PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma
Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Xyla, Vasileia [verfasserIn] Skopelitis, Elias [verfasserIn] Ziakas, Panayiotis D. [verfasserIn] Kontos, Athanasios [verfasserIn] Ioannidis, Eleftherios [verfasserIn] Kordossis, Theodore [verfasserIn] Aroni, Kyriaki [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
Mediterranean Kaposi’s sarcoma |
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| Übergeordnetes Werk: |
Enthalten in: Archives of dermatological research - Berlin : Springer, 1869, 305(2013), 10 vom: 14. Mai, Seite 917-923 |
|---|---|
| Übergeordnetes Werk: |
volume:305 ; year:2013 ; number:10 ; day:14 ; month:05 ; pages:917-923 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00403-013-1364-3 |
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| Katalog-ID: |
SPR005064600 |
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| 520 | |a Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. | ||
| 650 | 4 | |a Kaposi’s sarcoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mediterranean Kaposi’s sarcoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HIV-related Kaposi’s sarcoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunosuppressive-associated Kaposi’s sarcoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epidermal nerve fiber density |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HIV |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Skopelitis, Elias |e verfasserin |4 aut | |
| 700 | 1 | |a Ziakas, Panayiotis D. |e verfasserin |4 aut | |
| 700 | 1 | |a Kontos, Athanasios |e verfasserin |4 aut | |
| 700 | 1 | |a Ioannidis, Eleftherios |e verfasserin |4 aut | |
| 700 | 1 | |a Kordossis, Theodore |e verfasserin |4 aut | |
| 700 | 1 | |a Aroni, Kyriaki |e verfasserin |4 aut | |
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10.1007/s00403-013-1364-3 doi (DE-627)SPR005064600 (SPR)s00403-013-1364-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Xyla, Vasileia verfasserin aut PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Skopelitis, Elias verfasserin aut Ziakas, Panayiotis D. verfasserin aut Kontos, Athanasios verfasserin aut Ioannidis, Eleftherios verfasserin aut Kordossis, Theodore verfasserin aut Aroni, Kyriaki verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 305(2013), 10 vom: 14. Mai, Seite 917-923 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:305 year:2013 number:10 day:14 month:05 pages:917-923 https://dx.doi.org/10.1007/s00403-013-1364-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 305 2013 10 14 05 917-923 |
| spelling |
10.1007/s00403-013-1364-3 doi (DE-627)SPR005064600 (SPR)s00403-013-1364-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Xyla, Vasileia verfasserin aut PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Skopelitis, Elias verfasserin aut Ziakas, Panayiotis D. verfasserin aut Kontos, Athanasios verfasserin aut Ioannidis, Eleftherios verfasserin aut Kordossis, Theodore verfasserin aut Aroni, Kyriaki verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 305(2013), 10 vom: 14. Mai, Seite 917-923 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:305 year:2013 number:10 day:14 month:05 pages:917-923 https://dx.doi.org/10.1007/s00403-013-1364-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 305 2013 10 14 05 917-923 |
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10.1007/s00403-013-1364-3 doi (DE-627)SPR005064600 (SPR)s00403-013-1364-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Xyla, Vasileia verfasserin aut PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Skopelitis, Elias verfasserin aut Ziakas, Panayiotis D. verfasserin aut Kontos, Athanasios verfasserin aut Ioannidis, Eleftherios verfasserin aut Kordossis, Theodore verfasserin aut Aroni, Kyriaki verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 305(2013), 10 vom: 14. Mai, Seite 917-923 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:305 year:2013 number:10 day:14 month:05 pages:917-923 https://dx.doi.org/10.1007/s00403-013-1364-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 305 2013 10 14 05 917-923 |
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10.1007/s00403-013-1364-3 doi (DE-627)SPR005064600 (SPR)s00403-013-1364-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Xyla, Vasileia verfasserin aut PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Skopelitis, Elias verfasserin aut Ziakas, Panayiotis D. verfasserin aut Kontos, Athanasios verfasserin aut Ioannidis, Eleftherios verfasserin aut Kordossis, Theodore verfasserin aut Aroni, Kyriaki verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 305(2013), 10 vom: 14. Mai, Seite 917-923 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:305 year:2013 number:10 day:14 month:05 pages:917-923 https://dx.doi.org/10.1007/s00403-013-1364-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 305 2013 10 14 05 917-923 |
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10.1007/s00403-013-1364-3 doi (DE-627)SPR005064600 (SPR)s00403-013-1364-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Xyla, Vasileia verfasserin aut PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 Skopelitis, Elias verfasserin aut Ziakas, Panayiotis D. verfasserin aut Kontos, Athanasios verfasserin aut Ioannidis, Eleftherios verfasserin aut Kordossis, Theodore verfasserin aut Aroni, Kyriaki verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 305(2013), 10 vom: 14. Mai, Seite 917-923 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:305 year:2013 number:10 day:14 month:05 pages:917-923 https://dx.doi.org/10.1007/s00403-013-1364-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 305 2013 10 14 05 917-923 |
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Enthalten in Archives of dermatological research 305(2013), 10 vom: 14. Mai, Seite 917-923 volume:305 year:2013 number:10 day:14 month:05 pages:917-923 |
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Enthalten in Archives of dermatological research 305(2013), 10 vom: 14. Mai, Seite 917-923 volume:305 year:2013 number:10 day:14 month:05 pages:917-923 |
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Kaposi’s sarcoma Mediterranean Kaposi’s sarcoma HIV-related Kaposi’s sarcoma Immunosuppressive-associated Kaposi’s sarcoma Epidermal nerve fiber density HIV |
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Xyla, Vasileia @@aut@@ Skopelitis, Elias @@aut@@ Ziakas, Panayiotis D. @@aut@@ Kontos, Athanasios @@aut@@ Ioannidis, Eleftherios @@aut@@ Kordossis, Theodore @@aut@@ Aroni, Kyriaki @@aut@@ |
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2013-05-14T00:00:00Z |
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|
| author |
Xyla, Vasileia |
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Xyla, Vasileia ddc 610 bkl 44.93 misc Kaposi’s sarcoma misc Mediterranean Kaposi’s sarcoma misc HIV-related Kaposi’s sarcoma misc Immunosuppressive-associated Kaposi’s sarcoma misc Epidermal nerve fiber density misc HIV PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma |
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610 ASE 44.93 bkl PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma Kaposi’s sarcoma (dpeaa)DE-He213 Mediterranean Kaposi’s sarcoma (dpeaa)DE-He213 HIV-related Kaposi’s sarcoma (dpeaa)DE-He213 Immunosuppressive-associated Kaposi’s sarcoma (dpeaa)DE-He213 Epidermal nerve fiber density (dpeaa)DE-He213 HIV (dpeaa)DE-He213 |
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ddc 610 bkl 44.93 misc Kaposi’s sarcoma misc Mediterranean Kaposi’s sarcoma misc HIV-related Kaposi’s sarcoma misc Immunosuppressive-associated Kaposi’s sarcoma misc Epidermal nerve fiber density misc HIV |
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ddc 610 bkl 44.93 misc Kaposi’s sarcoma misc Mediterranean Kaposi’s sarcoma misc HIV-related Kaposi’s sarcoma misc Immunosuppressive-associated Kaposi’s sarcoma misc Epidermal nerve fiber density misc HIV |
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ddc 610 bkl 44.93 misc Kaposi’s sarcoma misc Mediterranean Kaposi’s sarcoma misc HIV-related Kaposi’s sarcoma misc Immunosuppressive-associated Kaposi’s sarcoma misc Epidermal nerve fiber density misc HIV |
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PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma |
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PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma |
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Xyla, Vasileia |
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Archives of dermatological research |
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Xyla, Vasileia Skopelitis, Elias Ziakas, Panayiotis D. Kontos, Athanasios Ioannidis, Eleftherios Kordossis, Theodore Aroni, Kyriaki |
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pgp 9.5 neuronal marker may differentiate immunohistochemically hiv-related from mediterranean and immunosuppression-associated kaposi’s sarcoma |
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PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma |
| abstract |
Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. |
| abstractGer |
Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. |
| abstract_unstemmed |
Abstract Mediterranean Kaposi’s sarcoma (MKS), HIV-related KS (HIV-KS) and immunosuppression-associated KS (IS-KS), caused by human herpes virus 8 (HHV-8), share similar histological features. The aim of this study was to investigate differences in epidermal nerve fibers (ENFs) between the three KS types and controls. Skin biopsies from 23 HIV-KS, 16 MKS, 28 IS-KS patients and 18 controls, age-gender matched, were immunostained with PGP 9.5; ENFs in upper epidermal layer (EL) and penetrating the basement membrane were measured. The mean number of nerve fibers penetrating ENFs was significantly lower in HIV-KS (p < 0.001) compared to all other groups. MKS and IS-KS had comparable ENFs but lower than controls (p < 0.00 1). In the upper EL all groups had comparable ENFs and lower than controls. In conclusion, HIV-KS can be distinguished histologically from other types, by counting ENFs. Moreover, KS is associated with decreased ENFs, which may be a histological reflection of nerve damage. This is even more pronounced in HIV-KS patients and could be explained by a neurotoxic action of HHV-8, HIV, and their co-existence. |
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PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi’s sarcoma |
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Skopelitis, Elias Ziakas, Panayiotis D. Kontos, Athanasios Ioannidis, Eleftherios Kordossis, Theodore Aroni, Kyriaki |
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Skopelitis, Elias Ziakas, Panayiotis D. Kontos, Athanasios Ioannidis, Eleftherios Kordossis, Theodore Aroni, Kyriaki |
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| score |
7.3995123 |