A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial
Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Whittaker, Anne [verfasserIn] Dinu, Monica [verfasserIn] Cesari, Francesca [verfasserIn] Gori, Anna Maria [verfasserIn] Fiorillo, Claudia [verfasserIn] Becatti, Matteo [verfasserIn] Casini, Alessandro [verfasserIn] Marcucci, Rossella [verfasserIn] Benedettelli, Stefano [verfasserIn] Sofi, Francesco [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Zeitschrift für Ernährungswissenschaft - Darmstadt : Steinkopff, 1960, 56(2016), 3 vom: 08. Feb., Seite 1191-1200 |
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| Übergeordnetes Werk: |
volume:56 ; year:2016 ; number:3 ; day:08 ; month:02 ; pages:1191-1200 |
| Links: |
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| DOI / URN: |
10.1007/s00394-016-1168-2 |
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SPR004874668 |
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| 245 | 1 | 2 | |a A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial |
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| 520 | |a Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. | ||
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| 650 | 4 | |a Khorasan wheat |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Type 2 diabetes mellitus |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Secondary prevention |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Glycaemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation cytokines |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Dinu, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Cesari, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Gori, Anna Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Fiorillo, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Becatti, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Casini, Alessandro |e verfasserin |4 aut | |
| 700 | 1 | |a Marcucci, Rossella |e verfasserin |4 aut | |
| 700 | 1 | |a Benedettelli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Sofi, Francesco |e verfasserin |4 aut | |
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10.1007/s00394-016-1168-2 doi (DE-627)SPR004874668 (SPR)s00394-016-1168-2-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Whittaker, Anne verfasserin aut A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. Organic wheat (dpeaa)DE-He213 Ancient wheat (dpeaa)DE-He213 Modern wheat (dpeaa)DE-He213 Khorasan wheat (dpeaa)DE-He213 Type 2 diabetes mellitus (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Glycaemia (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Inflammation cytokines (dpeaa)DE-He213 Dinu, Monica verfasserin aut Cesari, Francesca verfasserin aut Gori, Anna Maria verfasserin aut Fiorillo, Claudia verfasserin aut Becatti, Matteo verfasserin aut Casini, Alessandro verfasserin aut Marcucci, Rossella verfasserin aut Benedettelli, Stefano verfasserin aut Sofi, Francesco verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 56(2016), 3 vom: 08. Feb., Seite 1191-1200 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:56 year:2016 number:3 day:08 month:02 pages:1191-1200 https://dx.doi.org/10.1007/s00394-016-1168-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 56 2016 3 08 02 1191-1200 |
| spelling |
10.1007/s00394-016-1168-2 doi (DE-627)SPR004874668 (SPR)s00394-016-1168-2-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Whittaker, Anne verfasserin aut A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. Organic wheat (dpeaa)DE-He213 Ancient wheat (dpeaa)DE-He213 Modern wheat (dpeaa)DE-He213 Khorasan wheat (dpeaa)DE-He213 Type 2 diabetes mellitus (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Glycaemia (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Inflammation cytokines (dpeaa)DE-He213 Dinu, Monica verfasserin aut Cesari, Francesca verfasserin aut Gori, Anna Maria verfasserin aut Fiorillo, Claudia verfasserin aut Becatti, Matteo verfasserin aut Casini, Alessandro verfasserin aut Marcucci, Rossella verfasserin aut Benedettelli, Stefano verfasserin aut Sofi, Francesco verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 56(2016), 3 vom: 08. Feb., Seite 1191-1200 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:56 year:2016 number:3 day:08 month:02 pages:1191-1200 https://dx.doi.org/10.1007/s00394-016-1168-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 56 2016 3 08 02 1191-1200 |
| allfields_unstemmed |
10.1007/s00394-016-1168-2 doi (DE-627)SPR004874668 (SPR)s00394-016-1168-2-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Whittaker, Anne verfasserin aut A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. Organic wheat (dpeaa)DE-He213 Ancient wheat (dpeaa)DE-He213 Modern wheat (dpeaa)DE-He213 Khorasan wheat (dpeaa)DE-He213 Type 2 diabetes mellitus (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Glycaemia (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Inflammation cytokines (dpeaa)DE-He213 Dinu, Monica verfasserin aut Cesari, Francesca verfasserin aut Gori, Anna Maria verfasserin aut Fiorillo, Claudia verfasserin aut Becatti, Matteo verfasserin aut Casini, Alessandro verfasserin aut Marcucci, Rossella verfasserin aut Benedettelli, Stefano verfasserin aut Sofi, Francesco verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 56(2016), 3 vom: 08. Feb., Seite 1191-1200 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:56 year:2016 number:3 day:08 month:02 pages:1191-1200 https://dx.doi.org/10.1007/s00394-016-1168-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 56 2016 3 08 02 1191-1200 |
| allfieldsGer |
10.1007/s00394-016-1168-2 doi (DE-627)SPR004874668 (SPR)s00394-016-1168-2-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Whittaker, Anne verfasserin aut A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. Organic wheat (dpeaa)DE-He213 Ancient wheat (dpeaa)DE-He213 Modern wheat (dpeaa)DE-He213 Khorasan wheat (dpeaa)DE-He213 Type 2 diabetes mellitus (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Glycaemia (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Inflammation cytokines (dpeaa)DE-He213 Dinu, Monica verfasserin aut Cesari, Francesca verfasserin aut Gori, Anna Maria verfasserin aut Fiorillo, Claudia verfasserin aut Becatti, Matteo verfasserin aut Casini, Alessandro verfasserin aut Marcucci, Rossella verfasserin aut Benedettelli, Stefano verfasserin aut Sofi, Francesco verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 56(2016), 3 vom: 08. Feb., Seite 1191-1200 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:56 year:2016 number:3 day:08 month:02 pages:1191-1200 https://dx.doi.org/10.1007/s00394-016-1168-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 56 2016 3 08 02 1191-1200 |
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10.1007/s00394-016-1168-2 doi (DE-627)SPR004874668 (SPR)s00394-016-1168-2-e DE-627 ger DE-627 rakwb eng 630 640 610 ASE 44.21 bkl Whittaker, Anne verfasserin aut A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. Organic wheat (dpeaa)DE-He213 Ancient wheat (dpeaa)DE-He213 Modern wheat (dpeaa)DE-He213 Khorasan wheat (dpeaa)DE-He213 Type 2 diabetes mellitus (dpeaa)DE-He213 Secondary prevention (dpeaa)DE-He213 Glycaemia (dpeaa)DE-He213 Oxidative stress (dpeaa)DE-He213 Inflammation cytokines (dpeaa)DE-He213 Dinu, Monica verfasserin aut Cesari, Francesca verfasserin aut Gori, Anna Maria verfasserin aut Fiorillo, Claudia verfasserin aut Becatti, Matteo verfasserin aut Casini, Alessandro verfasserin aut Marcucci, Rossella verfasserin aut Benedettelli, Stefano verfasserin aut Sofi, Francesco verfasserin aut Enthalten in Zeitschrift für Ernährungswissenschaft Darmstadt : Steinkopff, 1960 56(2016), 3 vom: 08. Feb., Seite 1191-1200 (DE-627)461907356 (DE-600)2164295-3 1435-1293 nnns volume:56 year:2016 number:3 day:08 month:02 pages:1191-1200 https://dx.doi.org/10.1007/s00394-016-1168-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 44.21 ASE AR 56 2016 3 08 02 1191-1200 |
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A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial |
| abstract |
Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. |
| abstractGer |
Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. |
| abstract_unstemmed |
Purposes The aim of the present study was to examine whether a replacement diet with products made with organic ancient khorasan wheat could provide additive protective effects in reducing glucose, insulin, lipid and inflammatory risk factors, and in restoring blood redox balance in type 2 diabetes mellitus (T2DM) patients compared to diet with product made with modern organic wheat. Methods We conducted a randomized, double-blinded crossover trial with two intervention phases on 21 T2DM patients (14 females, 7 males). The participants were assigned to consume products (bread, pasta, crackers and biscuits) made using semi-whole flour from organic wheat that was either from ancient khorasan wheat or modern control wheat for 8 weeks in a random order. An 8-week washout period was implemented between the interventions. Laboratory analyses were performed both at the beginning and at the end of each intervention phase. Results The metabolic risk profile improved only after the khorasan intervention period, as measured by a reduction in total and LDL cholesterol (mean reduction: −3.7 and −3.4 %, respectively), insulin (−16.3 %) and blood glucose (−9.1 %). Similarly, there was a significant reduction in circulating levels of reactive oxygen species (ROS), vascular endothelial growth factor (VEGF) and interleukin-1ra, and a significant increase of total antioxidant capacity (+6.3 %). No significant differences from baseline were noted after the modern control wheat intervention phase. The change (from pre- to post-intervention) between the two intervention arms was significantly different (p < 0.05) for total and LDL-c, insulin and HOMA index. Conclusions A replacement diet with ancient khorasan wheat consumption provided additive protection in reducing total and LDL cholesterol, insulin, blood glucose, ROS production, and some inflammatory risk factors, which are all key factors warranting of control in secondary prevention of T2DM compared to a diet with products made with modern wheat. |
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| title_short |
A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial |
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https://dx.doi.org/10.1007/s00394-016-1168-2 |
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| author2 |
Dinu, Monica Cesari, Francesca Gori, Anna Maria Fiorillo, Claudia Becatti, Matteo Casini, Alessandro Marcucci, Rossella Benedettelli, Stefano Sofi, Francesco |
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Dinu, Monica Cesari, Francesca Gori, Anna Maria Fiorillo, Claudia Becatti, Matteo Casini, Alessandro Marcucci, Rossella Benedettelli, Stefano Sofi, Francesco |
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10.1007/s00394-016-1168-2 |
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