Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients
Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sinning, Christoph [verfasserIn] Ojeda, Francisco [verfasserIn] Wild, Philipp S. [verfasserIn] Schnabel, Renate B. [verfasserIn] Schwarzl, Michael [verfasserIn] Ohdah, Sevenai [verfasserIn] Lackner, Karl J. [verfasserIn] Pfeiffer, Norbert [verfasserIn] Michal, Matthias [verfasserIn] Blettner, Maria [verfasserIn] Munzel, Thomas [verfasserIn] Kempf, Tibor [verfasserIn] Wollert, Kai C. [verfasserIn] Kuulasmaa, Kari [verfasserIn] Blankenberg, Stefan [verfasserIn] Salomaa, Veikko [verfasserIn] Westermann, Dirk [verfasserIn] Zeller, Tanja [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Zeitschrift für Kardiologie - Darmstadt : Steinkopff, 1997, 106(2016), 6 vom: 21. Dez., Seite 401-410 |
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| Übergeordnetes Werk: |
volume:106 ; year:2016 ; number:6 ; day:21 ; month:12 ; pages:401-410 |
| Links: |
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| DOI / URN: |
10.1007/s00392-016-1066-x |
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| Katalog-ID: |
SPR004813790 |
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| 100 | 1 | |a Sinning, Christoph |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
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| 520 | |a Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. | ||
| 650 | 4 | |a Heart failure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Obesity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Growth differentiation factor-15 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MR-proADM |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NT-proBNP |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Natriuretic peptides |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ojeda, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Wild, Philipp S. |e verfasserin |4 aut | |
| 700 | 1 | |a Schnabel, Renate B. |e verfasserin |4 aut | |
| 700 | 1 | |a Schwarzl, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Ohdah, Sevenai |e verfasserin |4 aut | |
| 700 | 1 | |a Lackner, Karl J. |e verfasserin |4 aut | |
| 700 | 1 | |a Pfeiffer, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Michal, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Blettner, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Munzel, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Kempf, Tibor |e verfasserin |4 aut | |
| 700 | 1 | |a Wollert, Kai C. |e verfasserin |4 aut | |
| 700 | 1 | |a Kuulasmaa, Kari |e verfasserin |4 aut | |
| 700 | 1 | |a Blankenberg, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Salomaa, Veikko |e verfasserin |4 aut | |
| 700 | 1 | |a Westermann, Dirk |e verfasserin |4 aut | |
| 700 | 1 | |a Zeller, Tanja |e verfasserin |4 aut | |
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10.1007/s00392-016-1066-x doi (DE-627)SPR004813790 (SPR)s00392-016-1066-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Sinning, Christoph verfasserin aut Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Ojeda, Francisco verfasserin aut Wild, Philipp S. verfasserin aut Schnabel, Renate B. verfasserin aut Schwarzl, Michael verfasserin aut Ohdah, Sevenai verfasserin aut Lackner, Karl J. verfasserin aut Pfeiffer, Norbert verfasserin aut Michal, Matthias verfasserin aut Blettner, Maria verfasserin aut Munzel, Thomas verfasserin aut Kempf, Tibor verfasserin aut Wollert, Kai C. verfasserin aut Kuulasmaa, Kari verfasserin aut Blankenberg, Stefan verfasserin aut Salomaa, Veikko verfasserin aut Westermann, Dirk verfasserin aut Zeller, Tanja verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 106(2016), 6 vom: 21. Dez., Seite 401-410 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:106 year:2016 number:6 day:21 month:12 pages:401-410 https://dx.doi.org/10.1007/s00392-016-1066-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 106 2016 6 21 12 401-410 |
| spelling |
10.1007/s00392-016-1066-x doi (DE-627)SPR004813790 (SPR)s00392-016-1066-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Sinning, Christoph verfasserin aut Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Ojeda, Francisco verfasserin aut Wild, Philipp S. verfasserin aut Schnabel, Renate B. verfasserin aut Schwarzl, Michael verfasserin aut Ohdah, Sevenai verfasserin aut Lackner, Karl J. verfasserin aut Pfeiffer, Norbert verfasserin aut Michal, Matthias verfasserin aut Blettner, Maria verfasserin aut Munzel, Thomas verfasserin aut Kempf, Tibor verfasserin aut Wollert, Kai C. verfasserin aut Kuulasmaa, Kari verfasserin aut Blankenberg, Stefan verfasserin aut Salomaa, Veikko verfasserin aut Westermann, Dirk verfasserin aut Zeller, Tanja verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 106(2016), 6 vom: 21. Dez., Seite 401-410 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:106 year:2016 number:6 day:21 month:12 pages:401-410 https://dx.doi.org/10.1007/s00392-016-1066-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 106 2016 6 21 12 401-410 |
| allfields_unstemmed |
10.1007/s00392-016-1066-x doi (DE-627)SPR004813790 (SPR)s00392-016-1066-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Sinning, Christoph verfasserin aut Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Ojeda, Francisco verfasserin aut Wild, Philipp S. verfasserin aut Schnabel, Renate B. verfasserin aut Schwarzl, Michael verfasserin aut Ohdah, Sevenai verfasserin aut Lackner, Karl J. verfasserin aut Pfeiffer, Norbert verfasserin aut Michal, Matthias verfasserin aut Blettner, Maria verfasserin aut Munzel, Thomas verfasserin aut Kempf, Tibor verfasserin aut Wollert, Kai C. verfasserin aut Kuulasmaa, Kari verfasserin aut Blankenberg, Stefan verfasserin aut Salomaa, Veikko verfasserin aut Westermann, Dirk verfasserin aut Zeller, Tanja verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 106(2016), 6 vom: 21. Dez., Seite 401-410 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:106 year:2016 number:6 day:21 month:12 pages:401-410 https://dx.doi.org/10.1007/s00392-016-1066-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 106 2016 6 21 12 401-410 |
| allfieldsGer |
10.1007/s00392-016-1066-x doi (DE-627)SPR004813790 (SPR)s00392-016-1066-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Sinning, Christoph verfasserin aut Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Ojeda, Francisco verfasserin aut Wild, Philipp S. verfasserin aut Schnabel, Renate B. verfasserin aut Schwarzl, Michael verfasserin aut Ohdah, Sevenai verfasserin aut Lackner, Karl J. verfasserin aut Pfeiffer, Norbert verfasserin aut Michal, Matthias verfasserin aut Blettner, Maria verfasserin aut Munzel, Thomas verfasserin aut Kempf, Tibor verfasserin aut Wollert, Kai C. verfasserin aut Kuulasmaa, Kari verfasserin aut Blankenberg, Stefan verfasserin aut Salomaa, Veikko verfasserin aut Westermann, Dirk verfasserin aut Zeller, Tanja verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 106(2016), 6 vom: 21. Dez., Seite 401-410 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:106 year:2016 number:6 day:21 month:12 pages:401-410 https://dx.doi.org/10.1007/s00392-016-1066-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 106 2016 6 21 12 401-410 |
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10.1007/s00392-016-1066-x doi (DE-627)SPR004813790 (SPR)s00392-016-1066-x-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Sinning, Christoph verfasserin aut Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 Ojeda, Francisco verfasserin aut Wild, Philipp S. verfasserin aut Schnabel, Renate B. verfasserin aut Schwarzl, Michael verfasserin aut Ohdah, Sevenai verfasserin aut Lackner, Karl J. verfasserin aut Pfeiffer, Norbert verfasserin aut Michal, Matthias verfasserin aut Blettner, Maria verfasserin aut Munzel, Thomas verfasserin aut Kempf, Tibor verfasserin aut Wollert, Kai C. verfasserin aut Kuulasmaa, Kari verfasserin aut Blankenberg, Stefan verfasserin aut Salomaa, Veikko verfasserin aut Westermann, Dirk verfasserin aut Zeller, Tanja verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 106(2016), 6 vom: 21. Dez., Seite 401-410 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:106 year:2016 number:6 day:21 month:12 pages:401-410 https://dx.doi.org/10.1007/s00392-016-1066-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 106 2016 6 21 12 401-410 |
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Sinning, Christoph @@aut@@ Ojeda, Francisco @@aut@@ Wild, Philipp S. @@aut@@ Schnabel, Renate B. @@aut@@ Schwarzl, Michael @@aut@@ Ohdah, Sevenai @@aut@@ Lackner, Karl J. @@aut@@ Pfeiffer, Norbert @@aut@@ Michal, Matthias @@aut@@ Blettner, Maria @@aut@@ Munzel, Thomas @@aut@@ Kempf, Tibor @@aut@@ Wollert, Kai C. @@aut@@ Kuulasmaa, Kari @@aut@@ Blankenberg, Stefan @@aut@@ Salomaa, Veikko @@aut@@ Westermann, Dirk @@aut@@ Zeller, Tanja @@aut@@ |
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610 ASE 44.67 bkl 44.85 bkl Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients Heart failure (dpeaa)DE-He213 Obesity (dpeaa)DE-He213 Growth differentiation factor-15 (dpeaa)DE-He213 MR-proADM (dpeaa)DE-He213 NT-proBNP (dpeaa)DE-He213 Natriuretic peptides (dpeaa)DE-He213 |
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Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
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| title_full |
Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
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Sinning, Christoph |
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Zeitschrift für Kardiologie |
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Zeitschrift für Kardiologie |
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eng |
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Sinning, Christoph Ojeda, Francisco Wild, Philipp S. Schnabel, Renate B. Schwarzl, Michael Ohdah, Sevenai Lackner, Karl J. Pfeiffer, Norbert Michal, Matthias Blettner, Maria Munzel, Thomas Kempf, Tibor Wollert, Kai C. Kuulasmaa, Kari Blankenberg, Stefan Salomaa, Veikko Westermann, Dirk Zeller, Tanja |
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Sinning, Christoph |
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10.1007/s00392-016-1066-x |
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610 |
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verfasserin |
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midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
| title_auth |
Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
| abstract |
Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. |
| abstractGer |
Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. |
| abstract_unstemmed |
Background Obesity is a risk factor for heart failure (HF) and identification of symptomatic, and obese HF patients are challenging, because obesity can mimic HF symptoms. We aimed to evaluate novel biomarkers for HF in obese subjects of the general population. Methods Midregional proadrenomedullin (MR-proADM), growth differentiation factor-15 (GDF-15), midregional pro-atrial natriuretic peptide (MR-proANP), and NT-proBNP were measured in 5000 individuals of the population-based Gutenberg Health Study (GHS), including 1204 obese individuals (BMI ≥ 30 kg/$ m^{2} $) and 107 individuals with HF. Results NT-proBNP and MR-proANP were lower in obese vs. non-obese HF individuals (p = 0.013 and p = 0.01, respectively), whereas GDF-15 was similar and MR-proADM was higher in obese vs. non-obese HF individuals. All biomarkers increased the odds ratio (OR) for prevalent HF. For NT-proBNP and MR-proANP, this increase was lower in obese vs. non-obese individuals, whereas it was comparable for MR-proADM and GDF-15. All biomarkers were associated with increased all-cause mortality (median follow-up 7.3 years, 211 events). Results were validated in 8373 individuals (n = 1734 with BMI ≥ 30 kg/$ m^{2} $) of the FINRISK study with a median follow-up of 13.8 years (1030 events). Using a dichotomized biomarker cutoff for HF, the best predictor for all-cause mortality in obese subjects was GDF-15 (p < 0.001). Conclusion All biomarkers were associated with HF and higher risk for all-cause mortality in the general population. In contrast to the natriuretic peptides NT-proBNP and MR-proANP, the novel biomarkers MR-proADM and GDF-15 were not lower in obese HF individuals, indicating their potential to facilitate HF diagnosis and prognosis in an increasingly obese HF population. |
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Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients |
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https://dx.doi.org/10.1007/s00392-016-1066-x |
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Ojeda, Francisco Wild, Philipp S. Schnabel, Renate B. Schwarzl, Michael Ohdah, Sevenai Lackner, Karl J. Pfeiffer, Norbert Michal, Matthias Blettner, Maria Munzel, Thomas Kempf, Tibor Wollert, Kai C. Kuulasmaa, Kari Blankenberg, Stefan Salomaa, Veikko Westermann, Dirk Zeller, Tanja |
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Ojeda, Francisco Wild, Philipp S. Schnabel, Renate B. Schwarzl, Michael Ohdah, Sevenai Lackner, Karl J. Pfeiffer, Norbert Michal, Matthias Blettner, Maria Munzel, Thomas Kempf, Tibor Wollert, Kai C. Kuulasmaa, Kari Blankenberg, Stefan Salomaa, Veikko Westermann, Dirk Zeller, Tanja |
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