Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease
Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible...
Ausführliche Beschreibung
Autor*in: |
Xu, Y. [verfasserIn] Zhou, K. [verfasserIn] Yang, Z. [verfasserIn] Li, F. [verfasserIn] Wang, Z. [verfasserIn] Xu, F. [verfasserIn] He, C. [verfasserIn] |
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Englisch |
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2016 |
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Enthalten in: Zeitschrift für Rheumatologie - Steinkopff-Verlag, 1998, 75(2016), 9 vom: 22. Jan., Seite 932-938 |
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Übergeordnetes Werk: |
volume:75 ; year:2016 ; number:9 ; day:22 ; month:01 ; pages:932-938 |
Links: |
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DOI / URN: |
10.1007/s00393-015-0036-4 |
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Katalog-ID: |
SPR004836979 |
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520 | |a Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. | ||
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10.1007/s00393-015-0036-4 doi (DE-627)SPR004836979 (SPR)s00393-015-0036-4-e DE-627 ger DE-627 rakwb eng Xu, Y. verfasserin aut Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 Zhou, K. verfasserin aut Yang, Z. verfasserin aut Li, F. verfasserin aut Wang, Z. verfasserin aut Xu, F. verfasserin aut He, C. verfasserin aut Enthalten in Zeitschrift für Rheumatologie Steinkopff-Verlag, 1998 75(2016), 9 vom: 22. Jan., Seite 932-938 (DE-627)SPR004818482 nnns volume:75 year:2016 number:9 day:22 month:01 pages:932-938 https://dx.doi.org/10.1007/s00393-015-0036-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 75 2016 9 22 01 932-938 |
spelling |
10.1007/s00393-015-0036-4 doi (DE-627)SPR004836979 (SPR)s00393-015-0036-4-e DE-627 ger DE-627 rakwb eng Xu, Y. verfasserin aut Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 Zhou, K. verfasserin aut Yang, Z. verfasserin aut Li, F. verfasserin aut Wang, Z. verfasserin aut Xu, F. verfasserin aut He, C. verfasserin aut Enthalten in Zeitschrift für Rheumatologie Steinkopff-Verlag, 1998 75(2016), 9 vom: 22. Jan., Seite 932-938 (DE-627)SPR004818482 nnns volume:75 year:2016 number:9 day:22 month:01 pages:932-938 https://dx.doi.org/10.1007/s00393-015-0036-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 75 2016 9 22 01 932-938 |
allfields_unstemmed |
10.1007/s00393-015-0036-4 doi (DE-627)SPR004836979 (SPR)s00393-015-0036-4-e DE-627 ger DE-627 rakwb eng Xu, Y. verfasserin aut Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 Zhou, K. verfasserin aut Yang, Z. verfasserin aut Li, F. verfasserin aut Wang, Z. verfasserin aut Xu, F. verfasserin aut He, C. verfasserin aut Enthalten in Zeitschrift für Rheumatologie Steinkopff-Verlag, 1998 75(2016), 9 vom: 22. Jan., Seite 932-938 (DE-627)SPR004818482 nnns volume:75 year:2016 number:9 day:22 month:01 pages:932-938 https://dx.doi.org/10.1007/s00393-015-0036-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 75 2016 9 22 01 932-938 |
allfieldsGer |
10.1007/s00393-015-0036-4 doi (DE-627)SPR004836979 (SPR)s00393-015-0036-4-e DE-627 ger DE-627 rakwb eng Xu, Y. verfasserin aut Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 Zhou, K. verfasserin aut Yang, Z. verfasserin aut Li, F. verfasserin aut Wang, Z. verfasserin aut Xu, F. verfasserin aut He, C. verfasserin aut Enthalten in Zeitschrift für Rheumatologie Steinkopff-Verlag, 1998 75(2016), 9 vom: 22. Jan., Seite 932-938 (DE-627)SPR004818482 nnns volume:75 year:2016 number:9 day:22 month:01 pages:932-938 https://dx.doi.org/10.1007/s00393-015-0036-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 75 2016 9 22 01 932-938 |
allfieldsSound |
10.1007/s00393-015-0036-4 doi (DE-627)SPR004836979 (SPR)s00393-015-0036-4-e DE-627 ger DE-627 rakwb eng Xu, Y. verfasserin aut Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 Zhou, K. verfasserin aut Yang, Z. verfasserin aut Li, F. verfasserin aut Wang, Z. verfasserin aut Xu, F. verfasserin aut He, C. verfasserin aut Enthalten in Zeitschrift für Rheumatologie Steinkopff-Verlag, 1998 75(2016), 9 vom: 22. Jan., Seite 932-938 (DE-627)SPR004818482 nnns volume:75 year:2016 number:9 day:22 month:01 pages:932-938 https://dx.doi.org/10.1007/s00393-015-0036-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 75 2016 9 22 01 932-938 |
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Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. 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Xu, Y. misc Homozygote misc Vasculitis misc Etiology misc T-cells misc Alleles Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease |
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Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease Homozygote (dpeaa)DE-He213 Vasculitis (dpeaa)DE-He213 Etiology (dpeaa)DE-He213 T-cells (dpeaa)DE-He213 Alleles (dpeaa)DE-He213 |
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Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease |
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association of cytokine gene polymorphisms (il‑6, il‑12b, il‑18) with behcet’s disease |
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Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease |
abstract |
Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. |
abstractGer |
Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. |
abstract_unstemmed |
Purpose This study aims to investigate the association of cytokine gene polymorphisms with the risk of Behcet’s disease (BD) via comprehensive meta-analysis. Methods The Embase and PubMed databases covering the period from the earliest possible year to May 2015 were searched. A total of 13 eligible articles including 2,065 BD patients and 1,559 controls were recruited. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the associations. Potential publication bias was evaluated using Egger’s linear regression test. Results Meta-analysis indicated associations between IL‑6 rs1800795, IL‑12B rs3212227, and IL‑18 rs1946518 in all study subjects: IL‑18 rs1946518 in the dominant model (IL‑18 rs1946518: OR = 0.48, 95 % CI: 0.34–0.70, P = 0.000) and the homozygote model (IL‑18 rs1946518: OR = 0.40, 95 % CI: 0.25–0.65, P = 0.000); and IL‑6 rs1800795 and IL‑12B rs3212227 in the dominant model (IL‑6 rs1800795: OR = 0.53, 95 % CI: 0.39–0.72, P = 0.000; IL‑12B rs3212227: OR = 1.26, 95 % CI: 1.06–1.48, P = 0.007; IL‑18 rs1946518: OR = 0.46, 95 % CI: 0.33–0.65, P = 0.000). No significant evidence for associations of IL‑18 rs187238 polymorphisms with BD susceptibility was detected. Conclusion In summary, this meta-analysis finds that IL‑6 rs1800795 and IL‑18 rs1946518 polymorphisms decrease the risk of BD. However, IL‑12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary. |
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Association of cytokine gene polymorphisms (IL‑6, IL‑12B, IL‑18) with Behcet’s disease |
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