The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life
Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12...
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E-Artikel |
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Englisch |
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2012 |
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Enthalten in: Journal of neurology - [Darmstadt] : Steinkopff, 1891, 259(2012), 12 vom: 19. Juni, Seite 2621-2631 |
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| Übergeordnetes Werk: |
volume:259 ; year:2012 ; number:12 ; day:19 ; month:06 ; pages:2621-2631 |
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| DOI / URN: |
10.1007/s00415-012-6557-8 |
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| 100 | 1 | |a Antonini, Angelo |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life |
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| 520 | |a Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. | ||
| 650 | 4 | |a Parkinson’s disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-motor symptoms |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mortality |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cognition |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Motor progression |7 (dpeaa)DE-He213 | |
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10.1007/s00415-012-6557-8 doi (DE-627)SPR005346185 (SPR)s00415-012-6557-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 Barone, Paolo verfasserin aut Marconi, Roberto verfasserin aut Morgante, Letterio verfasserin aut Zappulla, Salvatore verfasserin aut Pontieri, Francesco Ernesto verfasserin aut Ramat, Silvia verfasserin aut Ceravolo, Maria Gabriella verfasserin aut Meco, Giuseppe verfasserin aut Cicarelli, Giulio verfasserin aut Pederzoli, Massimo verfasserin aut Manfredi, Michela verfasserin aut Ceravolo, Roberto verfasserin aut Mucchiut, Marco verfasserin aut Volpe, Giampiero verfasserin aut Abbruzzese, Giovanni verfasserin aut Bottacchi, Edo verfasserin aut Bartolomei, Luigi verfasserin aut Ciacci, Giuseppe verfasserin aut Cannas, Antonino verfasserin aut Randisi, Maria Giovanna verfasserin aut Petrone, Alfredo verfasserin aut Baratti, Mario verfasserin aut Toni, Vincenzo verfasserin aut Cossu, Giovanni verfasserin aut Del Dotto, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Abrignani, Michele verfasserin aut Scala, Rossana verfasserin aut Pennisi, Franco verfasserin aut Quatrale, Rocco verfasserin aut Gaglio, Rosa Maria verfasserin aut Nicoletti, Alessandra verfasserin aut Perini, Michele verfasserin aut Avarello, Tania verfasserin aut Pisani, Antonio verfasserin aut Scaglioni, Augusto verfasserin aut Martinelli, Paolo Emilio verfasserin aut Iemolo, Francesco verfasserin aut Ferigo, Laura verfasserin aut Simone, Pasqualino verfasserin aut Soliveri, Paola verfasserin aut Troianiello, Biagio verfasserin aut Consoli, Domenico verfasserin aut Mauro, Alessandro verfasserin aut Lopiano, Leonardo verfasserin aut Nastasi, Giuseppe verfasserin aut Colosimo, Carlo verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 259(2012), 12 vom: 19. Juni, Seite 2621-2631 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 https://dx.doi.org/10.1007/s00415-012-6557-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 259 2012 12 19 06 2621-2631 |
| spelling |
10.1007/s00415-012-6557-8 doi (DE-627)SPR005346185 (SPR)s00415-012-6557-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 Barone, Paolo verfasserin aut Marconi, Roberto verfasserin aut Morgante, Letterio verfasserin aut Zappulla, Salvatore verfasserin aut Pontieri, Francesco Ernesto verfasserin aut Ramat, Silvia verfasserin aut Ceravolo, Maria Gabriella verfasserin aut Meco, Giuseppe verfasserin aut Cicarelli, Giulio verfasserin aut Pederzoli, Massimo verfasserin aut Manfredi, Michela verfasserin aut Ceravolo, Roberto verfasserin aut Mucchiut, Marco verfasserin aut Volpe, Giampiero verfasserin aut Abbruzzese, Giovanni verfasserin aut Bottacchi, Edo verfasserin aut Bartolomei, Luigi verfasserin aut Ciacci, Giuseppe verfasserin aut Cannas, Antonino verfasserin aut Randisi, Maria Giovanna verfasserin aut Petrone, Alfredo verfasserin aut Baratti, Mario verfasserin aut Toni, Vincenzo verfasserin aut Cossu, Giovanni verfasserin aut Del Dotto, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Abrignani, Michele verfasserin aut Scala, Rossana verfasserin aut Pennisi, Franco verfasserin aut Quatrale, Rocco verfasserin aut Gaglio, Rosa Maria verfasserin aut Nicoletti, Alessandra verfasserin aut Perini, Michele verfasserin aut Avarello, Tania verfasserin aut Pisani, Antonio verfasserin aut Scaglioni, Augusto verfasserin aut Martinelli, Paolo Emilio verfasserin aut Iemolo, Francesco verfasserin aut Ferigo, Laura verfasserin aut Simone, Pasqualino verfasserin aut Soliveri, Paola verfasserin aut Troianiello, Biagio verfasserin aut Consoli, Domenico verfasserin aut Mauro, Alessandro verfasserin aut Lopiano, Leonardo verfasserin aut Nastasi, Giuseppe verfasserin aut Colosimo, Carlo verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 259(2012), 12 vom: 19. Juni, Seite 2621-2631 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 https://dx.doi.org/10.1007/s00415-012-6557-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 259 2012 12 19 06 2621-2631 |
| allfields_unstemmed |
10.1007/s00415-012-6557-8 doi (DE-627)SPR005346185 (SPR)s00415-012-6557-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 Barone, Paolo verfasserin aut Marconi, Roberto verfasserin aut Morgante, Letterio verfasserin aut Zappulla, Salvatore verfasserin aut Pontieri, Francesco Ernesto verfasserin aut Ramat, Silvia verfasserin aut Ceravolo, Maria Gabriella verfasserin aut Meco, Giuseppe verfasserin aut Cicarelli, Giulio verfasserin aut Pederzoli, Massimo verfasserin aut Manfredi, Michela verfasserin aut Ceravolo, Roberto verfasserin aut Mucchiut, Marco verfasserin aut Volpe, Giampiero verfasserin aut Abbruzzese, Giovanni verfasserin aut Bottacchi, Edo verfasserin aut Bartolomei, Luigi verfasserin aut Ciacci, Giuseppe verfasserin aut Cannas, Antonino verfasserin aut Randisi, Maria Giovanna verfasserin aut Petrone, Alfredo verfasserin aut Baratti, Mario verfasserin aut Toni, Vincenzo verfasserin aut Cossu, Giovanni verfasserin aut Del Dotto, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Abrignani, Michele verfasserin aut Scala, Rossana verfasserin aut Pennisi, Franco verfasserin aut Quatrale, Rocco verfasserin aut Gaglio, Rosa Maria verfasserin aut Nicoletti, Alessandra verfasserin aut Perini, Michele verfasserin aut Avarello, Tania verfasserin aut Pisani, Antonio verfasserin aut Scaglioni, Augusto verfasserin aut Martinelli, Paolo Emilio verfasserin aut Iemolo, Francesco verfasserin aut Ferigo, Laura verfasserin aut Simone, Pasqualino verfasserin aut Soliveri, Paola verfasserin aut Troianiello, Biagio verfasserin aut Consoli, Domenico verfasserin aut Mauro, Alessandro verfasserin aut Lopiano, Leonardo verfasserin aut Nastasi, Giuseppe verfasserin aut Colosimo, Carlo verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 259(2012), 12 vom: 19. Juni, Seite 2621-2631 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 https://dx.doi.org/10.1007/s00415-012-6557-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 259 2012 12 19 06 2621-2631 |
| allfieldsGer |
10.1007/s00415-012-6557-8 doi (DE-627)SPR005346185 (SPR)s00415-012-6557-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 Barone, Paolo verfasserin aut Marconi, Roberto verfasserin aut Morgante, Letterio verfasserin aut Zappulla, Salvatore verfasserin aut Pontieri, Francesco Ernesto verfasserin aut Ramat, Silvia verfasserin aut Ceravolo, Maria Gabriella verfasserin aut Meco, Giuseppe verfasserin aut Cicarelli, Giulio verfasserin aut Pederzoli, Massimo verfasserin aut Manfredi, Michela verfasserin aut Ceravolo, Roberto verfasserin aut Mucchiut, Marco verfasserin aut Volpe, Giampiero verfasserin aut Abbruzzese, Giovanni verfasserin aut Bottacchi, Edo verfasserin aut Bartolomei, Luigi verfasserin aut Ciacci, Giuseppe verfasserin aut Cannas, Antonino verfasserin aut Randisi, Maria Giovanna verfasserin aut Petrone, Alfredo verfasserin aut Baratti, Mario verfasserin aut Toni, Vincenzo verfasserin aut Cossu, Giovanni verfasserin aut Del Dotto, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Abrignani, Michele verfasserin aut Scala, Rossana verfasserin aut Pennisi, Franco verfasserin aut Quatrale, Rocco verfasserin aut Gaglio, Rosa Maria verfasserin aut Nicoletti, Alessandra verfasserin aut Perini, Michele verfasserin aut Avarello, Tania verfasserin aut Pisani, Antonio verfasserin aut Scaglioni, Augusto verfasserin aut Martinelli, Paolo Emilio verfasserin aut Iemolo, Francesco verfasserin aut Ferigo, Laura verfasserin aut Simone, Pasqualino verfasserin aut Soliveri, Paola verfasserin aut Troianiello, Biagio verfasserin aut Consoli, Domenico verfasserin aut Mauro, Alessandro verfasserin aut Lopiano, Leonardo verfasserin aut Nastasi, Giuseppe verfasserin aut Colosimo, Carlo verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 259(2012), 12 vom: 19. Juni, Seite 2621-2631 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 https://dx.doi.org/10.1007/s00415-012-6557-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 259 2012 12 19 06 2621-2631 |
| allfieldsSound |
10.1007/s00415-012-6557-8 doi (DE-627)SPR005346185 (SPR)s00415-012-6557-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Antonini, Angelo verfasserin aut The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 Barone, Paolo verfasserin aut Marconi, Roberto verfasserin aut Morgante, Letterio verfasserin aut Zappulla, Salvatore verfasserin aut Pontieri, Francesco Ernesto verfasserin aut Ramat, Silvia verfasserin aut Ceravolo, Maria Gabriella verfasserin aut Meco, Giuseppe verfasserin aut Cicarelli, Giulio verfasserin aut Pederzoli, Massimo verfasserin aut Manfredi, Michela verfasserin aut Ceravolo, Roberto verfasserin aut Mucchiut, Marco verfasserin aut Volpe, Giampiero verfasserin aut Abbruzzese, Giovanni verfasserin aut Bottacchi, Edo verfasserin aut Bartolomei, Luigi verfasserin aut Ciacci, Giuseppe verfasserin aut Cannas, Antonino verfasserin aut Randisi, Maria Giovanna verfasserin aut Petrone, Alfredo verfasserin aut Baratti, Mario verfasserin aut Toni, Vincenzo verfasserin aut Cossu, Giovanni verfasserin aut Del Dotto, Paolo verfasserin aut Bentivoglio, Anna Rita verfasserin aut Abrignani, Michele verfasserin aut Scala, Rossana verfasserin aut Pennisi, Franco verfasserin aut Quatrale, Rocco verfasserin aut Gaglio, Rosa Maria verfasserin aut Nicoletti, Alessandra verfasserin aut Perini, Michele verfasserin aut Avarello, Tania verfasserin aut Pisani, Antonio verfasserin aut Scaglioni, Augusto verfasserin aut Martinelli, Paolo Emilio verfasserin aut Iemolo, Francesco verfasserin aut Ferigo, Laura verfasserin aut Simone, Pasqualino verfasserin aut Soliveri, Paola verfasserin aut Troianiello, Biagio verfasserin aut Consoli, Domenico verfasserin aut Mauro, Alessandro verfasserin aut Lopiano, Leonardo verfasserin aut Nastasi, Giuseppe verfasserin aut Colosimo, Carlo verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 259(2012), 12 vom: 19. Juni, Seite 2621-2631 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 https://dx.doi.org/10.1007/s00415-012-6557-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 259 2012 12 19 06 2621-2631 |
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English |
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Enthalten in Journal of neurology 259(2012), 12 vom: 19. Juni, Seite 2621-2631 volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 |
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Enthalten in Journal of neurology 259(2012), 12 vom: 19. Juni, Seite 2621-2631 volume:259 year:2012 number:12 day:19 month:06 pages:2621-2631 |
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Article |
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findex.gbv.de |
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Parkinson’s disease Non-motor symptoms Mortality Cognition Quality of life Motor progression |
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Journal of neurology |
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Antonini, Angelo @@aut@@ Barone, Paolo @@aut@@ Marconi, Roberto @@aut@@ Morgante, Letterio @@aut@@ Zappulla, Salvatore @@aut@@ Pontieri, Francesco Ernesto @@aut@@ Ramat, Silvia @@aut@@ Ceravolo, Maria Gabriella @@aut@@ Meco, Giuseppe @@aut@@ Cicarelli, Giulio @@aut@@ Pederzoli, Massimo @@aut@@ Manfredi, Michela @@aut@@ Ceravolo, Roberto @@aut@@ Mucchiut, Marco @@aut@@ Volpe, Giampiero @@aut@@ Abbruzzese, Giovanni @@aut@@ Bottacchi, Edo @@aut@@ Bartolomei, Luigi @@aut@@ Ciacci, Giuseppe @@aut@@ Cannas, Antonino @@aut@@ Randisi, Maria Giovanna @@aut@@ Petrone, Alfredo @@aut@@ Baratti, Mario @@aut@@ Toni, Vincenzo @@aut@@ Cossu, Giovanni @@aut@@ Del Dotto, Paolo @@aut@@ Bentivoglio, Anna Rita @@aut@@ Abrignani, Michele @@aut@@ Scala, Rossana @@aut@@ Pennisi, Franco @@aut@@ Quatrale, Rocco @@aut@@ Gaglio, Rosa Maria @@aut@@ Nicoletti, Alessandra @@aut@@ Perini, Michele @@aut@@ Avarello, Tania @@aut@@ Pisani, Antonio @@aut@@ Scaglioni, Augusto @@aut@@ Martinelli, Paolo Emilio @@aut@@ Iemolo, Francesco @@aut@@ Ferigo, Laura @@aut@@ Simone, Pasqualino @@aut@@ Soliveri, Paola @@aut@@ Troianiello, Biagio @@aut@@ Consoli, Domenico @@aut@@ Mauro, Alessandro @@aut@@ Lopiano, Leonardo @@aut@@ Nastasi, Giuseppe @@aut@@ Colosimo, Carlo @@aut@@ |
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2012-06-19T00:00:00Z |
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242065155 |
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3610 |
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SPR005346185 |
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englisch |
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We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. 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| author |
Antonini, Angelo |
| spellingShingle |
Antonini, Angelo ddc 610 bkl 44.90 misc Parkinson’s disease misc Non-motor symptoms misc Mortality misc Cognition misc Quality of life misc Motor progression The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life |
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610 ASE 44.90 bkl The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life Parkinson’s disease (dpeaa)DE-He213 Non-motor symptoms (dpeaa)DE-He213 Mortality (dpeaa)DE-He213 Cognition (dpeaa)DE-He213 Quality of life (dpeaa)DE-He213 Motor progression (dpeaa)DE-He213 |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Non-motor symptoms misc Mortality misc Cognition misc Quality of life misc Motor progression |
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ddc 610 bkl 44.90 misc Parkinson’s disease misc Non-motor symptoms misc Mortality misc Cognition misc Quality of life misc Motor progression |
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The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life |
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Antonini, Angelo Barone, Paolo Marconi, Roberto Morgante, Letterio Zappulla, Salvatore Pontieri, Francesco Ernesto Ramat, Silvia Ceravolo, Maria Gabriella Meco, Giuseppe Cicarelli, Giulio Pederzoli, Massimo Manfredi, Michela Ceravolo, Roberto Mucchiut, Marco Volpe, Giampiero Abbruzzese, Giovanni Bottacchi, Edo Bartolomei, Luigi Ciacci, Giuseppe Cannas, Antonino Randisi, Maria Giovanna Petrone, Alfredo Baratti, Mario Toni, Vincenzo Cossu, Giovanni Del Dotto, Paolo Bentivoglio, Anna Rita Abrignani, Michele Scala, Rossana Pennisi, Franco Quatrale, Rocco Gaglio, Rosa Maria Nicoletti, Alessandra Perini, Michele Avarello, Tania Pisani, Antonio Scaglioni, Augusto Martinelli, Paolo Emilio Iemolo, Francesco Ferigo, Laura Simone, Pasqualino Soliveri, Paola Troianiello, Biagio Consoli, Domenico Mauro, Alessandro Lopiano, Leonardo Nastasi, Giuseppe Colosimo, Carlo |
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progression of non-motor symptoms in parkinson’s disease and their contribution to motor disability and quality of life |
| title_auth |
The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life |
| abstract |
Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. |
| abstractGer |
Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. |
| abstract_unstemmed |
Abstract Non-motor symptoms are gaining relevance in Parkinson’s disease (PD) management but little is known about their progression and contribution to deterioration of quality of life. We followed prospectively 707 PD patients (62 % males) for 2 years. We assessed non-motor symptoms referred to 12 different domains, each including 1–10 specific symptoms, as well as motor state (UPDRS), general cognition, and life quality. Hoehn & Yahr (H&Y) stage was used to categorize patient status (I–II mild; III moderate; IV–V severe). We found that individual non-motor symptoms had variable evolution over the 2-year follow-up with sleep, gastrointestinal, attention/memory and skin disturbances (hyperhidrosis and seborrhea) becoming more prevalent and psychiatric, cardiovascular, and respiratory disorders becoming less prevalent. Development of symptoms in the cardiovascular, apathy, urinary, psychiatric, and fatigue domains was associated with significant life-quality worsening (p < 0.0045, alpha with Bonferroni correction). During the observation period, 123 patients (17 %) worsened clinically while 584 were rated as stable. There was a fivefold greater increase in UPDRS motor score in worse compared with stable patients over 24 months (p < 0.0001 vs. baseline both in stable and worse group). The total number of reported non-motor symptoms increased over 24 months in patients with motor worsening compared to stable ones (p < 0.001). Thirty-nine patients died (3.4 % of patients evaluable at baseline) with mean age at death of 74 years. Deceased patients were older, had significantly higher H&Y stage and motor score, and reported a greater number of non-motor symptoms at baseline. In conclusion, overall non-motor symptom progression does not follow motor deterioration, is symptom-specific, and only development of specific domains negatively impacts quality of life. These results have consequences for drug studies targeting non-motor features. |
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The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life |
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Barone, Paolo Marconi, Roberto Morgante, Letterio Zappulla, Salvatore Pontieri, Francesco Ernesto Ramat, Silvia Ceravolo, Maria Gabriella Meco, Giuseppe Cicarelli, Giulio Pederzoli, Massimo Manfredi, Michela Ceravolo, Roberto Mucchiut, Marco Volpe, Giampiero Abbruzzese, Giovanni Bottacchi, Edo Bartolomei, Luigi Ciacci, Giuseppe Cannas, Antonino Randisi, Maria Giovanna Petrone, Alfredo Baratti, Mario Toni, Vincenzo Cossu, Giovanni Del Dotto, Paolo Bentivoglio, Anna Rita Abrignani, Michele Scala, Rossana Pennisi, Franco Quatrale, Rocco Gaglio, Rosa Maria Nicoletti, Alessandra Perini, Michele Avarello, Tania Pisani, Antonio Scaglioni, Augusto Martinelli, Paolo Emilio Iemolo, Francesco Ferigo, Laura Simone, Pasqualino Soliveri, Paola Troianiello, Biagio Consoli, Domenico Mauro, Alessandro Lopiano, Leonardo Nastasi, Giuseppe Colosimo, Carlo |
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Barone, Paolo Marconi, Roberto Morgante, Letterio Zappulla, Salvatore Pontieri, Francesco Ernesto Ramat, Silvia Ceravolo, Maria Gabriella Meco, Giuseppe Cicarelli, Giulio Pederzoli, Massimo Manfredi, Michela Ceravolo, Roberto Mucchiut, Marco Volpe, Giampiero Abbruzzese, Giovanni Bottacchi, Edo Bartolomei, Luigi Ciacci, Giuseppe Cannas, Antonino Randisi, Maria Giovanna Petrone, Alfredo Baratti, Mario Toni, Vincenzo Cossu, Giovanni Del Dotto, Paolo Bentivoglio, Anna Rita Abrignani, Michele Scala, Rossana Pennisi, Franco Quatrale, Rocco Gaglio, Rosa Maria Nicoletti, Alessandra Perini, Michele Avarello, Tania Pisani, Antonio Scaglioni, Augusto Martinelli, Paolo Emilio Iemolo, Francesco Ferigo, Laura Simone, Pasqualino Soliveri, Paola Troianiello, Biagio Consoli, Domenico Mauro, Alessandro Lopiano, Leonardo Nastasi, Giuseppe Colosimo, Carlo |
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10.1007/s00415-012-6557-8 |
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2024-07-03T15:41:25.922Z |
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| score |
7.403063 |