Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients

Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by t...
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Gespeichert in:

Autor*in:	Battista, Marco Johannes [verfasserIn] Cotarelo, Cristina [verfasserIn] Almstedt, Katrin [verfasserIn] Heimes, Anne-Sophie [verfasserIn] Makris, Georgios-Marios [verfasserIn] Weyer, Veronika [verfasserIn] Schmidt, Marcus [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Serous ovarian cancer Two-tier grading system Three-tier grading system Prognosis

Übergeordnetes Werk:	Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 294(2016), 3 vom: 18. März, Seite 599-606
Übergeordnetes Werk:	volume:294 ; year:2016 ; number:3 ; day:18 ; month:03 ; pages:599-606

Links:	Volltext

DOI / URN:	10.1007/s00404-016-4070-5

Katalog-ID:	SPR005131901

Internformat


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100	1		\|a Battista, Marco Johannes \|e verfasserin \|4 aut
245	1	0	\|a Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
264		1	\|c 2016
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520			\|a Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system.
650		4	\|a Serous ovarian cancer \|7 (dpeaa)DE-He213
650		4	\|a Two-tier grading system \|7 (dpeaa)DE-He213
650		4	\|a Three-tier grading system \|7 (dpeaa)DE-He213
650		4	\|a Prognosis \|7 (dpeaa)DE-He213
700	1		\|a Cotarelo, Cristina \|e verfasserin \|4 aut
700	1		\|a Almstedt, Katrin \|e verfasserin \|4 aut
700	1		\|a Heimes, Anne-Sophie \|e verfasserin \|4 aut
700	1		\|a Makris, Georgios-Marios \|e verfasserin \|4 aut
700	1		\|a Weyer, Veronika \|e verfasserin \|4 aut
700	1		\|a Schmidt, Marcus \|e verfasserin \|4 aut
773	0	8	\|i Enthalten in \|t Archives of gynecology and obstetrics \|d Berlin : Springer, 1870 \|g 294(2016), 3 vom: 18. März, Seite 599-606 \|w (DE-627)253390060 \|w (DE-600)1458450-5 \|x 1432-0711 \|7 nnns
773	1	8	\|g volume:294 \|g year:2016 \|g number:3 \|g day:18 \|g month:03 \|g pages:599-606
856	4	0	\|u https://dx.doi.org/10.1007/s00404-016-4070-5 \|z lizenzpflichtig \|3 Volltext
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912			\|a GBV_ILN_101
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
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912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
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912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
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912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
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912			\|a GBV_ILN_2188
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912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2472
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
912			\|a GBV_ILN_2548
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4046
912			\|a GBV_ILN_4112
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912			\|a GBV_ILN_4277
912			\|a GBV_ILN_4305
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912			\|a GBV_ILN_4307
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936	b	k	\|a 44.92 \|q ASE
951			\|a AR
952			\|d 294 \|j 2016 \|e 3 \|b 18 \|c 03 \|h 599-606

Indexfelder

author_variant	m j b mj mjb c c cc k a ka a s h ash g m m gmm v w vw m s ms
matchkey_str	article:14320711:2016----::aiainftoirrdnsseiauslcecneuieootfe
hierarchy_sort_str	2016
bklnumber	44.92
publishDate	2016
allfields	10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606
spelling	10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606
allfields_unstemmed	10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606
allfieldsGer	10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606
allfieldsSound	10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606
language	English
source	Enthalten in Archives of gynecology and obstetrics 294(2016), 3 vom: 18. März, Seite 599-606 volume:294 year:2016 number:3 day:18 month:03 pages:599-606
sourceStr	Enthalten in Archives of gynecology and obstetrics 294(2016), 3 vom: 18. März, Seite 599-606 volume:294 year:2016 number:3 day:18 month:03 pages:599-606
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Serous ovarian cancer Two-tier grading system Three-tier grading system Prognosis
dewey-raw	610
isfreeaccess_bool	false
container_title	Archives of gynecology and obstetrics
authorswithroles_txt_mv	Battista, Marco Johannes @@aut@@ Cotarelo, Cristina @@aut@@ Almstedt, Katrin @@aut@@ Heimes, Anne-Sophie @@aut@@ Makris, Georgios-Marios @@aut@@ Weyer, Veronika @@aut@@ Schmidt, Marcus @@aut@@
publishDateDaySort_date	2016-03-18T00:00:00Z
hierarchy_top_id	253390060
dewey-sort	3610
id	SPR005131901
language_de	englisch
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In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. 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author	Battista, Marco Johannes
spellingShingle	Battista, Marco Johannes ddc 610 bkl 44.92 misc Serous ovarian cancer misc Two-tier grading system misc Three-tier grading system misc Prognosis Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
authorStr	Battista, Marco Johannes
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topic_title	610 ASE 44.92 bkl Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213
topic	ddc 610 bkl 44.92 misc Serous ovarian cancer misc Two-tier grading system misc Three-tier grading system misc Prognosis
topic_unstemmed	ddc 610 bkl 44.92 misc Serous ovarian cancer misc Two-tier grading system misc Three-tier grading system misc Prognosis
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title	Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
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title_full	Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
author_sort	Battista, Marco Johannes
journal	Archives of gynecology and obstetrics
journalStr	Archives of gynecology and obstetrics
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author_browse	Battista, Marco Johannes Cotarelo, Cristina Almstedt, Katrin Heimes, Anne-Sophie Makris, Georgios-Marios Weyer, Veronika Schmidt, Marcus
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author2-role	verfasserin
title_sort	validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
title_auth	Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
abstract	Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system.
abstractGer	Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system.
abstract_unstemmed	Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system.
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container_issue	3
title_short	Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
url	https://dx.doi.org/10.1007/s00404-016-4070-5
remote_bool	true
author2	Cotarelo, Cristina Almstedt, Katrin Heimes, Anne-Sophie Makris, Georgios-Marios Weyer, Veronika Schmidt, Marcus
author2Str	Cotarelo, Cristina Almstedt, Katrin Heimes, Anne-Sophie Makris, Georgios-Marios Weyer, Veronika Schmidt, Marcus
ppnlink	253390060
mediatype_str_mv	c
isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s00404-016-4070-5
up_date	2024-07-03T14:12:51.590Z
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In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. 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Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients

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