In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate
Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alaibac, Mauro [verfasserIn] Pigozzi, Barbara [verfasserIn] Fortina, Anna Belloni [verfasserIn] Michelotto, Giorgio [verfasserIn] Peserico, Andrea [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of dermatological research - Berlin : Springer, 1869, 296(2004), 5 vom: 21. Sept., Seite 231-234 |
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| Übergeordnetes Werk: |
volume:296 ; year:2004 ; number:5 ; day:21 ; month:09 ; pages:231-234 |
| Links: |
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| DOI / URN: |
10.1007/s00403-004-0510-3 |
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| Katalog-ID: |
SPR00505608X |
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| 100 | 1 | |a Alaibac, Mauro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
| 264 | 1 | |c 2004 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 520 | |a Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. | ||
| 650 | 4 | |a LAT |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T lymphocytes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Skin immunology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antigen recognition |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Signal transduction |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pigozzi, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Fortina, Anna Belloni |e verfasserin |4 aut | |
| 700 | 1 | |a Michelotto, Giorgio |e verfasserin |4 aut | |
| 700 | 1 | |a Peserico, Andrea |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Archives of dermatological research |d Berlin : Springer, 1869 |g 296(2004), 5 vom: 21. Sept., Seite 231-234 |w (DE-627)253390044 |w (DE-600)1458448-7 |x 1432-069X |7 nnns |
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| 912 | |a GBV_ILN_2057 | ||
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| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2065 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2070 | ||
| 912 | |a GBV_ILN_2086 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2093 | ||
| 912 | |a GBV_ILN_2106 | ||
| 912 | |a GBV_ILN_2107 | ||
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10.1007/s00403-004-0510-3 doi (DE-627)SPR00505608X (SPR)s00403-004-0510-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Alaibac, Mauro verfasserin aut In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Pigozzi, Barbara verfasserin aut Fortina, Anna Belloni verfasserin aut Michelotto, Giorgio verfasserin aut Peserico, Andrea verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 296(2004), 5 vom: 21. Sept., Seite 231-234 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:296 year:2004 number:5 day:21 month:09 pages:231-234 https://dx.doi.org/10.1007/s00403-004-0510-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 296 2004 5 21 09 231-234 |
| spelling |
10.1007/s00403-004-0510-3 doi (DE-627)SPR00505608X (SPR)s00403-004-0510-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Alaibac, Mauro verfasserin aut In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Pigozzi, Barbara verfasserin aut Fortina, Anna Belloni verfasserin aut Michelotto, Giorgio verfasserin aut Peserico, Andrea verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 296(2004), 5 vom: 21. Sept., Seite 231-234 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:296 year:2004 number:5 day:21 month:09 pages:231-234 https://dx.doi.org/10.1007/s00403-004-0510-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 296 2004 5 21 09 231-234 |
| allfields_unstemmed |
10.1007/s00403-004-0510-3 doi (DE-627)SPR00505608X (SPR)s00403-004-0510-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Alaibac, Mauro verfasserin aut In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Pigozzi, Barbara verfasserin aut Fortina, Anna Belloni verfasserin aut Michelotto, Giorgio verfasserin aut Peserico, Andrea verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 296(2004), 5 vom: 21. Sept., Seite 231-234 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:296 year:2004 number:5 day:21 month:09 pages:231-234 https://dx.doi.org/10.1007/s00403-004-0510-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 296 2004 5 21 09 231-234 |
| allfieldsGer |
10.1007/s00403-004-0510-3 doi (DE-627)SPR00505608X (SPR)s00403-004-0510-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Alaibac, Mauro verfasserin aut In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Pigozzi, Barbara verfasserin aut Fortina, Anna Belloni verfasserin aut Michelotto, Giorgio verfasserin aut Peserico, Andrea verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 296(2004), 5 vom: 21. Sept., Seite 231-234 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:296 year:2004 number:5 day:21 month:09 pages:231-234 https://dx.doi.org/10.1007/s00403-004-0510-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 296 2004 5 21 09 231-234 |
| allfieldsSound |
10.1007/s00403-004-0510-3 doi (DE-627)SPR00505608X (SPR)s00403-004-0510-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Alaibac, Mauro verfasserin aut In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Pigozzi, Barbara verfasserin aut Fortina, Anna Belloni verfasserin aut Michelotto, Giorgio verfasserin aut Peserico, Andrea verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 296(2004), 5 vom: 21. Sept., Seite 231-234 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:296 year:2004 number:5 day:21 month:09 pages:231-234 https://dx.doi.org/10.1007/s00403-004-0510-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 296 2004 5 21 09 231-234 |
| language |
English |
| source |
Enthalten in Archives of dermatological research 296(2004), 5 vom: 21. Sept., Seite 231-234 volume:296 year:2004 number:5 day:21 month:09 pages:231-234 |
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Enthalten in Archives of dermatological research 296(2004), 5 vom: 21. Sept., Seite 231-234 volume:296 year:2004 number:5 day:21 month:09 pages:231-234 |
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Article |
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findex.gbv.de |
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LAT T lymphocytes Skin immunology Antigen recognition Signal transduction |
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610 |
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false |
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Archives of dermatological research |
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Alaibac, Mauro @@aut@@ Pigozzi, Barbara @@aut@@ Fortina, Anna Belloni @@aut@@ Michelotto, Giorgio @@aut@@ Peserico, Andrea @@aut@@ |
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2004-09-21T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR00505608X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519111352.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2004 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00403-004-0510-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR00505608X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00403-004-0510-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.93</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Alaibac, Mauro</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2004</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. 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Alaibac, Mauro |
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Alaibac, Mauro ddc 610 bkl 44.93 misc LAT misc T lymphocytes misc Skin immunology misc Antigen recognition misc Signal transduction In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
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610 ASE 44.93 bkl In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate LAT (dpeaa)DE-He213 T lymphocytes (dpeaa)DE-He213 Skin immunology (dpeaa)DE-He213 Antigen recognition (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 |
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ddc 610 bkl 44.93 misc LAT misc T lymphocytes misc Skin immunology misc Antigen recognition misc Signal transduction |
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ddc 610 bkl 44.93 misc LAT misc T lymphocytes misc Skin immunology misc Antigen recognition misc Signal transduction |
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In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
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(DE-627)SPR00505608X (SPR)s00403-004-0510-3-e |
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In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
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Alaibac, Mauro |
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Archives of dermatological research |
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Alaibac, Mauro Pigozzi, Barbara Fortina, Anna Belloni Michelotto, Giorgio Peserico, Andrea |
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Alaibac, Mauro |
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verfasserin |
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in situ expression of lat (linker for activation of t cells) in pathological human skin with t-lymphoid infiltrate |
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In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
| abstract |
Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. |
| abstractGer |
Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. |
| abstract_unstemmed |
Abstract LAT is a 36-kDa transmembrane protein that plays an important role in linking engagement of the T-cell antigen receptor (TCR) to the biochemical events of T-cell activation. It has been shown that LAT reacts with human T cells in normal and neoplastic lymphoid tissues, without restriction to any T cell subpopulation. This suggests that the expression of LAT in vivo may be a valuable addition to the panel of immunohistochemical markers used for immunostaining T cells. The expression of LAT has not yet been studied in human pathological skin conditions. We present our experience concerning LAT expression in both neoplastic and inflammatory dermatoses using an immunohistochemical approach on frozen sections from 42 patients. A variable reduction in LAT expression was observed in almost all the inflammatory and neoplastic skin conditions investigated, irrespective of the particular disease. Our study indicates that $ LAT^{−} $ T cells are more common within the skin T-lymphoid infiltrate than was previously demonstrated in both normal and neoplastic lymphoid tissues. These findings suggest that, using a conventional immunoenzymatic approach on fresh frozen sections, LAT staining is an unreliable marker for the identification of T cells in human pathological skin conditions. |
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5 |
| title_short |
In situ expression of LAT (linker for activation of T cells) in pathological human skin with T-lymphoid infiltrate |
| url |
https://dx.doi.org/10.1007/s00403-004-0510-3 |
| remote_bool |
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| author2 |
Pigozzi, Barbara Fortina, Anna Belloni Michelotto, Giorgio Peserico, Andrea |
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Pigozzi, Barbara Fortina, Anna Belloni Michelotto, Giorgio Peserico, Andrea |
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| doi_str |
10.1007/s00403-004-0510-3 |
| up_date |
2024-07-03T13:42:55.285Z |
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| score |
7.402934 |