Effects of endurance training on intracellular calcium concentration in T lymphocytes
Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for th...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Broadbent, Suzanne [verfasserIn] Gass, Gregory [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2006 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of applied physiology - Berlin : Springer, 1928, 98(2006), 3 vom: 12. Aug., Seite 242-249 |
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| Übergeordnetes Werk: |
volume:98 ; year:2006 ; number:3 ; day:12 ; month:08 ; pages:242-249 |
| Links: |
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| DOI / URN: |
10.1007/s00421-006-0268-8 |
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| Katalog-ID: |
SPR00551200X |
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| 520 | |a Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. | ||
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| 650 | 4 | |a Lymphocyte proliferation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Signal transduction |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a [Ca |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Gass, Gregory |e verfasserin |4 aut | |
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10.1007/s00421-006-0268-8 doi (DE-627)SPR00551200X (SPR)s00421-006-0268-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Broadbent, Suzanne verfasserin aut Effects of endurance training on intracellular calcium concentration in T lymphocytes 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 [Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 Gass, Gregory verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 98(2006), 3 vom: 12. Aug., Seite 242-249 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:98 year:2006 number:3 day:12 month:08 pages:242-249 https://dx.doi.org/10.1007/s00421-006-0268-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 98 2006 3 12 08 242-249 |
| spelling |
10.1007/s00421-006-0268-8 doi (DE-627)SPR00551200X (SPR)s00421-006-0268-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Broadbent, Suzanne verfasserin aut Effects of endurance training on intracellular calcium concentration in T lymphocytes 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 [Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 Gass, Gregory verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 98(2006), 3 vom: 12. Aug., Seite 242-249 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:98 year:2006 number:3 day:12 month:08 pages:242-249 https://dx.doi.org/10.1007/s00421-006-0268-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 98 2006 3 12 08 242-249 |
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10.1007/s00421-006-0268-8 doi (DE-627)SPR00551200X (SPR)s00421-006-0268-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Broadbent, Suzanne verfasserin aut Effects of endurance training on intracellular calcium concentration in T lymphocytes 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 [Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 Gass, Gregory verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 98(2006), 3 vom: 12. Aug., Seite 242-249 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:98 year:2006 number:3 day:12 month:08 pages:242-249 https://dx.doi.org/10.1007/s00421-006-0268-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 98 2006 3 12 08 242-249 |
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10.1007/s00421-006-0268-8 doi (DE-627)SPR00551200X (SPR)s00421-006-0268-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Broadbent, Suzanne verfasserin aut Effects of endurance training on intracellular calcium concentration in T lymphocytes 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 [Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 Gass, Gregory verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 98(2006), 3 vom: 12. Aug., Seite 242-249 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:98 year:2006 number:3 day:12 month:08 pages:242-249 https://dx.doi.org/10.1007/s00421-006-0268-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 98 2006 3 12 08 242-249 |
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10.1007/s00421-006-0268-8 doi (DE-627)SPR00551200X (SPR)s00421-006-0268-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Broadbent, Suzanne verfasserin aut Effects of endurance training on intracellular calcium concentration in T lymphocytes 2006 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 [Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 Gass, Gregory verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 98(2006), 3 vom: 12. Aug., Seite 242-249 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:98 year:2006 number:3 day:12 month:08 pages:242-249 https://dx.doi.org/10.1007/s00421-006-0268-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 98 2006 3 12 08 242-249 |
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Enthalten in European journal of applied physiology 98(2006), 3 vom: 12. Aug., Seite 242-249 volume:98 year:2006 number:3 day:12 month:08 pages:242-249 |
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Enthalten in European journal of applied physiology 98(2006), 3 vom: 12. Aug., Seite 242-249 volume:98 year:2006 number:3 day:12 month:08 pages:242-249 |
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Immunology Lymphocyte proliferation Signal transduction [Ca ]i |
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European journal of applied physiology |
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Broadbent, Suzanne @@aut@@ Gass, Gregory @@aut@@ |
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Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). 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[$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunology</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lymphocyte proliferation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Signal transduction</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">[Ca</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">]i</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gass, Gregory</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">European journal of applied physiology</subfield><subfield code="d">Berlin : Springer, 1928</subfield><subfield code="g">98(2006), 3 vom: 12. 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Broadbent, Suzanne |
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Broadbent, Suzanne ddc 610 bkl 44.37 misc Immunology misc Lymphocyte proliferation misc Signal transduction misc [Ca misc ]i Effects of endurance training on intracellular calcium concentration in T lymphocytes |
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610 ASE 44.37 bkl Effects of endurance training on intracellular calcium concentration in T lymphocytes Immunology (dpeaa)DE-He213 Lymphocyte proliferation (dpeaa)DE-He213 Signal transduction (dpeaa)DE-He213 Ca (dpeaa)DE-He213 ]i (dpeaa)DE-He213 |
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ddc 610 bkl 44.37 misc Immunology misc Lymphocyte proliferation misc Signal transduction misc [Ca misc ]i |
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Effects of endurance training on intracellular calcium concentration in T lymphocytes |
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Effects of endurance training on intracellular calcium concentration in T lymphocytes |
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effects of endurance training on intracellular calcium concentration in t lymphocytes |
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Effects of endurance training on intracellular calcium concentration in T lymphocytes |
| abstract |
Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. |
| abstractGer |
Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. |
| abstract_unstemmed |
Abstract The purpose of the present study was to determine whether 12 months of endurance training reduced [$ Ca^{2+} $]i in T helper ($ CD4^{+} $) lymphocytes in trained (TR) men compared to untrained (UT). Fourteen trained (Ironman triathletes) and nine untrained (sedentary) men volunteered for the study. The TR group averaged 12 km of swimming, 300 km of cycling and 60 km of running per week during the year. Resting blood samples were taken from TR (V$ O_{2peak} $ 64 ± 2 ml $ kg^{−1} $ $ min^{−1} $) and UT (V$ O_{2peak} $ 42 ± 2 ml $ kg^{−1} $ $ min^{−1} $) subjects every 4 weeks for 52 weeks (October 1, 1999–October 1, 2000). Leukocyte concentration was measured using a full blood count. Unstimulated $ CD4^{+} $ lymphocytes were separated and analysed for changes in free ([$ Ca^{2+} $]i) and total ([$ Ca^{2+} $]t) calcium using flow cytometry. There were no significant differences in leukocyte concentration between UT and TR groups. There were significant differences between TR and UT in [$ Ca^{2+} $]i (October B and November), and [$ Ca^{2+} $]t (January and March). There were also significant sequential monthly changes in both [$ Ca^{2+} $]i and [$ Ca^{2+} $]t for TR and UT groups during the study. Significant increases in [$ Ca^{2+} $]i and [$ Ca^{2+} $]t during summer (January and March) for both TR and UT groups suggest an increase in intracellular signalling during hot weather. [$ Ca^{2+} $]i and [$ Ca^{2+} $]t were significantly lower in TR lymphocytes during November and March, suggesting that endurance training during warmer months may decrease [$ Ca^{2+} $]i through altered intracellular signalling, possibly to maintain lymphocyte function during heat stress. |
| collection_details |
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| container_issue |
3 |
| title_short |
Effects of endurance training on intracellular calcium concentration in T lymphocytes |
| url |
https://dx.doi.org/10.1007/s00421-006-0268-8 |
| remote_bool |
true |
| author2 |
Gass, Gregory |
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| doi_str |
10.1007/s00421-006-0268-8 |
| up_date |
2024-07-03T16:50:52.243Z |
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| score |
7.401787 |