Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure
Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Behnes, Michael [verfasserIn] Hoffmann, Ursula [verfasserIn] Lang, Siegfried [verfasserIn] Weiss, Christel [verfasserIn] Ahmad-Nejad, Parviz [verfasserIn] Neumaier, Michael [verfasserIn] Borggrefe, Martin [verfasserIn] Brueckmann, Martina [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Zeitschrift für Kardiologie - Darmstadt : Steinkopff, 1997, 100(2010), 4 vom: 11. Nov., Seite 335-342 |
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| Übergeordnetes Werk: |
volume:100 ; year:2010 ; number:4 ; day:11 ; month:11 ; pages:335-342 |
| Links: |
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| DOI / URN: |
10.1007/s00392-010-0248-1 |
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| Katalog-ID: |
SPR004804635 |
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| 245 | 1 | 0 | |a Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure |
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| 520 | |a Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. | ||
| 650 | 4 | |a Atrial fibrillation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart failure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NT-proBNP |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Structural remodeling |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TGF-beta 1 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Hoffmann, Ursula |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Siegfried |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Christel |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad-Nejad, Parviz |e verfasserin |4 aut | |
| 700 | 1 | |a Neumaier, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Borggrefe, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Brueckmann, Martina |e verfasserin |4 aut | |
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10.1007/s00392-010-0248-1 doi (DE-627)SPR004804635 (SPR)s00392-010-0248-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Behnes, Michael verfasserin aut Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. Atrial fibrillation (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Structural remodeling (dpeaa)DE-He213 TGF-beta 1 (dpeaa)DE-He213 Hoffmann, Ursula verfasserin aut Lang, Siegfried verfasserin aut Weiss, Christel verfasserin aut Ahmad-Nejad, Parviz verfasserin aut Neumaier, Michael verfasserin aut Borggrefe, Martin verfasserin aut Brueckmann, Martina verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 100(2010), 4 vom: 11. Nov., Seite 335-342 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:100 year:2010 number:4 day:11 month:11 pages:335-342 https://dx.doi.org/10.1007/s00392-010-0248-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 100 2010 4 11 11 335-342 |
| spelling |
10.1007/s00392-010-0248-1 doi (DE-627)SPR004804635 (SPR)s00392-010-0248-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Behnes, Michael verfasserin aut Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. Atrial fibrillation (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Structural remodeling (dpeaa)DE-He213 TGF-beta 1 (dpeaa)DE-He213 Hoffmann, Ursula verfasserin aut Lang, Siegfried verfasserin aut Weiss, Christel verfasserin aut Ahmad-Nejad, Parviz verfasserin aut Neumaier, Michael verfasserin aut Borggrefe, Martin verfasserin aut Brueckmann, Martina verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 100(2010), 4 vom: 11. Nov., Seite 335-342 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:100 year:2010 number:4 day:11 month:11 pages:335-342 https://dx.doi.org/10.1007/s00392-010-0248-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 100 2010 4 11 11 335-342 |
| allfields_unstemmed |
10.1007/s00392-010-0248-1 doi (DE-627)SPR004804635 (SPR)s00392-010-0248-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Behnes, Michael verfasserin aut Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. Atrial fibrillation (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Structural remodeling (dpeaa)DE-He213 TGF-beta 1 (dpeaa)DE-He213 Hoffmann, Ursula verfasserin aut Lang, Siegfried verfasserin aut Weiss, Christel verfasserin aut Ahmad-Nejad, Parviz verfasserin aut Neumaier, Michael verfasserin aut Borggrefe, Martin verfasserin aut Brueckmann, Martina verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 100(2010), 4 vom: 11. Nov., Seite 335-342 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:100 year:2010 number:4 day:11 month:11 pages:335-342 https://dx.doi.org/10.1007/s00392-010-0248-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 100 2010 4 11 11 335-342 |
| allfieldsGer |
10.1007/s00392-010-0248-1 doi (DE-627)SPR004804635 (SPR)s00392-010-0248-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Behnes, Michael verfasserin aut Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. Atrial fibrillation (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Structural remodeling (dpeaa)DE-He213 TGF-beta 1 (dpeaa)DE-He213 Hoffmann, Ursula verfasserin aut Lang, Siegfried verfasserin aut Weiss, Christel verfasserin aut Ahmad-Nejad, Parviz verfasserin aut Neumaier, Michael verfasserin aut Borggrefe, Martin verfasserin aut Brueckmann, Martina verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 100(2010), 4 vom: 11. Nov., Seite 335-342 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:100 year:2010 number:4 day:11 month:11 pages:335-342 https://dx.doi.org/10.1007/s00392-010-0248-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 100 2010 4 11 11 335-342 |
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10.1007/s00392-010-0248-1 doi (DE-627)SPR004804635 (SPR)s00392-010-0248-1-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Behnes, Michael verfasserin aut Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. Atrial fibrillation (dpeaa)DE-He213 Heart failure (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Structural remodeling (dpeaa)DE-He213 TGF-beta 1 (dpeaa)DE-He213 Hoffmann, Ursula verfasserin aut Lang, Siegfried verfasserin aut Weiss, Christel verfasserin aut Ahmad-Nejad, Parviz verfasserin aut Neumaier, Michael verfasserin aut Borggrefe, Martin verfasserin aut Brueckmann, Martina verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 100(2010), 4 vom: 11. Nov., Seite 335-342 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:100 year:2010 number:4 day:11 month:11 pages:335-342 https://dx.doi.org/10.1007/s00392-010-0248-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 100 2010 4 11 11 335-342 |
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Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure |
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Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. |
| abstractGer |
Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. |
| abstract_unstemmed |
Purpose Atrial fibrillation (AF) and acute congestive heart failure (aCHF) are characterized by an adverse cardiac remodeling. Arrhythmogenic or structural remodeling can be caused by interstitial fibrosis. Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF. Methods 401 patients presenting with symptoms of dyspnea or peripheral edema were prospectively enrolled. Blood samples for measurement of TGF-beta 1 (R&D Systems, Inc.) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) (DadeBehring ltd.) were collected after the initial clinical evaluation. Results Median TGF-beta 1 levels were lower in patients with AF (21.0 ng/ml, interquartile range (IR) 15.4–27.6 ng/ml, n = 107) compared to those without (25.0 ng/ml, IR 18.5–31.6 ng/ml, n = 294) (p = 0.009). Patients with aCHF had lower TGF-beta 1 levels (median 22.0 ng/ml, IR 15.6–27.1 ng/ml, n = 122) than those without (median 24.9 ng/ml, IR 18.1–31.9 ng/ml, n = 279) (p = 0.0005). In logistic regression models TGF-beta 1 was still associated with AF (odds ratio (OR) 3.00, 95% CI 1.37–6.61, p = 0.0001) and aCHF (OR 3.98, 95% CI 1.55–10.19, p = 0.004). TGF-beta 1 inversely correlated with left atrial diameter (r = −0.30, p = 0.007) and NT-proBNP (r = −0.14, p = 0.007). Conclusions Low serum levels of TGF-beta 1 are associated with AF and aCHF. This decrease may result from a higher consumption of TGF-beta 1 within the impaired myocardium or antifibrotic functions of natriuretic peptides. |
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Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure |
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Hoffmann, Ursula Lang, Siegfried Weiss, Christel Ahmad-Nejad, Parviz Neumaier, Michael Borggrefe, Martin Brueckmann, Martina |
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Hoffmann, Ursula Lang, Siegfried Weiss, Christel Ahmad-Nejad, Parviz Neumaier, Michael Borggrefe, Martin Brueckmann, Martina |
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