Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study
Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections...
Ausführliche Beschreibung
Autor*in: |
Czyżewski, Krzysztof [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2019 |
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Übergeordnetes Werk: |
Enthalten in: Annals of hematology - Berlin : Springer, 1955, 98(2019), 9 vom: 18. Juli, Seite 2197-2211 |
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Übergeordnetes Werk: |
volume:98 ; year:2019 ; number:9 ; day:18 ; month:07 ; pages:2197-2211 |
Links: |
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DOI / URN: |
10.1007/s00277-019-03755-2 |
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Katalog-ID: |
SPR004013247 |
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100 | 1 | |a Czyżewski, Krzysztof |e verfasserin |4 aut | |
245 | 1 | 0 | |a Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
264 | 1 | |c 2019 | |
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500 | |a © The Author(s) 2019 | ||
520 | |a Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. | ||
650 | 4 | |a Hematopoietic cell transplantation |7 (dpeaa)DE-He213 | |
650 | 4 | |a Children |7 (dpeaa)DE-He213 | |
650 | 4 | |a Adults |7 (dpeaa)DE-He213 | |
650 | 4 | |a Incidence |7 (dpeaa)DE-He213 | |
650 | 4 | |a Outcome |7 (dpeaa)DE-He213 | |
650 | 4 | |a Bacterial infections |7 (dpeaa)DE-He213 | |
650 | 4 | |a Viral infections |7 (dpeaa)DE-He213 | |
650 | 4 | |a Invasive fungal disease |7 (dpeaa)DE-He213 | |
700 | 1 | |a Styczyński, Jan |0 (orcid)0000-0002-3158-119X |4 aut | |
700 | 1 | |a Giebel, Sebastian |4 aut | |
700 | 1 | |a Frączkiewicz, Jowita |4 aut | |
700 | 1 | |a Salamonowicz, Małgorzata |4 aut | |
700 | 1 | |a Zając-Spychala, Olga |4 aut | |
700 | 1 | |a Zaucha-Prażmo, Agnieszka |4 aut | |
700 | 1 | |a Drozd-Sokołowska, Joanna |4 aut | |
700 | 1 | |a Waszczuk-Gajda, Anna |4 aut | |
700 | 1 | |a Dybko, Jarosław |4 aut | |
700 | 1 | |a Mańko, Joanna |4 aut | |
700 | 1 | |a Zalas-Więcek, Patrycja |4 aut | |
700 | 1 | |a Gałązka, Przemysław |4 aut | |
700 | 1 | |a Wysocki, Mariusz |4 aut | |
700 | 1 | |a Kowalczyk, Jerzy |4 aut | |
700 | 1 | |a Wachowiak, Jacek |4 aut | |
700 | 1 | |a Goździk, Jolanta |4 aut | |
700 | 1 | |a Basak, Grzegorz W |4 aut | |
700 | 1 | |a Kałwak, Krzysztof |4 aut | |
700 | 1 | |a Adamska, Monika |4 aut | |
700 | 1 | |a Hus, Marek |4 aut | |
700 | 1 | |a Piekarska, Agnieszka |4 aut | |
700 | 1 | |a Sadowska-Klasa, Alicja |4 aut | |
700 | 1 | |a Mensah-Glanowska, Patrycja |4 aut | |
700 | 1 | |a Kyrcz-Krzemień, Sławomira |4 aut | |
700 | 1 | |a Biernat, Monika |4 aut | |
700 | 1 | |a Wierzbowska, Agnieszka |4 aut | |
700 | 1 | |a Rzepecki, Piotr |4 aut | |
700 | 1 | |a Tomaszewska, Agnieszka |4 aut | |
700 | 1 | |a Hałaburda, Kazimierz |4 aut | |
700 | 1 | |a Gil, Lidia |4 aut | |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
allfields_unstemmed |
10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
allfieldsGer |
10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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10.1007/s00277-019-03755-2 doi (DE-627)SPR004013247 (SPR)s00277-019-03755-2-e DE-627 ger DE-627 rakwb eng Czyżewski, Krzysztof verfasserin aut Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2019 Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 Styczyński, Jan (orcid)0000-0002-3158-119X aut Giebel, Sebastian aut Frączkiewicz, Jowita aut Salamonowicz, Małgorzata aut Zając-Spychala, Olga aut Zaucha-Prażmo, Agnieszka aut Drozd-Sokołowska, Joanna aut Waszczuk-Gajda, Anna aut Dybko, Jarosław aut Mańko, Joanna aut Zalas-Więcek, Patrycja aut Gałązka, Przemysław aut Wysocki, Mariusz aut Kowalczyk, Jerzy aut Wachowiak, Jacek aut Goździk, Jolanta aut Basak, Grzegorz W aut Kałwak, Krzysztof aut Adamska, Monika aut Hus, Marek aut Piekarska, Agnieszka aut Sadowska-Klasa, Alicja aut Mensah-Glanowska, Patrycja aut Kyrcz-Krzemień, Sławomira aut Biernat, Monika aut Wierzbowska, Agnieszka aut Rzepecki, Piotr aut Tomaszewska, Agnieszka aut Hałaburda, Kazimierz aut Gil, Lidia aut Enthalten in Annals of hematology Berlin : Springer, 1955 98(2019), 9 vom: 18. Juli, Seite 2197-2211 (DE-627)253389852 (DE-600)1458429-3 1432-0584 nnns volume:98 year:2019 number:9 day:18 month:07 pages:2197-2211 https://dx.doi.org/10.1007/s00277-019-03755-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 98 2019 9 18 07 2197-2211 |
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Czyżewski, Krzysztof @@aut@@ Styczyński, Jan @@aut@@ Giebel, Sebastian @@aut@@ Frączkiewicz, Jowita @@aut@@ Salamonowicz, Małgorzata @@aut@@ Zając-Spychala, Olga @@aut@@ Zaucha-Prażmo, Agnieszka @@aut@@ Drozd-Sokołowska, Joanna @@aut@@ Waszczuk-Gajda, Anna @@aut@@ Dybko, Jarosław @@aut@@ Mańko, Joanna @@aut@@ Zalas-Więcek, Patrycja @@aut@@ Gałązka, Przemysław @@aut@@ Wysocki, Mariusz @@aut@@ Kowalczyk, Jerzy @@aut@@ Wachowiak, Jacek @@aut@@ Goździk, Jolanta @@aut@@ Basak, Grzegorz W @@aut@@ Kałwak, Krzysztof @@aut@@ Adamska, Monika @@aut@@ Hus, Marek @@aut@@ Piekarska, Agnieszka @@aut@@ Sadowska-Klasa, Alicja @@aut@@ Mensah-Glanowska, Patrycja @@aut@@ Kyrcz-Krzemień, Sławomira @@aut@@ Biernat, Monika @@aut@@ Wierzbowska, Agnieszka @@aut@@ Rzepecki, Piotr @@aut@@ Tomaszewska, Agnieszka @@aut@@ Hałaburda, Kazimierz @@aut@@ Gil, Lidia @@aut@@ |
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Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. 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|
author |
Czyżewski, Krzysztof |
spellingShingle |
Czyżewski, Krzysztof misc Hematopoietic cell transplantation misc Children misc Adults misc Incidence misc Outcome misc Bacterial infections misc Viral infections misc Invasive fungal disease Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
authorStr |
Czyżewski, Krzysztof |
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@@773@@(DE-627)253389852 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
collection |
springer |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1432-0584 |
topic_title |
Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study Hematopoietic cell transplantation (dpeaa)DE-He213 Children (dpeaa)DE-He213 Adults (dpeaa)DE-He213 Incidence (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Bacterial infections (dpeaa)DE-He213 Viral infections (dpeaa)DE-He213 Invasive fungal disease (dpeaa)DE-He213 |
topic |
misc Hematopoietic cell transplantation misc Children misc Adults misc Incidence misc Outcome misc Bacterial infections misc Viral infections misc Invasive fungal disease |
topic_unstemmed |
misc Hematopoietic cell transplantation misc Children misc Adults misc Incidence misc Outcome misc Bacterial infections misc Viral infections misc Invasive fungal disease |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Czyżewski, Krzysztof Styczyński, Jan Giebel, Sebastian Frączkiewicz, Jowita Salamonowicz, Małgorzata Zając-Spychala, Olga Zaucha-Prażmo, Agnieszka Drozd-Sokołowska, Joanna Waszczuk-Gajda, Anna Dybko, Jarosław Mańko, Joanna Zalas-Więcek, Patrycja Gałązka, Przemysław Wysocki, Mariusz Kowalczyk, Jerzy Wachowiak, Jacek Goździk, Jolanta Basak, Grzegorz W Kałwak, Krzysztof Adamska, Monika Hus, Marek Piekarska, Agnieszka Sadowska-Klasa, Alicja Mensah-Glanowska, Patrycja Kyrcz-Krzemień, Sławomira Biernat, Monika Wierzbowska, Agnieszka Rzepecki, Piotr Tomaszewska, Agnieszka Hałaburda, Kazimierz Gil, Lidia |
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age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
abstract |
Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
abstractGer |
Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
abstract_unstemmed |
Abstract Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. © The Author(s) 2019 |
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Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation: lesson from the nationwide study |
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