Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD),...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Beach, Thomas G. [verfasserIn] Adler, Charles H. [verfasserIn] Sue, Lucia I. [verfasserIn] Vedders, Linda [verfasserIn] Lue, LihFen [verfasserIn] White III, Charles L. [verfasserIn] Akiyama, Haru [verfasserIn] Caviness, John N. [verfasserIn] Shill, Holly A. [verfasserIn] Sabbagh, Marwan N. [verfasserIn] Walker, Douglas G. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Acta neuropathologica - Berlin : Springer, 1961, 119(2010), 6 vom: 21. März, Seite 689-702 |
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| Übergeordnetes Werk: |
volume:119 ; year:2010 ; number:6 ; day:21 ; month:03 ; pages:689-702 |
| Links: |
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| DOI / URN: |
10.1007/s00401-010-0664-3 |
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| Katalog-ID: |
SPR004980980 |
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| 100 | 1 | |a Beach, Thomas G. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
| 264 | 1 | |c 2010 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. | ||
| 650 | 4 | |a Parkinson’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Parkinsonism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dementia with Lewy bodies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Alzheimer’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incidental Lewy bodies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a α-Synuclein |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Spinal cord |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sympathetic nervous system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Peripheral nervous system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autonomic nervous system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Enteric nervous system |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Submandibular gland |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Esophagus |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adrenal gland |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Heart |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Stomach |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gastrointestinal system |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Adler, Charles H. |e verfasserin |4 aut | |
| 700 | 1 | |a Sue, Lucia I. |e verfasserin |4 aut | |
| 700 | 1 | |a Vedders, Linda |e verfasserin |4 aut | |
| 700 | 1 | |a Lue, LihFen |e verfasserin |4 aut | |
| 700 | 1 | |a White III, Charles L. |e verfasserin |4 aut | |
| 700 | 1 | |a Akiyama, Haru |e verfasserin |4 aut | |
| 700 | 1 | |a Caviness, John N. |e verfasserin |4 aut | |
| 700 | 1 | |a Shill, Holly A. |e verfasserin |4 aut | |
| 700 | 1 | |a Sabbagh, Marwan N. |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Douglas G. |e verfasserin |4 aut | |
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10.1007/s00401-010-0664-3 doi (DE-627)SPR004980980 (SPR)s00401-010-0664-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Beach, Thomas G. verfasserin aut Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 Adler, Charles H. verfasserin aut Sue, Lucia I. verfasserin aut Vedders, Linda verfasserin aut Lue, LihFen verfasserin aut White III, Charles L. verfasserin aut Akiyama, Haru verfasserin aut Caviness, John N. verfasserin aut Shill, Holly A. verfasserin aut Sabbagh, Marwan N. verfasserin aut Walker, Douglas G. verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 119(2010), 6 vom: 21. März, Seite 689-702 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:119 year:2010 number:6 day:21 month:03 pages:689-702 https://dx.doi.org/10.1007/s00401-010-0664-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 119 2010 6 21 03 689-702 |
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10.1007/s00401-010-0664-3 doi (DE-627)SPR004980980 (SPR)s00401-010-0664-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Beach, Thomas G. verfasserin aut Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 Adler, Charles H. verfasserin aut Sue, Lucia I. verfasserin aut Vedders, Linda verfasserin aut Lue, LihFen verfasserin aut White III, Charles L. verfasserin aut Akiyama, Haru verfasserin aut Caviness, John N. verfasserin aut Shill, Holly A. verfasserin aut Sabbagh, Marwan N. verfasserin aut Walker, Douglas G. verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 119(2010), 6 vom: 21. März, Seite 689-702 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:119 year:2010 number:6 day:21 month:03 pages:689-702 https://dx.doi.org/10.1007/s00401-010-0664-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 119 2010 6 21 03 689-702 |
| allfields_unstemmed |
10.1007/s00401-010-0664-3 doi (DE-627)SPR004980980 (SPR)s00401-010-0664-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Beach, Thomas G. verfasserin aut Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 Adler, Charles H. verfasserin aut Sue, Lucia I. verfasserin aut Vedders, Linda verfasserin aut Lue, LihFen verfasserin aut White III, Charles L. verfasserin aut Akiyama, Haru verfasserin aut Caviness, John N. verfasserin aut Shill, Holly A. verfasserin aut Sabbagh, Marwan N. verfasserin aut Walker, Douglas G. verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 119(2010), 6 vom: 21. März, Seite 689-702 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:119 year:2010 number:6 day:21 month:03 pages:689-702 https://dx.doi.org/10.1007/s00401-010-0664-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 119 2010 6 21 03 689-702 |
| allfieldsGer |
10.1007/s00401-010-0664-3 doi (DE-627)SPR004980980 (SPR)s00401-010-0664-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Beach, Thomas G. verfasserin aut Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 Adler, Charles H. verfasserin aut Sue, Lucia I. verfasserin aut Vedders, Linda verfasserin aut Lue, LihFen verfasserin aut White III, Charles L. verfasserin aut Akiyama, Haru verfasserin aut Caviness, John N. verfasserin aut Shill, Holly A. verfasserin aut Sabbagh, Marwan N. verfasserin aut Walker, Douglas G. verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 119(2010), 6 vom: 21. März, Seite 689-702 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:119 year:2010 number:6 day:21 month:03 pages:689-702 https://dx.doi.org/10.1007/s00401-010-0664-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 119 2010 6 21 03 689-702 |
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10.1007/s00401-010-0664-3 doi (DE-627)SPR004980980 (SPR)s00401-010-0664-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl Beach, Thomas G. verfasserin aut Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 Adler, Charles H. verfasserin aut Sue, Lucia I. verfasserin aut Vedders, Linda verfasserin aut Lue, LihFen verfasserin aut White III, Charles L. verfasserin aut Akiyama, Haru verfasserin aut Caviness, John N. verfasserin aut Shill, Holly A. verfasserin aut Sabbagh, Marwan N. verfasserin aut Walker, Douglas G. verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 119(2010), 6 vom: 21. März, Seite 689-702 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:119 year:2010 number:6 day:21 month:03 pages:689-702 https://dx.doi.org/10.1007/s00401-010-0664-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 119 2010 6 21 03 689-702 |
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Parkinson’s disease Parkinsonism Dementia with Lewy bodies Alzheimer’s disease Incidental Lewy bodies α-Synuclein Spinal cord Sympathetic nervous system Peripheral nervous system Autonomic nervous system Enteric nervous system Submandibular gland Esophagus Adrenal gland Heart Stomach Gastrointestinal system |
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Beach, Thomas G. @@aut@@ Adler, Charles H. @@aut@@ Sue, Lucia I. @@aut@@ Vedders, Linda @@aut@@ Lue, LihFen @@aut@@ White III, Charles L. @@aut@@ Akiyama, Haru @@aut@@ Caviness, John N. @@aut@@ Shill, Holly A. @@aut@@ Sabbagh, Marwan N. @@aut@@ Walker, Douglas G. @@aut@@ |
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| author |
Beach, Thomas G. |
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Beach, Thomas G. ddc 610 bkl 44.90 misc Parkinson’s disease misc Parkinsonism misc Dementia with Lewy bodies misc Alzheimer’s disease misc Incidental Lewy bodies misc α-Synuclein misc Spinal cord misc Sympathetic nervous system misc Peripheral nervous system misc Autonomic nervous system misc Enteric nervous system misc Submandibular gland misc Esophagus misc Adrenal gland misc Heart misc Stomach misc Gastrointestinal system Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
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1432-0533 |
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610 ASE 44.90 bkl Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders Parkinson’s disease (dpeaa)DE-He213 Parkinsonism (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Alzheimer’s disease (dpeaa)DE-He213 Incidental Lewy bodies (dpeaa)DE-He213 α-Synuclein (dpeaa)DE-He213 Spinal cord (dpeaa)DE-He213 Sympathetic nervous system (dpeaa)DE-He213 Peripheral nervous system (dpeaa)DE-He213 Autonomic nervous system (dpeaa)DE-He213 Enteric nervous system (dpeaa)DE-He213 Submandibular gland (dpeaa)DE-He213 Esophagus (dpeaa)DE-He213 Adrenal gland (dpeaa)DE-He213 Heart (dpeaa)DE-He213 Stomach (dpeaa)DE-He213 Gastrointestinal system (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.90 misc Parkinson’s disease misc Parkinsonism misc Dementia with Lewy bodies misc Alzheimer’s disease misc Incidental Lewy bodies misc α-Synuclein misc Spinal cord misc Sympathetic nervous system misc Peripheral nervous system misc Autonomic nervous system misc Enteric nervous system misc Submandibular gland misc Esophagus misc Adrenal gland misc Heart misc Stomach misc Gastrointestinal system |
| topic_unstemmed |
ddc 610 bkl 44.90 misc Parkinson’s disease misc Parkinsonism misc Dementia with Lewy bodies misc Alzheimer’s disease misc Incidental Lewy bodies misc α-Synuclein misc Spinal cord misc Sympathetic nervous system misc Peripheral nervous system misc Autonomic nervous system misc Enteric nervous system misc Submandibular gland misc Esophagus misc Adrenal gland misc Heart misc Stomach misc Gastrointestinal system |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Parkinsonism misc Dementia with Lewy bodies misc Alzheimer’s disease misc Incidental Lewy bodies misc α-Synuclein misc Spinal cord misc Sympathetic nervous system misc Peripheral nervous system misc Autonomic nervous system misc Enteric nervous system misc Submandibular gland misc Esophagus misc Adrenal gland misc Heart misc Stomach misc Gastrointestinal system |
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Acta neuropathologica |
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Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
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(DE-627)SPR004980980 (SPR)s00401-010-0664-3-e |
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Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
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Beach, Thomas G. |
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Acta neuropathologica |
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Beach, Thomas G. Adler, Charles H. Sue, Lucia I. Vedders, Linda Lue, LihFen White III, Charles L. Akiyama, Haru Caviness, John N. Shill, Holly A. Sabbagh, Marwan N. Walker, Douglas G. |
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610 ASE 44.90 bkl |
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Elektronische Aufsätze |
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Beach, Thomas G. |
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10.1007/s00401-010-0664-3 |
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610 |
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verfasserin |
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multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with lewy body disorders |
| title_auth |
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
| abstract |
Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. |
| abstractGer |
Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. |
| abstract_unstemmed |
Abstract A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. |
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Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders |
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https://dx.doi.org/10.1007/s00401-010-0664-3 |
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Adler, Charles H. Sue, Lucia I. Vedders, Linda Lue, LihFen White III, Charles L. Akiyama, Haru Caviness, John N. Shill, Holly A. Sabbagh, Marwan N. Walker, Douglas G. |
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Adler, Charles H. Sue, Lucia I. Vedders, Linda Lue, LihFen White III, Charles L. Akiyama, Haru Caviness, John N. Shill, Holly A. Sabbagh, Marwan N. Walker, Douglas G. |
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10.1007/s00401-010-0664-3 |
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2024-07-04T03:16:22.218Z |
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| score |
7.401615 |