aut@@ Kim, Yoo-Jin @@aut@@ Kim, Hee-Je @@aut@@ Lee, Seok @@aut@@ Cho, Seok-Goo @@aut@@ Kim, Dong-Wook @@aut@@ Lee, Jong Wook @@aut@@ Min, Chang-Ki @@aut@@ |
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| author |
Lee, Sung-Eun |
| spellingShingle |
Lee, Sung-Eun misc Multiple myeloma misc Lenalidomide misc Low-dose dexamethasone misc Infection misc CD4 misc CD161 misc T cells Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
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Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment Multiple myeloma (dpeaa)DE-He213 Lenalidomide (dpeaa)DE-He213 Low-dose dexamethasone (dpeaa)DE-He213 Infection (dpeaa)DE-He213 CD4 (dpeaa)DE-He213 CD161 (dpeaa)DE-He213 T cells (dpeaa)DE-He213 |
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misc Multiple myeloma misc Lenalidomide misc Low-dose dexamethasone misc Infection misc CD4 misc CD161 misc T cells |
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misc Multiple myeloma misc Lenalidomide misc Low-dose dexamethasone misc Infection misc CD4 misc CD161 misc T cells |
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misc Multiple myeloma misc Lenalidomide misc Low-dose dexamethasone misc Infection misc CD4 misc CD161 misc T cells |
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Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
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| title_full |
Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
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Lee, Sung-Eun Lim, Ji-Young Ryu, Da-Bin Kim, Tae Woo Park, Sung Soo Jeon, Young-Woo Yoon, Jae-Ho Cho, Byung-Sik Eom, Ki-Seong Kim, Yoo-Jin Kim, Hee-Je Lee, Seok Cho, Seok-Goo Kim, Dong-Wook Lee, Jong Wook Min, Chang-Ki |
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Lee, Sung-Eun |
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10.1007/s00277-018-3401-y |
| title_sort |
low frequency of $ cd3^{+} %$ cd4^{+} %$ cd161^{+} $ t cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
| title_auth |
Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
| abstract |
Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. © Springer-Verlag GmbH Germany, part of Springer Nature 2018 |
| abstractGer |
Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. © Springer-Verlag GmbH Germany, part of Springer Nature 2018 |
| abstract_unstemmed |
Abstract The aim of this study was to explore the predictive implications of the composition of immune cell populations prior to lenalidomide plus high-dose dexamethasone (Len-Dex) initiation for the occurrence of infections. We prospectively examined immune cell populations in peripheral blood taken at baseline of lenalidomide plus low-dose dexamethasone (Len-dex) therapy and reviewed clinical and microbiology records in 90 patients with refractory/relapsed multiple myeloma (RRMM). Risk factors for infection were analyzed using logistic regression. During a median of 11 cycles of Len-dex treatment, 52 (57.8%) patients experienced at least 1 infection episode. Of a total of 92 episodes of infection, 58 (63%) episodes were clinically defined, 29 (31.5%) episodes were microbiologically defined, and 5 (5.4%) episodes were fever of unknown origin. Severe episodes were more frequently observed during the first 3 cycles. After adjusting for risk factors for infection based on univariate analyses, multivariate analyses showed that lower Hb (< 10 g/dL) was a clinically independent factor associated with occurrence of infections. Lower frequency (P = 0.044) and absolute count (P = 0.014) of circulating $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells prior to Len-dex treatment were also associated with the occurrence of infection, especially during the first 3 cycles of Len-dex therapy. In addition to several clinical predictive factors, we found that $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ cells may provide additional information for predicting the occurrence of infection in the early period of Len-dex therapy. © Springer-Verlag GmbH Germany, part of Springer Nature 2018 |
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| title_short |
Low frequency of $ CD3^{+} %$ CD4^{+} %$ CD161^{+} $ T cells correlates with the occurrence of infections in refractory/relapsed multiple myeloma patients receiving lenalidomide plus low-dose dexamethasone treatment |
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Lim, Ji-Young Ryu, Da-Bin Kim, Tae Woo Park, Sung Soo Jeon, Young-Woo Yoon, Jae-Ho Cho, Byung-Sik Eom, Ki-Seong Kim, Yoo-Jin Kim, Hee-Je Lee, Seok Cho, Seok-Goo Kim, Dong-Wook Lee, Jong Wook Min, Chang-Ki |
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Lim, Ji-Young Ryu, Da-Bin Kim, Tae Woo Park, Sung Soo Jeon, Young-Woo Yoon, Jae-Ho Cho, Byung-Sik Eom, Ki-Seong Kim, Yoo-Jin Kim, Hee-Je Lee, Seok Cho, Seok-Goo Kim, Dong-Wook Lee, Jong Wook Min, Chang-Ki |
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