Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system
Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bertho, Jean-Marc [verfasserIn] Louiba, Sonia [verfasserIn] Faure, Marie-Cécile [verfasserIn] Tourlonias, Elie [verfasserIn] Stefani, Johanna [verfasserIn] Siffert, Baptiste [verfasserIn] Paquet, François [verfasserIn] Dublineau, Isabelle [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Radiation and environmental biophysics - Berlin : Springer, 1963, 49(2010), 2 vom: 16. Feb., Seite 239-248 |
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| Übergeordnetes Werk: |
volume:49 ; year:2010 ; number:2 ; day:16 ; month:02 ; pages:239-248 |
| Links: |
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| DOI / URN: |
10.1007/s00411-010-0267-3 |
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| Katalog-ID: |
SPR005264839 |
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| 245 | 1 | 0 | |a Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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| 520 | |a Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. | ||
| 650 | 4 | |a 137Cs Activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chernobyl Accident |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hematopoietic System |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a 137Cs Concentration |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a 137Cs Content |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Louiba, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Faure, Marie-Cécile |e verfasserin |4 aut | |
| 700 | 1 | |a Tourlonias, Elie |e verfasserin |4 aut | |
| 700 | 1 | |a Stefani, Johanna |e verfasserin |4 aut | |
| 700 | 1 | |a Siffert, Baptiste |e verfasserin |4 aut | |
| 700 | 1 | |a Paquet, François |e verfasserin |4 aut | |
| 700 | 1 | |a Dublineau, Isabelle |e verfasserin |4 aut | |
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10.1007/s00411-010-0267-3 doi (DE-627)SPR005264839 (SPR)s00411-010-0267-3-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 Louiba, Sonia verfasserin aut Faure, Marie-Cécile verfasserin aut Tourlonias, Elie verfasserin aut Stefani, Johanna verfasserin aut Siffert, Baptiste verfasserin aut Paquet, François verfasserin aut Dublineau, Isabelle verfasserin aut Enthalten in Radiation and environmental biophysics Berlin : Springer, 1963 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)254630375 (DE-600)1462083-2 1432-2099 nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://dx.doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-GGO SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE 42.14 ASE 44.64 ASE 43.68 ASE AR 49 2010 2 16 02 239-248 |
| spelling |
10.1007/s00411-010-0267-3 doi (DE-627)SPR005264839 (SPR)s00411-010-0267-3-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 Louiba, Sonia verfasserin aut Faure, Marie-Cécile verfasserin aut Tourlonias, Elie verfasserin aut Stefani, Johanna verfasserin aut Siffert, Baptiste verfasserin aut Paquet, François verfasserin aut Dublineau, Isabelle verfasserin aut Enthalten in Radiation and environmental biophysics Berlin : Springer, 1963 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)254630375 (DE-600)1462083-2 1432-2099 nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://dx.doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-GGO SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE 42.14 ASE 44.64 ASE 43.68 ASE AR 49 2010 2 16 02 239-248 |
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10.1007/s00411-010-0267-3 doi (DE-627)SPR005264839 (SPR)s00411-010-0267-3-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 Louiba, Sonia verfasserin aut Faure, Marie-Cécile verfasserin aut Tourlonias, Elie verfasserin aut Stefani, Johanna verfasserin aut Siffert, Baptiste verfasserin aut Paquet, François verfasserin aut Dublineau, Isabelle verfasserin aut Enthalten in Radiation and environmental biophysics Berlin : Springer, 1963 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)254630375 (DE-600)1462083-2 1432-2099 nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://dx.doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-GGO SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE 42.14 ASE 44.64 ASE 43.68 ASE AR 49 2010 2 16 02 239-248 |
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10.1007/s00411-010-0267-3 doi (DE-627)SPR005264839 (SPR)s00411-010-0267-3-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 Louiba, Sonia verfasserin aut Faure, Marie-Cécile verfasserin aut Tourlonias, Elie verfasserin aut Stefani, Johanna verfasserin aut Siffert, Baptiste verfasserin aut Paquet, François verfasserin aut Dublineau, Isabelle verfasserin aut Enthalten in Radiation and environmental biophysics Berlin : Springer, 1963 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)254630375 (DE-600)1462083-2 1432-2099 nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://dx.doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-GGO SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE 42.14 ASE 44.64 ASE 43.68 ASE AR 49 2010 2 16 02 239-248 |
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10.1007/s00411-010-0267-3 doi (DE-627)SPR005264839 (SPR)s00411-010-0267-3-e DE-627 ger DE-627 rakwb eng 570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Bertho, Jean-Marc verfasserin aut Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 Louiba, Sonia verfasserin aut Faure, Marie-Cécile verfasserin aut Tourlonias, Elie verfasserin aut Stefani, Johanna verfasserin aut Siffert, Baptiste verfasserin aut Paquet, François verfasserin aut Dublineau, Isabelle verfasserin aut Enthalten in Radiation and environmental biophysics Berlin : Springer, 1963 49(2010), 2 vom: 16. Feb., Seite 239-248 (DE-627)254630375 (DE-600)1462083-2 1432-2099 nnns volume:49 year:2010 number:2 day:16 month:02 pages:239-248 https://dx.doi.org/10.1007/s00411-010-0267-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA SSG-OPC-GGO SSG-OPC-ASE GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 42.12 ASE 42.14 ASE 44.64 ASE 43.68 ASE AR 49 2010 2 16 02 239-248 |
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Enthalten in Radiation and environmental biophysics 49(2010), 2 vom: 16. Feb., Seite 239-248 volume:49 year:2010 number:2 day:16 month:02 pages:239-248 |
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Enthalten in Radiation and environmental biophysics 49(2010), 2 vom: 16. Feb., Seite 239-248 volume:49 year:2010 number:2 day:16 month:02 pages:239-248 |
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137Cs Activity Chernobyl Accident Hematopoietic System 137Cs Concentration 137Cs Content |
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Bertho, Jean-Marc @@aut@@ Louiba, Sonia @@aut@@ Faure, Marie-Cécile @@aut@@ Tourlonias, Elie @@aut@@ Stefani, Johanna @@aut@@ Siffert, Baptiste @@aut@@ Paquet, François @@aut@@ Dublineau, Isabelle @@aut@@ |
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A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. 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|
| author |
Bertho, Jean-Marc |
| spellingShingle |
Bertho, Jean-Marc ddc 570 bkl 42.12 bkl 42.14 bkl 44.64 bkl 43.68 misc 137Cs Activity misc Chernobyl Accident misc Hematopoietic System misc 137Cs Concentration misc 137Cs Content Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Bertho, Jean-Marc |
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@@773@@(DE-627)254630375 |
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electronic Article |
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570 - Life sciences; biology 530 - Physics |
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keep |
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Not Illustrated |
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1432-2099 |
| topic_title |
570 530 ASE 42.12 bkl 42.14 bkl 44.64 bkl 43.68 bkl Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system 137Cs Activity (dpeaa)DE-He213 Chernobyl Accident (dpeaa)DE-He213 Hematopoietic System (dpeaa)DE-He213 137Cs Concentration (dpeaa)DE-He213 137Cs Content (dpeaa)DE-He213 |
| topic |
ddc 570 bkl 42.12 bkl 42.14 bkl 44.64 bkl 43.68 misc 137Cs Activity misc Chernobyl Accident misc Hematopoietic System misc 137Cs Concentration misc 137Cs Content |
| topic_unstemmed |
ddc 570 bkl 42.12 bkl 42.14 bkl 44.64 bkl 43.68 misc 137Cs Activity misc Chernobyl Accident misc Hematopoietic System misc 137Cs Concentration misc 137Cs Content |
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ddc 570 bkl 42.12 bkl 42.14 bkl 44.64 bkl 43.68 misc 137Cs Activity misc Chernobyl Accident misc Hematopoietic System misc 137Cs Concentration misc 137Cs Content |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Radiation and environmental biophysics |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Bertho, Jean-Marc |
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Radiation and environmental biophysics |
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Bertho, Jean-Marc Louiba, Sonia Faure, Marie-Cécile Tourlonias, Elie Stefani, Johanna Siffert, Baptiste Paquet, François Dublineau, Isabelle |
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biodistribution of 137cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
| abstract |
Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. |
| abstractGer |
Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. |
| abstract_unstemmed |
Abstract The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq $ l^{−1} $. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. |
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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system |
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| score |
7.402135 |