Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease
Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Coelho, Maria Cecília M. [verfasserIn] Tannuri, Uenis [verfasserIn] Benditt, Israel [verfasserIn] Santos, Maria Merces [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Pediatric surgery international - Berlin : Springer, 1986, 24(2008), 9 vom: 30. Juli, Seite 1017-1021 |
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| Übergeordnetes Werk: |
volume:24 ; year:2008 ; number:9 ; day:30 ; month:07 ; pages:1017-1021 |
| Links: |
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| DOI / URN: |
10.1007/s00383-008-2207-8 |
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| Katalog-ID: |
SPR004709055 |
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| 245 | 1 | 0 | |a Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
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| 520 | |a Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. | ||
| 650 | 4 | |a Hirschsprung’s disesase |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aganglionosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Acetylcholinesterase histochemistry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a proto-oncogene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reverse transcription-polymerase chain reaction |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tannuri, Uenis |e verfasserin |4 aut | |
| 700 | 1 | |a Benditt, Israel |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Maria Merces |e verfasserin |4 aut | |
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10.1007/s00383-008-2207-8 doi (DE-627)SPR004709055 (SPR)s00383-008-2207-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Coelho, Maria Cecília M. verfasserin aut Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. Hirschsprung’s disesase (dpeaa)DE-He213 Aganglionosis (dpeaa)DE-He213 Acetylcholinesterase histochemistry (dpeaa)DE-He213 proto-oncogene (dpeaa)DE-He213 Reverse transcription-polymerase chain reaction (dpeaa)DE-He213 Tannuri, Uenis verfasserin aut Benditt, Israel verfasserin aut Santos, Maria Merces verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 24(2008), 9 vom: 30. Juli, Seite 1017-1021 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 https://dx.doi.org/10.1007/s00383-008-2207-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 24 2008 9 30 07 1017-1021 |
| spelling |
10.1007/s00383-008-2207-8 doi (DE-627)SPR004709055 (SPR)s00383-008-2207-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Coelho, Maria Cecília M. verfasserin aut Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. Hirschsprung’s disesase (dpeaa)DE-He213 Aganglionosis (dpeaa)DE-He213 Acetylcholinesterase histochemistry (dpeaa)DE-He213 proto-oncogene (dpeaa)DE-He213 Reverse transcription-polymerase chain reaction (dpeaa)DE-He213 Tannuri, Uenis verfasserin aut Benditt, Israel verfasserin aut Santos, Maria Merces verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 24(2008), 9 vom: 30. Juli, Seite 1017-1021 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 https://dx.doi.org/10.1007/s00383-008-2207-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 24 2008 9 30 07 1017-1021 |
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10.1007/s00383-008-2207-8 doi (DE-627)SPR004709055 (SPR)s00383-008-2207-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Coelho, Maria Cecília M. verfasserin aut Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. Hirschsprung’s disesase (dpeaa)DE-He213 Aganglionosis (dpeaa)DE-He213 Acetylcholinesterase histochemistry (dpeaa)DE-He213 proto-oncogene (dpeaa)DE-He213 Reverse transcription-polymerase chain reaction (dpeaa)DE-He213 Tannuri, Uenis verfasserin aut Benditt, Israel verfasserin aut Santos, Maria Merces verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 24(2008), 9 vom: 30. Juli, Seite 1017-1021 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 https://dx.doi.org/10.1007/s00383-008-2207-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 24 2008 9 30 07 1017-1021 |
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10.1007/s00383-008-2207-8 doi (DE-627)SPR004709055 (SPR)s00383-008-2207-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Coelho, Maria Cecília M. verfasserin aut Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. Hirschsprung’s disesase (dpeaa)DE-He213 Aganglionosis (dpeaa)DE-He213 Acetylcholinesterase histochemistry (dpeaa)DE-He213 proto-oncogene (dpeaa)DE-He213 Reverse transcription-polymerase chain reaction (dpeaa)DE-He213 Tannuri, Uenis verfasserin aut Benditt, Israel verfasserin aut Santos, Maria Merces verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 24(2008), 9 vom: 30. Juli, Seite 1017-1021 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 https://dx.doi.org/10.1007/s00383-008-2207-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 24 2008 9 30 07 1017-1021 |
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English |
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Enthalten in Pediatric surgery international 24(2008), 9 vom: 30. Juli, Seite 1017-1021 volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 |
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Enthalten in Pediatric surgery international 24(2008), 9 vom: 30. Juli, Seite 1017-1021 volume:24 year:2008 number:9 day:30 month:07 pages:1017-1021 |
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findex.gbv.de |
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Hirschsprung’s disesase Aganglionosis Acetylcholinesterase histochemistry proto-oncogene Reverse transcription-polymerase chain reaction |
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Pediatric surgery international |
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Coelho, Maria Cecília M. @@aut@@ Tannuri, Uenis @@aut@@ Benditt, Israel @@aut@@ Santos, Maria Merces @@aut@@ |
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2008-07-30T00:00:00Z |
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The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. 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| author |
Coelho, Maria Cecília M. |
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Coelho, Maria Cecília M. ddc 610 bkl 44.65 bkl 44.67 misc Hirschsprung’s disesase misc Aganglionosis misc Acetylcholinesterase histochemistry misc proto-oncogene misc Reverse transcription-polymerase chain reaction Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
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610 ASE 44.65 bkl 44.67 bkl Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease Hirschsprung’s disesase (dpeaa)DE-He213 Aganglionosis (dpeaa)DE-He213 Acetylcholinesterase histochemistry (dpeaa)DE-He213 proto-oncogene (dpeaa)DE-He213 Reverse transcription-polymerase chain reaction (dpeaa)DE-He213 |
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ddc 610 bkl 44.65 bkl 44.67 misc Hirschsprung’s disesase misc Aganglionosis misc Acetylcholinesterase histochemistry misc proto-oncogene misc Reverse transcription-polymerase chain reaction |
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ddc 610 bkl 44.65 bkl 44.67 misc Hirschsprung’s disesase misc Aganglionosis misc Acetylcholinesterase histochemistry misc proto-oncogene misc Reverse transcription-polymerase chain reaction |
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Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
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Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
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Coelho, Maria Cecília M. |
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studies of ret gene expression and acetylcholinesterase activity in a series of sporadic hirschsprung’s disease |
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Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
| abstract |
Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. |
| abstractGer |
Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. |
| abstract_unstemmed |
Abstract The purpose is to present the studies of RET gene expression and acetylcholinesterase activity in 23 patients operated for Hirschsprung’s disease (HD). The patients underwent either transanal endorectal pull-through or Duhamell’s procedure. Full-thickness intestinal samples from the three different segments (ganglionic, intermediate and aganglionic) were collected. Each tissue sample was divided in two portions, one for AChE histochemical staining and the other for examination of RET mRNA expression level. All patients had an uneventful postoperative recovery. In all patients, the AChE stainings demonstrated the absence of activity in the ganglionic area, the marked increase of positive fibers in the aganglionic area, and little increase of positive fibers in the intermediate area. In the ganglionic and intermediate areas, all patients (100%) showed significant RET gene expression. In the aganglionic area, 18 patients (78.3%) did not present gene expression and the other five patients (21.7%) presented gene expression that was similar to the ganglionic and intermediate areas. The results reinforce the conclusion that the method of AChE staining is effective for the diagnosis of intestinal aganglionosis and confirm the knowledge that genes beyond RET may be implicated in the genesis of sporadic cases of HD. |
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Studies of RET gene expression and acetylcholinesterase activity in a series of sporadic Hirschsprung’s disease |
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| score |
7.4016895 |