Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken
Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess...
Ausführliche Beschreibung
Autor*in: |
Alvine, Travis [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2013 |
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Schlagwörter: |
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Anmerkung: |
© Springer-Verlag Berlin Heidelberg 2013 |
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Übergeordnetes Werk: |
Enthalten in: Journal of comparative physiology - Berlin : Springer, 1984, 184(2013), 1 vom: 05. Sept., Seite 107-123 |
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Übergeordnetes Werk: |
volume:184 ; year:2013 ; number:1 ; day:05 ; month:09 ; pages:107-123 |
Links: |
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DOI / URN: |
10.1007/s00360-013-0777-9 |
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Katalog-ID: |
SPR00449007X |
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520 | |a Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. | ||
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650 | 4 | |a Retinoids |7 (dpeaa)DE-He213 | |
650 | 4 | |a Developmental patterns |7 (dpeaa)DE-He213 | |
700 | 1 | |a Burggren, Warren W. |4 aut | |
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10.1007/s00360-013-0777-9 doi (DE-627)SPR00449007X (SPR)s00360-013-0777-9-e DE-627 ger DE-627 rakwb eng Alvine, Travis verfasserin aut Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2013 Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 Burggren, Warren W. aut Enthalten in Journal of comparative physiology Berlin : Springer, 1984 184(2013), 1 vom: 05. Sept., Seite 107-123 (DE-627)25376968X (DE-600)1459302-6 1432-136X nnns volume:184 year:2013 number:1 day:05 month:09 pages:107-123 https://dx.doi.org/10.1007/s00360-013-0777-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 184 2013 1 05 09 107-123 |
spelling |
10.1007/s00360-013-0777-9 doi (DE-627)SPR00449007X (SPR)s00360-013-0777-9-e DE-627 ger DE-627 rakwb eng Alvine, Travis verfasserin aut Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2013 Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 Burggren, Warren W. aut Enthalten in Journal of comparative physiology Berlin : Springer, 1984 184(2013), 1 vom: 05. Sept., Seite 107-123 (DE-627)25376968X (DE-600)1459302-6 1432-136X nnns volume:184 year:2013 number:1 day:05 month:09 pages:107-123 https://dx.doi.org/10.1007/s00360-013-0777-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 184 2013 1 05 09 107-123 |
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10.1007/s00360-013-0777-9 doi (DE-627)SPR00449007X (SPR)s00360-013-0777-9-e DE-627 ger DE-627 rakwb eng Alvine, Travis verfasserin aut Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2013 Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 Burggren, Warren W. aut Enthalten in Journal of comparative physiology Berlin : Springer, 1984 184(2013), 1 vom: 05. Sept., Seite 107-123 (DE-627)25376968X (DE-600)1459302-6 1432-136X nnns volume:184 year:2013 number:1 day:05 month:09 pages:107-123 https://dx.doi.org/10.1007/s00360-013-0777-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 184 2013 1 05 09 107-123 |
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10.1007/s00360-013-0777-9 doi (DE-627)SPR00449007X (SPR)s00360-013-0777-9-e DE-627 ger DE-627 rakwb eng Alvine, Travis verfasserin aut Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2013 Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 Burggren, Warren W. aut Enthalten in Journal of comparative physiology Berlin : Springer, 1984 184(2013), 1 vom: 05. Sept., Seite 107-123 (DE-627)25376968X (DE-600)1459302-6 1432-136X nnns volume:184 year:2013 number:1 day:05 month:09 pages:107-123 https://dx.doi.org/10.1007/s00360-013-0777-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 184 2013 1 05 09 107-123 |
allfieldsSound |
10.1007/s00360-013-0777-9 doi (DE-627)SPR00449007X (SPR)s00360-013-0777-9-e DE-627 ger DE-627 rakwb eng Alvine, Travis verfasserin aut Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Springer-Verlag Berlin Heidelberg 2013 Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 Burggren, Warren W. aut Enthalten in Journal of comparative physiology Berlin : Springer, 1984 184(2013), 1 vom: 05. Sept., Seite 107-123 (DE-627)25376968X (DE-600)1459302-6 1432-136X nnns volume:184 year:2013 number:1 day:05 month:09 pages:107-123 https://dx.doi.org/10.1007/s00360-013-0777-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 184 2013 1 05 09 107-123 |
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Enthalten in Journal of comparative physiology 184(2013), 1 vom: 05. Sept., Seite 107-123 volume:184 year:2013 number:1 day:05 month:09 pages:107-123 |
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Enthalten in Journal of comparative physiology 184(2013), 1 vom: 05. Sept., Seite 107-123 volume:184 year:2013 number:1 day:05 month:09 pages:107-123 |
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Alvine, Travis @@aut@@ Burggren, Warren W. @@aut@@ |
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The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. 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Alvine, Travis |
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Alvine, Travis misc Chicken embryo misc Blood osmolality misc Retinoids misc Developmental patterns Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
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Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken Chicken embryo (dpeaa)DE-He213 Blood osmolality (dpeaa)DE-He213 Retinoids (dpeaa)DE-He213 Developmental patterns (dpeaa)DE-He213 |
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Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
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Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
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Journal of comparative physiology |
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renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
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Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
abstract |
Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. © Springer-Verlag Berlin Heidelberg 2013 |
abstractGer |
Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. © Springer-Verlag Berlin Heidelberg 2013 |
abstract_unstemmed |
Abstract All-trans-retinoic acid (tRA), an active metabolite of vitamin A, directly influences the developing kidney, and is a major regulatory signal during vertebrate organogenesis. The aim of the current study was to specifically target potential critical windows in renal development, and assess altered renal function through disruptions in embryonic fluid compartments. In addition, the effect of exogenous tRA administration on embryonic growth and metabolism was determined. Embryos were exposed to 0.1 or 0.3 mg tRA on embryonic day 8. Morphological and physiological measurements were made on days 12, 14, 16 and 18. Embryo wet mass on day 18 was reduced by 23 % (0.1 mg tRA) and 44 % (0.3 mg tRA). tRA exposure elevated mass-specific oxygen consumption in embryos exposed to 0.1 mg (21.2 ± 0.3 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) and 0.3 mg (23.4 ± 0.4 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) when compared to sham (18.9 ± 0.6 $ μL^{−1} $ $ g^{−1} $ $ min^{−1} $) on day 14, but not subsequent incubation days. Osmolality of blood plasma was transiently lowered in embryos exposed to 0.3 mg tRA between days 14 and 16. Allantoic fluid osmolality was significantly elevated by tRA to ~220 mmol $ L^{−1} $ from days 16 to 18 compared to controls. Blood plasma [$ Na^{+} $] was reduced by ~17 % over the same period, while allantoic fluid [$ Na^{+} $] was elevated in tRA-treated embryos compared to control embryos. Collectively, our data indicates that exogenous administration of tRA produces significant alterations to the developmental trajectory of the developing embryonic chicken. © Springer-Verlag Berlin Heidelberg 2013 |
collection_details |
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container_issue |
1 |
title_short |
Renal, metabolic and hematological effects of trans-retinoic acid during critical developmental windows in the embryonic chicken |
url |
https://dx.doi.org/10.1007/s00360-013-0777-9 |
remote_bool |
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author2 |
Burggren, Warren W. |
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doi_str |
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up_date |
2024-07-04T01:19:17.518Z |
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score |
7.4007626 |