Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits
Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ohno, Tamio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2012 |
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| Schlagwörter: |
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| Anmerkung: |
© Springer Science+Business Media New York 2012 |
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| Übergeordnetes Werk: |
Enthalten in: Mammalian genome - New York, NY : Springer, 1991, 23(2012), 11-12 vom: 10. Okt., Seite 764-769 |
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| Übergeordnetes Werk: |
volume:23 ; year:2012 ; number:11-12 ; day:10 ; month:10 ; pages:764-769 |
| Links: |
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| DOI / URN: |
10.1007/s00335-012-9435-x |
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| Katalog-ID: |
SPR004421531 |
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| 245 | 1 | 0 | |a Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
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| 520 | |a Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. | ||
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| 650 | 4 | |a Recombinant Inbred Strain |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Baba, Taisuke |4 aut | |
| 700 | 1 | |a Io, Fusayo |4 aut | |
| 700 | 1 | |a Kobayashi, Misato |4 aut | |
| 700 | 1 | |a Horio, Fumihiko |4 aut | |
| 700 | 1 | |a Nishimura, Masahiko |4 aut | |
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10.1007/s00335-012-9435-x doi (DE-627)SPR004421531 (SPR)s00335-012-9435-x-e DE-627 ger DE-627 rakwb eng Ohno, Tamio verfasserin aut Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2012 Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 Hata, Keiko aut Baba, Taisuke aut Io, Fusayo aut Kobayashi, Misato aut Horio, Fumihiko aut Nishimura, Masahiko aut Enthalten in Mammalian genome New York, NY : Springer, 1991 23(2012), 11-12 vom: 10. Okt., Seite 764-769 (DE-627)253770513 (DE-600)1459397-X 1432-1777 nnns volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 https://dx.doi.org/10.1007/s00335-012-9435-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 23 2012 11-12 10 10 764-769 |
| spelling |
10.1007/s00335-012-9435-x doi (DE-627)SPR004421531 (SPR)s00335-012-9435-x-e DE-627 ger DE-627 rakwb eng Ohno, Tamio verfasserin aut Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2012 Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 Hata, Keiko aut Baba, Taisuke aut Io, Fusayo aut Kobayashi, Misato aut Horio, Fumihiko aut Nishimura, Masahiko aut Enthalten in Mammalian genome New York, NY : Springer, 1991 23(2012), 11-12 vom: 10. Okt., Seite 764-769 (DE-627)253770513 (DE-600)1459397-X 1432-1777 nnns volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 https://dx.doi.org/10.1007/s00335-012-9435-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 23 2012 11-12 10 10 764-769 |
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10.1007/s00335-012-9435-x doi (DE-627)SPR004421531 (SPR)s00335-012-9435-x-e DE-627 ger DE-627 rakwb eng Ohno, Tamio verfasserin aut Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2012 Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 Hata, Keiko aut Baba, Taisuke aut Io, Fusayo aut Kobayashi, Misato aut Horio, Fumihiko aut Nishimura, Masahiko aut Enthalten in Mammalian genome New York, NY : Springer, 1991 23(2012), 11-12 vom: 10. Okt., Seite 764-769 (DE-627)253770513 (DE-600)1459397-X 1432-1777 nnns volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 https://dx.doi.org/10.1007/s00335-012-9435-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 23 2012 11-12 10 10 764-769 |
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10.1007/s00335-012-9435-x doi (DE-627)SPR004421531 (SPR)s00335-012-9435-x-e DE-627 ger DE-627 rakwb eng Ohno, Tamio verfasserin aut Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2012 Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 Hata, Keiko aut Baba, Taisuke aut Io, Fusayo aut Kobayashi, Misato aut Horio, Fumihiko aut Nishimura, Masahiko aut Enthalten in Mammalian genome New York, NY : Springer, 1991 23(2012), 11-12 vom: 10. Okt., Seite 764-769 (DE-627)253770513 (DE-600)1459397-X 1432-1777 nnns volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 https://dx.doi.org/10.1007/s00335-012-9435-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 23 2012 11-12 10 10 764-769 |
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10.1007/s00335-012-9435-x doi (DE-627)SPR004421531 (SPR)s00335-012-9435-x-e DE-627 ger DE-627 rakwb eng Ohno, Tamio verfasserin aut Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer Science+Business Media New York 2012 Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 Hata, Keiko aut Baba, Taisuke aut Io, Fusayo aut Kobayashi, Misato aut Horio, Fumihiko aut Nishimura, Masahiko aut Enthalten in Mammalian genome New York, NY : Springer, 1991 23(2012), 11-12 vom: 10. Okt., Seite 764-769 (DE-627)253770513 (DE-600)1459397-X 1432-1777 nnns volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 https://dx.doi.org/10.1007/s00335-012-9435-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 23 2012 11-12 10 10 764-769 |
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English |
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Enthalten in Mammalian genome 23(2012), 11-12 vom: 10. Okt., Seite 764-769 volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 |
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Enthalten in Mammalian genome 23(2012), 11-12 vom: 10. Okt., Seite 764-769 volume:23 year:2012 number:11-12 day:10 month:10 pages:764-769 |
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Recombinant Inbred Congenic Strain Recombinant Inbred Strain Blood Lipid Level Chromosome Substitution Strain |
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Mammalian genome |
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Ohno, Tamio @@aut@@ Hata, Keiko @@aut@@ Baba, Taisuke @@aut@@ Io, Fusayo @@aut@@ Kobayashi, Misato @@aut@@ Horio, Fumihiko @@aut@@ Nishimura, Masahiko @@aut@@ |
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2012-10-10T00:00:00Z |
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In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. 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Ohno, Tamio |
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Ohno, Tamio misc Recombinant Inbred misc Congenic Strain misc Recombinant Inbred Strain misc Blood Lipid Level misc Chromosome Substitution Strain Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
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Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits Recombinant Inbred (dpeaa)DE-He213 Congenic Strain (dpeaa)DE-He213 Recombinant Inbred Strain (dpeaa)DE-He213 Blood Lipid Level (dpeaa)DE-He213 Chromosome Substitution Strain (dpeaa)DE-He213 |
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Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
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Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
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| title_sort |
establishment of consomic strains derived from a/j and sm/j mice for genetic analysis of complex traits |
| title_auth |
Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
| abstract |
Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. © Springer Science+Business Media New York 2012 |
| abstractGer |
Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. © Springer Science+Business Media New York 2012 |
| abstract_unstemmed |
Abstract Consomic strains, in which one chromosome is derived from a donor strain and the other chromosomes are derived from the recipient strain, provide a powerful tool for the dissection of complex genetic traits. In this study we established ten consomic strains (A-$ 2^{SM} $, A-$ 6^{SM} $, A-$ 11^{SM} $, A-$ 12^{SM} $, A-$ 13^{SM} $, A-$ 15^{SM} $, A-$ 17^{SM} $, A-$ 18^{SM} $, A-$ 19^{SM} $, A-$ Y^{SM} $) using the SM/J strain as the donor and the A/J strain as the recipient; these are the parental strains of a set of SMXA recombinant inbred (RI) strains that we had developed previously. We analyzed body weights and blood lipid levels in the consomic and parental strains. The mean values for each trait showed a continuous range of variation in the consomic strains suggesting that they are controlled by multiple genes. We previously identified suggestive QTLs for body weight on chromosome 6 in SMXA RI strains and (SM/J × A/J)$ F_{2} $ mice. The observation that the A-$ 6^{SM} $ consomic strain had a significantly lower mean body weight than the A/J strain supports the presence of this QTL on chromosome 6. Similarly, the higher blood triglyceride level in the A-$ 11^{SM} $ strain shows the existence of a previously mapped QTL on chromosome 11, and the A-$ 12^{SM} $ strain provides evidence of a QTL for blood total cholesterol level on chromosome 12. These consomic strains, along with the previously developed set of SMXA RI strains from A/J and SM/J mice, offer an invaluable and powerful resource for the analysis of complex genetic traits in mice. © Springer Science+Business Media New York 2012 |
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11-12 |
| title_short |
Establishment of consomic strains derived from A/J and SM/J mice for genetic analysis of complex traits |
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https://dx.doi.org/10.1007/s00335-012-9435-x |
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Hata, Keiko Baba, Taisuke Io, Fusayo Kobayashi, Misato Horio, Fumihiko Nishimura, Masahiko |
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2024-07-04T01:03:13.847Z |
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| score |
7.4010277 |