Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata
Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were perf...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, Xiaoting [verfasserIn] Zhao, Ying [verfasserIn] Ye, Yanting [verfasserIn] Li, Shuifeng [verfasserIn] Qi, Shiling [verfasserIn] Yang, Yuqing [verfasserIn] Cao, Hui [verfasserIn] Yang, Jian [verfasserIn] Zhang, Xingqi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of dermatological research - Berlin : Springer, 1869, 307(2015), 4 vom: 01. Feb., Seite 319-331 |
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| Übergeordnetes Werk: |
volume:307 ; year:2015 ; number:4 ; day:01 ; month:02 ; pages:319-331 |
| Links: |
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| DOI / URN: |
10.1007/s00403-015-1539-1 |
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| Katalog-ID: |
SPR005067405 |
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| 100 | 1 | |a Zhang, Xiaoting |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
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| 520 | |a Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. | ||
| 650 | 4 | |a Alopecia areata |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Histopathology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mast cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Langerhans cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a T lymphocyte |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cytokines |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunohistochemistry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Semi-quantitative real time PCR |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhao, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Yanting |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shuifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Shiling |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yuqing |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xingqi |e verfasserin |4 aut | |
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10.1007/s00403-015-1539-1 doi (DE-627)SPR005067405 (SPR)s00403-015-1539-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Zhang, Xiaoting verfasserin aut Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 Zhao, Ying verfasserin aut Ye, Yanting verfasserin aut Li, Shuifeng verfasserin aut Qi, Shiling verfasserin aut Yang, Yuqing verfasserin aut Cao, Hui verfasserin aut Yang, Jian verfasserin aut Zhang, Xingqi verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 307(2015), 4 vom: 01. Feb., Seite 319-331 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:307 year:2015 number:4 day:01 month:02 pages:319-331 https://dx.doi.org/10.1007/s00403-015-1539-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 307 2015 4 01 02 319-331 |
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10.1007/s00403-015-1539-1 doi (DE-627)SPR005067405 (SPR)s00403-015-1539-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Zhang, Xiaoting verfasserin aut Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 Zhao, Ying verfasserin aut Ye, Yanting verfasserin aut Li, Shuifeng verfasserin aut Qi, Shiling verfasserin aut Yang, Yuqing verfasserin aut Cao, Hui verfasserin aut Yang, Jian verfasserin aut Zhang, Xingqi verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 307(2015), 4 vom: 01. Feb., Seite 319-331 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:307 year:2015 number:4 day:01 month:02 pages:319-331 https://dx.doi.org/10.1007/s00403-015-1539-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 307 2015 4 01 02 319-331 |
| allfields_unstemmed |
10.1007/s00403-015-1539-1 doi (DE-627)SPR005067405 (SPR)s00403-015-1539-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Zhang, Xiaoting verfasserin aut Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 Zhao, Ying verfasserin aut Ye, Yanting verfasserin aut Li, Shuifeng verfasserin aut Qi, Shiling verfasserin aut Yang, Yuqing verfasserin aut Cao, Hui verfasserin aut Yang, Jian verfasserin aut Zhang, Xingqi verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 307(2015), 4 vom: 01. Feb., Seite 319-331 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:307 year:2015 number:4 day:01 month:02 pages:319-331 https://dx.doi.org/10.1007/s00403-015-1539-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 307 2015 4 01 02 319-331 |
| allfieldsGer |
10.1007/s00403-015-1539-1 doi (DE-627)SPR005067405 (SPR)s00403-015-1539-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Zhang, Xiaoting verfasserin aut Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 Zhao, Ying verfasserin aut Ye, Yanting verfasserin aut Li, Shuifeng verfasserin aut Qi, Shiling verfasserin aut Yang, Yuqing verfasserin aut Cao, Hui verfasserin aut Yang, Jian verfasserin aut Zhang, Xingqi verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 307(2015), 4 vom: 01. Feb., Seite 319-331 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:307 year:2015 number:4 day:01 month:02 pages:319-331 https://dx.doi.org/10.1007/s00403-015-1539-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 307 2015 4 01 02 319-331 |
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10.1007/s00403-015-1539-1 doi (DE-627)SPR005067405 (SPR)s00403-015-1539-1-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Zhang, Xiaoting verfasserin aut Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 Zhao, Ying verfasserin aut Ye, Yanting verfasserin aut Li, Shuifeng verfasserin aut Qi, Shiling verfasserin aut Yang, Yuqing verfasserin aut Cao, Hui verfasserin aut Yang, Jian verfasserin aut Zhang, Xingqi verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 307(2015), 4 vom: 01. Feb., Seite 319-331 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:307 year:2015 number:4 day:01 month:02 pages:319-331 https://dx.doi.org/10.1007/s00403-015-1539-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 307 2015 4 01 02 319-331 |
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Enthalten in Archives of dermatological research 307(2015), 4 vom: 01. Feb., Seite 319-331 volume:307 year:2015 number:4 day:01 month:02 pages:319-331 |
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Enthalten in Archives of dermatological research 307(2015), 4 vom: 01. Feb., Seite 319-331 volume:307 year:2015 number:4 day:01 month:02 pages:319-331 |
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Alopecia areata Histopathology Mast cell Langerhans cell T lymphocyte Cytokines Immunohistochemistry Semi-quantitative real time PCR |
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Zhang, Xiaoting @@aut@@ Zhao, Ying @@aut@@ Ye, Yanting @@aut@@ Li, Shuifeng @@aut@@ Qi, Shiling @@aut@@ Yang, Yuqing @@aut@@ Cao, Hui @@aut@@ Yang, Jian @@aut@@ Zhang, Xingqi @@aut@@ |
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2015-02-01T00:00:00Z |
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| author |
Zhang, Xiaoting |
| spellingShingle |
Zhang, Xiaoting ddc 610 bkl 44.93 misc Alopecia areata misc Histopathology misc Mast cell misc Langerhans cell misc T lymphocyte misc Cytokines misc Immunohistochemistry misc Semi-quantitative real time PCR Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
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610 ASE 44.93 bkl Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata Alopecia areata (dpeaa)DE-He213 Histopathology (dpeaa)DE-He213 Mast cell (dpeaa)DE-He213 Langerhans cell (dpeaa)DE-He213 T lymphocyte (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Semi-quantitative real time PCR (dpeaa)DE-He213 |
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ddc 610 bkl 44.93 misc Alopecia areata misc Histopathology misc Mast cell misc Langerhans cell misc T lymphocyte misc Cytokines misc Immunohistochemistry misc Semi-quantitative real time PCR |
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ddc 610 bkl 44.93 misc Alopecia areata misc Histopathology misc Mast cell misc Langerhans cell misc T lymphocyte misc Cytokines misc Immunohistochemistry misc Semi-quantitative real time PCR |
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ddc 610 bkl 44.93 misc Alopecia areata misc Histopathology misc Mast cell misc Langerhans cell misc T lymphocyte misc Cytokines misc Immunohistochemistry misc Semi-quantitative real time PCR |
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| title |
Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
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(DE-627)SPR005067405 (SPR)s00403-015-1539-1-e |
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Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
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Zhang, Xiaoting |
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Archives of dermatological research |
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Zhang, Xiaoting Zhao, Ying Ye, Yanting Li, Shuifeng Qi, Shiling Yang, Yuqing Cao, Hui Yang, Jian Zhang, Xingqi |
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lesional infiltration of mast cells, langerhans cells, t cells and local cytokine profiles in alopecia areata |
| title_auth |
Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
| abstract |
Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. |
| abstractGer |
Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. |
| abstract_unstemmed |
Abstract Alopecia areata (AA) is a chronic inflammatory disease mediated by an array of cells and cytokines. Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. Also, Th1-type cytokine are related to disease activity of alopecia areata, whereas Th2-type cytokines may be associated with persistence of AA. |
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Lesional infiltration of mast cells, Langerhans cells, T cells and local cytokine profiles in alopecia areata |
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https://dx.doi.org/10.1007/s00403-015-1539-1 |
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Zhao, Ying Ye, Yanting Li, Shuifeng Qi, Shiling Yang, Yuqing Cao, Hui Yang, Jian Zhang, Xingqi |
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Zhao, Ying Ye, Yanting Li, Shuifeng Qi, Shiling Yang, Yuqing Cao, Hui Yang, Jian Zhang, Xingqi |
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10.1007/s00403-015-1539-1 |
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2024-07-03T13:47:35.434Z |
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Immunohistochemistry (IHC) of histological sections with antibodies to mast cell tryptase, CD4, CD8, CD1a and semi-quantitative real-time PCR analysis of Th1- and Th2-type cytokines were performed in 55 patients to investigate the infiltration features of mast cells (MCs), T lymphocytes and Langerhans cells (LCs) in scalp lesions of patients with AA. In AA patients, increased MCs mainly infiltrated the peri-follicular and peri-vascular areas, and correlated positively with numbers of $ CD8^{+} $ T lymphocytes in deep peri-follicular areas (P = 0.04), but negatively with $ CD4^{+} $ T lymphocytes in deep peri-vascular areas (P = 0.031). In patients with active hair loss, LCs in epidermis, deep dermis and peri-vascular were elevated (Ps < 0.05). Infiltration of LCs in upper peri-vascular areas and $ CD8^{+} $ T cell infiltration in deep peri-follicular areas were positively correlated (R = 0.618, P = 0.011), as well as LCs in deep peri-vascular areas with $ CD8^{+} $ T cells in upper peri-follicular areas (R = 0.570, P = 0.017). In patients with active hair loss, Th1-type cytokine (IL-2, IL-8, TNF-α) mRNA expression in deep dermis were higher than in upper dermis (Ps < 0.05). However, in patients with non-active hair loss, Th2-type cytokine (IL-5, IL-10) mRNA expression in deep dermis was higher than that in the upper dermis (Ps < 0.05). Positive correlations were found existing between MCs and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells. In conclusion, findings in this study allow us to propose a close relationship between mast cells and $ CD8^{+} $ T cells, as well as between LCs and $ CD8^{+} $ T cells in AA, as well as allergy may interfere with infiltrating T lymphocytes in AA lesional regions. 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| score |
7.4001446 |