Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial
Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kolben, Theresa M. [verfasserIn] Bergauer, Florian [verfasserIn] Moeckel, Jochen [verfasserIn] Boettcher, Berit [verfasserIn] Thaler, Christian J. [verfasserIn] Kolben, Thomas [verfasserIn] Crispin, Alexander [verfasserIn] Dannecker, Christian [verfasserIn] Mahner, Sven [verfasserIn] Gallwas, Julia [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 295(2017), 6 vom: 12. Apr., Seite 1427-1433 |
|---|---|
| Übergeordnetes Werk: |
volume:295 ; year:2017 ; number:6 ; day:12 ; month:04 ; pages:1427-1433 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00404-017-4369-x |
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| Katalog-ID: |
SPR005134803 |
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| 245 | 1 | 0 | |a Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial |
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| 520 | |a Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. | ||
| 650 | 4 | |a Pap smear |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cervical cytology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Liquid-based cytology |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HPV |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cervical dysplasia |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bergauer, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Moeckel, Jochen |e verfasserin |4 aut | |
| 700 | 1 | |a Boettcher, Berit |e verfasserin |4 aut | |
| 700 | 1 | |a Thaler, Christian J. |e verfasserin |4 aut | |
| 700 | 1 | |a Kolben, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Crispin, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Dannecker, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Mahner, Sven |e verfasserin |4 aut | |
| 700 | 1 | |a Gallwas, Julia |e verfasserin |4 aut | |
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10.1007/s00404-017-4369-x doi (DE-627)SPR005134803 (SPR)s00404-017-4369-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Kolben, Theresa M. verfasserin aut Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 Bergauer, Florian verfasserin aut Moeckel, Jochen verfasserin aut Boettcher, Berit verfasserin aut Thaler, Christian J. verfasserin aut Kolben, Thomas verfasserin aut Crispin, Alexander verfasserin aut Dannecker, Christian verfasserin aut Mahner, Sven verfasserin aut Gallwas, Julia verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 295(2017), 6 vom: 12. Apr., Seite 1427-1433 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 https://dx.doi.org/10.1007/s00404-017-4369-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 295 2017 6 12 04 1427-1433 |
| spelling |
10.1007/s00404-017-4369-x doi (DE-627)SPR005134803 (SPR)s00404-017-4369-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Kolben, Theresa M. verfasserin aut Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 Bergauer, Florian verfasserin aut Moeckel, Jochen verfasserin aut Boettcher, Berit verfasserin aut Thaler, Christian J. verfasserin aut Kolben, Thomas verfasserin aut Crispin, Alexander verfasserin aut Dannecker, Christian verfasserin aut Mahner, Sven verfasserin aut Gallwas, Julia verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 295(2017), 6 vom: 12. Apr., Seite 1427-1433 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 https://dx.doi.org/10.1007/s00404-017-4369-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 295 2017 6 12 04 1427-1433 |
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10.1007/s00404-017-4369-x doi (DE-627)SPR005134803 (SPR)s00404-017-4369-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Kolben, Theresa M. verfasserin aut Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 Bergauer, Florian verfasserin aut Moeckel, Jochen verfasserin aut Boettcher, Berit verfasserin aut Thaler, Christian J. verfasserin aut Kolben, Thomas verfasserin aut Crispin, Alexander verfasserin aut Dannecker, Christian verfasserin aut Mahner, Sven verfasserin aut Gallwas, Julia verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 295(2017), 6 vom: 12. Apr., Seite 1427-1433 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 https://dx.doi.org/10.1007/s00404-017-4369-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 295 2017 6 12 04 1427-1433 |
| allfieldsGer |
10.1007/s00404-017-4369-x doi (DE-627)SPR005134803 (SPR)s00404-017-4369-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Kolben, Theresa M. verfasserin aut Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 Bergauer, Florian verfasserin aut Moeckel, Jochen verfasserin aut Boettcher, Berit verfasserin aut Thaler, Christian J. verfasserin aut Kolben, Thomas verfasserin aut Crispin, Alexander verfasserin aut Dannecker, Christian verfasserin aut Mahner, Sven verfasserin aut Gallwas, Julia verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 295(2017), 6 vom: 12. Apr., Seite 1427-1433 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 https://dx.doi.org/10.1007/s00404-017-4369-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 295 2017 6 12 04 1427-1433 |
| allfieldsSound |
10.1007/s00404-017-4369-x doi (DE-627)SPR005134803 (SPR)s00404-017-4369-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Kolben, Theresa M. verfasserin aut Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 Bergauer, Florian verfasserin aut Moeckel, Jochen verfasserin aut Boettcher, Berit verfasserin aut Thaler, Christian J. verfasserin aut Kolben, Thomas verfasserin aut Crispin, Alexander verfasserin aut Dannecker, Christian verfasserin aut Mahner, Sven verfasserin aut Gallwas, Julia verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 295(2017), 6 vom: 12. Apr., Seite 1427-1433 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 https://dx.doi.org/10.1007/s00404-017-4369-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 295 2017 6 12 04 1427-1433 |
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Enthalten in Archives of gynecology and obstetrics 295(2017), 6 vom: 12. Apr., Seite 1427-1433 volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 |
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Enthalten in Archives of gynecology and obstetrics 295(2017), 6 vom: 12. Apr., Seite 1427-1433 volume:295 year:2017 number:6 day:12 month:04 pages:1427-1433 |
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Pap smear Cervical cytology Liquid-based cytology HPV Cervical dysplasia |
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Kolben, Theresa M. @@aut@@ Bergauer, Florian @@aut@@ Moeckel, Jochen @@aut@@ Boettcher, Berit @@aut@@ Thaler, Christian J. @@aut@@ Kolben, Thomas @@aut@@ Crispin, Alexander @@aut@@ Dannecker, Christian @@aut@@ Mahner, Sven @@aut@@ Gallwas, Julia @@aut@@ |
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A prospective randomized trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. 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Kolben, Theresa M. |
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Kolben, Theresa M. ddc 610 bkl 44.92 misc Pap smear misc Cervical cytology misc Liquid-based cytology misc HPV misc Cervical dysplasia Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial |
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610 ASE 44.92 bkl Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial Pap smear (dpeaa)DE-He213 Cervical cytology (dpeaa)DE-He213 Liquid-based cytology (dpeaa)DE-He213 HPV (dpeaa)DE-He213 Cervical dysplasia (dpeaa)DE-He213 |
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ddc 610 bkl 44.92 misc Pap smear misc Cervical cytology misc Liquid-based cytology misc HPV misc Cervical dysplasia |
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ddc 610 bkl 44.92 misc Pap smear misc Cervical cytology misc Liquid-based cytology misc HPV misc Cervical dysplasia |
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ddc 610 bkl 44.92 misc Pap smear misc Cervical cytology misc Liquid-based cytology misc HPV misc Cervical dysplasia |
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Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial |
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Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial |
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Archives of gynecology and obstetrics |
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Kolben, Theresa M. Bergauer, Florian Moeckel, Jochen Boettcher, Berit Thaler, Christian J. Kolben, Thomas Crispin, Alexander Dannecker, Christian Mahner, Sven Gallwas, Julia |
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short interval between two pap smears: effect on the result of the second smear? a prospective randomized trial |
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Short interval between two Pap smears: effect on the result of the second smear? A prospective randomized trial |
| abstract |
Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. |
| abstractGer |
Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. |
| abstract_unstemmed |
Purpose A repeat Pap smear is sometimes necessary after a short time interval or even immediately, when patients seek for a second opinion or due to study participation. Only limited information is available on the possible impact of a short interval between two Pap smears. Most institutions therefore practice a minimum time span of 6–8 weeks before obtaining a second smear since a short interval is commonly believed to be associated with an increase of false negative results in the second smear. Methods Two consecutive Pap smears were obtained from 81 women. 41 smears were processed using the conventional technique, whereas liquid-based cytology was used in the remaining 40 women. Smears were independently evaluated by four different cytopathologists. We analyzed the effect of time interval, both processing techniques and inter-observer variance in cytological evaluation. Results While the result of the second smear shows a tendency towards a more benign outcome (odds ratio (OR) 1.436, 95% CI 0.972–2.121), this difference was not statistically significant (p = 0.07). No significant differences were observed between conservative and liquid-based cytology (OR 1.554, 95% CI 0.659–3.667, p = 0.31). There was considerable inter-observer variability, and the observer was a strong predictor of the cytological result (OR 0.632–5.083, 95% CI 0.355–8.975, p < 0.01). Conclusions We document a tendency towards a more benign outcome without statistical significance in the second smear. Inter-observer variability of different cytopathologists is high and should be kept in mind when evaluating cytology results. |
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| score |
7.3996515 |