Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?

Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Taşkara, Ersoy [verfasserIn] Gör, Atilla [verfasserIn] Kutlu, Ömer [verfasserIn] Karagüzel, Ersagun [verfasserIn] Çobanoğlu, Ümit [verfasserIn] Topbaş, Murat [verfasserIn] Şenel, Ahmet Can [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Testis Reperfusion injury Propofol Rats

Übergeordnetes Werk:	Enthalten in: Pediatric surgery international - Berlin : Springer, 1986, 27(2011), 9 vom: 06. Apr., Seite 1003-1007
Übergeordnetes Werk:	volume:27 ; year:2011 ; number:9 ; day:06 ; month:04 ; pages:1003-1007

Links:	Volltext

DOI / URN:	10.1007/s00383-011-2895-3

Katalog-ID:	SPR004716388

Internformat


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520			\|a Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion.
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700	1		\|a Şenel, Ahmet Can \|e verfasserin \|4 aut
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912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
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912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
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912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
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912			\|a GBV_ILN_2108
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912			\|a GBV_ILN_4307
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Indexfelder

author_variant	e t et a g ag ö k ök e k ek ü ç üç m t mt a c ş ac acş
matchkey_str	article:14379813:2011----::osrpflrvntsiuaiceirpruinnuyu
hierarchy_sort_str	2011
bklnumber	44.65 44.67
publishDate	2011
allfields	10.1007/s00383-011-2895-3 doi (DE-627)SPR004716388 (SPR)s00383-011-2895-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Taşkara, Ersoy verfasserin aut Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion. Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213 Gör, Atilla verfasserin aut Kutlu, Ömer verfasserin aut Karagüzel, Ersagun verfasserin aut Çobanoğlu, Ümit verfasserin aut Topbaş, Murat verfasserin aut Şenel, Ahmet Can verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 27(2011), 9 vom: 06. Apr., Seite 1003-1007 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007 https://dx.doi.org/10.1007/s00383-011-2895-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 27 2011 9 06 04 1003-1007
spelling	10.1007/s00383-011-2895-3 doi (DE-627)SPR004716388 (SPR)s00383-011-2895-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Taşkara, Ersoy verfasserin aut Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion. Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213 Gör, Atilla verfasserin aut Kutlu, Ömer verfasserin aut Karagüzel, Ersagun verfasserin aut Çobanoğlu, Ümit verfasserin aut Topbaş, Murat verfasserin aut Şenel, Ahmet Can verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 27(2011), 9 vom: 06. Apr., Seite 1003-1007 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007 https://dx.doi.org/10.1007/s00383-011-2895-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 27 2011 9 06 04 1003-1007
allfields_unstemmed	10.1007/s00383-011-2895-3 doi (DE-627)SPR004716388 (SPR)s00383-011-2895-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Taşkara, Ersoy verfasserin aut Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion. Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213 Gör, Atilla verfasserin aut Kutlu, Ömer verfasserin aut Karagüzel, Ersagun verfasserin aut Çobanoğlu, Ümit verfasserin aut Topbaş, Murat verfasserin aut Şenel, Ahmet Can verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 27(2011), 9 vom: 06. Apr., Seite 1003-1007 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007 https://dx.doi.org/10.1007/s00383-011-2895-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 27 2011 9 06 04 1003-1007
allfieldsGer	10.1007/s00383-011-2895-3 doi (DE-627)SPR004716388 (SPR)s00383-011-2895-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Taşkara, Ersoy verfasserin aut Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion. Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213 Gör, Atilla verfasserin aut Kutlu, Ömer verfasserin aut Karagüzel, Ersagun verfasserin aut Çobanoğlu, Ümit verfasserin aut Topbaş, Murat verfasserin aut Şenel, Ahmet Can verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 27(2011), 9 vom: 06. Apr., Seite 1003-1007 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007 https://dx.doi.org/10.1007/s00383-011-2895-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 27 2011 9 06 04 1003-1007
allfieldsSound	10.1007/s00383-011-2895-3 doi (DE-627)SPR004716388 (SPR)s00383-011-2895-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl 44.67 bkl Taşkara, Ersoy verfasserin aut Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion. Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213 Gör, Atilla verfasserin aut Kutlu, Ömer verfasserin aut Karagüzel, Ersagun verfasserin aut Çobanoğlu, Ümit verfasserin aut Topbaş, Murat verfasserin aut Şenel, Ahmet Can verfasserin aut Enthalten in Pediatric surgery international Berlin : Springer, 1986 27(2011), 9 vom: 06. Apr., Seite 1003-1007 (DE-627)254638937 (DE-600)1463010-2 1437-9813 nnns volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007 https://dx.doi.org/10.1007/s00383-011-2895-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE 44.67 ASE AR 27 2011 9 06 04 1003-1007
language	English
source	Enthalten in Pediatric surgery international 27(2011), 9 vom: 06. Apr., Seite 1003-1007 volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007
sourceStr	Enthalten in Pediatric surgery international 27(2011), 9 vom: 06. Apr., Seite 1003-1007 volume:27 year:2011 number:9 day:06 month:04 pages:1003-1007
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Testis Reperfusion injury Propofol Rats
dewey-raw	610
isfreeaccess_bool	false
container_title	Pediatric surgery international
authorswithroles_txt_mv	Taşkara, Ersoy @@aut@@ Gör, Atilla @@aut@@ Kutlu, Ömer @@aut@@ Karagüzel, Ersagun @@aut@@ Çobanoğlu, Ümit @@aut@@ Topbaş, Murat @@aut@@ Şenel, Ahmet Can @@aut@@
publishDateDaySort_date	2011-04-06T00:00:00Z
hierarchy_top_id	254638937
dewey-sort	3610
id	SPR004716388
language_de	englisch
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Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). 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author	Taşkara, Ersoy
spellingShingle	Taşkara, Ersoy ddc 610 bkl 44.65 bkl 44.67 misc Testis misc Reperfusion injury misc Propofol misc Rats Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
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topic_title	610 ASE 44.65 bkl 44.67 bkl Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term? Testis (dpeaa)DE-He213 Reperfusion injury (dpeaa)DE-He213 Propofol (dpeaa)DE-He213 Rats (dpeaa)DE-He213
topic	ddc 610 bkl 44.65 bkl 44.67 misc Testis misc Reperfusion injury misc Propofol misc Rats
topic_unstemmed	ddc 610 bkl 44.65 bkl 44.67 misc Testis misc Reperfusion injury misc Propofol misc Rats
topic_browse	ddc 610 bkl 44.65 bkl 44.67 misc Testis misc Reperfusion injury misc Propofol misc Rats
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title	Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
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title_full	Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
author_sort	Taşkara, Ersoy
journal	Pediatric surgery international
journalStr	Pediatric surgery international
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author_browse	Taşkara, Ersoy Gör, Atilla Kutlu, Ömer Karagüzel, Ersagun Çobanoğlu, Ümit Topbaş, Murat Şenel, Ahmet Can
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class	610 ASE 44.65 bkl 44.67 bkl
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author-letter	Taşkara, Ersoy
doi_str_mv	10.1007/s00383-011-2895-3
dewey-full	610
author2-role	verfasserin
title_sort	does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
title_auth	Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
abstract	Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion.
abstractGer	Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion.
abstract_unstemmed	Objectives Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia–reperfusion injury in a rat model. Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). Similarly, the Johnsen’s mean testicular biopsy scores of the T/D groups were lower than those of the control and sham-operated groups, but no positive effect was determined with the administration of propofol in the T/D groups (p 0.1797). Conclusions Our results showed that there is no apparent long-term therapeutic potential attendant on using propofol in the treatment of testicular ischemia–reperfusion injury caused by testis torsion.
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container_issue	9
title_short	Does propofol prevent testicular ischemia–reperfusion injury due to torsion in the long term?
url	https://dx.doi.org/10.1007/s00383-011-2895-3
remote_bool	true
author2	Gör, Atilla Kutlu, Ömer Karagüzel, Ersagun Çobanoğlu, Ümit Topbaş, Murat Şenel, Ahmet Can
author2Str	Gör, Atilla Kutlu, Ömer Karagüzel, Ersagun Çobanoğlu, Ümit Topbaş, Murat Şenel, Ahmet Can
ppnlink	254638937
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s00383-011-2895-3
up_date	2024-07-04T02:19:06.020Z
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Methods Twenty-four adult male Sprague–Dawley rats were randomly divided into four groups (n = 6 for each group), control, sham-operated, torsion/detorsion (T/D) and T/D + propofol. Testicular ischemia was achieved by twisting the left testis 720° clockwise for 2 h. Half an hour before detorsion, 50 mg/kg propofol was given intraperitoneally to the T/D + propofol group. Ipsilateral orchiectomies to determine mean testicular weights and histopathological examination according to Johnsen’s mean testicular biopsy score criteria were performed 30 days after surgical procedure in all groups. Results Mean testicular weights were 1.57 ± 0.12 g in group I, 1.59 ± 0.36 g in group II, 0.84 ± 0.20 g in group III and 0.87 ± 0.29 g in group IV. Mean testicular weights decreased significantly in the T/D groups, but no improvement in testicular weight was observed with propofol administration (p 0.9372). 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