Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease
Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration ra...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Spithoven, E. M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2015 |
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| Übergeordnetes Werk: |
Enthalten in: European radiology - Berlin : Springer, 1991, 26(2015), 3 vom: 11. Juli, Seite 683-692 |
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| Übergeordnetes Werk: |
volume:26 ; year:2015 ; number:3 ; day:11 ; month:07 ; pages:683-692 |
| Links: |
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| DOI / URN: |
10.1007/s00330-015-3877-y |
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| Katalog-ID: |
SPR004023307 |
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| 100 | 1 | |a Spithoven, E. M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease |
| 264 | 1 | |c 2015 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 500 | |a © The Author(s) 2015 | ||
| 520 | |a Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. | ||
| 650 | 4 | |a Renal blood flow measurement |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phase-contrast MRI |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hippuran |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ADPKD |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phantom |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Meijer, E. |4 aut | |
| 700 | 1 | |a Borns, C. |4 aut | |
| 700 | 1 | |a Boertien, W. E. |4 aut | |
| 700 | 1 | |a Gaillard, C. A. J. M. |4 aut | |
| 700 | 1 | |a Kappert, P. |4 aut | |
| 700 | 1 | |a Greuter, M. J. W. |4 aut | |
| 700 | 1 | |a van der Jagt, E. |4 aut | |
| 700 | 1 | |a Vart, P. |4 aut | |
| 700 | 1 | |a de Jong, P. E. |4 aut | |
| 700 | 1 | |a Gansevoort, R. T. |4 aut | |
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| 773 | 1 | 8 | |g volume:26 |g year:2015 |g number:3 |g day:11 |g month:07 |g pages:683-692 |
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10.1007/s00330-015-3877-y doi (DE-627)SPR004023307 (SPR)s00330-015-3877-y-e DE-627 ger DE-627 rakwb eng Spithoven, E. M. verfasserin aut Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2015 Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 Meijer, E. aut Borns, C. aut Boertien, W. E. aut Gaillard, C. A. J. M. aut Kappert, P. aut Greuter, M. J. W. aut van der Jagt, E. aut Vart, P. aut de Jong, P. E. aut Gansevoort, R. T. aut Enthalten in European radiology Berlin : Springer, 1991 26(2015), 3 vom: 11. Juli, Seite 683-692 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:26 year:2015 number:3 day:11 month:07 pages:683-692 https://dx.doi.org/10.1007/s00330-015-3877-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2015 3 11 07 683-692 |
| spelling |
10.1007/s00330-015-3877-y doi (DE-627)SPR004023307 (SPR)s00330-015-3877-y-e DE-627 ger DE-627 rakwb eng Spithoven, E. M. verfasserin aut Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2015 Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 Meijer, E. aut Borns, C. aut Boertien, W. E. aut Gaillard, C. A. J. M. aut Kappert, P. aut Greuter, M. J. W. aut van der Jagt, E. aut Vart, P. aut de Jong, P. E. aut Gansevoort, R. T. aut Enthalten in European radiology Berlin : Springer, 1991 26(2015), 3 vom: 11. Juli, Seite 683-692 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:26 year:2015 number:3 day:11 month:07 pages:683-692 https://dx.doi.org/10.1007/s00330-015-3877-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2015 3 11 07 683-692 |
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10.1007/s00330-015-3877-y doi (DE-627)SPR004023307 (SPR)s00330-015-3877-y-e DE-627 ger DE-627 rakwb eng Spithoven, E. M. verfasserin aut Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2015 Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 Meijer, E. aut Borns, C. aut Boertien, W. E. aut Gaillard, C. A. J. M. aut Kappert, P. aut Greuter, M. J. W. aut van der Jagt, E. aut Vart, P. aut de Jong, P. E. aut Gansevoort, R. T. aut Enthalten in European radiology Berlin : Springer, 1991 26(2015), 3 vom: 11. Juli, Seite 683-692 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:26 year:2015 number:3 day:11 month:07 pages:683-692 https://dx.doi.org/10.1007/s00330-015-3877-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2015 3 11 07 683-692 |
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10.1007/s00330-015-3877-y doi (DE-627)SPR004023307 (SPR)s00330-015-3877-y-e DE-627 ger DE-627 rakwb eng Spithoven, E. M. verfasserin aut Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2015 Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 Meijer, E. aut Borns, C. aut Boertien, W. E. aut Gaillard, C. A. J. M. aut Kappert, P. aut Greuter, M. J. W. aut van der Jagt, E. aut Vart, P. aut de Jong, P. E. aut Gansevoort, R. T. aut Enthalten in European radiology Berlin : Springer, 1991 26(2015), 3 vom: 11. Juli, Seite 683-692 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:26 year:2015 number:3 day:11 month:07 pages:683-692 https://dx.doi.org/10.1007/s00330-015-3877-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2015 3 11 07 683-692 |
| allfieldsSound |
10.1007/s00330-015-3877-y doi (DE-627)SPR004023307 (SPR)s00330-015-3877-y-e DE-627 ger DE-627 rakwb eng Spithoven, E. M. verfasserin aut Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2015 Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 Meijer, E. aut Borns, C. aut Boertien, W. E. aut Gaillard, C. A. J. M. aut Kappert, P. aut Greuter, M. J. W. aut van der Jagt, E. aut Vart, P. aut de Jong, P. E. aut Gansevoort, R. T. aut Enthalten in European radiology Berlin : Springer, 1991 26(2015), 3 vom: 11. Juli, Seite 683-692 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:26 year:2015 number:3 day:11 month:07 pages:683-692 https://dx.doi.org/10.1007/s00330-015-3877-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 26 2015 3 11 07 683-692 |
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Enthalten in European radiology 26(2015), 3 vom: 11. Juli, Seite 683-692 volume:26 year:2015 number:3 day:11 month:07 pages:683-692 |
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Enthalten in European radiology 26(2015), 3 vom: 11. Juli, Seite 683-692 volume:26 year:2015 number:3 day:11 month:07 pages:683-692 |
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Renal blood flow measurement Phase-contrast MRI Hippuran ADPKD Phantom |
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Spithoven, E. M. @@aut@@ Meijer, E. @@aut@@ Borns, C. @@aut@@ Boertien, W. E. @@aut@@ Gaillard, C. A. J. M. @@aut@@ Kappert, P. @@aut@@ Greuter, M. J. W. @@aut@@ van der Jagt, E. @@aut@@ Vart, P. @@aut@@ de Jong, P. E. @@aut@@ Gansevoort, R. T. @@aut@@ |
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M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Renal blood flow measurement</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phase-contrast MRI</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hippuran</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ADPKD</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phantom</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Meijer, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Borns, C.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Boertien, W. 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Spithoven, E. M. |
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Spithoven, E. M. misc Renal blood flow measurement misc Phase-contrast MRI misc Hippuran misc ADPKD misc Phantom Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease |
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Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease Renal blood flow measurement (dpeaa)DE-He213 Phase-contrast MRI (dpeaa)DE-He213 Hippuran (dpeaa)DE-He213 ADPKD (dpeaa)DE-He213 Phantom (dpeaa)DE-He213 |
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Spithoven, E. M. Meijer, E. Borns, C. Boertien, W. E. Gaillard, C. A. J. M. Kappert, P. Greuter, M. J. W. van der Jagt, E. Vart, P. de Jong, P. E. Gansevoort, R. T. |
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Elektronische Aufsätze |
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Spithoven, E. M. |
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10.1007/s00330-015-3877-y |
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feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease |
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Feasibility of measuring renal blood flow by phase-contrast magnetic resonance imaging in patients with autosomal dominant polycystic kidney disease |
| abstract |
Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. © The Author(s) 2015 |
| abstractGer |
Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. © The Author(s) 2015 |
| abstract_unstemmed |
Objectives Renal blood flow (RBF) has been shown to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). We investigated the feasibility and accuracy of phase-contrast RBF by MRI ($ RBF_{MRI} $) in ADPKD patients with a wide range of estimated glomerular filtration rate (eGFR) values. Methods First, we validated $ RBF_{MRI} $ measurement using phantoms simulating renal artery hemodynamics. Thereafter, we investigated in a test-set of 21 patients intra- and inter-observer coefficient of variation of $ RBF_{MRI} $. After validation, we measured $ RBF_{MRI} $ in a cohort of 91 patients and compared the variability explained by characteristics indicative for disease severity for $ RBF_{MRI} $ and RBF measured by continuous hippuran infusion. Results The correlation in flow measurement using phantoms by phase-contrast MRI was high and fluid collection was high (CCC=0.969). Technical problems that precluded $ RBF_{MRI} $ measurement occurred predominantly in patients with a lower eGFR (34% vs. 16%). In subjects with higher eGFRs, variability in RBF explained by disease characteristics was similar for $ RBF_{MRI} $ compared to $ RBF_{Hip,} $ whereas in subjects with lower eGFRs, this was significantly less for $ RBF_{MRI} $. Conclusions Our study shows that RBF can be measured accurately in ADPKD patients by phase-contrast, but this technique may be less feasible in subjects with a lower eGFR. Key points • Renal blood flow (RBF) can be accurately measured by phase-contrast MRI in ADPKD patients. • RBF measured by phase-contrast is associated with ADPKD disease severity. • RBF measurement by phase-contrast MRI may be less feasible in patients with an impaired eGFR. © The Author(s) 2015 |
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| score |
7.400731 |