Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients
Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by t...
Ausführliche Beschreibung
Autor*in: |
Battista, Marco Johannes [verfasserIn] Cotarelo, Cristina [verfasserIn] Almstedt, Katrin [verfasserIn] Heimes, Anne-Sophie [verfasserIn] Makris, Georgios-Marios [verfasserIn] Weyer, Veronika [verfasserIn] Schmidt, Marcus [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2016 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 294(2016), 3 vom: 18. März, Seite 599-606 |
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Übergeordnetes Werk: |
volume:294 ; year:2016 ; number:3 ; day:18 ; month:03 ; pages:599-606 |
Links: |
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DOI / URN: |
10.1007/s00404-016-4070-5 |
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Katalog-ID: |
SPR005131901 |
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245 | 1 | 0 | |a Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients |
264 | 1 | |c 2016 | |
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520 | |a Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. | ||
650 | 4 | |a Serous ovarian cancer |7 (dpeaa)DE-He213 | |
650 | 4 | |a Two-tier grading system |7 (dpeaa)DE-He213 | |
650 | 4 | |a Three-tier grading system |7 (dpeaa)DE-He213 | |
650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
700 | 1 | |a Cotarelo, Cristina |e verfasserin |4 aut | |
700 | 1 | |a Almstedt, Katrin |e verfasserin |4 aut | |
700 | 1 | |a Heimes, Anne-Sophie |e verfasserin |4 aut | |
700 | 1 | |a Makris, Georgios-Marios |e verfasserin |4 aut | |
700 | 1 | |a Weyer, Veronika |e verfasserin |4 aut | |
700 | 1 | |a Schmidt, Marcus |e verfasserin |4 aut | |
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2016 |
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10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606 |
spelling |
10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606 |
allfields_unstemmed |
10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606 |
allfieldsGer |
10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606 |
allfieldsSound |
10.1007/s00404-016-4070-5 doi (DE-627)SPR005131901 (SPR)s00404-016-4070-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Battista, Marco Johannes verfasserin aut Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cotarelo, Cristina verfasserin aut Almstedt, Katrin verfasserin aut Heimes, Anne-Sophie verfasserin aut Makris, Georgios-Marios verfasserin aut Weyer, Veronika verfasserin aut Schmidt, Marcus verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 294(2016), 3 vom: 18. März, Seite 599-606 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:294 year:2016 number:3 day:18 month:03 pages:599-606 https://dx.doi.org/10.1007/s00404-016-4070-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 294 2016 3 18 03 599-606 |
language |
English |
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Enthalten in Archives of gynecology and obstetrics 294(2016), 3 vom: 18. März, Seite 599-606 volume:294 year:2016 number:3 day:18 month:03 pages:599-606 |
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Enthalten in Archives of gynecology and obstetrics 294(2016), 3 vom: 18. März, Seite 599-606 volume:294 year:2016 number:3 day:18 month:03 pages:599-606 |
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Serous ovarian cancer Two-tier grading system Three-tier grading system Prognosis |
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Archives of gynecology and obstetrics |
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Battista, Marco Johannes @@aut@@ Cotarelo, Cristina @@aut@@ Almstedt, Katrin @@aut@@ Heimes, Anne-Sophie @@aut@@ Makris, Georgios-Marios @@aut@@ Weyer, Veronika @@aut@@ Schmidt, Marcus @@aut@@ |
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2016-03-18T00:00:00Z |
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In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. 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Battista, Marco Johannes |
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Battista, Marco Johannes ddc 610 bkl 44.92 misc Serous ovarian cancer misc Two-tier grading system misc Three-tier grading system misc Prognosis Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients |
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610 ASE 44.92 bkl Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients Serous ovarian cancer (dpeaa)DE-He213 Two-tier grading system (dpeaa)DE-He213 Three-tier grading system (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 |
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Battista, Marco Johannes Cotarelo, Cristina Almstedt, Katrin Heimes, Anne-Sophie Makris, Georgios-Marios Weyer, Veronika Schmidt, Marcus |
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Battista, Marco Johannes |
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validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients |
title_auth |
Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients |
abstract |
Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. |
abstractGer |
Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. |
abstract_unstemmed |
Purpose New insights into the carcinogenesis of ovarian cancer (OC) lead to the definition of low-grade and high-grade serous OC. In this study, we validated the MD Anderson Cancer Center (MDACC) two-tier grading system and compared it with the traditional three-tier grading system as suggested by the International Federation of Gynecology and Obstetrics (FIGO). Methods Consecutive patients with serous OC were enrolled. These two grading systems were assessed independently from each other. Kaplan–Meier estimates and Cox-regression analyses were performed to validate and compare their prognostic impact. Results 143 consecutive patients entered the study. According to the Kaplan–Meier estimates, the MDACC grading system (p = 0.001) predicted the progression free survival (PFS) more precisely than the FIGO system (p = 0.025). The MDACC grading system (p = 0.008) but not the FIGO system (p = 0.329) showed a statistically significant difference in terms of disease specific survival (DSS). Multivariable Cox-regression analyses revealed an independent prognostic impact of the MDACC grading system but not of the FIGO system for PFS (HR 1.570; 95 % CI 1.007–2.449; p = 0.047, and HR 0.712; 95 % CI 0.476–1.066; p = 0.099, respectively). Concerning DSS, the two-tier grading system but not the FIGO system showed a prognostic impact in a univariable Cox-regression analysis (HR 2.152; 95 % CI 1.207–3.835; p = 0.009, and HR 1.258; 95 % CI 0.801–1.975; p = 0.319, respectively). Conclusions We were able to validate the MDACC grading system in serous OC. Moreover, this grading system was stronger associated with survival than the FIGO system. |
collection_details |
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Validation of a two-tier grading system in an unselected, consecutive cohort of serous ovarian cancer patients |
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Cotarelo, Cristina Almstedt, Katrin Heimes, Anne-Sophie Makris, Georgios-Marios Weyer, Veronika Schmidt, Marcus |
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score |
7.4003353 |