Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells
Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1}...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Milenkovic, Ivan [verfasserIn] Weick, Michael [verfasserIn] Wiedemann, Peter [verfasserIn] Reichenbach, Andreas [verfasserIn] Bringmann, Andreas [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Graefe's archive for clinical and experimental ophthalmology - Berlin : Springer, 1854, 242(2004), 11 vom: 04. Aug., Seite 944-950 |
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| Übergeordnetes Werk: |
volume:242 ; year:2004 ; number:11 ; day:04 ; month:08 ; pages:944-950 |
| Links: |
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| DOI / URN: |
10.1007/s00417-004-0954-3 |
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| Katalog-ID: |
SPR005393817 |
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| 245 | 1 | 0 | |a Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells |
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| 520 | |a Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. | ||
| 650 | 4 | |a Retinal Detachment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mitogenic Effect |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Proliferative Vitreoretinopathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Retinal Glial Cell |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Glial Cell Proliferation |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Weick, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Wiedemann, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Reichenbach, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Bringmann, Andreas |e verfasserin |4 aut | |
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10.1007/s00417-004-0954-3 doi (DE-627)SPR005393817 (SPR)s00417-004-0954-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Milenkovic, Ivan verfasserin aut Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 Weick, Michael verfasserin aut Wiedemann, Peter verfasserin aut Reichenbach, Andreas verfasserin aut Bringmann, Andreas verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 242(2004), 11 vom: 04. Aug., Seite 944-950 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:242 year:2004 number:11 day:04 month:08 pages:944-950 https://dx.doi.org/10.1007/s00417-004-0954-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 242 2004 11 04 08 944-950 |
| spelling |
10.1007/s00417-004-0954-3 doi (DE-627)SPR005393817 (SPR)s00417-004-0954-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Milenkovic, Ivan verfasserin aut Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 Weick, Michael verfasserin aut Wiedemann, Peter verfasserin aut Reichenbach, Andreas verfasserin aut Bringmann, Andreas verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 242(2004), 11 vom: 04. Aug., Seite 944-950 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:242 year:2004 number:11 day:04 month:08 pages:944-950 https://dx.doi.org/10.1007/s00417-004-0954-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 242 2004 11 04 08 944-950 |
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10.1007/s00417-004-0954-3 doi (DE-627)SPR005393817 (SPR)s00417-004-0954-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Milenkovic, Ivan verfasserin aut Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 Weick, Michael verfasserin aut Wiedemann, Peter verfasserin aut Reichenbach, Andreas verfasserin aut Bringmann, Andreas verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 242(2004), 11 vom: 04. Aug., Seite 944-950 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:242 year:2004 number:11 day:04 month:08 pages:944-950 https://dx.doi.org/10.1007/s00417-004-0954-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 242 2004 11 04 08 944-950 |
| allfieldsGer |
10.1007/s00417-004-0954-3 doi (DE-627)SPR005393817 (SPR)s00417-004-0954-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Milenkovic, Ivan verfasserin aut Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 Weick, Michael verfasserin aut Wiedemann, Peter verfasserin aut Reichenbach, Andreas verfasserin aut Bringmann, Andreas verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 242(2004), 11 vom: 04. Aug., Seite 944-950 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:242 year:2004 number:11 day:04 month:08 pages:944-950 https://dx.doi.org/10.1007/s00417-004-0954-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 242 2004 11 04 08 944-950 |
| allfieldsSound |
10.1007/s00417-004-0954-3 doi (DE-627)SPR005393817 (SPR)s00417-004-0954-3-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Milenkovic, Ivan verfasserin aut Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 Weick, Michael verfasserin aut Wiedemann, Peter verfasserin aut Reichenbach, Andreas verfasserin aut Bringmann, Andreas verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 242(2004), 11 vom: 04. Aug., Seite 944-950 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:242 year:2004 number:11 day:04 month:08 pages:944-950 https://dx.doi.org/10.1007/s00417-004-0954-3 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 242 2004 11 04 08 944-950 |
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English |
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Enthalten in Graefe's archive for clinical and experimental ophthalmology 242(2004), 11 vom: 04. Aug., Seite 944-950 volume:242 year:2004 number:11 day:04 month:08 pages:944-950 |
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Enthalten in Graefe's archive for clinical and experimental ophthalmology 242(2004), 11 vom: 04. Aug., Seite 944-950 volume:242 year:2004 number:11 day:04 month:08 pages:944-950 |
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findex.gbv.de |
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Retinal Detachment Mitogenic Effect Proliferative Vitreoretinopathy Retinal Glial Cell Glial Cell Proliferation |
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Milenkovic, Ivan @@aut@@ Weick, Michael @@aut@@ Wiedemann, Peter @@aut@@ Reichenbach, Andreas @@aut@@ Bringmann, Andreas @@aut@@ |
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2004-08-04T00:00:00Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR005393817</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230520005237.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201001s2004 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00417-004-0954-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR005393817</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00417-004-0954-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.95</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Milenkovic, Ivan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2004</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Retinal Detachment</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogenic Effect</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Proliferative Vitreoretinopathy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Retinal Glial Cell</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glial Cell Proliferation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Weick, Michael</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wiedemann, Peter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reichenbach, Andreas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bringmann, Andreas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Graefe's archive for clinical and experimental ophthalmology</subfield><subfield code="d">Berlin : Springer, 1854</subfield><subfield code="g">242(2004), 11 vom: 04. 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Milenkovic, Ivan |
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Milenkovic, Ivan ddc 610 bkl 44.95 misc Retinal Detachment misc Mitogenic Effect misc Proliferative Vitreoretinopathy misc Retinal Glial Cell misc Glial Cell Proliferation Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells |
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610 ASE 44.95 bkl Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells Retinal Detachment (dpeaa)DE-He213 Mitogenic Effect (dpeaa)DE-He213 Proliferative Vitreoretinopathy (dpeaa)DE-He213 Retinal Glial Cell (dpeaa)DE-He213 Glial Cell Proliferation (dpeaa)DE-He213 |
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Milenkovic, Ivan Weick, Michael Wiedemann, Peter Reichenbach, Andreas Bringmann, Andreas |
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neuropeptide y-evoked proliferation of retinal glial (müller) cells |
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Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells |
| abstract |
Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. |
| abstractGer |
Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. |
| abstract_unstemmed |
Background Glial cells in human retinas and in fibrocellular membranes from patients with proliferative vitreoretinopathy (PVR) have been described to upregulate their expression of $ Y_{1} $ receptors for neuropeptide Y (NPY) (Soler et al.: Glia 39:320, 2002). However, it is unknown whether $ Y_{1} $ receptor activation causes proliferation of retinal glial cells. We investigated whether NPY exerts a proliferation-stimulating effect on retinal glial cells, and compared the NPY-evoked signaling with the signaling of purinergic P2Y receptors. Methods Proliferation assays using bromodeoxyuridine were carried out on primarily cultured Müller glial cells of the guinea pig, in the absence and presence of blockers of $ Y_{1} $ receptors, of receptor tyrosine kinases (RTKs), of mitogen-activated protein kinases (MAPKs) and of phosphatidylinositol-3 kinase (PI3K). Results NPY exerted a biphasic effect on Müller cell proliferation. At low concentrations (0.1 ng/ml and 1 ng/ml) it decreased the proliferation rate of the cells, while at higher concentration (100 ng/ml) it increased Müller cell proliferation. The NPY-evoked proliferation was mediated by $ Y_{1} $ receptor stimulation and by activation of the p44/p42 MAPKs and partially of the p38 MAPK. Moreover, $ Y_{1} $ receptor-induced activation of PI3K as well as transactivations of the platelet-derived and the epidermal growth factor RTKs were necessary for full mitogenic effect of NPY. $ Y_{1} $ and P2Y receptors share partially common signal transduction pathways in Müller cells. Conclusion It is suggested that NPY may be involved in stimulation of retinal glial cell proliferation during PVR when it is released at higher amounts into the injured retina. |
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Neuropeptide Y-evoked proliferation of retinal glial (Müller) cells |
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| score |
7.3995314 |