Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma
Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods T...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Matsuo, Koji [verfasserIn] Tanabe, Kazuhiro [verfasserIn] Ikeda, Masae [verfasserIn] Shibata, Takeo [verfasserIn] Kajiwara, Hiroshi [verfasserIn] Miyazawa, Masaki [verfasserIn] Miyazawa, Mariko [verfasserIn] Hayashi, Masaru [verfasserIn] Shida, Masako [verfasserIn] Hirasawa, Takeshi [verfasserIn] Roman, Lynda D. [verfasserIn] Mikami, Mikio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Archives of gynecology and obstetrics - Berlin : Springer, 1870, 297(2018), 3 vom: 16. Jan., Seite 749-756 |
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| Übergeordnetes Werk: |
volume:297 ; year:2018 ; number:3 ; day:16 ; month:01 ; pages:749-756 |
| Links: |
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| DOI / URN: |
10.1007/s00404-018-4658-z |
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| Katalog-ID: |
SPR00513756X |
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| 024 | 7 | |a 10.1007/s00404-018-4658-z |2 doi | |
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| 035 | |a (SPR)s00404-018-4658-z-e | ||
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| 100 | 1 | |a Matsuo, Koji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. | ||
| 650 | 4 | |a Complement 4-binding protein |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Full sialylation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Liquid chromatography–mass spectrometry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epithelial ovarian carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Biomarker |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Survival |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tanabe, Kazuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ikeda, Masae |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Takeo |e verfasserin |4 aut | |
| 700 | 1 | |a Kajiwara, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Miyazawa, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Miyazawa, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashi, Masaru |e verfasserin |4 aut | |
| 700 | 1 | |a Shida, Masako |e verfasserin |4 aut | |
| 700 | 1 | |a Hirasawa, Takeshi |e verfasserin |4 aut | |
| 700 | 1 | |a Roman, Lynda D. |e verfasserin |4 aut | |
| 700 | 1 | |a Mikami, Mikio |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Archives of gynecology and obstetrics |d Berlin : Springer, 1870 |g 297(2018), 3 vom: 16. Jan., Seite 749-756 |w (DE-627)253390060 |w (DE-600)1458450-5 |x 1432-0711 |7 nnns |
| 773 | 1 | 8 | |g volume:297 |g year:2018 |g number:3 |g day:16 |g month:01 |g pages:749-756 |
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10.1007/s00404-018-4658-z doi (DE-627)SPR00513756X (SPR)s00404-018-4658-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Matsuo, Koji verfasserin aut Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Tanabe, Kazuhiro verfasserin aut Ikeda, Masae verfasserin aut Shibata, Takeo verfasserin aut Kajiwara, Hiroshi verfasserin aut Miyazawa, Masaki verfasserin aut Miyazawa, Mariko verfasserin aut Hayashi, Masaru verfasserin aut Shida, Masako verfasserin aut Hirasawa, Takeshi verfasserin aut Roman, Lynda D. verfasserin aut Mikami, Mikio verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 297(2018), 3 vom: 16. Jan., Seite 749-756 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:297 year:2018 number:3 day:16 month:01 pages:749-756 https://dx.doi.org/10.1007/s00404-018-4658-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 297 2018 3 16 01 749-756 |
| spelling |
10.1007/s00404-018-4658-z doi (DE-627)SPR00513756X (SPR)s00404-018-4658-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Matsuo, Koji verfasserin aut Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Tanabe, Kazuhiro verfasserin aut Ikeda, Masae verfasserin aut Shibata, Takeo verfasserin aut Kajiwara, Hiroshi verfasserin aut Miyazawa, Masaki verfasserin aut Miyazawa, Mariko verfasserin aut Hayashi, Masaru verfasserin aut Shida, Masako verfasserin aut Hirasawa, Takeshi verfasserin aut Roman, Lynda D. verfasserin aut Mikami, Mikio verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 297(2018), 3 vom: 16. Jan., Seite 749-756 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:297 year:2018 number:3 day:16 month:01 pages:749-756 https://dx.doi.org/10.1007/s00404-018-4658-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 297 2018 3 16 01 749-756 |
| allfields_unstemmed |
10.1007/s00404-018-4658-z doi (DE-627)SPR00513756X (SPR)s00404-018-4658-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Matsuo, Koji verfasserin aut Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Tanabe, Kazuhiro verfasserin aut Ikeda, Masae verfasserin aut Shibata, Takeo verfasserin aut Kajiwara, Hiroshi verfasserin aut Miyazawa, Masaki verfasserin aut Miyazawa, Mariko verfasserin aut Hayashi, Masaru verfasserin aut Shida, Masako verfasserin aut Hirasawa, Takeshi verfasserin aut Roman, Lynda D. verfasserin aut Mikami, Mikio verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 297(2018), 3 vom: 16. Jan., Seite 749-756 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:297 year:2018 number:3 day:16 month:01 pages:749-756 https://dx.doi.org/10.1007/s00404-018-4658-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 297 2018 3 16 01 749-756 |
| allfieldsGer |
10.1007/s00404-018-4658-z doi (DE-627)SPR00513756X (SPR)s00404-018-4658-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Matsuo, Koji verfasserin aut Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Tanabe, Kazuhiro verfasserin aut Ikeda, Masae verfasserin aut Shibata, Takeo verfasserin aut Kajiwara, Hiroshi verfasserin aut Miyazawa, Masaki verfasserin aut Miyazawa, Mariko verfasserin aut Hayashi, Masaru verfasserin aut Shida, Masako verfasserin aut Hirasawa, Takeshi verfasserin aut Roman, Lynda D. verfasserin aut Mikami, Mikio verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 297(2018), 3 vom: 16. Jan., Seite 749-756 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:297 year:2018 number:3 day:16 month:01 pages:749-756 https://dx.doi.org/10.1007/s00404-018-4658-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 297 2018 3 16 01 749-756 |
| allfieldsSound |
10.1007/s00404-018-4658-z doi (DE-627)SPR00513756X (SPR)s00404-018-4658-z-e DE-627 ger DE-627 rakwb eng 610 ASE 44.92 bkl Matsuo, Koji verfasserin aut Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Tanabe, Kazuhiro verfasserin aut Ikeda, Masae verfasserin aut Shibata, Takeo verfasserin aut Kajiwara, Hiroshi verfasserin aut Miyazawa, Masaki verfasserin aut Miyazawa, Mariko verfasserin aut Hayashi, Masaru verfasserin aut Shida, Masako verfasserin aut Hirasawa, Takeshi verfasserin aut Roman, Lynda D. verfasserin aut Mikami, Mikio verfasserin aut Enthalten in Archives of gynecology and obstetrics Berlin : Springer, 1870 297(2018), 3 vom: 16. Jan., Seite 749-756 (DE-627)253390060 (DE-600)1458450-5 1432-0711 nnns volume:297 year:2018 number:3 day:16 month:01 pages:749-756 https://dx.doi.org/10.1007/s00404-018-4658-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.92 ASE AR 297 2018 3 16 01 749-756 |
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Enthalten in Archives of gynecology and obstetrics 297(2018), 3 vom: 16. Jan., Seite 749-756 volume:297 year:2018 number:3 day:16 month:01 pages:749-756 |
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Enthalten in Archives of gynecology and obstetrics 297(2018), 3 vom: 16. Jan., Seite 749-756 volume:297 year:2018 number:3 day:16 month:01 pages:749-756 |
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Complement 4-binding protein Full sialylation Liquid chromatography–mass spectrometry Epithelial ovarian carcinoma Biomarker Survival |
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Archives of gynecology and obstetrics |
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Matsuo, Koji @@aut@@ Tanabe, Kazuhiro @@aut@@ Ikeda, Masae @@aut@@ Shibata, Takeo @@aut@@ Kajiwara, Hiroshi @@aut@@ Miyazawa, Masaki @@aut@@ Miyazawa, Mariko @@aut@@ Hayashi, Masaru @@aut@@ Shida, Masako @@aut@@ Hirasawa, Takeshi @@aut@@ Roman, Lynda D. @@aut@@ Mikami, Mikio @@aut@@ |
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2018-01-16T00:00:00Z |
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This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). 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|
| author |
Matsuo, Koji |
| spellingShingle |
Matsuo, Koji ddc 610 bkl 44.92 misc Complement 4-binding protein misc Full sialylation misc Liquid chromatography–mass spectrometry misc Epithelial ovarian carcinoma misc Biomarker misc Survival Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
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1432-0711 |
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610 ASE 44.92 bkl Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma Complement 4-binding protein (dpeaa)DE-He213 Full sialylation (dpeaa)DE-He213 Liquid chromatography–mass spectrometry (dpeaa)DE-He213 Epithelial ovarian carcinoma (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Survival (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.92 misc Complement 4-binding protein misc Full sialylation misc Liquid chromatography–mass spectrometry misc Epithelial ovarian carcinoma misc Biomarker misc Survival |
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ddc 610 bkl 44.92 misc Complement 4-binding protein misc Full sialylation misc Liquid chromatography–mass spectrometry misc Epithelial ovarian carcinoma misc Biomarker misc Survival |
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ddc 610 bkl 44.92 misc Complement 4-binding protein misc Full sialylation misc Liquid chromatography–mass spectrometry misc Epithelial ovarian carcinoma misc Biomarker misc Survival |
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Archives of gynecology and obstetrics |
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610 - Medicine & health |
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Archives of gynecology and obstetrics |
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Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
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(DE-627)SPR00513756X (SPR)s00404-018-4658-z-e |
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Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
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Matsuo, Koji |
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Archives of gynecology and obstetrics |
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Archives of gynecology and obstetrics |
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Matsuo, Koji Tanabe, Kazuhiro Ikeda, Masae Shibata, Takeo Kajiwara, Hiroshi Miyazawa, Masaki Miyazawa, Mariko Hayashi, Masaru Shida, Masako Hirasawa, Takeshi Roman, Lynda D. Mikami, Mikio |
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Matsuo, Koji |
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10.1007/s00404-018-4658-z |
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610 |
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verfasserin |
| title_sort |
fully sialylated alpha-chain of complement 4-binding protein (a2160): a novel prognostic marker for epithelial ovarian carcinoma |
| title_auth |
Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
| abstract |
Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. |
| abstractGer |
Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. |
| abstract_unstemmed |
Purpose Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). On univariable analysis, higher A2160 levels were significantly associated with decreased progression-free survival (64–100 versus 1–33%ile, 5-year rates 53.4 versus 78.9%, P = 0.029). After controlling for age, CA-125 level, cytoreductive status, histology, and stage, higher A2160 levels remained an independent prognostic factor for decreased progression-free survival (adjusted-hazard ratio (HR) 2.48, 95% confidence interval (CI) 1.01–6.11, P = 0.049). Similarly, higher A2160 levels were independently associated with decreased cause-specific survival on multivariable analysis (adjusted-HR 3.07, 95% CI 1.19–7.93, P = 0.021). Conclusion Our study suggests that A2160 may be a useful prognostic biomarker for epithelial ovarian cancer, and higher pretreatment levels of A2160 predicts poor survival outcome. |
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Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma |
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https://dx.doi.org/10.1007/s00404-018-4658-z |
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Tanabe, Kazuhiro Ikeda, Masae Shibata, Takeo Kajiwara, Hiroshi Miyazawa, Masaki Miyazawa, Mariko Hayashi, Masaru Shida, Masako Hirasawa, Takeshi Roman, Lynda D. Mikami, Mikio |
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Tanabe, Kazuhiro Ikeda, Masae Shibata, Takeo Kajiwara, Hiroshi Miyazawa, Masaki Miyazawa, Mariko Hayashi, Masaru Shida, Masako Hirasawa, Takeshi Roman, Lynda D. Mikami, Mikio |
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| doi_str |
10.1007/s00404-018-4658-z |
| up_date |
2024-07-03T14:15:13.351Z |
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1803567616073138176 |
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This study examined the utility of A2160 as a prognostic biomarker for this disease. Methods This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I–IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014. Pretreatment A2160 levels were correlated to clinico-pathological factors and survival outcome. Results Women with advanced-stage disease had significantly higher 2160 levels compared to those with early stage disease (stage I–II versus III–IV, median 2.17–2.70 versus 5.31–8.70 U/mL, P < 0.01). Women with high-grade serous ovarian carcinoma had higher A2160 levels compared to other histologies (6.60 versus 3.01 U/mL, P = 0.05). Women who had suboptimal cytoreduction had significantly higher A2160 levels than those who achieved optimal/complete cytoreduction (7.02 versus 2.30–3.17 U/mL, P < 0.01). 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| score |
7.399722 |