Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study
Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Czyżewski, Krzysztof [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Annals of hematology - Berlin : Springer, 1955, 98(2019), 9 vom: 18. Juli, Seite 2197-2211 |
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| Übergeordnetes Werk: |
volume:98 ; year:2019 ; number:9 ; day:18 ; month:07 ; pages:2197-2211 |
| Links: |
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| DOI / URN: |
10.1007/s00277-019-03755-2 |
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| Katalog-ID: |
SPR004013247 |
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| 100 | 1 | |a Czyżewski, Krzysztof |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © The Author(s) 2019 | ||
| 520 | |a Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. | ||
| 650 | 4 | |a Hematopoietic cell transplantation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Children |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adults |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incidence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Outcome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bacterial infections |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Viral infections |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Invasive fungal disease |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Styczyński, Jan |0 (orcid)0000-0002-3158-119X |4 aut | |
| 700 | 1 | |a Giebel, Sebastian |4 aut | |
| 700 | 1 | |a Frączkiewicz, Jowita |4 aut | |
| 700 | 1 | |a Salamonowicz, Małgorzata |4 aut | |
| 700 | 1 | |a Zając-Spychala, Olga |4 aut | |
| 700 | 1 | |a Zaucha-Prażmo, Agnieszka |4 aut | |
| 700 | 1 | |a Drozd-Sokołowska, Joanna |4 aut | |
| 700 | 1 | |a Waszczuk-Gajda, Anna |4 aut | |
| 700 | 1 | |a Dybko, Jarosław |4 aut | |
| 700 | 1 | |a Mańko, Joanna |4 aut | |
| 700 | 1 | |a Zalas-Więcek, Patrycja |4 aut | |
| 700 | 1 | |a Gałązka, Przemysław |4 aut | |
| 700 | 1 | |a Wysocki, Mariusz |4 aut | |
| 700 | 1 | |a Kowalczyk, Jerzy |4 aut | |
| 700 | 1 | |a Wachowiak, Jacek |4 aut | |
| 700 | 1 | |a Goździk, Jolanta |4 aut | |
| 700 | 1 | |a Basak, Grzegorz W |4 aut | |
| 700 | 1 | |a Kałwak, Krzysztof |4 aut | |
| 700 | 1 | |a Adamska, Monika |4 aut | |
| 700 | 1 | |a Hus, Marek |4 aut | |
| 700 | 1 | |a Piekarska, Agnieszka |4 aut | |
| 700 | 1 | |a Sadowska-Klasa, Alicja |4 aut | |
| 700 | 1 | |a Mensah-Glanowska, Patrycja |4 aut | |
| 700 | 1 | |a Kyrcz-Krzemień, Sławomira |4 aut | |
| 700 | 1 | |a Biernat, Monika |4 aut | |
| 700 | 1 | |a Wierzbowska, Agnieszka |4 aut | |
| 700 | 1 | |a Rzepecki, Piotr |4 aut | |
| 700 | 1 | |a Tomaszewska, Agnieszka |4 aut | |
| 700 | 1 | |a Hałaburda, Kazimierz |4 aut | |
| 700 | 1 | |a Gil, Lidia |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of hematology |d Berlin : Springer, 1955 |g 98(2019), 9 vom: 18. Juli, Seite 2197-2211 |w (DE-627)253389852 |w (DE-600)1458429-3 |x 1432-0584 |7 nnns |
| 773 | 1 | 8 | |g volume:98 |g year:2019 |g number:9 |g day:18 |g month:07 |g pages:2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
| allfields_unstemmed |
10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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Enthalten in Annals of hematology 98(2019), 9 vom: 18. Juli, Seite 2197-2211 volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 |
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Hematopoietic cell transplantation Children Adults Incidence Outcome Bacterial infections Viral infections Invasive fungal disease |
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Czyżewski, Krzysztof @@aut@@ Styczyński, Jan @@aut@@ Giebel, Sebastian @@aut@@ Frączkiewicz, Jowita @@aut@@ Salamonowicz, Małgorzata @@aut@@ Zając-Spychala, Olga @@aut@@ Zaucha-Prażmo, Agnieszka @@aut@@ Drozd-Sokołowska, Joanna @@aut@@ Waszczuk-Gajda, Anna @@aut@@ Dybko, Jarosław @@aut@@ Mańko, Joanna @@aut@@ Zalas-Więcek, Patrycja @@aut@@ Gałązka, Przemysław @@aut@@ Wysocki, Mariusz @@aut@@ Kowalczyk, Jerzy @@aut@@ Wachowiak, Jacek @@aut@@ Goździk, Jolanta @@aut@@ Basak, Grzegorz W @@aut@@ Kałwak, Krzysztof @@aut@@ Adamska, Monika @@aut@@ Hus, Marek @@aut@@ Piekarska, Agnieszka @@aut@@ Sadowska-Klasa, Alicja @@aut@@ Mensah-Glanowska, Patrycja @@aut@@ Kyrcz-Krzemień, Sławomira @@aut@@ Biernat, Monika @@aut@@ Wierzbowska, Agnieszka @@aut@@ Rzepecki, Piotr @@aut@@ Tomaszewska, Agnieszka @@aut@@ Hałaburda, Kazimierz @@aut@@ Gil, Lidia @@aut@@ |
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Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. 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|
| author |
Czyżewski, Krzysztof |
| spellingShingle |
Czyżewski, Krzysztof misc Hematopoietic cell transplantation misc Children misc Adults misc Incidence misc Outcome misc Bacterial infections misc Viral infections misc Invasive fungal disease Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Czyżewski, Krzysztof |
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electronic Article |
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springer |
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true |
| illustrated |
Not Illustrated |
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1432-0584 |
| topic_title |
Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 |
| topic |
misc Hematopoietic cell transplantation misc Children misc Adults misc Incidence misc Outcome misc Bacterial infections misc Viral infections misc Invasive fungal disease |
| topic_unstemmed |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Czyżewski, Krzysztof Styczyński, Jan Giebel, Sebastian Frączkiewicz, Jowita Salamonowicz, Małgorzata Zając-Spychala, Olga Zaucha-Prażmo, Agnieszka Drozd-Sokołowska, Joanna Waszczuk-Gajda, Anna Dybko, Jarosław Mańko, Joanna Zalas-Więcek, Patrycja Gałązka, Przemysław Wysocki, Mariusz Kowalczyk, Jerzy Wachowiak, Jacek Goździk, Jolanta Basak, Grzegorz W Kałwak, Krzysztof Adamska, Monika Hus, Marek Piekarska, Agnieszka Sadowska-Klasa, Alicja Mensah-Glanowska, Patrycja Kyrcz-Krzemień, Sławomira Biernat, Monika Wierzbowska, Agnieszka Rzepecki, Piotr Tomaszewska, Agnieszka Hałaburda, Kazimierz Gil, Lidia |
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age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
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Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
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Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
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