Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy
Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ upta...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bravo, Daniela M. [verfasserIn] Gimenes, Ana Cristina [verfasserIn] Nascimento, Rúbia B. [verfasserIn] Ferreira, Eloara V. M. [verfasserIn] Siqueira, Ana Cristina B. [verfasserIn] Meda, Ethiane D. S. [verfasserIn] Neder, J. Alberto [verfasserIn] Nery, Luiz Eduardo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of applied physiology - Berlin : Springer, 1928, 112(2011), 5 vom: 04. Sept., Seite 1763-1771 |
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| Übergeordnetes Werk: |
volume:112 ; year:2011 ; number:5 ; day:04 ; month:09 ; pages:1763-1771 |
| Links: |
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| DOI / URN: |
10.1007/s00421-011-2136-4 |
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| Katalog-ID: |
SPR005538815 |
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| 100 | 1 | |a Bravo, Daniela M. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
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| 520 | |a Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. | ||
| 650 | 4 | |a Mitochondrial myopathy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Reoxygenation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxygen uptake |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Kinetics |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Exercise recovery |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gimenes, Ana Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Nascimento, Rúbia B. |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Eloara V. M. |e verfasserin |4 aut | |
| 700 | 1 | |a Siqueira, Ana Cristina B. |e verfasserin |4 aut | |
| 700 | 1 | |a Meda, Ethiane D. S. |e verfasserin |4 aut | |
| 700 | 1 | |a Neder, J. Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Nery, Luiz Eduardo |e verfasserin |4 aut | |
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10.1007/s00421-011-2136-4 doi (DE-627)SPR005538815 (SPR)s00421-011-2136-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Bravo, Daniela M. verfasserin aut Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 Gimenes, Ana Cristina verfasserin aut Nascimento, Rúbia B. verfasserin aut Ferreira, Eloara V. M. verfasserin aut Siqueira, Ana Cristina B. verfasserin aut Meda, Ethiane D. S. verfasserin aut Neder, J. Alberto verfasserin aut Nery, Luiz Eduardo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 112(2011), 5 vom: 04. Sept., Seite 1763-1771 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 https://dx.doi.org/10.1007/s00421-011-2136-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 112 2011 5 04 09 1763-1771 |
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10.1007/s00421-011-2136-4 doi (DE-627)SPR005538815 (SPR)s00421-011-2136-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Bravo, Daniela M. verfasserin aut Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 Gimenes, Ana Cristina verfasserin aut Nascimento, Rúbia B. verfasserin aut Ferreira, Eloara V. M. verfasserin aut Siqueira, Ana Cristina B. verfasserin aut Meda, Ethiane D. S. verfasserin aut Neder, J. Alberto verfasserin aut Nery, Luiz Eduardo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 112(2011), 5 vom: 04. Sept., Seite 1763-1771 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 https://dx.doi.org/10.1007/s00421-011-2136-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 112 2011 5 04 09 1763-1771 |
| allfields_unstemmed |
10.1007/s00421-011-2136-4 doi (DE-627)SPR005538815 (SPR)s00421-011-2136-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Bravo, Daniela M. verfasserin aut Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 Gimenes, Ana Cristina verfasserin aut Nascimento, Rúbia B. verfasserin aut Ferreira, Eloara V. M. verfasserin aut Siqueira, Ana Cristina B. verfasserin aut Meda, Ethiane D. S. verfasserin aut Neder, J. Alberto verfasserin aut Nery, Luiz Eduardo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 112(2011), 5 vom: 04. Sept., Seite 1763-1771 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 https://dx.doi.org/10.1007/s00421-011-2136-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 112 2011 5 04 09 1763-1771 |
| allfieldsGer |
10.1007/s00421-011-2136-4 doi (DE-627)SPR005538815 (SPR)s00421-011-2136-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Bravo, Daniela M. verfasserin aut Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 Gimenes, Ana Cristina verfasserin aut Nascimento, Rúbia B. verfasserin aut Ferreira, Eloara V. M. verfasserin aut Siqueira, Ana Cristina B. verfasserin aut Meda, Ethiane D. S. verfasserin aut Neder, J. Alberto verfasserin aut Nery, Luiz Eduardo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 112(2011), 5 vom: 04. Sept., Seite 1763-1771 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 https://dx.doi.org/10.1007/s00421-011-2136-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 112 2011 5 04 09 1763-1771 |
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10.1007/s00421-011-2136-4 doi (DE-627)SPR005538815 (SPR)s00421-011-2136-4-e DE-627 ger DE-627 rakwb eng 610 ASE 44.37 bkl Bravo, Daniela M. verfasserin aut Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 Gimenes, Ana Cristina verfasserin aut Nascimento, Rúbia B. verfasserin aut Ferreira, Eloara V. M. verfasserin aut Siqueira, Ana Cristina B. verfasserin aut Meda, Ethiane D. S. verfasserin aut Neder, J. Alberto verfasserin aut Nery, Luiz Eduardo verfasserin aut Enthalten in European journal of applied physiology Berlin : Springer, 1928 112(2011), 5 vom: 04. Sept., Seite 1763-1771 (DE-627)253722780 (DE-600)1459054-2 1439-6327 nnns volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 https://dx.doi.org/10.1007/s00421-011-2136-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.37 ASE AR 112 2011 5 04 09 1763-1771 |
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Enthalten in European journal of applied physiology 112(2011), 5 vom: 04. Sept., Seite 1763-1771 volume:112 year:2011 number:5 day:04 month:09 pages:1763-1771 |
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Mitochondrial myopathy Reoxygenation Oxygen uptake Kinetics Exercise recovery |
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European journal of applied physiology |
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Bravo, Daniela M. @@aut@@ Gimenes, Ana Cristina @@aut@@ Nascimento, Rúbia B. @@aut@@ Ferreira, Eloara V. M. @@aut@@ Siqueira, Ana Cristina B. @@aut@@ Meda, Ethiane D. S. @@aut@@ Neder, J. Alberto @@aut@@ Nery, Luiz Eduardo @@aut@@ |
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2011-09-04T00:00:00Z |
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253722780 |
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3610 |
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SPR005538815 |
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| author |
Bravo, Daniela M. |
| spellingShingle |
Bravo, Daniela M. ddc 610 bkl 44.37 misc Mitochondrial myopathy misc Reoxygenation misc Oxygen uptake misc Kinetics misc Exercise recovery Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
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Bravo, Daniela M. |
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1439-6327 |
| topic_title |
610 ASE 44.37 bkl Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy Mitochondrial myopathy (dpeaa)DE-He213 Reoxygenation (dpeaa)DE-He213 Oxygen uptake (dpeaa)DE-He213 Kinetics (dpeaa)DE-He213 Exercise recovery (dpeaa)DE-He213 |
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ddc 610 bkl 44.37 misc Mitochondrial myopathy misc Reoxygenation misc Oxygen uptake misc Kinetics misc Exercise recovery |
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ddc 610 bkl 44.37 misc Mitochondrial myopathy misc Reoxygenation misc Oxygen uptake misc Kinetics misc Exercise recovery |
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ddc 610 bkl 44.37 misc Mitochondrial myopathy misc Reoxygenation misc Oxygen uptake misc Kinetics misc Exercise recovery |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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European journal of applied physiology |
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European journal of applied physiology |
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Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
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(DE-627)SPR005538815 (SPR)s00421-011-2136-4-e |
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Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
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Bravo, Daniela M. |
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European journal of applied physiology |
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European journal of applied physiology |
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Bravo, Daniela M. Gimenes, Ana Cristina Nascimento, Rúbia B. Ferreira, Eloara V. M. Siqueira, Ana Cristina B. Meda, Ethiane D. S. Neder, J. Alberto Nery, Luiz Eduardo |
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610 ASE 44.37 bkl |
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Elektronische Aufsätze |
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Bravo, Daniela M. |
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10.1007/s00421-011-2136-4 |
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610 |
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verfasserin |
| title_sort |
skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
| title_auth |
Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
| abstract |
Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. |
| abstractGer |
Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. |
| abstract_unstemmed |
Abstract This study addressed whether $ O_{2} $ delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to $ O_{2} $ utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary $ O_{2} $ uptake %$ (\dot{V}{\text{O}}_{2} {\text{p}}), %$ (2) an index of fractional $ O_{2} $ extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (QT′) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). QT′, however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than %$ \dot{V}{\text{O}}_{2} {\text{p}} %$ in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$ in patients and controls, respectively. In fact, there were no between-group differences in %$ \tau \dot{V}{\text{O}}_{2} {\text{p}} %$/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular $ O_{2} $ delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular $ O_{2} $ delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. |
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5 |
| title_short |
Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy |
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https://dx.doi.org/10.1007/s00421-011-2136-4 |
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| author2 |
Gimenes, Ana Cristina Nascimento, Rúbia B. Ferreira, Eloara V. M. Siqueira, Ana Cristina B. Meda, Ethiane D. S. Neder, J. Alberto Nery, Luiz Eduardo |
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Gimenes, Ana Cristina Nascimento, Rúbia B. Ferreira, Eloara V. M. Siqueira, Ana Cristina B. Meda, Ethiane D. S. Neder, J. Alberto Nery, Luiz Eduardo |
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| doi_str |
10.1007/s00421-011-2136-4 |
| up_date |
2024-07-03T17:01:32.066Z |
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| score |
7.398429 |