A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity...
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Acta neuropathologica - Berlin : Springer, 1961, 138(2019), 2 vom: 26. Mai, Seite 237-250 |
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| Übergeordnetes Werk: |
volume:138 ; year:2019 ; number:2 ; day:26 ; month:05 ; pages:237-250 |
| Links: |
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| DOI / URN: |
10.1007/s00401-019-02026-8 |
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SPR004994450 |
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| 024 | 7 | |a 10.1007/s00401-019-02026-8 |2 doi | |
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| 100 | 1 | |a van der Lee, Sven J. |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. | ||
| 650 | 4 | |a Alzheimer’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Frontotemporal dementia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Dementia with Lewy bodies |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Progressive supranuclear palsy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Parkinson’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Amyotrophic lateral sclerosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Multiple sclerosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neurodegenerative disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Longevity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PLCG2 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Phospholipase C Gamma 2 |7 (dpeaa)DE-He213 | |
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10.1007/s00401-019-02026-8 doi (DE-627)SPR004994450 (SPR)s00401-019-02026-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl van der Lee, Sven J. verfasserin aut A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 Conway, Olivia J. verfasserin aut Jansen, Iris verfasserin aut Carrasquillo, Minerva M. verfasserin aut Kleineidam, Luca verfasserin aut van den Akker, Erik verfasserin aut Hernández, Isabel verfasserin aut van Eijk, Kristel R. verfasserin aut Stringa, Najada verfasserin aut Chen, Jason A. verfasserin aut Zettergren, Anna verfasserin aut Andlauer, Till F. M. verfasserin aut Diez-Fairen, Monica verfasserin aut Simon-Sanchez, Javier verfasserin aut Lleó, Alberto verfasserin aut Zetterberg, Henrik verfasserin aut Nygaard, Marianne verfasserin aut Blauwendraat, Cornelis verfasserin aut Savage, Jeanne E. verfasserin aut Mengel-From, Jonas verfasserin aut Moreno-Grau, Sonia verfasserin aut Wagner, Michael verfasserin aut Fortea, Juan verfasserin aut Keogh, Michael J. verfasserin aut Blennow, Kaj verfasserin aut Skoog, Ingmar verfasserin aut Friese, Manuel A. verfasserin aut Pletnikova, Olga verfasserin aut Zulaica, Miren verfasserin aut Lage, Carmen verfasserin aut de Rojas, Itziar verfasserin aut Riedel-Heller, Steffi verfasserin aut Illán-Gala, Ignacio verfasserin aut Wei, Wei verfasserin aut Jeune, Bernard verfasserin aut Orellana, Adelina verfasserin aut Then Bergh, Florian verfasserin aut Wang, Xue verfasserin aut Hulsman, Marc verfasserin aut Beker, Nina verfasserin aut Tesi, Niccolo verfasserin aut Morris, Christopher M. verfasserin aut Indakoetxea, Begoña verfasserin aut Collij, Lyduine E. verfasserin aut Scherer, Martin verfasserin aut Morenas-Rodríguez, Estrella verfasserin aut Ironside, James W. verfasserin aut van Berckel, Bart N. M. verfasserin aut Alcolea, Daniel verfasserin aut Wiendl, Heinz verfasserin aut Strickland, Samantha L. verfasserin aut Pastor, Pau verfasserin aut Rodríguez Rodríguez, Eloy verfasserin aut Boeve, Bradley F. verfasserin aut Petersen, Ronald C. verfasserin aut Ferman, Tanis J. verfasserin aut van Gerpen, Jay A. verfasserin aut Reinders, Marcel J. T. verfasserin aut Uitti, Ryan J. verfasserin aut Tárraga, Lluís verfasserin aut Maier, Wolfgang verfasserin aut Dols-Icardo, Oriol verfasserin aut Kawalia, Amit verfasserin aut Dalmasso, Maria Carolina verfasserin aut Boada, Mercè verfasserin aut Zettl, Uwe K. verfasserin aut van Schoor, Natasja M. verfasserin aut Beekman, Marian verfasserin aut Allen, Mariet verfasserin aut Masliah, Eliezer verfasserin aut de Munain, Adolfo López verfasserin aut Pantelyat, Alexander verfasserin aut Wszolek, Zbigniew K. verfasserin aut Ross, Owen A. verfasserin aut Dickson, Dennis W. verfasserin aut Graff-Radford, Neill R. verfasserin aut Knopman, David verfasserin aut Rademakers, Rosa verfasserin aut Lemstra, Afina W. verfasserin aut Pijnenburg, Yolande A. L. verfasserin aut Scheltens, Philip verfasserin aut Gasser, Thomas verfasserin aut Chinnery, Patrick F verfasserin aut Hemmer, Bernhard verfasserin aut Huisman, Martijn A. verfasserin aut Troncoso, Juan verfasserin aut Moreno, Fermin verfasserin aut Nohr, Ellen A. verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Heutink, Peter verfasserin aut Sánchez-Juan, Pascual verfasserin aut Posthuma, Danielle verfasserin aut Clarimón, Jordi verfasserin aut Christensen, Kaare verfasserin aut Ertekin-Taner, Nilüfer verfasserin aut Scholz, Sonja W. verfasserin aut Ramirez, Alfredo verfasserin aut Ruiz, Agustín verfasserin aut Slagboom, Eline verfasserin aut van der Flier, Wiesje M. verfasserin aut Holstege, Henne verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 138(2019), 2 vom: 26. Mai, Seite 237-250 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:138 year:2019 number:2 day:26 month:05 pages:237-250 https://dx.doi.org/10.1007/s00401-019-02026-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 138 2019 2 26 05 237-250 |
| spelling |
10.1007/s00401-019-02026-8 doi (DE-627)SPR004994450 (SPR)s00401-019-02026-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl van der Lee, Sven J. verfasserin aut A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 Conway, Olivia J. verfasserin aut Jansen, Iris verfasserin aut Carrasquillo, Minerva M. verfasserin aut Kleineidam, Luca verfasserin aut van den Akker, Erik verfasserin aut Hernández, Isabel verfasserin aut van Eijk, Kristel R. verfasserin aut Stringa, Najada verfasserin aut Chen, Jason A. verfasserin aut Zettergren, Anna verfasserin aut Andlauer, Till F. M. verfasserin aut Diez-Fairen, Monica verfasserin aut Simon-Sanchez, Javier verfasserin aut Lleó, Alberto verfasserin aut Zetterberg, Henrik verfasserin aut Nygaard, Marianne verfasserin aut Blauwendraat, Cornelis verfasserin aut Savage, Jeanne E. verfasserin aut Mengel-From, Jonas verfasserin aut Moreno-Grau, Sonia verfasserin aut Wagner, Michael verfasserin aut Fortea, Juan verfasserin aut Keogh, Michael J. verfasserin aut Blennow, Kaj verfasserin aut Skoog, Ingmar verfasserin aut Friese, Manuel A. verfasserin aut Pletnikova, Olga verfasserin aut Zulaica, Miren verfasserin aut Lage, Carmen verfasserin aut de Rojas, Itziar verfasserin aut Riedel-Heller, Steffi verfasserin aut Illán-Gala, Ignacio verfasserin aut Wei, Wei verfasserin aut Jeune, Bernard verfasserin aut Orellana, Adelina verfasserin aut Then Bergh, Florian verfasserin aut Wang, Xue verfasserin aut Hulsman, Marc verfasserin aut Beker, Nina verfasserin aut Tesi, Niccolo verfasserin aut Morris, Christopher M. verfasserin aut Indakoetxea, Begoña verfasserin aut Collij, Lyduine E. verfasserin aut Scherer, Martin verfasserin aut Morenas-Rodríguez, Estrella verfasserin aut Ironside, James W. verfasserin aut van Berckel, Bart N. M. verfasserin aut Alcolea, Daniel verfasserin aut Wiendl, Heinz verfasserin aut Strickland, Samantha L. verfasserin aut Pastor, Pau verfasserin aut Rodríguez Rodríguez, Eloy verfasserin aut Boeve, Bradley F. verfasserin aut Petersen, Ronald C. verfasserin aut Ferman, Tanis J. verfasserin aut van Gerpen, Jay A. verfasserin aut Reinders, Marcel J. T. verfasserin aut Uitti, Ryan J. verfasserin aut Tárraga, Lluís verfasserin aut Maier, Wolfgang verfasserin aut Dols-Icardo, Oriol verfasserin aut Kawalia, Amit verfasserin aut Dalmasso, Maria Carolina verfasserin aut Boada, Mercè verfasserin aut Zettl, Uwe K. verfasserin aut van Schoor, Natasja M. verfasserin aut Beekman, Marian verfasserin aut Allen, Mariet verfasserin aut Masliah, Eliezer verfasserin aut de Munain, Adolfo López verfasserin aut Pantelyat, Alexander verfasserin aut Wszolek, Zbigniew K. verfasserin aut Ross, Owen A. verfasserin aut Dickson, Dennis W. verfasserin aut Graff-Radford, Neill R. verfasserin aut Knopman, David verfasserin aut Rademakers, Rosa verfasserin aut Lemstra, Afina W. verfasserin aut Pijnenburg, Yolande A. L. verfasserin aut Scheltens, Philip verfasserin aut Gasser, Thomas verfasserin aut Chinnery, Patrick F verfasserin aut Hemmer, Bernhard verfasserin aut Huisman, Martijn A. verfasserin aut Troncoso, Juan verfasserin aut Moreno, Fermin verfasserin aut Nohr, Ellen A. verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Heutink, Peter verfasserin aut Sánchez-Juan, Pascual verfasserin aut Posthuma, Danielle verfasserin aut Clarimón, Jordi verfasserin aut Christensen, Kaare verfasserin aut Ertekin-Taner, Nilüfer verfasserin aut Scholz, Sonja W. verfasserin aut Ramirez, Alfredo verfasserin aut Ruiz, Agustín verfasserin aut Slagboom, Eline verfasserin aut van der Flier, Wiesje M. verfasserin aut Holstege, Henne verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 138(2019), 2 vom: 26. Mai, Seite 237-250 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:138 year:2019 number:2 day:26 month:05 pages:237-250 https://dx.doi.org/10.1007/s00401-019-02026-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 138 2019 2 26 05 237-250 |
| allfields_unstemmed |
10.1007/s00401-019-02026-8 doi (DE-627)SPR004994450 (SPR)s00401-019-02026-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl van der Lee, Sven J. verfasserin aut A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 Conway, Olivia J. verfasserin aut Jansen, Iris verfasserin aut Carrasquillo, Minerva M. verfasserin aut Kleineidam, Luca verfasserin aut van den Akker, Erik verfasserin aut Hernández, Isabel verfasserin aut van Eijk, Kristel R. verfasserin aut Stringa, Najada verfasserin aut Chen, Jason A. verfasserin aut Zettergren, Anna verfasserin aut Andlauer, Till F. M. verfasserin aut Diez-Fairen, Monica verfasserin aut Simon-Sanchez, Javier verfasserin aut Lleó, Alberto verfasserin aut Zetterberg, Henrik verfasserin aut Nygaard, Marianne verfasserin aut Blauwendraat, Cornelis verfasserin aut Savage, Jeanne E. verfasserin aut Mengel-From, Jonas verfasserin aut Moreno-Grau, Sonia verfasserin aut Wagner, Michael verfasserin aut Fortea, Juan verfasserin aut Keogh, Michael J. verfasserin aut Blennow, Kaj verfasserin aut Skoog, Ingmar verfasserin aut Friese, Manuel A. verfasserin aut Pletnikova, Olga verfasserin aut Zulaica, Miren verfasserin aut Lage, Carmen verfasserin aut de Rojas, Itziar verfasserin aut Riedel-Heller, Steffi verfasserin aut Illán-Gala, Ignacio verfasserin aut Wei, Wei verfasserin aut Jeune, Bernard verfasserin aut Orellana, Adelina verfasserin aut Then Bergh, Florian verfasserin aut Wang, Xue verfasserin aut Hulsman, Marc verfasserin aut Beker, Nina verfasserin aut Tesi, Niccolo verfasserin aut Morris, Christopher M. verfasserin aut Indakoetxea, Begoña verfasserin aut Collij, Lyduine E. verfasserin aut Scherer, Martin verfasserin aut Morenas-Rodríguez, Estrella verfasserin aut Ironside, James W. verfasserin aut van Berckel, Bart N. M. verfasserin aut Alcolea, Daniel verfasserin aut Wiendl, Heinz verfasserin aut Strickland, Samantha L. verfasserin aut Pastor, Pau verfasserin aut Rodríguez Rodríguez, Eloy verfasserin aut Boeve, Bradley F. verfasserin aut Petersen, Ronald C. verfasserin aut Ferman, Tanis J. verfasserin aut van Gerpen, Jay A. verfasserin aut Reinders, Marcel J. T. verfasserin aut Uitti, Ryan J. verfasserin aut Tárraga, Lluís verfasserin aut Maier, Wolfgang verfasserin aut Dols-Icardo, Oriol verfasserin aut Kawalia, Amit verfasserin aut Dalmasso, Maria Carolina verfasserin aut Boada, Mercè verfasserin aut Zettl, Uwe K. verfasserin aut van Schoor, Natasja M. verfasserin aut Beekman, Marian verfasserin aut Allen, Mariet verfasserin aut Masliah, Eliezer verfasserin aut de Munain, Adolfo López verfasserin aut Pantelyat, Alexander verfasserin aut Wszolek, Zbigniew K. verfasserin aut Ross, Owen A. verfasserin aut Dickson, Dennis W. verfasserin aut Graff-Radford, Neill R. verfasserin aut Knopman, David verfasserin aut Rademakers, Rosa verfasserin aut Lemstra, Afina W. verfasserin aut Pijnenburg, Yolande A. L. verfasserin aut Scheltens, Philip verfasserin aut Gasser, Thomas verfasserin aut Chinnery, Patrick F verfasserin aut Hemmer, Bernhard verfasserin aut Huisman, Martijn A. verfasserin aut Troncoso, Juan verfasserin aut Moreno, Fermin verfasserin aut Nohr, Ellen A. verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Heutink, Peter verfasserin aut Sánchez-Juan, Pascual verfasserin aut Posthuma, Danielle verfasserin aut Clarimón, Jordi verfasserin aut Christensen, Kaare verfasserin aut Ertekin-Taner, Nilüfer verfasserin aut Scholz, Sonja W. verfasserin aut Ramirez, Alfredo verfasserin aut Ruiz, Agustín verfasserin aut Slagboom, Eline verfasserin aut van der Flier, Wiesje M. verfasserin aut Holstege, Henne verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 138(2019), 2 vom: 26. Mai, Seite 237-250 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:138 year:2019 number:2 day:26 month:05 pages:237-250 https://dx.doi.org/10.1007/s00401-019-02026-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 138 2019 2 26 05 237-250 |
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10.1007/s00401-019-02026-8 doi (DE-627)SPR004994450 (SPR)s00401-019-02026-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl van der Lee, Sven J. verfasserin aut A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 Conway, Olivia J. verfasserin aut Jansen, Iris verfasserin aut Carrasquillo, Minerva M. verfasserin aut Kleineidam, Luca verfasserin aut van den Akker, Erik verfasserin aut Hernández, Isabel verfasserin aut van Eijk, Kristel R. verfasserin aut Stringa, Najada verfasserin aut Chen, Jason A. verfasserin aut Zettergren, Anna verfasserin aut Andlauer, Till F. M. verfasserin aut Diez-Fairen, Monica verfasserin aut Simon-Sanchez, Javier verfasserin aut Lleó, Alberto verfasserin aut Zetterberg, Henrik verfasserin aut Nygaard, Marianne verfasserin aut Blauwendraat, Cornelis verfasserin aut Savage, Jeanne E. verfasserin aut Mengel-From, Jonas verfasserin aut Moreno-Grau, Sonia verfasserin aut Wagner, Michael verfasserin aut Fortea, Juan verfasserin aut Keogh, Michael J. verfasserin aut Blennow, Kaj verfasserin aut Skoog, Ingmar verfasserin aut Friese, Manuel A. verfasserin aut Pletnikova, Olga verfasserin aut Zulaica, Miren verfasserin aut Lage, Carmen verfasserin aut de Rojas, Itziar verfasserin aut Riedel-Heller, Steffi verfasserin aut Illán-Gala, Ignacio verfasserin aut Wei, Wei verfasserin aut Jeune, Bernard verfasserin aut Orellana, Adelina verfasserin aut Then Bergh, Florian verfasserin aut Wang, Xue verfasserin aut Hulsman, Marc verfasserin aut Beker, Nina verfasserin aut Tesi, Niccolo verfasserin aut Morris, Christopher M. verfasserin aut Indakoetxea, Begoña verfasserin aut Collij, Lyduine E. verfasserin aut Scherer, Martin verfasserin aut Morenas-Rodríguez, Estrella verfasserin aut Ironside, James W. verfasserin aut van Berckel, Bart N. M. verfasserin aut Alcolea, Daniel verfasserin aut Wiendl, Heinz verfasserin aut Strickland, Samantha L. verfasserin aut Pastor, Pau verfasserin aut Rodríguez Rodríguez, Eloy verfasserin aut Boeve, Bradley F. verfasserin aut Petersen, Ronald C. verfasserin aut Ferman, Tanis J. verfasserin aut van Gerpen, Jay A. verfasserin aut Reinders, Marcel J. T. verfasserin aut Uitti, Ryan J. verfasserin aut Tárraga, Lluís verfasserin aut Maier, Wolfgang verfasserin aut Dols-Icardo, Oriol verfasserin aut Kawalia, Amit verfasserin aut Dalmasso, Maria Carolina verfasserin aut Boada, Mercè verfasserin aut Zettl, Uwe K. verfasserin aut van Schoor, Natasja M. verfasserin aut Beekman, Marian verfasserin aut Allen, Mariet verfasserin aut Masliah, Eliezer verfasserin aut de Munain, Adolfo López verfasserin aut Pantelyat, Alexander verfasserin aut Wszolek, Zbigniew K. verfasserin aut Ross, Owen A. verfasserin aut Dickson, Dennis W. verfasserin aut Graff-Radford, Neill R. verfasserin aut Knopman, David verfasserin aut Rademakers, Rosa verfasserin aut Lemstra, Afina W. verfasserin aut Pijnenburg, Yolande A. L. verfasserin aut Scheltens, Philip verfasserin aut Gasser, Thomas verfasserin aut Chinnery, Patrick F verfasserin aut Hemmer, Bernhard verfasserin aut Huisman, Martijn A. verfasserin aut Troncoso, Juan verfasserin aut Moreno, Fermin verfasserin aut Nohr, Ellen A. verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Heutink, Peter verfasserin aut Sánchez-Juan, Pascual verfasserin aut Posthuma, Danielle verfasserin aut Clarimón, Jordi verfasserin aut Christensen, Kaare verfasserin aut Ertekin-Taner, Nilüfer verfasserin aut Scholz, Sonja W. verfasserin aut Ramirez, Alfredo verfasserin aut Ruiz, Agustín verfasserin aut Slagboom, Eline verfasserin aut van der Flier, Wiesje M. verfasserin aut Holstege, Henne verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 138(2019), 2 vom: 26. Mai, Seite 237-250 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:138 year:2019 number:2 day:26 month:05 pages:237-250 https://dx.doi.org/10.1007/s00401-019-02026-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 138 2019 2 26 05 237-250 |
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10.1007/s00401-019-02026-8 doi (DE-627)SPR004994450 (SPR)s00401-019-02026-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.90 bkl van der Lee, Sven J. verfasserin aut A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 Conway, Olivia J. verfasserin aut Jansen, Iris verfasserin aut Carrasquillo, Minerva M. verfasserin aut Kleineidam, Luca verfasserin aut van den Akker, Erik verfasserin aut Hernández, Isabel verfasserin aut van Eijk, Kristel R. verfasserin aut Stringa, Najada verfasserin aut Chen, Jason A. verfasserin aut Zettergren, Anna verfasserin aut Andlauer, Till F. M. verfasserin aut Diez-Fairen, Monica verfasserin aut Simon-Sanchez, Javier verfasserin aut Lleó, Alberto verfasserin aut Zetterberg, Henrik verfasserin aut Nygaard, Marianne verfasserin aut Blauwendraat, Cornelis verfasserin aut Savage, Jeanne E. verfasserin aut Mengel-From, Jonas verfasserin aut Moreno-Grau, Sonia verfasserin aut Wagner, Michael verfasserin aut Fortea, Juan verfasserin aut Keogh, Michael J. verfasserin aut Blennow, Kaj verfasserin aut Skoog, Ingmar verfasserin aut Friese, Manuel A. verfasserin aut Pletnikova, Olga verfasserin aut Zulaica, Miren verfasserin aut Lage, Carmen verfasserin aut de Rojas, Itziar verfasserin aut Riedel-Heller, Steffi verfasserin aut Illán-Gala, Ignacio verfasserin aut Wei, Wei verfasserin aut Jeune, Bernard verfasserin aut Orellana, Adelina verfasserin aut Then Bergh, Florian verfasserin aut Wang, Xue verfasserin aut Hulsman, Marc verfasserin aut Beker, Nina verfasserin aut Tesi, Niccolo verfasserin aut Morris, Christopher M. verfasserin aut Indakoetxea, Begoña verfasserin aut Collij, Lyduine E. verfasserin aut Scherer, Martin verfasserin aut Morenas-Rodríguez, Estrella verfasserin aut Ironside, James W. verfasserin aut van Berckel, Bart N. M. verfasserin aut Alcolea, Daniel verfasserin aut Wiendl, Heinz verfasserin aut Strickland, Samantha L. verfasserin aut Pastor, Pau verfasserin aut Rodríguez Rodríguez, Eloy verfasserin aut Boeve, Bradley F. verfasserin aut Petersen, Ronald C. verfasserin aut Ferman, Tanis J. verfasserin aut van Gerpen, Jay A. verfasserin aut Reinders, Marcel J. T. verfasserin aut Uitti, Ryan J. verfasserin aut Tárraga, Lluís verfasserin aut Maier, Wolfgang verfasserin aut Dols-Icardo, Oriol verfasserin aut Kawalia, Amit verfasserin aut Dalmasso, Maria Carolina verfasserin aut Boada, Mercè verfasserin aut Zettl, Uwe K. verfasserin aut van Schoor, Natasja M. verfasserin aut Beekman, Marian verfasserin aut Allen, Mariet verfasserin aut Masliah, Eliezer verfasserin aut de Munain, Adolfo López verfasserin aut Pantelyat, Alexander verfasserin aut Wszolek, Zbigniew K. verfasserin aut Ross, Owen A. verfasserin aut Dickson, Dennis W. verfasserin aut Graff-Radford, Neill R. verfasserin aut Knopman, David verfasserin aut Rademakers, Rosa verfasserin aut Lemstra, Afina W. verfasserin aut Pijnenburg, Yolande A. L. verfasserin aut Scheltens, Philip verfasserin aut Gasser, Thomas verfasserin aut Chinnery, Patrick F verfasserin aut Hemmer, Bernhard verfasserin aut Huisman, Martijn A. verfasserin aut Troncoso, Juan verfasserin aut Moreno, Fermin verfasserin aut Nohr, Ellen A. verfasserin aut Sørensen, Thorkild I. A. verfasserin aut Heutink, Peter verfasserin aut Sánchez-Juan, Pascual verfasserin aut Posthuma, Danielle verfasserin aut Clarimón, Jordi verfasserin aut Christensen, Kaare verfasserin aut Ertekin-Taner, Nilüfer verfasserin aut Scholz, Sonja W. verfasserin aut Ramirez, Alfredo verfasserin aut Ruiz, Agustín verfasserin aut Slagboom, Eline verfasserin aut van der Flier, Wiesje M. verfasserin aut Holstege, Henne verfasserin aut Enthalten in Acta neuropathologica Berlin : Springer, 1961 138(2019), 2 vom: 26. Mai, Seite 237-250 (DE-627)253389666 (DE-600)1458410-4 1432-0533 nnns volume:138 year:2019 number:2 day:26 month:05 pages:237-250 https://dx.doi.org/10.1007/s00401-019-02026-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 138 2019 2 26 05 237-250 |
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Acta neuropathologica |
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van der Lee, Sven J. @@aut@@ Conway, Olivia J. @@aut@@ Jansen, Iris @@aut@@ Carrasquillo, Minerva M. @@aut@@ Kleineidam, Luca @@aut@@ van den Akker, Erik @@aut@@ Hernández, Isabel @@aut@@ van Eijk, Kristel R. @@aut@@ Stringa, Najada @@aut@@ Chen, Jason A. @@aut@@ Zettergren, Anna @@aut@@ Andlauer, Till F. M. @@aut@@ Diez-Fairen, Monica @@aut@@ Simon-Sanchez, Javier @@aut@@ Lleó, Alberto @@aut@@ Zetterberg, Henrik @@aut@@ Nygaard, Marianne @@aut@@ Blauwendraat, Cornelis @@aut@@ Savage, Jeanne E. @@aut@@ Mengel-From, Jonas @@aut@@ Moreno-Grau, Sonia @@aut@@ Wagner, Michael @@aut@@ Fortea, Juan @@aut@@ Keogh, Michael J. @@aut@@ Blennow, Kaj @@aut@@ Skoog, Ingmar @@aut@@ Friese, Manuel A. @@aut@@ Pletnikova, Olga @@aut@@ Zulaica, Miren @@aut@@ Lage, Carmen @@aut@@ de Rojas, Itziar @@aut@@ Riedel-Heller, Steffi @@aut@@ Illán-Gala, Ignacio @@aut@@ Wei, Wei @@aut@@ Jeune, Bernard @@aut@@ Orellana, Adelina @@aut@@ Then Bergh, Florian @@aut@@ Wang, Xue @@aut@@ Hulsman, Marc @@aut@@ Beker, Nina @@aut@@ Tesi, Niccolo @@aut@@ Morris, Christopher M. @@aut@@ Indakoetxea, Begoña @@aut@@ Collij, Lyduine E. @@aut@@ Scherer, Martin @@aut@@ Morenas-Rodríguez, Estrella @@aut@@ Ironside, James W. @@aut@@ van Berckel, Bart N. M. @@aut@@ Alcolea, Daniel @@aut@@ Wiendl, Heinz @@aut@@ Strickland, Samantha L. @@aut@@ Pastor, Pau @@aut@@ Rodríguez Rodríguez, Eloy @@aut@@ Boeve, Bradley F. @@aut@@ Petersen, Ronald C. @@aut@@ Ferman, Tanis J. @@aut@@ van Gerpen, Jay A. @@aut@@ Reinders, Marcel J. T. @@aut@@ Uitti, Ryan J. @@aut@@ Tárraga, Lluís @@aut@@ Maier, Wolfgang @@aut@@ Dols-Icardo, Oriol @@aut@@ Kawalia, Amit @@aut@@ Dalmasso, Maria Carolina @@aut@@ Boada, Mercè @@aut@@ Zettl, Uwe K. @@aut@@ van Schoor, Natasja M. @@aut@@ Beekman, Marian @@aut@@ Allen, Mariet @@aut@@ Masliah, Eliezer @@aut@@ de Munain, Adolfo López @@aut@@ Pantelyat, Alexander @@aut@@ Wszolek, Zbigniew K. @@aut@@ Ross, Owen A. @@aut@@ Dickson, Dennis W. @@aut@@ Graff-Radford, Neill R. @@aut@@ Knopman, David @@aut@@ Rademakers, Rosa @@aut@@ Lemstra, Afina W. @@aut@@ Pijnenburg, Yolande A. L. @@aut@@ Scheltens, Philip @@aut@@ Gasser, Thomas @@aut@@ Chinnery, Patrick F @@aut@@ Hemmer, Bernhard @@aut@@ Huisman, Martijn A. @@aut@@ Troncoso, Juan @@aut@@ Moreno, Fermin @@aut@@ Nohr, Ellen A. @@aut@@ Sørensen, Thorkild I. A. @@aut@@ Heutink, Peter @@aut@@ Sánchez-Juan, Pascual @@aut@@ Posthuma, Danielle @@aut@@ Clarimón, Jordi @@aut@@ Christensen, Kaare @@aut@@ Ertekin-Taner, Nilüfer @@aut@@ Scholz, Sonja W. @@aut@@ Ramirez, Alfredo @@aut@@ Ruiz, Agustín @@aut@@ Slagboom, Eline @@aut@@ van der Flier, Wiesje M. @@aut@@ Holstege, Henne @@aut@@ |
| publishDateDaySort_date |
2019-05-26T00:00:00Z |
| hierarchy_top_id |
253389666 |
| dewey-sort |
3610 |
| id |
SPR004994450 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR004994450</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519073319.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2019 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00401-019-02026-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR004994450</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00401-019-02026-8-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.90</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">van der Lee, Sven J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2019</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. 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|
| author |
van der Lee, Sven J. |
| spellingShingle |
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610 ASE 44.90 bkl A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity Alzheimer’s disease (dpeaa)DE-He213 Frontotemporal dementia (dpeaa)DE-He213 Dementia with Lewy bodies (dpeaa)DE-He213 Progressive supranuclear palsy (dpeaa)DE-He213 Parkinson’s disease (dpeaa)DE-He213 Amyotrophic lateral sclerosis (dpeaa)DE-He213 Multiple sclerosis (dpeaa)DE-He213 Neurodegenerative disease (dpeaa)DE-He213 Longevity (dpeaa)DE-He213 PLCG2 (dpeaa)DE-He213 Phospholipase C Gamma 2 (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Alzheimer’s disease misc Frontotemporal dementia misc Dementia with Lewy bodies misc Progressive supranuclear palsy misc Parkinson’s disease misc Amyotrophic lateral sclerosis misc Multiple sclerosis misc Neurodegenerative disease misc Longevity misc PLCG2 misc Phospholipase C Gamma 2 |
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ddc 610 bkl 44.90 misc Alzheimer’s disease misc Frontotemporal dementia misc Dementia with Lewy bodies misc Progressive supranuclear palsy misc Parkinson’s disease misc Amyotrophic lateral sclerosis misc Multiple sclerosis misc Neurodegenerative disease misc Longevity misc PLCG2 misc Phospholipase C Gamma 2 |
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity |
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van der Lee, Sven J. Conway, Olivia J. Jansen, Iris Carrasquillo, Minerva M. Kleineidam, Luca van den Akker, Erik Hernández, Isabel van Eijk, Kristel R. Stringa, Najada Chen, Jason A. Zettergren, Anna Andlauer, Till F. M. Diez-Fairen, Monica Simon-Sanchez, Javier Lleó, Alberto Zetterberg, Henrik Nygaard, Marianne Blauwendraat, Cornelis Savage, Jeanne E. Mengel-From, Jonas Moreno-Grau, Sonia Wagner, Michael Fortea, Juan Keogh, Michael J. Blennow, Kaj Skoog, Ingmar Friese, Manuel A. Pletnikova, Olga Zulaica, Miren Lage, Carmen de Rojas, Itziar Riedel-Heller, Steffi Illán-Gala, Ignacio Wei, Wei Jeune, Bernard Orellana, Adelina Then Bergh, Florian Wang, Xue Hulsman, Marc Beker, Nina Tesi, Niccolo Morris, Christopher M. Indakoetxea, Begoña Collij, Lyduine E. Scherer, Martin Morenas-Rodríguez, Estrella Ironside, James W. van Berckel, Bart N. M. Alcolea, Daniel Wiendl, Heinz Strickland, Samantha L. Pastor, Pau Rodríguez Rodríguez, Eloy Boeve, Bradley F. Petersen, Ronald C. Ferman, Tanis J. van Gerpen, Jay A. Reinders, Marcel J. T. Uitti, Ryan J. Tárraga, Lluís Maier, Wolfgang Dols-Icardo, Oriol Kawalia, Amit Dalmasso, Maria Carolina Boada, Mercè Zettl, Uwe K. van Schoor, Natasja M. Beekman, Marian Allen, Mariet Masliah, Eliezer de Munain, Adolfo López Pantelyat, Alexander Wszolek, Zbigniew K. Ross, Owen A. Dickson, Dennis W. Graff-Radford, Neill R. Knopman, David Rademakers, Rosa Lemstra, Afina W. Pijnenburg, Yolande A. L. Scheltens, Philip Gasser, Thomas Chinnery, Patrick F Hemmer, Bernhard Huisman, Martijn A. Troncoso, Juan Moreno, Fermin Nohr, Ellen A. Sørensen, Thorkild I. A. Heutink, Peter Sánchez-Juan, Pascual Posthuma, Danielle Clarimón, Jordi Christensen, Kaare Ertekin-Taner, Nilüfer Scholz, Sonja W. Ramirez, Alfredo Ruiz, Agustín Slagboom, Eline van der Flier, Wiesje M. Holstege, Henne |
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nonsynonymous mutation in plcg2 reduces the risk of alzheimer’s disease, dementia with lewy bodies and frontotemporal dementia, and increases the likelihood of longevity |
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity |
| abstract |
Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. |
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Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. |
| abstract_unstemmed |
Abstract The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. |
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity |
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Conway, Olivia J. Jansen, Iris Carrasquillo, Minerva M. Kleineidam, Luca van den Akker, Erik Hernández, Isabel van Eijk, Kristel R. Stringa, Najada Chen, Jason A. Zettergren, Anna Andlauer, Till F. M. Diez-Fairen, Monica Simon-Sanchez, Javier Lleó, Alberto Zetterberg, Henrik Nygaard, Marianne Blauwendraat, Cornelis Savage, Jeanne E. Mengel-From, Jonas Moreno-Grau, Sonia Wagner, Michael Fortea, Juan Keogh, Michael J. Blennow, Kaj Skoog, Ingmar Friese, Manuel A. Pletnikova, Olga Zulaica, Miren Lage, Carmen de Rojas, Itziar Riedel-Heller, Steffi Illán-Gala, Ignacio Wei, Wei Jeune, Bernard Orellana, Adelina Then Bergh, Florian Wang, Xue Hulsman, Marc Beker, Nina Tesi, Niccolo Morris, Christopher M. Indakoetxea, Begoña Collij, Lyduine E. Scherer, Martin Morenas-Rodríguez, Estrella Ironside, James W. van Berckel, Bart N. M. Alcolea, Daniel Wiendl, Heinz Strickland, Samantha L. Pastor, Pau Rodríguez Rodríguez, Eloy Boeve, Bradley F. Petersen, Ronald C. Ferman, Tanis J. van Gerpen, Jay A. Reinders, Marcel J. T. Uitti, Ryan J. Tárraga, Lluís Maier, Wolfgang Dols-Icardo, Oriol Kawalia, Amit Dalmasso, Maria Carolina Boada, Mercè Zettl, Uwe K. van Schoor, Natasja M. Beekman, Marian Allen, Mariet Masliah, Eliezer de Munain, Adolfo López Pantelyat, Alexander Wszolek, Zbigniew K. Ross, Owen A. Dickson, Dennis W. Graff-Radford, Neill R. Knopman, David Rademakers, Rosa Lemstra, Afina W. Pijnenburg, Yolande A. L. Scheltens, Philip Gasser, Thomas Chinnery, Patrick F Hemmer, Bernhard Huisman, Martijn A. Troncoso, Juan Moreno, Fermin Nohr, Ellen A. Sørensen, Thorkild I. A. Heutink, Peter Sánchez-Juan, Pascual Posthuma, Danielle Clarimón, Jordi Christensen, Kaare Ertekin-Taner, Nilüfer Scholz, Sonja W. Ramirez, Alfredo Ruiz, Agustín Slagboom, Eline van der Flier, Wiesje M. Holstege, Henne |
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| score |
7.401434 |