Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience

Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in...
Ausführliche Beschreibung

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Autor*in:	Bamberg, Fabian [verfasserIn] Klotz, Ernst Flohr, Thomas Becker, Alexander Becker, Christoph R. Schmidt, Bernhard Wintersperger, Bernd J. Reiser, Maximilian F. Nikolaou, Konstantin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Cardiac CT Coronary artery disease Myocardial perfusion imaging Coronary stenosis

Anmerkung:	© European Society of Radiology 2010

Übergeordnetes Werk:	Enthalten in: European radiology - Berlin : Springer, 1991, 20(2010), 5 vom: 24. März, Seite 1168-1173
Übergeordnetes Werk:	volume:20 ; year:2010 ; number:5 ; day:24 ; month:03 ; pages:1168-1173

Links:	Volltext

DOI / URN:	10.1007/s00330-010-1715-9

Katalog-ID:	SPR003998487

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245	1	0	\|a Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
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520			\|a Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease.
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700	1		\|a Reiser, Maximilian F. \|4 aut
700	1		\|a Nikolaou, Konstantin \|4 aut
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allfields	10.1007/s00330-010-1715-9 doi (DE-627)SPR003998487 (SPR)s00330-010-1715-9-e DE-627 ger DE-627 rakwb eng Bamberg, Fabian verfasserin aut Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Society of Radiology 2010 Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213 Klotz, Ernst aut Flohr, Thomas aut Becker, Alexander aut Becker, Christoph R. aut Schmidt, Bernhard aut Wintersperger, Bernd J. aut Reiser, Maximilian F. aut Nikolaou, Konstantin aut Enthalten in European radiology Berlin : Springer, 1991 20(2010), 5 vom: 24. März, Seite 1168-1173 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173 https://dx.doi.org/10.1007/s00330-010-1715-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 20 2010 5 24 03 1168-1173
spelling	10.1007/s00330-010-1715-9 doi (DE-627)SPR003998487 (SPR)s00330-010-1715-9-e DE-627 ger DE-627 rakwb eng Bamberg, Fabian verfasserin aut Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Society of Radiology 2010 Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213 Klotz, Ernst aut Flohr, Thomas aut Becker, Alexander aut Becker, Christoph R. aut Schmidt, Bernhard aut Wintersperger, Bernd J. aut Reiser, Maximilian F. aut Nikolaou, Konstantin aut Enthalten in European radiology Berlin : Springer, 1991 20(2010), 5 vom: 24. März, Seite 1168-1173 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173 https://dx.doi.org/10.1007/s00330-010-1715-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 20 2010 5 24 03 1168-1173
allfields_unstemmed	10.1007/s00330-010-1715-9 doi (DE-627)SPR003998487 (SPR)s00330-010-1715-9-e DE-627 ger DE-627 rakwb eng Bamberg, Fabian verfasserin aut Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Society of Radiology 2010 Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213 Klotz, Ernst aut Flohr, Thomas aut Becker, Alexander aut Becker, Christoph R. aut Schmidt, Bernhard aut Wintersperger, Bernd J. aut Reiser, Maximilian F. aut Nikolaou, Konstantin aut Enthalten in European radiology Berlin : Springer, 1991 20(2010), 5 vom: 24. März, Seite 1168-1173 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173 https://dx.doi.org/10.1007/s00330-010-1715-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 20 2010 5 24 03 1168-1173
allfieldsGer	10.1007/s00330-010-1715-9 doi (DE-627)SPR003998487 (SPR)s00330-010-1715-9-e DE-627 ger DE-627 rakwb eng Bamberg, Fabian verfasserin aut Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Society of Radiology 2010 Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213 Klotz, Ernst aut Flohr, Thomas aut Becker, Alexander aut Becker, Christoph R. aut Schmidt, Bernhard aut Wintersperger, Bernd J. aut Reiser, Maximilian F. aut Nikolaou, Konstantin aut Enthalten in European radiology Berlin : Springer, 1991 20(2010), 5 vom: 24. März, Seite 1168-1173 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173 https://dx.doi.org/10.1007/s00330-010-1715-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 20 2010 5 24 03 1168-1173
allfieldsSound	10.1007/s00330-010-1715-9 doi (DE-627)SPR003998487 (SPR)s00330-010-1715-9-e DE-627 ger DE-627 rakwb eng Bamberg, Fabian verfasserin aut Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © European Society of Radiology 2010 Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213 Klotz, Ernst aut Flohr, Thomas aut Becker, Alexander aut Becker, Christoph R. aut Schmidt, Bernhard aut Wintersperger, Bernd J. aut Reiser, Maximilian F. aut Nikolaou, Konstantin aut Enthalten in European radiology Berlin : Springer, 1991 20(2010), 5 vom: 24. März, Seite 1168-1173 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173 https://dx.doi.org/10.1007/s00330-010-1715-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 20 2010 5 24 03 1168-1173
language	English
source	Enthalten in European radiology 20(2010), 5 vom: 24. März, Seite 1168-1173 volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173
sourceStr	Enthalten in European radiology 20(2010), 5 vom: 24. März, Seite 1168-1173 volume:20 year:2010 number:5 day:24 month:03 pages:1168-1173
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cardiac CT Coronary artery disease Myocardial perfusion imaging Coronary stenosis
isfreeaccess_bool	false
container_title	European radiology
authorswithroles_txt_mv	Bamberg, Fabian @@aut@@ Klotz, Ernst @@aut@@ Flohr, Thomas @@aut@@ Becker, Alexander @@aut@@ Becker, Christoph R. @@aut@@ Schmidt, Bernhard @@aut@@ Wintersperger, Bernd J. @@aut@@ Reiser, Maximilian F. @@aut@@ Nikolaou, Konstantin @@aut@@
publishDateDaySort_date	2010-03-24T00:00:00Z
hierarchy_top_id	268757526
id	SPR003998487
language_de	englisch
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author	Bamberg, Fabian
spellingShingle	Bamberg, Fabian misc Cardiac CT misc Coronary artery disease misc Myocardial perfusion imaging misc Coronary stenosis Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
authorStr	Bamberg, Fabian
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topic_title	Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience Cardiac CT (dpeaa)DE-He213 Coronary artery disease (dpeaa)DE-He213 Myocardial perfusion imaging (dpeaa)DE-He213 Coronary stenosis (dpeaa)DE-He213
topic	misc Cardiac CT misc Coronary artery disease misc Myocardial perfusion imaging misc Coronary stenosis
topic_unstemmed	misc Cardiac CT misc Coronary artery disease misc Myocardial perfusion imaging misc Coronary stenosis
topic_browse	misc Cardiac CT misc Coronary artery disease misc Myocardial perfusion imaging misc Coronary stenosis
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title	Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
ctrlnum	(DE-627)SPR003998487 (SPR)s00330-010-1715-9-e
title_full	Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
author_sort	Bamberg, Fabian
journal	European radiology
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author_browse	Bamberg, Fabian Klotz, Ernst Flohr, Thomas Becker, Alexander Becker, Christoph R. Schmidt, Bernhard Wintersperger, Bernd J. Reiser, Maximilian F. Nikolaou, Konstantin
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author-letter	Bamberg, Fabian
doi_str_mv	10.1007/s00330-010-1715-9
title_sort	dynamic myocardial stress perfusion imaging using fast dual-source ct with alternating table positions: initial experience
title_auth	Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
abstract	Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. © European Society of Radiology 2010
abstractGer	Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. © European Society of Radiology 2010
abstract_unstemmed	Objective To detail the principles of using model-based determination of regional myocardial blood flow (MBF) by computed tomography (CT) and demonstrate its in vivo applicability. Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. If confirmed in feasibility studies, cardiac CT may allow for parallel assessment of morphology and haemodynamic relevance of coronary artery disease. © European Society of Radiology 2010
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title_short	Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience
url	https://dx.doi.org/10.1007/s00330-010-1715-9
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author2	Klotz, Ernst Flohr, Thomas Becker, Alexander Becker, Christoph R. Schmidt, Bernhard Wintersperger, Bernd J. Reiser, Maximilian F. Nikolaou, Konstantin
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up_date	2024-07-03T23:01:00.686Z
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Methods Dual-source CT was performed with a dynamic protocol comprising acquisition with alternating table positions in ECG-triggered end-systolic timing every second for 30 s. The results of two reconstructions were merged into one final image stack (coverage 73 mm), with low spatial frequency components from a 360° reconstruction and high spatial frequency components from a dual-source cardiac partial image reconstruction. A parametric deconvolution technique was used to fit the time–attenuation curves (TAC), the maximum slope of which was used to derive MBF. Results One study participant underwent dynamic myocardial stress perfusion imaging (9.6 mSv) followed by invasive coronary angiography and measurement of fractional flow reserve as the gold standard. MBF was 159 ml/100 ml/min in the non-ischaemic anterolateral and 86 ml/100 ml/min in the inferoseptal ischaemic wall. Conclusion This first evaluation indicates that mathematical modelling of voxel TACs can potentially be used to quantify differences in MBF in a clinical setting. 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Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial experience

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