Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study
Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gasslitter, Irina [verfasserIn] Kirsten, Natalia [verfasserIn] Augustin, Matthias [verfasserIn] Torz, Kaspar [verfasserIn] Mrowietz, Ulrich [verfasserIn] Eyerich, Kilian [verfasserIn] Puig, Lluís [verfasserIn] Hoetzenecker, Wolfram [verfasserIn] Schütz-Bergmayr, Martina [verfasserIn] Weger, Wolfgang [verfasserIn] Wolf, Peter [verfasserIn] Reider, Norbert [verfasserIn] Ratzinger, Gudrun [verfasserIn] Papageorgiou, Karolina [verfasserIn] Meier, Thomas O. [verfasserIn] Maul, Julia-Tatjana [verfasserIn] Anzengruber, Florian [verfasserIn] Navarini, Alexander A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of dermatological research - Berlin : Springer, 1869, 311(2019), 5 vom: 16. März, Seite 421-424 |
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| Übergeordnetes Werk: |
volume:311 ; year:2019 ; number:5 ; day:16 ; month:03 ; pages:421-424 |
| Links: |
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| DOI / URN: |
10.1007/s00403-019-01907-y |
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| Katalog-ID: |
SPR00507147X |
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| 100 | 1 | |a Gasslitter, Irina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
| 264 | 1 | |c 2019 | |
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| 520 | |a Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. | ||
| 650 | 4 | |a Interleukin-17 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IL-17 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IL-17A |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IL-17 receptor blocker |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Secukinumab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ixekizumab |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Brodalumab |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kirsten, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Augustin, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Torz, Kaspar |e verfasserin |4 aut | |
| 700 | 1 | |a Mrowietz, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Eyerich, Kilian |e verfasserin |4 aut | |
| 700 | 1 | |a Puig, Lluís |e verfasserin |4 aut | |
| 700 | 1 | |a Hoetzenecker, Wolfram |e verfasserin |4 aut | |
| 700 | 1 | |a Schütz-Bergmayr, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a Weger, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Wolf, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Reider, Norbert |e verfasserin |4 aut | |
| 700 | 1 | |a Ratzinger, Gudrun |e verfasserin |4 aut | |
| 700 | 1 | |a Papageorgiou, Karolina |e verfasserin |4 aut | |
| 700 | 1 | |a Meier, Thomas O. |e verfasserin |4 aut | |
| 700 | 1 | |a Maul, Julia-Tatjana |e verfasserin |4 aut | |
| 700 | 1 | |a Anzengruber, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Navarini, Alexander A. |e verfasserin |4 aut | |
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10.1007/s00403-019-01907-y doi (DE-627)SPR00507147X (SPR)s00403-019-01907-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Gasslitter, Irina verfasserin aut Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 Kirsten, Natalia verfasserin aut Augustin, Matthias verfasserin aut Torz, Kaspar verfasserin aut Mrowietz, Ulrich verfasserin aut Eyerich, Kilian verfasserin aut Puig, Lluís verfasserin aut Hoetzenecker, Wolfram verfasserin aut Schütz-Bergmayr, Martina verfasserin aut Weger, Wolfgang verfasserin aut Wolf, Peter verfasserin aut Reider, Norbert verfasserin aut Ratzinger, Gudrun verfasserin aut Papageorgiou, Karolina verfasserin aut Meier, Thomas O. verfasserin aut Maul, Julia-Tatjana verfasserin aut Anzengruber, Florian verfasserin aut Navarini, Alexander A. verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 311(2019), 5 vom: 16. März, Seite 421-424 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:311 year:2019 number:5 day:16 month:03 pages:421-424 https://dx.doi.org/10.1007/s00403-019-01907-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 311 2019 5 16 03 421-424 |
| spelling |
10.1007/s00403-019-01907-y doi (DE-627)SPR00507147X (SPR)s00403-019-01907-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Gasslitter, Irina verfasserin aut Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 Kirsten, Natalia verfasserin aut Augustin, Matthias verfasserin aut Torz, Kaspar verfasserin aut Mrowietz, Ulrich verfasserin aut Eyerich, Kilian verfasserin aut Puig, Lluís verfasserin aut Hoetzenecker, Wolfram verfasserin aut Schütz-Bergmayr, Martina verfasserin aut Weger, Wolfgang verfasserin aut Wolf, Peter verfasserin aut Reider, Norbert verfasserin aut Ratzinger, Gudrun verfasserin aut Papageorgiou, Karolina verfasserin aut Meier, Thomas O. verfasserin aut Maul, Julia-Tatjana verfasserin aut Anzengruber, Florian verfasserin aut Navarini, Alexander A. verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 311(2019), 5 vom: 16. März, Seite 421-424 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:311 year:2019 number:5 day:16 month:03 pages:421-424 https://dx.doi.org/10.1007/s00403-019-01907-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 311 2019 5 16 03 421-424 |
| allfields_unstemmed |
10.1007/s00403-019-01907-y doi (DE-627)SPR00507147X (SPR)s00403-019-01907-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Gasslitter, Irina verfasserin aut Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 Kirsten, Natalia verfasserin aut Augustin, Matthias verfasserin aut Torz, Kaspar verfasserin aut Mrowietz, Ulrich verfasserin aut Eyerich, Kilian verfasserin aut Puig, Lluís verfasserin aut Hoetzenecker, Wolfram verfasserin aut Schütz-Bergmayr, Martina verfasserin aut Weger, Wolfgang verfasserin aut Wolf, Peter verfasserin aut Reider, Norbert verfasserin aut Ratzinger, Gudrun verfasserin aut Papageorgiou, Karolina verfasserin aut Meier, Thomas O. verfasserin aut Maul, Julia-Tatjana verfasserin aut Anzengruber, Florian verfasserin aut Navarini, Alexander A. verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 311(2019), 5 vom: 16. März, Seite 421-424 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:311 year:2019 number:5 day:16 month:03 pages:421-424 https://dx.doi.org/10.1007/s00403-019-01907-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 311 2019 5 16 03 421-424 |
| allfieldsGer |
10.1007/s00403-019-01907-y doi (DE-627)SPR00507147X (SPR)s00403-019-01907-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Gasslitter, Irina verfasserin aut Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 Kirsten, Natalia verfasserin aut Augustin, Matthias verfasserin aut Torz, Kaspar verfasserin aut Mrowietz, Ulrich verfasserin aut Eyerich, Kilian verfasserin aut Puig, Lluís verfasserin aut Hoetzenecker, Wolfram verfasserin aut Schütz-Bergmayr, Martina verfasserin aut Weger, Wolfgang verfasserin aut Wolf, Peter verfasserin aut Reider, Norbert verfasserin aut Ratzinger, Gudrun verfasserin aut Papageorgiou, Karolina verfasserin aut Meier, Thomas O. verfasserin aut Maul, Julia-Tatjana verfasserin aut Anzengruber, Florian verfasserin aut Navarini, Alexander A. verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 311(2019), 5 vom: 16. März, Seite 421-424 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:311 year:2019 number:5 day:16 month:03 pages:421-424 https://dx.doi.org/10.1007/s00403-019-01907-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 311 2019 5 16 03 421-424 |
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10.1007/s00403-019-01907-y doi (DE-627)SPR00507147X (SPR)s00403-019-01907-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.93 bkl Gasslitter, Irina verfasserin aut Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 Kirsten, Natalia verfasserin aut Augustin, Matthias verfasserin aut Torz, Kaspar verfasserin aut Mrowietz, Ulrich verfasserin aut Eyerich, Kilian verfasserin aut Puig, Lluís verfasserin aut Hoetzenecker, Wolfram verfasserin aut Schütz-Bergmayr, Martina verfasserin aut Weger, Wolfgang verfasserin aut Wolf, Peter verfasserin aut Reider, Norbert verfasserin aut Ratzinger, Gudrun verfasserin aut Papageorgiou, Karolina verfasserin aut Meier, Thomas O. verfasserin aut Maul, Julia-Tatjana verfasserin aut Anzengruber, Florian verfasserin aut Navarini, Alexander A. verfasserin aut Enthalten in Archives of dermatological research Berlin : Springer, 1869 311(2019), 5 vom: 16. März, Seite 421-424 (DE-627)253390044 (DE-600)1458448-7 1432-069X nnns volume:311 year:2019 number:5 day:16 month:03 pages:421-424 https://dx.doi.org/10.1007/s00403-019-01907-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.93 ASE AR 311 2019 5 16 03 421-424 |
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Enthalten in Archives of dermatological research 311(2019), 5 vom: 16. März, Seite 421-424 volume:311 year:2019 number:5 day:16 month:03 pages:421-424 |
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Enthalten in Archives of dermatological research 311(2019), 5 vom: 16. März, Seite 421-424 volume:311 year:2019 number:5 day:16 month:03 pages:421-424 |
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Interleukin-17 IL-17 IL-17A IL-17 receptor blocker Secukinumab Ixekizumab Brodalumab |
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Gasslitter, Irina @@aut@@ Kirsten, Natalia @@aut@@ Augustin, Matthias @@aut@@ Torz, Kaspar @@aut@@ Mrowietz, Ulrich @@aut@@ Eyerich, Kilian @@aut@@ Puig, Lluís @@aut@@ Hoetzenecker, Wolfram @@aut@@ Schütz-Bergmayr, Martina @@aut@@ Weger, Wolfgang @@aut@@ Wolf, Peter @@aut@@ Reider, Norbert @@aut@@ Ratzinger, Gudrun @@aut@@ Papageorgiou, Karolina @@aut@@ Meier, Thomas O. @@aut@@ Maul, Julia-Tatjana @@aut@@ Anzengruber, Florian @@aut@@ Navarini, Alexander A. @@aut@@ |
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2019-03-16T00:00:00Z |
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SPR00507147X |
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| author |
Gasslitter, Irina |
| spellingShingle |
Gasslitter, Irina ddc 610 bkl 44.93 misc Interleukin-17 misc IL-17 misc IL-17A misc IL-17 receptor blocker misc Secukinumab misc Ixekizumab misc Brodalumab Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
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| topic_title |
610 ASE 44.93 bkl Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study Interleukin-17 (dpeaa)DE-He213 IL-17 (dpeaa)DE-He213 IL-17A (dpeaa)DE-He213 IL-17 receptor blocker (dpeaa)DE-He213 Secukinumab (dpeaa)DE-He213 Ixekizumab (dpeaa)DE-He213 Brodalumab (dpeaa)DE-He213 |
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ddc 610 bkl 44.93 misc Interleukin-17 misc IL-17 misc IL-17A misc IL-17 receptor blocker misc Secukinumab misc Ixekizumab misc Brodalumab |
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ddc 610 bkl 44.93 misc Interleukin-17 misc IL-17 misc IL-17A misc IL-17 receptor blocker misc Secukinumab misc Ixekizumab misc Brodalumab |
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ddc 610 bkl 44.93 misc Interleukin-17 misc IL-17 misc IL-17A misc IL-17 receptor blocker misc Secukinumab misc Ixekizumab misc Brodalumab |
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Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
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Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
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Gasslitter, Irina |
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2019 |
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Gasslitter, Irina Kirsten, Natalia Augustin, Matthias Torz, Kaspar Mrowietz, Ulrich Eyerich, Kilian Puig, Lluís Hoetzenecker, Wolfram Schütz-Bergmayr, Martina Weger, Wolfgang Wolf, Peter Reider, Norbert Ratzinger, Gudrun Papageorgiou, Karolina Meier, Thomas O. Maul, Julia-Tatjana Anzengruber, Florian Navarini, Alexander A. |
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610 ASE 44.93 bkl |
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Elektronische Aufsätze |
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Gasslitter, Irina |
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10.1007/s00403-019-01907-y |
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610 |
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verfasserin |
| title_sort |
successful intra-class switching among il-17 antagonists: a multicentre, multinational, retrospective study |
| title_auth |
Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
| abstract |
Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. |
| abstractGer |
Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. |
| abstract_unstemmed |
Abstract IL-17 blockers are among the newer anti-psoriatic treatment options and little is known about the interclass switching. We have thus initiated a multi-center, multi-national, retrospective study to assess the treatment response of patients who were switched from one IL-17 blocker to another. Analysis consisted of data from patients with moderate-to-severe psoriasis who did not respond satisfactorily to one of the available IL-17 blockers (secukinumab, ixekizumab, brodalumab) and were subsequently switched to another drug of this class. After 12 weeks of treatment, patients’ PASIs were evaluated. Treatment success was defined as reaching PASI 75 after 12 weeks. Topical treatment was allowed and used in all patients. 26 patients were included (13 male, 13 female) and 29 switches were evaluated. Overall, 29 switches in 21 patients were evaluated. 18 patients changed their therapy from secukinumab to ixekizumab, or in 7 cases to brodalumab. Brodalumab was used in 3 cases after failure of treatment with ixekizumab. Only in one case, non-response of brodalumab resulted in a therapy switch to secukinumab. In 15 (52%) cases, PASI 75 was reached. In 6 (20%) patients, the switch led to a PASI 50 response. No success of treatment was seen among 8 (28%) participants. When patients fail to respond or do not tolerate an IL-17 blocker, switching to another anti-IL-17A/RA is a promising viable option. Larger studies are needed to confirm our results. |
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5 |
| title_short |
Successful intra-class switching among IL-17 antagonists: a multicentre, multinational, retrospective study |
| url |
https://dx.doi.org/10.1007/s00403-019-01907-y |
| remote_bool |
true |
| author2 |
Kirsten, Natalia Augustin, Matthias Torz, Kaspar Mrowietz, Ulrich Eyerich, Kilian Puig, Lluís Hoetzenecker, Wolfram Schütz-Bergmayr, Martina Weger, Wolfgang Wolf, Peter Reider, Norbert Ratzinger, Gudrun Papageorgiou, Karolina Meier, Thomas O. Maul, Julia-Tatjana Anzengruber, Florian Navarini, Alexander A. |
| author2Str |
Kirsten, Natalia Augustin, Matthias Torz, Kaspar Mrowietz, Ulrich Eyerich, Kilian Puig, Lluís Hoetzenecker, Wolfram Schütz-Bergmayr, Martina Weger, Wolfgang Wolf, Peter Reider, Norbert Ratzinger, Gudrun Papageorgiou, Karolina Meier, Thomas O. Maul, Julia-Tatjana Anzengruber, Florian Navarini, Alexander A. |
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| doi_str |
10.1007/s00403-019-01907-y |
| up_date |
2024-07-03T13:49:15.279Z |
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| score |
7.3992977 |