Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris

Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. W...
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Autor*in:	Umemoto, Tomio [verfasserIn] Yasu, Takanori [verfasserIn] Arao, Kenshiro [verfasserIn] Ikeda, Nahoko [verfasserIn] Horie, Yasuto [verfasserIn] Sugimura, Hiroyuki [verfasserIn] Kawakami, Masanobu [verfasserIn] Fujita, Hideo [verfasserIn] Momomura, Shin-ichi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Angina pectoris Endothelial function Hemorheology Postprandial Statin

Übergeordnetes Werk:	Enthalten in: Heart and vessels - Tokyo : Springer, 1985, 32(2017), 9 vom: 10. Apr., Seite 1051-1061
Übergeordnetes Werk:	volume:32 ; year:2017 ; number:9 ; day:10 ; month:04 ; pages:1051-1061

Links:	Volltext

DOI / URN:	10.1007/s00380-017-0974-7

Katalog-ID:	SPR004564359

Internformat


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245	1	0	\|a Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
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520			\|a Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
650		4	\|a Angina pectoris \|7 (dpeaa)DE-He213
650		4	\|a Endothelial function \|7 (dpeaa)DE-He213
650		4	\|a Hemorheology \|7 (dpeaa)DE-He213
650		4	\|a Postprandial \|7 (dpeaa)DE-He213
650		4	\|a Statin \|7 (dpeaa)DE-He213
700	1		\|a Yasu, Takanori \|e verfasserin \|4 aut
700	1		\|a Arao, Kenshiro \|e verfasserin \|4 aut
700	1		\|a Ikeda, Nahoko \|e verfasserin \|4 aut
700	1		\|a Horie, Yasuto \|e verfasserin \|4 aut
700	1		\|a Sugimura, Hiroyuki \|e verfasserin \|4 aut
700	1		\|a Kawakami, Masanobu \|e verfasserin \|4 aut
700	1		\|a Fujita, Hideo \|e verfasserin \|4 aut
700	1		\|a Momomura, Shin-ichi \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Heart and vessels \|d Tokyo : Springer, 1985 \|g 32(2017), 9 vom: 10. Apr., Seite 1051-1061 \|w (DE-627)300183879 \|w (DE-600)1481441-9 \|x 1615-2573 \|7 nnns
773	1	8	\|g volume:32 \|g year:2017 \|g number:9 \|g day:10 \|g month:04 \|g pages:1051-1061
856	4	0	\|u https://dx.doi.org/10.1007/s00380-017-0974-7 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
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912			\|a GBV_ILN_285
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912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
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912			\|a GBV_ILN_2112
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912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
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952			\|d 32 \|j 2017 \|e 9 \|b 10 \|c 04 \|h 1051-1061

Indexfelder

author_variant	t u tu t y ty k a ka n i ni y h yh h s hs m k mk h f hf s i m sim
matchkey_str	article:16152573:2017----::rvsaiipoepspadaedteilyfntoadeohooiadtroainn
hierarchy_sort_str	2017
bklnumber	44.85
publishDate	2017
allfields	10.1007/s00380-017-0974-7 doi (DE-627)SPR004564359 (SPR)s00380-017-0974-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Umemoto, Tomio verfasserin aut Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients. Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213 Yasu, Takanori verfasserin aut Arao, Kenshiro verfasserin aut Ikeda, Nahoko verfasserin aut Horie, Yasuto verfasserin aut Sugimura, Hiroyuki verfasserin aut Kawakami, Masanobu verfasserin aut Fujita, Hideo verfasserin aut Momomura, Shin-ichi verfasserin aut Enthalten in Heart and vessels Tokyo : Springer, 1985 32(2017), 9 vom: 10. Apr., Seite 1051-1061 (DE-627)300183879 (DE-600)1481441-9 1615-2573 nnns volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061 https://dx.doi.org/10.1007/s00380-017-0974-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 32 2017 9 10 04 1051-1061
spelling	10.1007/s00380-017-0974-7 doi (DE-627)SPR004564359 (SPR)s00380-017-0974-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Umemoto, Tomio verfasserin aut Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients. Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213 Yasu, Takanori verfasserin aut Arao, Kenshiro verfasserin aut Ikeda, Nahoko verfasserin aut Horie, Yasuto verfasserin aut Sugimura, Hiroyuki verfasserin aut Kawakami, Masanobu verfasserin aut Fujita, Hideo verfasserin aut Momomura, Shin-ichi verfasserin aut Enthalten in Heart and vessels Tokyo : Springer, 1985 32(2017), 9 vom: 10. Apr., Seite 1051-1061 (DE-627)300183879 (DE-600)1481441-9 1615-2573 nnns volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061 https://dx.doi.org/10.1007/s00380-017-0974-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 32 2017 9 10 04 1051-1061
allfields_unstemmed	10.1007/s00380-017-0974-7 doi (DE-627)SPR004564359 (SPR)s00380-017-0974-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Umemoto, Tomio verfasserin aut Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients. Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213 Yasu, Takanori verfasserin aut Arao, Kenshiro verfasserin aut Ikeda, Nahoko verfasserin aut Horie, Yasuto verfasserin aut Sugimura, Hiroyuki verfasserin aut Kawakami, Masanobu verfasserin aut Fujita, Hideo verfasserin aut Momomura, Shin-ichi verfasserin aut Enthalten in Heart and vessels Tokyo : Springer, 1985 32(2017), 9 vom: 10. Apr., Seite 1051-1061 (DE-627)300183879 (DE-600)1481441-9 1615-2573 nnns volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061 https://dx.doi.org/10.1007/s00380-017-0974-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 32 2017 9 10 04 1051-1061
allfieldsGer	10.1007/s00380-017-0974-7 doi (DE-627)SPR004564359 (SPR)s00380-017-0974-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Umemoto, Tomio verfasserin aut Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients. Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213 Yasu, Takanori verfasserin aut Arao, Kenshiro verfasserin aut Ikeda, Nahoko verfasserin aut Horie, Yasuto verfasserin aut Sugimura, Hiroyuki verfasserin aut Kawakami, Masanobu verfasserin aut Fujita, Hideo verfasserin aut Momomura, Shin-ichi verfasserin aut Enthalten in Heart and vessels Tokyo : Springer, 1985 32(2017), 9 vom: 10. Apr., Seite 1051-1061 (DE-627)300183879 (DE-600)1481441-9 1615-2573 nnns volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061 https://dx.doi.org/10.1007/s00380-017-0974-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 32 2017 9 10 04 1051-1061
allfieldsSound	10.1007/s00380-017-0974-7 doi (DE-627)SPR004564359 (SPR)s00380-017-0974-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.85 bkl Umemoto, Tomio verfasserin aut Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients. Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213 Yasu, Takanori verfasserin aut Arao, Kenshiro verfasserin aut Ikeda, Nahoko verfasserin aut Horie, Yasuto verfasserin aut Sugimura, Hiroyuki verfasserin aut Kawakami, Masanobu verfasserin aut Fujita, Hideo verfasserin aut Momomura, Shin-ichi verfasserin aut Enthalten in Heart and vessels Tokyo : Springer, 1985 32(2017), 9 vom: 10. Apr., Seite 1051-1061 (DE-627)300183879 (DE-600)1481441-9 1615-2573 nnns volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061 https://dx.doi.org/10.1007/s00380-017-0974-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.85 ASE AR 32 2017 9 10 04 1051-1061
language	English
source	Enthalten in Heart and vessels 32(2017), 9 vom: 10. Apr., Seite 1051-1061 volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061
sourceStr	Enthalten in Heart and vessels 32(2017), 9 vom: 10. Apr., Seite 1051-1061 volume:32 year:2017 number:9 day:10 month:04 pages:1051-1061
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Angina pectoris Endothelial function Hemorheology Postprandial Statin
dewey-raw	610
isfreeaccess_bool	false
container_title	Heart and vessels
authorswithroles_txt_mv	Umemoto, Tomio @@aut@@ Yasu, Takanori @@aut@@ Arao, Kenshiro @@aut@@ Ikeda, Nahoko @@aut@@ Horie, Yasuto @@aut@@ Sugimura, Hiroyuki @@aut@@ Kawakami, Masanobu @@aut@@ Fujita, Hideo @@aut@@ Momomura, Shin-ichi @@aut@@
publishDateDaySort_date	2017-04-10T00:00:00Z
hierarchy_top_id	300183879
dewey-sort	3610
id	SPR004564359
language_de	englisch
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The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). 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author	Umemoto, Tomio
spellingShingle	Umemoto, Tomio ddc 610 bkl 44.85 misc Angina pectoris misc Endothelial function misc Hemorheology misc Postprandial misc Statin Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
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topic_title	610 ASE 44.85 bkl Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris Angina pectoris (dpeaa)DE-He213 Endothelial function (dpeaa)DE-He213 Hemorheology (dpeaa)DE-He213 Postprandial (dpeaa)DE-He213 Statin (dpeaa)DE-He213
topic	ddc 610 bkl 44.85 misc Angina pectoris misc Endothelial function misc Hemorheology misc Postprandial misc Statin
topic_unstemmed	ddc 610 bkl 44.85 misc Angina pectoris misc Endothelial function misc Hemorheology misc Postprandial misc Statin
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title	Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
ctrlnum	(DE-627)SPR004564359 (SPR)s00380-017-0974-7-e
title_full	Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
author_sort	Umemoto, Tomio
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author_browse	Umemoto, Tomio Yasu, Takanori Arao, Kenshiro Ikeda, Nahoko Horie, Yasuto Sugimura, Hiroyuki Kawakami, Masanobu Fujita, Hideo Momomura, Shin-ichi
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title_sort	pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
title_auth	Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
abstract	Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
abstractGer	Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
abstract_unstemmed	Abstract Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.
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container_issue	9
title_short	Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris
url	https://dx.doi.org/10.1007/s00380-017-0974-7
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author2	Yasu, Takanori Arao, Kenshiro Ikeda, Nahoko Horie, Yasuto Sugimura, Hiroyuki Kawakami, Masanobu Fujita, Hideo Momomura, Shin-ichi
author2Str	Yasu, Takanori Arao, Kenshiro Ikeda, Nahoko Horie, Yasuto Sugimura, Hiroyuki Kawakami, Masanobu Fujita, Hideo Momomura, Shin-ichi
ppnlink	300183879
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doi_str	10.1007/s00380-017-0974-7
up_date	2024-07-04T01:38:37.367Z
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Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris

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