Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dickson, Dennis W. [verfasserIn] Fujishiro, Hiroshige [verfasserIn] DelleDonne, Anthony [verfasserIn] Menke, Joshua [verfasserIn] Ahmed, Zeshan [verfasserIn] Klos, Kevin J. [verfasserIn] Josephs, Keith A. [verfasserIn] Frigerio, Roberta [verfasserIn] Burnett, Melinda [verfasserIn] Parisi, Joseph E. [verfasserIn] Ahlskog, J. Eric [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2008 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Acta neuropathologica - Berlin : Springer, 1961, 115(2008), 4 vom: 09. Feb., Seite 437-444 |
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| Übergeordnetes Werk: |
volume:115 ; year:2008 ; number:4 ; day:09 ; month:02 ; pages:437-444 |
| Links: |
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| DOI / URN: |
10.1007/s00401-008-0345-7 |
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| Katalog-ID: |
SPR004977734 |
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| 520 | |a Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. | ||
| 650 | 4 | |a Immunohistochemistry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incidental Lewy bodies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Parkinson’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Striatum |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tyrosine hydroxylase |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Fujishiro, Hiroshige |e verfasserin |4 aut | |
| 700 | 1 | |a DelleDonne, Anthony |e verfasserin |4 aut | |
| 700 | 1 | |a Menke, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmed, Zeshan |e verfasserin |4 aut | |
| 700 | 1 | |a Klos, Kevin J. |e verfasserin |4 aut | |
| 700 | 1 | |a Josephs, Keith A. |e verfasserin |4 aut | |
| 700 | 1 | |a Frigerio, Roberta |e verfasserin |4 aut | |
| 700 | 1 | |a Burnett, Melinda |e verfasserin |4 aut | |
| 700 | 1 | |a Parisi, Joseph E. |e verfasserin |4 aut | |
| 700 | 1 | |a Ahlskog, J. Eric |e verfasserin |4 aut | |
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10.1007/s00401-008-0345-7 doi (DE-627)SPR004977734 (SPR)s00401-008-0345-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Dickson, Dennis W. verfasserin aut Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Fujishiro, Hiroshige verfasserin aut DelleDonne, Anthony verfasserin aut Menke, Joshua verfasserin aut Ahmed, Zeshan verfasserin aut Klos, Kevin J. verfasserin aut Josephs, Keith A. verfasserin aut Frigerio, Roberta verfasserin aut Burnett, Melinda verfasserin aut Parisi, Joseph E. verfasserin aut Ahlskog, J. Eric verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 115(2008), 4 vom: 09. Feb., Seite 437-444 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:115 year:2008 number:4 day:09 month:02 pages:437-444 https://dx.doi.org/10.1007/s00401-008-0345-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 115 2008 4 09 02 437-444 |
| spelling |
10.1007/s00401-008-0345-7 doi (DE-627)SPR004977734 (SPR)s00401-008-0345-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Dickson, Dennis W. verfasserin aut Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Fujishiro, Hiroshige verfasserin aut DelleDonne, Anthony verfasserin aut Menke, Joshua verfasserin aut Ahmed, Zeshan verfasserin aut Klos, Kevin J. verfasserin aut Josephs, Keith A. verfasserin aut Frigerio, Roberta verfasserin aut Burnett, Melinda verfasserin aut Parisi, Joseph E. verfasserin aut Ahlskog, J. Eric verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 115(2008), 4 vom: 09. Feb., Seite 437-444 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:115 year:2008 number:4 day:09 month:02 pages:437-444 https://dx.doi.org/10.1007/s00401-008-0345-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 115 2008 4 09 02 437-444 |
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10.1007/s00401-008-0345-7 doi (DE-627)SPR004977734 (SPR)s00401-008-0345-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Dickson, Dennis W. verfasserin aut Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Fujishiro, Hiroshige verfasserin aut DelleDonne, Anthony verfasserin aut Menke, Joshua verfasserin aut Ahmed, Zeshan verfasserin aut Klos, Kevin J. verfasserin aut Josephs, Keith A. verfasserin aut Frigerio, Roberta verfasserin aut Burnett, Melinda verfasserin aut Parisi, Joseph E. verfasserin aut Ahlskog, J. Eric verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 115(2008), 4 vom: 09. Feb., Seite 437-444 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:115 year:2008 number:4 day:09 month:02 pages:437-444 https://dx.doi.org/10.1007/s00401-008-0345-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 115 2008 4 09 02 437-444 |
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10.1007/s00401-008-0345-7 doi (DE-627)SPR004977734 (SPR)s00401-008-0345-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Dickson, Dennis W. verfasserin aut Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Fujishiro, Hiroshige verfasserin aut DelleDonne, Anthony verfasserin aut Menke, Joshua verfasserin aut Ahmed, Zeshan verfasserin aut Klos, Kevin J. verfasserin aut Josephs, Keith A. verfasserin aut Frigerio, Roberta verfasserin aut Burnett, Melinda verfasserin aut Parisi, Joseph E. verfasserin aut Ahlskog, J. Eric verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 115(2008), 4 vom: 09. Feb., Seite 437-444 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:115 year:2008 number:4 day:09 month:02 pages:437-444 https://dx.doi.org/10.1007/s00401-008-0345-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 115 2008 4 09 02 437-444 |
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10.1007/s00401-008-0345-7 doi (DE-627)SPR004977734 (SPR)s00401-008-0345-7-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Dickson, Dennis W. verfasserin aut Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 Fujishiro, Hiroshige verfasserin aut DelleDonne, Anthony verfasserin aut Menke, Joshua verfasserin aut Ahmed, Zeshan verfasserin aut Klos, Kevin J. verfasserin aut Josephs, Keith A. verfasserin aut Frigerio, Roberta verfasserin aut Burnett, Melinda verfasserin aut Parisi, Joseph E. verfasserin aut Ahlskog, J. Eric verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 115(2008), 4 vom: 09. Feb., Seite 437-444 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:115 year:2008 number:4 day:09 month:02 pages:437-444 https://dx.doi.org/10.1007/s00401-008-0345-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 115 2008 4 09 02 437-444 |
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Enthalten in Acta neuropathologica 115(2008), 4 vom: 09. Feb., Seite 437-444 volume:115 year:2008 number:4 day:09 month:02 pages:437-444 |
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Immunohistochemistry Incidental Lewy bodies Heart Parkinson’s disease Striatum Tyrosine hydroxylase |
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Dickson, Dennis W. @@aut@@ Fujishiro, Hiroshige @@aut@@ DelleDonne, Anthony @@aut@@ Menke, Joshua @@aut@@ Ahmed, Zeshan @@aut@@ Klos, Kevin J. @@aut@@ Josephs, Keith A. @@aut@@ Frigerio, Roberta @@aut@@ Burnett, Melinda @@aut@@ Parisi, Joseph E. @@aut@@ Ahlskog, J. Eric @@aut@@ |
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2008-02-09T00:00:00Z |
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Dickson, Dennis W. |
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Dickson, Dennis W. ddc 610 bkl 44.90 misc Immunohistochemistry misc Incidental Lewy bodies misc Heart misc Parkinson’s disease misc Striatum misc Tyrosine hydroxylase Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease |
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610 ASE 44.90 bkl Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease Immunohistochemistry (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Striatum (dpeaa)DE-He213 Tyrosine hydroxylase (dpeaa)DE-He213 |
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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease |
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Dickson, Dennis W. |
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Acta neuropathologica |
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Dickson, Dennis W. Fujishiro, Hiroshige DelleDonne, Anthony Menke, Joshua Ahmed, Zeshan Klos, Kevin J. Josephs, Keith A. Frigerio, Roberta Burnett, Melinda Parisi, Joseph E. Ahlskog, J. Eric |
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evidence that incidental lewy body disease is pre-symptomatic parkinson’s disease |
| title_auth |
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease |
| abstract |
Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. |
| abstractGer |
Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. |
| abstract_unstemmed |
Abstract Lewy bodies, the histologic hallmark of Parkinson’s disease (PD), are detected in the brains of about 10% of clinically normal people over the age of 60 years. When Lewy bodies are found in normal individuals, the process is sometimes referred to as incidental Lewy body disease (iLBD). The distribution of Lewy bodies in iLBD is similar to the distribution in PD, but neuronal populations vulnerable to Lewy bodies do not show significant neuronal loss in iLBD. It remains unknown if Lewy bodies in this setting represent pre-symptomatic PD or an age-related change unrelated to PD. To address this question we identified cases of iLBD and used a marker for dopaminergic and noradrenergic neurons, tyrosine hydroxylase (TH), to determine if there were changes similar to those found in PD. TH immunoreactivity in the striatum and the epicardial nerve fibers was decreased in iLBD compared to normal controls, but not to the same extent as in PD. The findings suggest that iLBD is preclinical PD and that the lack of symptoms is due to subthreshold pathology. |
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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease |
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Fujishiro, Hiroshige DelleDonne, Anthony Menke, Joshua Ahmed, Zeshan Klos, Kevin J. Josephs, Keith A. Frigerio, Roberta Burnett, Melinda Parisi, Joseph E. Ahlskog, J. Eric |
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Fujishiro, Hiroshige DelleDonne, Anthony Menke, Joshua Ahmed, Zeshan Klos, Kevin J. Josephs, Keith A. Frigerio, Roberta Burnett, Melinda Parisi, Joseph E. Ahlskog, J. Eric |
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| score |
7.401613 |