Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes
Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, cours...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sepúlveda, Maria [verfasserIn] Armangue, Thaís [verfasserIn] Martinez-Hernandez, Eugenia [verfasserIn] Arrambide, Georgina [verfasserIn] Sola-Valls, Nuria [verfasserIn] Sabater, Lidia [verfasserIn] Téllez, Nieves [verfasserIn] Midaglia, Luciana [verfasserIn] Ariño, Helena [verfasserIn] Peschl, Patrick [verfasserIn] Reindl, Markus [verfasserIn] Rovira, Alex [verfasserIn] Montalban, Xavier [verfasserIn] Blanco, Yolanda [verfasserIn] Dalmau, Josep [verfasserIn] Graus, Francesc [verfasserIn] Saiz, Albert [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
Longitudinally extensive myelitis |
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| Übergeordnetes Werk: |
Enthalten in: Journal of neurology - [Darmstadt] : Steinkopff, 1891, 263(2016), 7 vom: 04. Mai, Seite 1349-1360 |
|---|---|
| Übergeordnetes Werk: |
volume:263 ; year:2016 ; number:7 ; day:04 ; month:05 ; pages:1349-1360 |
| Links: |
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| DOI / URN: |
10.1007/s00415-016-8147-7 |
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| Katalog-ID: |
SPR005367379 |
|---|
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| 100 | 1 | |a Sepúlveda, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. | ||
| 650 | 4 | |a Neuromyelitis optica |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Longitudinally extensive myelitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Optic neuritis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antibodies to myelin oligodendrocyte glycoprotein |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunohistochemistry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cell-based assays |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MRI |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Armangue, Thaís |e verfasserin |4 aut | |
| 700 | 1 | |a Martinez-Hernandez, Eugenia |e verfasserin |4 aut | |
| 700 | 1 | |a Arrambide, Georgina |e verfasserin |4 aut | |
| 700 | 1 | |a Sola-Valls, Nuria |e verfasserin |4 aut | |
| 700 | 1 | |a Sabater, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Téllez, Nieves |e verfasserin |4 aut | |
| 700 | 1 | |a Midaglia, Luciana |e verfasserin |4 aut | |
| 700 | 1 | |a Ariño, Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Peschl, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Reindl, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Rovira, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a Montalban, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Blanco, Yolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Dalmau, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Graus, Francesc |e verfasserin |4 aut | |
| 700 | 1 | |a Saiz, Albert |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurology |d [Darmstadt] : Steinkopff, 1891 |g 263(2016), 7 vom: 04. Mai, Seite 1349-1360 |w (DE-627)242065155 |w (DE-600)1421299-7 |x 1432-1459 |7 nnns |
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| 912 | |a GBV_ILN_4249 | ||
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10.1007/s00415-016-8147-7 doi (DE-627)SPR005367379 (SPR)s00415-016-8147-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Sepúlveda, Maria verfasserin aut Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Armangue, Thaís verfasserin aut Martinez-Hernandez, Eugenia verfasserin aut Arrambide, Georgina verfasserin aut Sola-Valls, Nuria verfasserin aut Sabater, Lidia verfasserin aut Téllez, Nieves verfasserin aut Midaglia, Luciana verfasserin aut Ariño, Helena verfasserin aut Peschl, Patrick verfasserin aut Reindl, Markus verfasserin aut Rovira, Alex verfasserin aut Montalban, Xavier verfasserin aut Blanco, Yolanda verfasserin aut Dalmau, Josep verfasserin aut Graus, Francesc verfasserin aut Saiz, Albert verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 263(2016), 7 vom: 04. Mai, Seite 1349-1360 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 https://dx.doi.org/10.1007/s00415-016-8147-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 263 2016 7 04 05 1349-1360 |
| spelling |
10.1007/s00415-016-8147-7 doi (DE-627)SPR005367379 (SPR)s00415-016-8147-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Sepúlveda, Maria verfasserin aut Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Armangue, Thaís verfasserin aut Martinez-Hernandez, Eugenia verfasserin aut Arrambide, Georgina verfasserin aut Sola-Valls, Nuria verfasserin aut Sabater, Lidia verfasserin aut Téllez, Nieves verfasserin aut Midaglia, Luciana verfasserin aut Ariño, Helena verfasserin aut Peschl, Patrick verfasserin aut Reindl, Markus verfasserin aut Rovira, Alex verfasserin aut Montalban, Xavier verfasserin aut Blanco, Yolanda verfasserin aut Dalmau, Josep verfasserin aut Graus, Francesc verfasserin aut Saiz, Albert verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 263(2016), 7 vom: 04. Mai, Seite 1349-1360 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 https://dx.doi.org/10.1007/s00415-016-8147-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 263 2016 7 04 05 1349-1360 |
| allfields_unstemmed |
10.1007/s00415-016-8147-7 doi (DE-627)SPR005367379 (SPR)s00415-016-8147-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Sepúlveda, Maria verfasserin aut Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Armangue, Thaís verfasserin aut Martinez-Hernandez, Eugenia verfasserin aut Arrambide, Georgina verfasserin aut Sola-Valls, Nuria verfasserin aut Sabater, Lidia verfasserin aut Téllez, Nieves verfasserin aut Midaglia, Luciana verfasserin aut Ariño, Helena verfasserin aut Peschl, Patrick verfasserin aut Reindl, Markus verfasserin aut Rovira, Alex verfasserin aut Montalban, Xavier verfasserin aut Blanco, Yolanda verfasserin aut Dalmau, Josep verfasserin aut Graus, Francesc verfasserin aut Saiz, Albert verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 263(2016), 7 vom: 04. Mai, Seite 1349-1360 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 https://dx.doi.org/10.1007/s00415-016-8147-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 263 2016 7 04 05 1349-1360 |
| allfieldsGer |
10.1007/s00415-016-8147-7 doi (DE-627)SPR005367379 (SPR)s00415-016-8147-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Sepúlveda, Maria verfasserin aut Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Armangue, Thaís verfasserin aut Martinez-Hernandez, Eugenia verfasserin aut Arrambide, Georgina verfasserin aut Sola-Valls, Nuria verfasserin aut Sabater, Lidia verfasserin aut Téllez, Nieves verfasserin aut Midaglia, Luciana verfasserin aut Ariño, Helena verfasserin aut Peschl, Patrick verfasserin aut Reindl, Markus verfasserin aut Rovira, Alex verfasserin aut Montalban, Xavier verfasserin aut Blanco, Yolanda verfasserin aut Dalmau, Josep verfasserin aut Graus, Francesc verfasserin aut Saiz, Albert verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 263(2016), 7 vom: 04. Mai, Seite 1349-1360 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 https://dx.doi.org/10.1007/s00415-016-8147-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 263 2016 7 04 05 1349-1360 |
| allfieldsSound |
10.1007/s00415-016-8147-7 doi (DE-627)SPR005367379 (SPR)s00415-016-8147-7-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.90 bkl Sepúlveda, Maria verfasserin aut Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 Armangue, Thaís verfasserin aut Martinez-Hernandez, Eugenia verfasserin aut Arrambide, Georgina verfasserin aut Sola-Valls, Nuria verfasserin aut Sabater, Lidia verfasserin aut Téllez, Nieves verfasserin aut Midaglia, Luciana verfasserin aut Ariño, Helena verfasserin aut Peschl, Patrick verfasserin aut Reindl, Markus verfasserin aut Rovira, Alex verfasserin aut Montalban, Xavier verfasserin aut Blanco, Yolanda verfasserin aut Dalmau, Josep verfasserin aut Graus, Francesc verfasserin aut Saiz, Albert verfasserin aut Enthalten in Journal of neurology [Darmstadt] : Steinkopff, 1891 263(2016), 7 vom: 04. Mai, Seite 1349-1360 (DE-627)242065155 (DE-600)1421299-7 1432-1459 nnns volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 https://dx.doi.org/10.1007/s00415-016-8147-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.90 ASE AR 263 2016 7 04 05 1349-1360 |
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Enthalten in Journal of neurology 263(2016), 7 vom: 04. Mai, Seite 1349-1360 volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 |
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Enthalten in Journal of neurology 263(2016), 7 vom: 04. Mai, Seite 1349-1360 volume:263 year:2016 number:7 day:04 month:05 pages:1349-1360 |
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findex.gbv.de |
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Neuromyelitis optica Longitudinally extensive myelitis Optic neuritis Antibodies to myelin oligodendrocyte glycoprotein Immunohistochemistry Cell-based assays MRI |
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Sepúlveda, Maria @@aut@@ Armangue, Thaís @@aut@@ Martinez-Hernandez, Eugenia @@aut@@ Arrambide, Georgina @@aut@@ Sola-Valls, Nuria @@aut@@ Sabater, Lidia @@aut@@ Téllez, Nieves @@aut@@ Midaglia, Luciana @@aut@@ Ariño, Helena @@aut@@ Peschl, Patrick @@aut@@ Reindl, Markus @@aut@@ Rovira, Alex @@aut@@ Montalban, Xavier @@aut@@ Blanco, Yolanda @@aut@@ Dalmau, Josep @@aut@@ Graus, Francesc @@aut@@ Saiz, Albert @@aut@@ |
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2016-05-04T00:00:00Z |
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242065155 |
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3610 |
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SPR005367379 |
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englisch |
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|
| author |
Sepúlveda, Maria |
| spellingShingle |
Sepúlveda, Maria ddc 610 bkl 44.90 misc Neuromyelitis optica misc Longitudinally extensive myelitis misc Optic neuritis misc Antibodies to myelin oligodendrocyte glycoprotein misc Immunohistochemistry misc Cell-based assays misc MRI Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
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Sepúlveda, Maria |
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Not Illustrated |
| issn |
1432-1459 |
| topic_title |
610 ASE 44.90 bkl Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes Neuromyelitis optica (dpeaa)DE-He213 Longitudinally extensive myelitis (dpeaa)DE-He213 Optic neuritis (dpeaa)DE-He213 Antibodies to myelin oligodendrocyte glycoprotein (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Cell-based assays (dpeaa)DE-He213 MRI (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.90 misc Neuromyelitis optica misc Longitudinally extensive myelitis misc Optic neuritis misc Antibodies to myelin oligodendrocyte glycoprotein misc Immunohistochemistry misc Cell-based assays misc MRI |
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ddc 610 bkl 44.90 misc Neuromyelitis optica misc Longitudinally extensive myelitis misc Optic neuritis misc Antibodies to myelin oligodendrocyte glycoprotein misc Immunohistochemistry misc Cell-based assays misc MRI |
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ddc 610 bkl 44.90 misc Neuromyelitis optica misc Longitudinally extensive myelitis misc Optic neuritis misc Antibodies to myelin oligodendrocyte glycoprotein misc Immunohistochemistry misc Cell-based assays misc MRI |
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Journal of neurology |
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Journal of neurology |
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Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
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| title_full |
Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
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Sepúlveda, Maria |
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Journal of neurology |
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Journal of neurology |
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2016 |
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Sepúlveda, Maria Armangue, Thaís Martinez-Hernandez, Eugenia Arrambide, Georgina Sola-Valls, Nuria Sabater, Lidia Téllez, Nieves Midaglia, Luciana Ariño, Helena Peschl, Patrick Reindl, Markus Rovira, Alex Montalban, Xavier Blanco, Yolanda Dalmau, Josep Graus, Francesc Saiz, Albert |
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610 ASE 44.90 bkl |
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Elektronische Aufsätze |
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Sepúlveda, Maria |
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10.1007/s00415-016-8147-7 |
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610 |
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verfasserin |
| title_sort |
clinical spectrum associated with mog autoimmunity in adults: significance of sharing rodent mog epitopes |
| title_auth |
Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
| abstract |
Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. |
| abstractGer |
Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. |
| abstract_unstemmed |
Abstract The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18–70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4–554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. |
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Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes |
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https://dx.doi.org/10.1007/s00415-016-8147-7 |
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Armangue, Thaís Martinez-Hernandez, Eugenia Arrambide, Georgina Sola-Valls, Nuria Sabater, Lidia Téllez, Nieves Midaglia, Luciana Ariño, Helena Peschl, Patrick Reindl, Markus Rovira, Alex Montalban, Xavier Blanco, Yolanda Dalmau, Josep Graus, Francesc Saiz, Albert |
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Armangue, Thaís Martinez-Hernandez, Eugenia Arrambide, Georgina Sola-Valls, Nuria Sabater, Lidia Téllez, Nieves Midaglia, Luciana Ariño, Helena Peschl, Patrick Reindl, Markus Rovira, Alex Montalban, Xavier Blanco, Yolanda Dalmau, Josep Graus, Francesc Saiz, Albert |
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10.1007/s00415-016-8147-7 |
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2024-07-03T15:50:21.336Z |
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| score |
7.402767 |