Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. How...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ito, Taisuke [verfasserIn] Aoshima, Masahiro [verfasserIn] Ito, Natsuho [verfasserIn] Uchiyama, Izumi [verfasserIn] Sakamoto, Keiko [verfasserIn] Kawamura, Tetsuya [verfasserIn] Yagi, Hiroaki [verfasserIn] Hashizume, Hideo [verfasserIn] Takigawa, Masahiro [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of dermatological research - Berlin : Springer, 1869, 301(2009), 5 vom: 20. März, Seite 373-380 |
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| Übergeordnetes Werk: |
volume:301 ; year:2009 ; number:5 ; day:20 ; month:03 ; pages:373-380 |
| Links: |
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| DOI / URN: |
10.1007/s00403-009-0936-8 |
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| Katalog-ID: |
SPR005060796 |
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| 520 | |a Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. | ||
| 650 | 4 | |a Alopecia areata |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PUVA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Corticosteroid |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Regulatory T cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD8 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Aoshima, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Natsuho |e verfasserin |4 aut | |
| 700 | 1 | |a Uchiyama, Izumi |e verfasserin |4 aut | |
| 700 | 1 | |a Sakamoto, Keiko |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamura, Tetsuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yagi, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hashizume, Hideo |e verfasserin |4 aut | |
| 700 | 1 | |a Takigawa, Masahiro |e verfasserin |4 aut | |
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10.1007/s00403-009-0936-8 doi (DE-627)SPR005060796 (SPR)s00403-009-0936-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Ito, Taisuke verfasserin aut Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 Aoshima, Masahiro verfasserin aut Ito, Natsuho verfasserin aut Uchiyama, Izumi verfasserin aut Sakamoto, Keiko verfasserin aut Kawamura, Tetsuya verfasserin aut Yagi, Hiroaki verfasserin aut Hashizume, Hideo verfasserin aut Takigawa, Masahiro verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 301(2009), 5 vom: 20. März, Seite 373-380 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:301 year:2009 number:5 day:20 month:03 pages:373-380 https://dx.doi.org/10.1007/s00403-009-0936-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 301 2009 5 20 03 373-380 |
| spelling |
10.1007/s00403-009-0936-8 doi (DE-627)SPR005060796 (SPR)s00403-009-0936-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Ito, Taisuke verfasserin aut Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 Aoshima, Masahiro verfasserin aut Ito, Natsuho verfasserin aut Uchiyama, Izumi verfasserin aut Sakamoto, Keiko verfasserin aut Kawamura, Tetsuya verfasserin aut Yagi, Hiroaki verfasserin aut Hashizume, Hideo verfasserin aut Takigawa, Masahiro verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 301(2009), 5 vom: 20. März, Seite 373-380 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:301 year:2009 number:5 day:20 month:03 pages:373-380 https://dx.doi.org/10.1007/s00403-009-0936-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 301 2009 5 20 03 373-380 |
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10.1007/s00403-009-0936-8 doi (DE-627)SPR005060796 (SPR)s00403-009-0936-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Ito, Taisuke verfasserin aut Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 Aoshima, Masahiro verfasserin aut Ito, Natsuho verfasserin aut Uchiyama, Izumi verfasserin aut Sakamoto, Keiko verfasserin aut Kawamura, Tetsuya verfasserin aut Yagi, Hiroaki verfasserin aut Hashizume, Hideo verfasserin aut Takigawa, Masahiro verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 301(2009), 5 vom: 20. März, Seite 373-380 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:301 year:2009 number:5 day:20 month:03 pages:373-380 https://dx.doi.org/10.1007/s00403-009-0936-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 301 2009 5 20 03 373-380 |
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10.1007/s00403-009-0936-8 doi (DE-627)SPR005060796 (SPR)s00403-009-0936-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Ito, Taisuke verfasserin aut Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 Aoshima, Masahiro verfasserin aut Ito, Natsuho verfasserin aut Uchiyama, Izumi verfasserin aut Sakamoto, Keiko verfasserin aut Kawamura, Tetsuya verfasserin aut Yagi, Hiroaki verfasserin aut Hashizume, Hideo verfasserin aut Takigawa, Masahiro verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 301(2009), 5 vom: 20. März, Seite 373-380 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:301 year:2009 number:5 day:20 month:03 pages:373-380 https://dx.doi.org/10.1007/s00403-009-0936-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 301 2009 5 20 03 373-380 |
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10.1007/s00403-009-0936-8 doi (DE-627)SPR005060796 (SPR)s00403-009-0936-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Ito, Taisuke verfasserin aut Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 Aoshima, Masahiro verfasserin aut Ito, Natsuho verfasserin aut Uchiyama, Izumi verfasserin aut Sakamoto, Keiko verfasserin aut Kawamura, Tetsuya verfasserin aut Yagi, Hiroaki verfasserin aut Hashizume, Hideo verfasserin aut Takigawa, Masahiro verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 301(2009), 5 vom: 20. März, Seite 373-380 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:301 year:2009 number:5 day:20 month:03 pages:373-380 https://dx.doi.org/10.1007/s00403-009-0936-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 301 2009 5 20 03 373-380 |
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English |
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Enthalten in Archives of dermatological research 301(2009), 5 vom: 20. März, Seite 373-380 volume:301 year:2009 number:5 day:20 month:03 pages:373-380 |
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Enthalten in Archives of dermatological research 301(2009), 5 vom: 20. März, Seite 373-380 volume:301 year:2009 number:5 day:20 month:03 pages:373-380 |
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findex.gbv.de |
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Alopecia areata PUVA Corticosteroid Regulatory T cell CD8 |
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610 |
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Archives of dermatological research |
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Ito, Taisuke @@aut@@ Aoshima, Masahiro @@aut@@ Ito, Natsuho @@aut@@ Uchiyama, Izumi @@aut@@ Sakamoto, Keiko @@aut@@ Kawamura, Tetsuya @@aut@@ Yagi, Hiroaki @@aut@@ Hashizume, Hideo @@aut@@ Takigawa, Masahiro @@aut@@ |
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2009-03-20T00:00:00Z |
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However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. 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Ito, Taisuke |
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Ito, Taisuke ddc 610 bkl 44.93 misc Alopecia areata misc PUVA misc Corticosteroid misc Regulatory T cell misc CD8 Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata |
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610 ASE 44.93 bkl Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata Alopecia areata (dpeaa)DE-He213 PUVA (dpeaa)DE-He213 Corticosteroid (dpeaa)DE-He213 Regulatory T cell (dpeaa)DE-He213 CD8 (dpeaa)DE-He213 |
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ddc 610 bkl 44.93 misc Alopecia areata misc PUVA misc Corticosteroid misc Regulatory T cell misc CD8 |
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ddc 610 bkl 44.93 misc Alopecia areata misc PUVA misc Corticosteroid misc Regulatory T cell misc CD8 |
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ddc 610 bkl 44.93 misc Alopecia areata misc PUVA misc Corticosteroid misc Regulatory T cell misc CD8 |
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Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata |
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Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata |
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Ito, Taisuke |
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Archives of dermatological research |
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Ito, Taisuke Aoshima, Masahiro Ito, Natsuho Uchiyama, Izumi Sakamoto, Keiko Kawamura, Tetsuya Yagi, Hiroaki Hashizume, Hideo Takigawa, Masahiro |
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Ito, Taisuke |
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combination therapy with oral puva and corticosteroid for recalcitrant alopecia areata |
| title_auth |
Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata |
| abstract |
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. |
| abstractGer |
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. |
| abstract_unstemmed |
Abstract Alopecia areata (AA) is regarded as a tissue-specific autoimmune disease for which several therapies have been suggested to modify the immune reaction against HFs, such as contact immunotherapy, psoralen plus ultraviolet A (PUVA), corticosteroids, cyclosporine, minoxidil, and dithranol. However, severe type AA, such as alopecia totalis (AT) and alopecia universalis (AU), often show resistance against these therapies. We applied a combination therapy with oral corticosteroid and oral PUVA for intractable cases of AT and AU. These patients took 20 mg/day corticosteroid and were irradiated with UVA on the whole body 2 h after taking methoxsalen for 1 month. In all patients, the terminal hair on the whole scalp regrew after 2 months. Two patients had a relapse of hair loss 3 months after the termination of the treatment. FACS analysis revealed that the $ CD4^{+} %$ CD25^{high} $ and $ CD4^{+} %$ CD25^{+} %$ FOXP3^{+} $ Treg population in PBMC was increased after the combination therapy. Furthermore, the number of infiltrating cells decreased and $ FOXP3^{+} $ cells were often found in lesion skin after the combination therapy. Mitogen-induced proliferation tests showed low responses against PHA and Con A after the combination therapy. Taken together, the combination therapy may modify the systemic immune system and increase the number of Treg cells, resulting in improvement of recalcitrant AA. |
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Combination therapy with oral PUVA and corticosteroid for recalcitrant alopecia areata |
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Aoshima, Masahiro Ito, Natsuho Uchiyama, Izumi Sakamoto, Keiko Kawamura, Tetsuya Yagi, Hiroaki Hashizume, Hideo Takigawa, Masahiro |
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| score |
7.399088 |