The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults
Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palma...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Allsopp, Philip [verfasserIn] Crowe, William [verfasserIn] Bahar, Bojlul [verfasserIn] Harnedy, Pádraigín A. [verfasserIn] Brown, Emma S. [verfasserIn] Taylor, Sonja S. [verfasserIn] Smyth, Thomas J. [verfasserIn] Soler-Vila, Anna [verfasserIn] Magee, Pamela J. [verfasserIn] Gill, Chris I. R. [verfasserIn] Strain, Conall R. [verfasserIn] Hegan, Vicky [verfasserIn] Devaney, Martin [verfasserIn] Wallace, Julie M. W. [verfasserIn] Cherry, Paul [verfasserIn] FitzGerald, Richard J. [verfasserIn] Strain, J. J. [verfasserIn] O’Doherty, John V. [verfasserIn] McSorley, Emeir M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Zeitschrift für Ernährungswissenschaft - Darmstadt : Steinkopff, 1960, 55(2015), 5 vom: 08. Aug., Seite 1951-1962 |
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| Übergeordnetes Werk: |
volume:55 ; year:2015 ; number:5 ; day:08 ; month:08 ; pages:1951-1962 |
| Links: |
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| DOI / URN: |
10.1007/s00394-015-1011-1 |
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SPR004872819 |
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| 245 | 1 | 4 | |a The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults |
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| 520 | |a Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. | ||
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| 650 | 4 | |a Human intervention |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lipid |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Crowe, William |e verfasserin |4 aut | |
| 700 | 1 | |a Bahar, Bojlul |e verfasserin |4 aut | |
| 700 | 1 | |a Harnedy, Pádraigín A. |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Emma S. |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Sonja S. |e verfasserin |4 aut | |
| 700 | 1 | |a Smyth, Thomas J. |e verfasserin |4 aut | |
| 700 | 1 | |a Soler-Vila, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Magee, Pamela J. |e verfasserin |4 aut | |
| 700 | 1 | |a Gill, Chris I. R. |e verfasserin |4 aut | |
| 700 | 1 | |a Strain, Conall R. |e verfasserin |4 aut | |
| 700 | 1 | |a Hegan, Vicky |e verfasserin |4 aut | |
| 700 | 1 | |a Devaney, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Wallace, Julie M. W. |e verfasserin |4 aut | |
| 700 | 1 | |a Cherry, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a FitzGerald, Richard J. |e verfasserin |4 aut | |
| 700 | 1 | |a Strain, J. J. |e verfasserin |4 aut | |
| 700 | 1 | |a O’Doherty, John V. |e verfasserin |4 aut | |
| 700 | 1 | |a McSorley, Emeir M. |e verfasserin |4 aut | |
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10.1007/s00394-015-1011-1 doi (DE-627)SPR004872819 (SPR)s00394-015-1011-1-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Allsopp, Philip verfasserin aut The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. Seaweed (dpeaa)DE-He213 Human intervention (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Lipid (dpeaa)DE-He213 Crowe, William verfasserin aut Bahar, Bojlul verfasserin aut Harnedy, Pádraigín A. verfasserin aut Brown, Emma S. verfasserin aut Taylor, Sonja S. verfasserin aut Smyth, Thomas J. verfasserin aut Soler-Vila, Anna verfasserin aut Magee, Pamela J. verfasserin aut Gill, Chris I. R. verfasserin aut Strain, Conall R. verfasserin aut Hegan, Vicky verfasserin aut Devaney, Martin verfasserin aut Wallace, Julie M. W. verfasserin aut Cherry, Paul verfasserin aut FitzGerald, Richard J. verfasserin aut Strain, J. J. verfasserin aut O’Doherty, John V. verfasserin aut McSorley, Emeir M. verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 55(2015), 5 vom: 08. Aug., Seite 1951-1962 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:55 year:2015 number:5 day:08 month:08 pages:1951-1962 https://dx.doi.org/10.1007/s00394-015-1011-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 55 2015 5 08 08 1951-1962 |
| spelling |
10.1007/s00394-015-1011-1 doi (DE-627)SPR004872819 (SPR)s00394-015-1011-1-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Allsopp, Philip verfasserin aut The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. Seaweed (dpeaa)DE-He213 Human intervention (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Lipid (dpeaa)DE-He213 Crowe, William verfasserin aut Bahar, Bojlul verfasserin aut Harnedy, Pádraigín A. verfasserin aut Brown, Emma S. verfasserin aut Taylor, Sonja S. verfasserin aut Smyth, Thomas J. verfasserin aut Soler-Vila, Anna verfasserin aut Magee, Pamela J. verfasserin aut Gill, Chris I. R. verfasserin aut Strain, Conall R. verfasserin aut Hegan, Vicky verfasserin aut Devaney, Martin verfasserin aut Wallace, Julie M. W. verfasserin aut Cherry, Paul verfasserin aut FitzGerald, Richard J. verfasserin aut Strain, J. J. verfasserin aut O’Doherty, John V. verfasserin aut McSorley, Emeir M. verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 55(2015), 5 vom: 08. Aug., Seite 1951-1962 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:55 year:2015 number:5 day:08 month:08 pages:1951-1962 https://dx.doi.org/10.1007/s00394-015-1011-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 55 2015 5 08 08 1951-1962 |
| allfields_unstemmed |
10.1007/s00394-015-1011-1 doi (DE-627)SPR004872819 (SPR)s00394-015-1011-1-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Allsopp, Philip verfasserin aut The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. Seaweed (dpeaa)DE-He213 Human intervention (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Lipid (dpeaa)DE-He213 Crowe, William verfasserin aut Bahar, Bojlul verfasserin aut Harnedy, Pádraigín A. verfasserin aut Brown, Emma S. verfasserin aut Taylor, Sonja S. verfasserin aut Smyth, Thomas J. verfasserin aut Soler-Vila, Anna verfasserin aut Magee, Pamela J. verfasserin aut Gill, Chris I. R. verfasserin aut Strain, Conall R. verfasserin aut Hegan, Vicky verfasserin aut Devaney, Martin verfasserin aut Wallace, Julie M. W. verfasserin aut Cherry, Paul verfasserin aut FitzGerald, Richard J. verfasserin aut Strain, J. J. verfasserin aut O’Doherty, John V. verfasserin aut McSorley, Emeir M. verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 55(2015), 5 vom: 08. Aug., Seite 1951-1962 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:55 year:2015 number:5 day:08 month:08 pages:1951-1962 https://dx.doi.org/10.1007/s00394-015-1011-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 55 2015 5 08 08 1951-1962 |
| allfieldsGer |
10.1007/s00394-015-1011-1 doi (DE-627)SPR004872819 (SPR)s00394-015-1011-1-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Allsopp, Philip verfasserin aut The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. Seaweed (dpeaa)DE-He213 Human intervention (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Lipid (dpeaa)DE-He213 Crowe, William verfasserin aut Bahar, Bojlul verfasserin aut Harnedy, Pádraigín A. verfasserin aut Brown, Emma S. verfasserin aut Taylor, Sonja S. verfasserin aut Smyth, Thomas J. verfasserin aut Soler-Vila, Anna verfasserin aut Magee, Pamela J. verfasserin aut Gill, Chris I. R. verfasserin aut Strain, Conall R. verfasserin aut Hegan, Vicky verfasserin aut Devaney, Martin verfasserin aut Wallace, Julie M. W. verfasserin aut Cherry, Paul verfasserin aut FitzGerald, Richard J. verfasserin aut Strain, J. J. verfasserin aut O’Doherty, John V. verfasserin aut McSorley, Emeir M. verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 55(2015), 5 vom: 08. Aug., Seite 1951-1962 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:55 year:2015 number:5 day:08 month:08 pages:1951-1962 https://dx.doi.org/10.1007/s00394-015-1011-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 55 2015 5 08 08 1951-1962 |
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10.1007/s00394-015-1011-1 doi (DE-627)SPR004872819 (SPR)s00394-015-1011-1-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Allsopp, Philip verfasserin aut The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. Seaweed (dpeaa)DE-He213 Human intervention (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Lipid (dpeaa)DE-He213 Crowe, William verfasserin aut Bahar, Bojlul verfasserin aut Harnedy, Pádraigín A. verfasserin aut Brown, Emma S. verfasserin aut Taylor, Sonja S. verfasserin aut Smyth, Thomas J. verfasserin aut Soler-Vila, Anna verfasserin aut Magee, Pamela J. verfasserin aut Gill, Chris I. R. verfasserin aut Strain, Conall R. verfasserin aut Hegan, Vicky verfasserin aut Devaney, Martin verfasserin aut Wallace, Julie M. W. verfasserin aut Cherry, Paul verfasserin aut FitzGerald, Richard J. verfasserin aut Strain, J. J. verfasserin aut O’Doherty, John V. verfasserin aut McSorley, Emeir M. verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 55(2015), 5 vom: 08. Aug., Seite 1951-1962 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:55 year:2015 number:5 day:08 month:08 pages:1951-1962 https://dx.doi.org/10.1007/s00394-015-1011-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 55 2015 5 08 08 1951-1962 |
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Allsopp, Philip Crowe, William Bahar, Bojlul Harnedy, Pádraigín A. Brown, Emma S. Taylor, Sonja S. Smyth, Thomas J. Soler-Vila, Anna Magee, Pamela J. Gill, Chris I. R. Strain, Conall R. Hegan, Vicky Devaney, Martin Wallace, Julie M. W. Cherry, Paul FitzGerald, Richard J. Strain, J. J. O’Doherty, John V. McSorley, Emeir M. |
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effect of consuming palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults |
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The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults |
| abstract |
Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. |
| abstractGer |
Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. |
| abstract_unstemmed |
Purpose Palmaria palmata (P. Palmata) is reported to contain anti-inflammatory and antioxidant compounds albeit no study has investigated these effects in humans. Methods A randomised parallel placebo-controlled human intervention study was carried out to investigate the effect of consuming P. Palmata (5 g/day) incorporated into a bread on serum markers of inflammation [C-reactive protein (CRP); cytokine analysis] with secondary analysis investigating changes in lipids (cholesterol, triglycerides), thyroid function [thyroid-stimulating hormone (TSH)] and antioxidant status ferric reducing antioxidant power. ANCOVA with baseline values as covariates, controlling for age, BMI, sex and smoking status, was used to compare differences between treatment groups over time. In vitro studies investigated the inflammatory activity of P. Palmata extracts (hot water, cold water and ethanol extract), protein extracts and associated protein hydrolysates using a Caco-2 inflammation cell model. Results Consumption of P. Palmata-enriched bread significantly increased serum CRP (+16.1 %, P = 0.011), triglycerides (+31.9 %, P = 0.001) and TSH (+17.2 %, P = 0.017) when compared to the control group. In vitro evaluation of P. palmata extracts and protein hydrolysates identified a significant induction of IL-8 secretion by Caco-2 cells, and the hot water P. palmata extract was shown to increase adipocyte glycerol release (P < 0.05). Conclusion Evidence from this human study suggests that P. palmata stimulates inflammation, increases serum triglycerides and alters thyroid function; however, these changes are not likely to impact health as changes remained within the normal clinical range. The data from the in vitro study provided indications that IL-8 may contribute to the apparent immunostimulation noted in the human study. |
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The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults |
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Crowe, William Bahar, Bojlul Harnedy, Pádraigín A. Brown, Emma S. Taylor, Sonja S. Smyth, Thomas J. Soler-Vila, Anna Magee, Pamela J. Gill, Chris I. R. Strain, Conall R. Hegan, Vicky Devaney, Martin Wallace, Julie M. W. Cherry, Paul FitzGerald, Richard J. Strain, J. J. O’Doherty, John V. McSorley, Emeir M. |
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