Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle

Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from hig...
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Autor*in:	Arsac, Laurent M. [verfasserIn] Thiaudière, Eric [verfasserIn] Diolez, Philippe [verfasserIn] Gerville-Réache, Léo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	Phosphocreatine Model Muscle acidosis P-magnetic resonance spectroscopy Monte Carlo simulation

Übergeordnetes Werk:	Enthalten in: European journal of applied physiology - Berlin : Springer, 1928, 91(2003), 4 vom: 19. Nov., Seite 419-424
Übergeordnetes Werk:	volume:91 ; year:2003 ; number:4 ; day:19 ; month:11 ; pages:419-424

Links:	Volltext

DOI / URN:	10.1007/s00421-003-1001-5

Katalog-ID:	SPR005505410

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245	1	0	\|a Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
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520			\|a Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed.
650		4	\|a Phosphocreatine \|7 (dpeaa)DE-He213
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700	1		\|a Thiaudière, Eric \|e verfasserin \|4 aut
700	1		\|a Diolez, Philippe \|e verfasserin \|4 aut
700	1		\|a Gerville-Réache, Léo \|e verfasserin \|4 aut
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allfields	10.1007/s00421-003-1001-5 doi (DE-627)SPR005505410 (SPR)s00421-003-1001-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Arsac, Laurent M. verfasserin aut Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed. Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Thiaudière, Eric verfasserin aut Diolez, Philippe verfasserin aut Gerville-Réache, Léo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 91(2003), 4 vom: 19. Nov., Seite 419-424 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:91 year:2003 number:4 day:19 month:11 pages:419-424 https://dx.doi.org/10.1007/s00421-003-1001-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 91 2003 4 19 11 419-424
spelling	10.1007/s00421-003-1001-5 doi (DE-627)SPR005505410 (SPR)s00421-003-1001-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Arsac, Laurent M. verfasserin aut Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed. Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Thiaudière, Eric verfasserin aut Diolez, Philippe verfasserin aut Gerville-Réache, Léo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 91(2003), 4 vom: 19. Nov., Seite 419-424 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:91 year:2003 number:4 day:19 month:11 pages:419-424 https://dx.doi.org/10.1007/s00421-003-1001-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 91 2003 4 19 11 419-424
allfields_unstemmed	10.1007/s00421-003-1001-5 doi (DE-627)SPR005505410 (SPR)s00421-003-1001-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Arsac, Laurent M. verfasserin aut Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed. Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Thiaudière, Eric verfasserin aut Diolez, Philippe verfasserin aut Gerville-Réache, Léo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 91(2003), 4 vom: 19. Nov., Seite 419-424 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:91 year:2003 number:4 day:19 month:11 pages:419-424 https://dx.doi.org/10.1007/s00421-003-1001-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 91 2003 4 19 11 419-424
allfieldsGer	10.1007/s00421-003-1001-5 doi (DE-627)SPR005505410 (SPR)s00421-003-1001-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Arsac, Laurent M. verfasserin aut Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed. Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Thiaudière, Eric verfasserin aut Diolez, Philippe verfasserin aut Gerville-Réache, Léo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 91(2003), 4 vom: 19. Nov., Seite 419-424 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:91 year:2003 number:4 day:19 month:11 pages:419-424 https://dx.doi.org/10.1007/s00421-003-1001-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 91 2003 4 19 11 419-424
allfieldsSound	10.1007/s00421-003-1001-5 doi (DE-627)SPR005505410 (SPR)s00421-003-1001-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Arsac, Laurent M. verfasserin aut Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed. Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213 Thiaudière, Eric verfasserin aut Diolez, Philippe verfasserin aut Gerville-Réache, Léo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 91(2003), 4 vom: 19. Nov., Seite 419-424 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:91 year:2003 number:4 day:19 month:11 pages:419-424 https://dx.doi.org/10.1007/s00421-003-1001-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 91 2003 4 19 11 419-424
language	English
source	Enthalten in European journal of applied physiology 91(2003), 4 vom: 19. Nov., Seite 419-424 volume:91 year:2003 number:4 day:19 month:11 pages:419-424
sourceStr	Enthalten in European journal of applied physiology 91(2003), 4 vom: 19. Nov., Seite 419-424 volume:91 year:2003 number:4 day:19 month:11 pages:419-424
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Phosphocreatine Model Muscle acidosis P-magnetic resonance spectroscopy Monte Carlo simulation
dewey-raw	610
isfreeaccess_bool	false
container_title	European journal of applied physiology
authorswithroles_txt_mv	Arsac, Laurent M. @@aut@@ Thiaudière, Eric @@aut@@ Diolez, Philippe @@aut@@ Gerville-Réache, Léo @@aut@@
publishDateDaySort_date	2003-11-19T00:00:00Z
hierarchy_top_id	253722780
dewey-sort	3610
id	SPR005505410
language_de	englisch
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author	Arsac, Laurent M.
spellingShingle	Arsac, Laurent M. ddc 610 bkl 44.37 misc Phosphocreatine misc Model misc Muscle acidosis misc P-magnetic resonance spectroscopy misc Monte Carlo simulation Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
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topic_title	610 ASE 44.37 bkl Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle Phosphocreatine (dpeaa)DE-He213 Model (dpeaa)DE-He213 Muscle acidosis (dpeaa)DE-He213 P-magnetic resonance spectroscopy (dpeaa)DE-He213 Monte Carlo simulation (dpeaa)DE-He213
topic	ddc 610 bkl 44.37 misc Phosphocreatine misc Model misc Muscle acidosis misc P-magnetic resonance spectroscopy misc Monte Carlo simulation
topic_unstemmed	ddc 610 bkl 44.37 misc Phosphocreatine misc Model misc Muscle acidosis misc P-magnetic resonance spectroscopy misc Monte Carlo simulation
topic_browse	ddc 610 bkl 44.37 misc Phosphocreatine misc Model misc Muscle acidosis misc P-magnetic resonance spectroscopy misc Monte Carlo simulation
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title	Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
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title_full	Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
author_sort	Arsac, Laurent M.
journal	European journal of applied physiology
journalStr	European journal of applied physiology
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author_browse	Arsac, Laurent M. Thiaudière, Eric Diolez, Philippe Gerville-Réache, Léo
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title_sort	parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
title_auth	Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
abstract	Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed.
abstractGer	Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed.
abstract_unstemmed	Abstract Commonly, muscle phosphocreatine (PCr) recovery from exercise has been fitted to a monoexponential function. However, a number of experiments indicate that at low muscle pH, a monoexponential fit is not suitable. We have performed in vivo 31P-MRS measurements of PCr during recovery from high-intensity intermittent exercise where muscle pH dropped below 6.5 (35 out of 40 cases). Results of a statistical analysis showed that monoexponentiality should be rejected in 32 out of 40 cases. Therefore, a Monte Carlo simulation was carried out to test the quality of competing models used in the literature at low pH: monoexponential, biexponential and changing rate utilization resource (CRUR). For each model, random Gaussian-distributed errors were imposed on simulated PCr recovery before performing the fits. A monoexponential function (three estimated parameters) provided a correct estimation of parameters (unbiased, normally distributed, poorly correlated estimates) and, therefore, should be preferred. When alternative functions are required, as in 32 cases out of 40 in the present study, it is demonstrated that a biexponential function (five estimated parameters) is not well suited (estimates were correlated), whereas a CRUR function (four estimated parameters) provides correct estimation of the parameters. It is concluded that a biexponential fit to PCr recovery is too sensitive to experimental errors to be practicable. Statistical and physiological relevance of CRUR are discussed.
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title_short	Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle
url	https://dx.doi.org/10.1007/s00421-003-1001-5
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author2	Thiaudière, Eric Diolez, Philippe Gerville-Réache, Léo
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up_date	2024-07-03T16:48:00.816Z
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Parameter estimation in modeling phosphocreatine recovery in human skeletal muscle

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