Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography

Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two indep...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Krebs, Ilse [verfasserIn] Ansari-Shahrezaei, Siamak [verfasserIn] Goll, Alexandra [verfasserIn] Binder, Susanne [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Schlagwörter:	Age-related macular degeneration Bevacizumab Choroidal neovascularisation Optical coherence tomography

Übergeordnetes Werk:	Enthalten in: Graefe's archive for clinical and experimental ophthalmology - Berlin : Springer, 1854, 246(2008), 6 vom: 15. Jan., Seite 811-815
Übergeordnetes Werk:	volume:246 ; year:2008 ; number:6 ; day:15 ; month:01 ; pages:811-815

Links:	Volltext

DOI / URN:	10.1007/s00417-007-0755-6

Katalog-ID:	SPR005405742

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520			\|a Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated.
650		4	\|a Age-related macular degeneration \|7 (dpeaa)DE-He213
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650		4	\|a Choroidal neovascularisation \|7 (dpeaa)DE-He213
650		4	\|a Optical coherence tomography \|7 (dpeaa)DE-He213
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700	1		\|a Goll, Alexandra \|e verfasserin \|4 aut
700	1		\|a Binder, Susanne \|e verfasserin \|4 aut
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matchkey_str	article:1435702X:2008----::ciiyfevsualsosraewtbvczmboprsneweotcloeectm
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publishDate	2008
allfields	10.1007/s00417-007-0755-6 doi (DE-627)SPR005405742 (SPR)s00417-007-0755-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Krebs, Ilse verfasserin aut Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated. Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Ansari-Shahrezaei, Siamak verfasserin aut Goll, Alexandra verfasserin aut Binder, Susanne verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 246(2008), 6 vom: 15. Jan., Seite 811-815 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:246 year:2008 number:6 day:15 month:01 pages:811-815 https://dx.doi.org/10.1007/s00417-007-0755-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 246 2008 6 15 01 811-815
spelling	10.1007/s00417-007-0755-6 doi (DE-627)SPR005405742 (SPR)s00417-007-0755-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Krebs, Ilse verfasserin aut Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated. Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Ansari-Shahrezaei, Siamak verfasserin aut Goll, Alexandra verfasserin aut Binder, Susanne verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 246(2008), 6 vom: 15. Jan., Seite 811-815 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:246 year:2008 number:6 day:15 month:01 pages:811-815 https://dx.doi.org/10.1007/s00417-007-0755-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 246 2008 6 15 01 811-815
allfields_unstemmed	10.1007/s00417-007-0755-6 doi (DE-627)SPR005405742 (SPR)s00417-007-0755-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Krebs, Ilse verfasserin aut Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated. Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Ansari-Shahrezaei, Siamak verfasserin aut Goll, Alexandra verfasserin aut Binder, Susanne verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 246(2008), 6 vom: 15. Jan., Seite 811-815 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:246 year:2008 number:6 day:15 month:01 pages:811-815 https://dx.doi.org/10.1007/s00417-007-0755-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 246 2008 6 15 01 811-815
allfieldsGer	10.1007/s00417-007-0755-6 doi (DE-627)SPR005405742 (SPR)s00417-007-0755-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Krebs, Ilse verfasserin aut Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated. Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Ansari-Shahrezaei, Siamak verfasserin aut Goll, Alexandra verfasserin aut Binder, Susanne verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 246(2008), 6 vom: 15. Jan., Seite 811-815 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:246 year:2008 number:6 day:15 month:01 pages:811-815 https://dx.doi.org/10.1007/s00417-007-0755-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 246 2008 6 15 01 811-815
allfieldsSound	10.1007/s00417-007-0755-6 doi (DE-627)SPR005405742 (SPR)s00417-007-0755-6-e DE-627 ger DE-627 rakwb eng 610 ASE 44.95 bkl Krebs, Ilse verfasserin aut Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated. Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Ansari-Shahrezaei, Siamak verfasserin aut Goll, Alexandra verfasserin aut Binder, Susanne verfasserin aut Enthalten in Graefe's archive for clinical and experimental ophthalmology Berlin : Springer, 1854 246(2008), 6 vom: 15. Jan., Seite 811-815 (DE-627)253723728 (DE-600)1459159-5 1435-702X nnns volume:246 year:2008 number:6 day:15 month:01 pages:811-815 https://dx.doi.org/10.1007/s00417-007-0755-6 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.95 ASE AR 246 2008 6 15 01 811-815
language	English
source	Enthalten in Graefe's archive for clinical and experimental ophthalmology 246(2008), 6 vom: 15. Jan., Seite 811-815 volume:246 year:2008 number:6 day:15 month:01 pages:811-815
sourceStr	Enthalten in Graefe's archive for clinical and experimental ophthalmology 246(2008), 6 vom: 15. Jan., Seite 811-815 volume:246 year:2008 number:6 day:15 month:01 pages:811-815
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Age-related macular degeneration Bevacizumab Choroidal neovascularisation Optical coherence tomography
dewey-raw	610
isfreeaccess_bool	false
container_title	Graefe's archive for clinical and experimental ophthalmology
authorswithroles_txt_mv	Krebs, Ilse @@aut@@ Ansari-Shahrezaei, Siamak @@aut@@ Goll, Alexandra @@aut@@ Binder, Susanne @@aut@@
publishDateDaySort_date	2008-01-15T00:00:00Z
hierarchy_top_id	253723728
dewey-sort	3610
id	SPR005405742
language_de	englisch
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Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. 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author	Krebs, Ilse
spellingShingle	Krebs, Ilse ddc 610 bkl 44.95 misc Age-related macular degeneration misc Bevacizumab misc Choroidal neovascularisation misc Optical coherence tomography Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
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topic_title	610 ASE 44.95 bkl Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography Age-related macular degeneration (dpeaa)DE-He213 Bevacizumab (dpeaa)DE-He213 Choroidal neovascularisation (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213
topic	ddc 610 bkl 44.95 misc Age-related macular degeneration misc Bevacizumab misc Choroidal neovascularisation misc Optical coherence tomography
topic_unstemmed	ddc 610 bkl 44.95 misc Age-related macular degeneration misc Bevacizumab misc Choroidal neovascularisation misc Optical coherence tomography
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title	Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
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title_full	Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
author_sort	Krebs, Ilse
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author_browse	Krebs, Ilse Ansari-Shahrezaei, Siamak Goll, Alexandra Binder, Susanne
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title_sort	activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
title_auth	Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
abstract	Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated.
abstractGer	Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated.
abstract_unstemmed	Purpose To investigate whether examination with the non-invasive optical coherence tomography (OCT) alone is sufficient to ascertain the need of re-treatment with bevacizumab for exudative age-related macular degeneration (AMD) or the invasive fluorescein angiography (FA) is needed. Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. Conclusion There is evidence of agreement between both examinations, the OCT was even more sensitive to detect activity of a lesion. In conducting studies based on OCT as single examination, it should be clearly defined how long fibrotic lesions or lesions with pigment epithelial detachment should be re-treated.
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title_short	Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography
url	https://dx.doi.org/10.1007/s00417-007-0755-6
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author2	Ansari-Shahrezaei, Siamak Goll, Alexandra Binder, Susanne
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doi_str	10.1007/s00417-007-0755-6
up_date	2024-07-03T16:06:09.106Z
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Method Two independent examiners reviewed FA and OCT images and performed a semi-quantitative assessment from 0=no activity to activity 1–3, mild, moderate and advanced, respectively. Weighted Kappa indices were performed to calculate the concordance between OCT and FA. Results A total of 153 OCT and FA examinations of 69 patients were evaluated, mean 2.2 examinations per patient. The mean age was 77.1±7.9 (55–89) years; 29.0% were male, 71.0% female. The weighted Kappa index showed concordance for activity in OCT and FA weak concerning the first investigation 4–6 weeks after initial treatment (0.3847) and obvious concerning the second investigation 8–10 weeks after initial treatment (0.4170). Higher values of activity were found with the OCT compared to FA. The most frequent reasons for discrepancies were detachment of the pigmentepithelium and fibrosis. 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Activity of neovascular lesions treated with bevacizumab: comparison between optical coherence tomography and fluorescein angiography

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