Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest

Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Weidner, Kathrin [verfasserIn] Behnes, Michael [verfasserIn] Schupp, Tobias [verfasserIn] Rusnak, Jonas [verfasserIn] Reiser, Linda [verfasserIn] Taton, Gabriel [verfasserIn] Reichelt, Thomas [verfasserIn] Ellguth, Dominik [verfasserIn] Engelke, Niko [verfasserIn] Bollow, Armin [verfasserIn] El-Battrawy, Ibrahim [verfasserIn] Ansari, Uzair [verfasserIn] Hoppner, Jorge [verfasserIn] Nienaber, Christoph A. [verfasserIn] Mashayekhi, Kambis [verfasserIn] Weiß, Christel [verfasserIn] Akin, Muharrem [verfasserIn] Borggrefe, Martin [verfasserIn] Akin, Ibrahim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Ventricular tachyarrhythmia Sudden cardiac arrest Chronic kidney disease Renal replacement therapy

Übergeordnetes Werk:	Enthalten in: Zeitschrift für Kardiologie - Darmstadt : Steinkopff, 1997, 108(2018), 6 vom: 21. Dez., Seite 669-682
Übergeordnetes Werk:	volume:108 ; year:2018 ; number:6 ; day:21 ; month:12 ; pages:669-682

Links:	Volltext

DOI / URN:	10.1007/s00392-018-1396-y

Katalog-ID:	SPR004817419

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245	1	0	\|a Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
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520			\|a Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h.
650		4	\|a Ventricular tachyarrhythmia \|7 (dpeaa)DE-He213
650		4	\|a Sudden cardiac arrest \|7 (dpeaa)DE-He213
650		4	\|a Chronic kidney disease \|7 (dpeaa)DE-He213
650		4	\|a Renal replacement therapy \|7 (dpeaa)DE-He213
700	1		\|a Behnes, Michael \|e verfasserin \|4 aut
700	1		\|a Schupp, Tobias \|e verfasserin \|4 aut
700	1		\|a Rusnak, Jonas \|e verfasserin \|4 aut
700	1		\|a Reiser, Linda \|e verfasserin \|4 aut
700	1		\|a Taton, Gabriel \|e verfasserin \|4 aut
700	1		\|a Reichelt, Thomas \|e verfasserin \|4 aut
700	1		\|a Ellguth, Dominik \|e verfasserin \|4 aut
700	1		\|a Engelke, Niko \|e verfasserin \|4 aut
700	1		\|a Bollow, Armin \|e verfasserin \|4 aut
700	1		\|a El-Battrawy, Ibrahim \|e verfasserin \|4 aut
700	1		\|a Ansari, Uzair \|e verfasserin \|4 aut
700	1		\|a Hoppner, Jorge \|e verfasserin \|4 aut
700	1		\|a Nienaber, Christoph A. \|e verfasserin \|4 aut
700	1		\|a Mashayekhi, Kambis \|e verfasserin \|4 aut
700	1		\|a Weiß, Christel \|e verfasserin \|4 aut
700	1		\|a Akin, Muharrem \|e verfasserin \|4 aut
700	1		\|a Borggrefe, Martin \|e verfasserin \|4 aut
700	1		\|a Akin, Ibrahim \|e verfasserin \|4 aut
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allfields	10.1007/s00392-018-1396-y doi (DE-627)SPR004817419 (SPR)s00392-018-1396-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Weidner, Kathrin verfasserin aut Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213 Behnes, Michael verfasserin aut Schupp, Tobias verfasserin aut Rusnak, Jonas verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut El-Battrawy, Ibrahim verfasserin aut Ansari, Uzair verfasserin aut Hoppner, Jorge verfasserin aut Nienaber, Christoph A. verfasserin aut Mashayekhi, Kambis verfasserin aut Weiß, Christel verfasserin aut Akin, Muharrem verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 108(2018), 6 vom: 21. Dez., Seite 669-682 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:108 year:2018 number:6 day:21 month:12 pages:669-682 https://dx.doi.org/10.1007/s00392-018-1396-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 108 2018 6 21 12 669-682
spelling	10.1007/s00392-018-1396-y doi (DE-627)SPR004817419 (SPR)s00392-018-1396-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Weidner, Kathrin verfasserin aut Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213 Behnes, Michael verfasserin aut Schupp, Tobias verfasserin aut Rusnak, Jonas verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut El-Battrawy, Ibrahim verfasserin aut Ansari, Uzair verfasserin aut Hoppner, Jorge verfasserin aut Nienaber, Christoph A. verfasserin aut Mashayekhi, Kambis verfasserin aut Weiß, Christel verfasserin aut Akin, Muharrem verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 108(2018), 6 vom: 21. Dez., Seite 669-682 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:108 year:2018 number:6 day:21 month:12 pages:669-682 https://dx.doi.org/10.1007/s00392-018-1396-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 108 2018 6 21 12 669-682
allfields_unstemmed	10.1007/s00392-018-1396-y doi (DE-627)SPR004817419 (SPR)s00392-018-1396-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Weidner, Kathrin verfasserin aut Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213 Behnes, Michael verfasserin aut Schupp, Tobias verfasserin aut Rusnak, Jonas verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut El-Battrawy, Ibrahim verfasserin aut Ansari, Uzair verfasserin aut Hoppner, Jorge verfasserin aut Nienaber, Christoph A. verfasserin aut Mashayekhi, Kambis verfasserin aut Weiß, Christel verfasserin aut Akin, Muharrem verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 108(2018), 6 vom: 21. Dez., Seite 669-682 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:108 year:2018 number:6 day:21 month:12 pages:669-682 https://dx.doi.org/10.1007/s00392-018-1396-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 108 2018 6 21 12 669-682
allfieldsGer	10.1007/s00392-018-1396-y doi (DE-627)SPR004817419 (SPR)s00392-018-1396-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Weidner, Kathrin verfasserin aut Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213 Behnes, Michael verfasserin aut Schupp, Tobias verfasserin aut Rusnak, Jonas verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut El-Battrawy, Ibrahim verfasserin aut Ansari, Uzair verfasserin aut Hoppner, Jorge verfasserin aut Nienaber, Christoph A. verfasserin aut Mashayekhi, Kambis verfasserin aut Weiß, Christel verfasserin aut Akin, Muharrem verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 108(2018), 6 vom: 21. Dez., Seite 669-682 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:108 year:2018 number:6 day:21 month:12 pages:669-682 https://dx.doi.org/10.1007/s00392-018-1396-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 108 2018 6 21 12 669-682
allfieldsSound	10.1007/s00392-018-1396-y doi (DE-627)SPR004817419 (SPR)s00392-018-1396-y-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.67 bkl 44.85 bkl Weidner, Kathrin verfasserin aut Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213 Behnes, Michael verfasserin aut Schupp, Tobias verfasserin aut Rusnak, Jonas verfasserin aut Reiser, Linda verfasserin aut Taton, Gabriel verfasserin aut Reichelt, Thomas verfasserin aut Ellguth, Dominik verfasserin aut Engelke, Niko verfasserin aut Bollow, Armin verfasserin aut El-Battrawy, Ibrahim verfasserin aut Ansari, Uzair verfasserin aut Hoppner, Jorge verfasserin aut Nienaber, Christoph A. verfasserin aut Mashayekhi, Kambis verfasserin aut Weiß, Christel verfasserin aut Akin, Muharrem verfasserin aut Borggrefe, Martin verfasserin aut Akin, Ibrahim verfasserin aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 108(2018), 6 vom: 21. Dez., Seite 669-682 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:108 year:2018 number:6 day:21 month:12 pages:669-682 https://dx.doi.org/10.1007/s00392-018-1396-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 44.67 ASE 44.85 ASE AR 108 2018 6 21 12 669-682
language	English
source	Enthalten in Zeitschrift für Kardiologie 108(2018), 6 vom: 21. Dez., Seite 669-682 volume:108 year:2018 number:6 day:21 month:12 pages:669-682
sourceStr	Enthalten in Zeitschrift für Kardiologie 108(2018), 6 vom: 21. Dez., Seite 669-682 volume:108 year:2018 number:6 day:21 month:12 pages:669-682
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Ventricular tachyarrhythmia Sudden cardiac arrest Chronic kidney disease Renal replacement therapy
dewey-raw	610
isfreeaccess_bool	false
container_title	Zeitschrift für Kardiologie
authorswithroles_txt_mv	Weidner, Kathrin @@aut@@ Behnes, Michael @@aut@@ Schupp, Tobias @@aut@@ Rusnak, Jonas @@aut@@ Reiser, Linda @@aut@@ Taton, Gabriel @@aut@@ Reichelt, Thomas @@aut@@ Ellguth, Dominik @@aut@@ Engelke, Niko @@aut@@ Bollow, Armin @@aut@@ El-Battrawy, Ibrahim @@aut@@ Ansari, Uzair @@aut@@ Hoppner, Jorge @@aut@@ Nienaber, Christoph A. @@aut@@ Mashayekhi, Kambis @@aut@@ Weiß, Christel @@aut@@ Akin, Muharrem @@aut@@ Borggrefe, Martin @@aut@@ Akin, Ibrahim @@aut@@
publishDateDaySort_date	2018-12-21T00:00:00Z
hierarchy_top_id	254911137
dewey-sort	3610
id	SPR004817419
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR004817419</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519174938.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00392-018-1396-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR004817419</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00392-018-1396-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.67</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.85</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weidner, Kathrin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. 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author	Weidner, Kathrin
spellingShingle	Weidner, Kathrin ddc 610 bkl 44.67 bkl 44.85 misc Ventricular tachyarrhythmia misc Sudden cardiac arrest misc Chronic kidney disease misc Renal replacement therapy Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
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topic_title	610 ASE 44.67 bkl 44.85 bkl Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest Ventricular tachyarrhythmia (dpeaa)DE-He213 Sudden cardiac arrest (dpeaa)DE-He213 Chronic kidney disease (dpeaa)DE-He213 Renal replacement therapy (dpeaa)DE-He213
topic	ddc 610 bkl 44.67 bkl 44.85 misc Ventricular tachyarrhythmia misc Sudden cardiac arrest misc Chronic kidney disease misc Renal replacement therapy
topic_unstemmed	ddc 610 bkl 44.67 bkl 44.85 misc Ventricular tachyarrhythmia misc Sudden cardiac arrest misc Chronic kidney disease misc Renal replacement therapy
topic_browse	ddc 610 bkl 44.67 bkl 44.85 misc Ventricular tachyarrhythmia misc Sudden cardiac arrest misc Chronic kidney disease misc Renal replacement therapy
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title	Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
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title_full	Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
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author_browse	Weidner, Kathrin Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bollow, Armin El-Battrawy, Ibrahim Ansari, Uzair Hoppner, Jorge Nienaber, Christoph A. Mashayekhi, Kambis Weiß, Christel Akin, Muharrem Borggrefe, Martin Akin, Ibrahim
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title_sort	prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
title_auth	Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
abstract	Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h.
abstractGer	Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h.
abstract_unstemmed	Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h.
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title_short	Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest
url	https://dx.doi.org/10.1007/s00392-018-1396-y
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author2	Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bollow, Armin El-Battrawy, Ibrahim Ansari, Uzair Hoppner, Jorge Nienaber, Christoph A. Mashayekhi, Kambis Weiß, Christel Akin, Muharrem Borggrefe, Martin Akin, Ibrahim
author2Str	Behnes, Michael Schupp, Tobias Rusnak, Jonas Reiser, Linda Taton, Gabriel Reichelt, Thomas Ellguth, Dominik Engelke, Niko Bollow, Armin El-Battrawy, Ibrahim Ansari, Uzair Hoppner, Jorge Nienaber, Christoph A. Mashayekhi, Kambis Weiß, Christel Akin, Muharrem Borggrefe, Martin Akin, Ibrahim
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up_date	2024-07-04T02:42:36.276Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR004817419</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519174938.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2018 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00392-018-1396-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR004817419</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00392-018-1396-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.67</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.85</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weidner, Kathrin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background The study sought to assess the prognostic impact of chronic kidney disease (CKD) and renal replacement therapy (RRT) in patients with ventricular tachyarrhythmias and sudden cardiac arrest (SCA) on admission. Methods A large retrospective registry was used including all consecutive patients presenting with ventricular tachycardia (VT), fibrillation (VF) and SCA on admission from 2002 to 2016. Non-CKD vs. “CKD without RRT”, and “CKD without RRT” vs. “CKD with RRT” were compared applying multivariable Cox regression models and propensity-score matching for evaluation of the primary prognostic endpoint defined as long-term all-cause mortality at 2 years. Secondary prognostic endpoints were cardiac death at 24 h, in-hospital death at index and the composite endpoint of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h. Results In 2686 unmatched high-risk patients with ventricular tachyarrhythmias and SCA, non-CKD was present in 46%, “CKD without RRT” in 46% and “CKD with RRT” in 8%. Each, VT and VF occurred in about one-third of CKD patients. Multivariable Cox regression models revealed that “CKD without RRT” (HR = 2.118; p = 0.001) and “CKD with RRT” (HR = 3.043; p = 0.001) patients were associated with the primary endpoint of long-term mortality at 2 years, which was also proven after propensity-score matching (non-CKD vs. “CKD without RRT”: 43% vs. 27%, log rank p = 0.001; HR = 1.847; “CKD without RRT” vs. “CKD with RRT”: 74% vs. 51%, log rank p = 0.001; HR = 2.129). The rates of secondary endpoints were higher for cardiac death at 24 h, in-hospital death at index and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h, respectively, for “CKD without RRT” and “CKD with RRT” patients. Conclusion In patients presenting with ventricular tachyarrhythmias and aborted SCA on admission, the presence of CKD, especially combined with RRT, is independently associated with an increase of long-term all-cause mortality at 2 years, cardiac death at 24 h, in-hospital death and the composite of recurrent ventricular tachyarrhythmias, appropriate ICD therapies and cardiac death at 24 h.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ventricular tachyarrhythmia</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sudden cardiac arrest</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic kidney disease</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Renal replacement therapy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Behnes, Michael</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Schupp, Tobias</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rusnak, Jonas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reiser, Linda</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Taton, Gabriel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reichelt, Thomas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ellguth, Dominik</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Engelke, Niko</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bollow, Armin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">El-Battrawy, Ibrahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ansari, Uzair</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hoppner, Jorge</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nienaber, Christoph A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mashayekhi, Kambis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weiß, Christel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Akin, Muharrem</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Borggrefe, Martin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Akin, Ibrahim</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Zeitschrift für Kardiologie</subfield><subfield code="d">Darmstadt : Steinkopff, 1997</subfield><subfield code="g">108(2018), 6 vom: 21. 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Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest

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