Metachronous bilateral soft tissue sarcoma of the extremities

Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Daigeler, A. [verfasserIn] Lehnhardt, M. [verfasserIn] Sebastian, A. [verfasserIn] Belyaev, O. [verfasserIn] Steinstraesser, L. [verfasserIn] Steinau, H. U. [verfasserIn] Kuhnen, C. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Bilateral sarcoma Metachronous sarcoma Heterochronous sarcoma Symmetrical sarcoma Leiomyosarcoma

Übergeordnetes Werk:	Enthalten in: Langenbeck's archives of surgery - Berlin : Springer, 1948, 393(2007), 2 vom: 23. Jan., Seite 207-212
Übergeordnetes Werk:	volume:393 ; year:2007 ; number:2 ; day:23 ; month:01 ; pages:207-212

Links:	Volltext

DOI / URN:	10.1007/s00423-006-0145-2

Katalog-ID:	SPR005574854

Internformat


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245	1	0	\|a Metachronous bilateral soft tissue sarcoma of the extremities
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520			\|a Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome.
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650		4	\|a Metachronous sarcoma \|7 (dpeaa)DE-He213
650		4	\|a Heterochronous sarcoma \|7 (dpeaa)DE-He213
650		4	\|a Symmetrical sarcoma \|7 (dpeaa)DE-He213
650		4	\|a Leiomyosarcoma \|7 (dpeaa)DE-He213
700	1		\|a Lehnhardt, M. \|e verfasserin \|4 aut
700	1		\|a Sebastian, A. \|e verfasserin \|4 aut
700	1		\|a Belyaev, O. \|e verfasserin \|4 aut
700	1		\|a Steinstraesser, L. \|e verfasserin \|4 aut
700	1		\|a Steinau, H. U. \|e verfasserin \|4 aut
700	1		\|a Kuhnen, C. \|e verfasserin \|4 aut
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Indexfelder

author_variant	a d ad m l ml a s as o b ob l s ls h u s hu hus c k ck
matchkey_str	article:14352451:2007----::eahoosiaeasftsusroa
hierarchy_sort_str	2007
bklnumber	44.65
publishDate	2007
allfields	10.1007/s00423-006-0145-2 doi (DE-627)SPR005574854 (SPR)s00423-006-0145-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Daigeler, A. verfasserin aut Metachronous bilateral soft tissue sarcoma of the extremities 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome. Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 Lehnhardt, M. verfasserin aut Sebastian, A. verfasserin aut Belyaev, O. verfasserin aut Steinstraesser, L. verfasserin aut Steinau, H. U. verfasserin aut Kuhnen, C. verfasserin aut Enthalten in Langenbeck's archives of surgery Berlin : Springer, 1948 393(2007), 2 vom: 23. Jan., Seite 207-212 (DE-627)253770440 (DE-600)1459390-7 1435-2451 nnns volume:393 year:2007 number:2 day:23 month:01 pages:207-212 https://dx.doi.org/10.1007/s00423-006-0145-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 393 2007 2 23 01 207-212
spelling	10.1007/s00423-006-0145-2 doi (DE-627)SPR005574854 (SPR)s00423-006-0145-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Daigeler, A. verfasserin aut Metachronous bilateral soft tissue sarcoma of the extremities 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome. Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 Lehnhardt, M. verfasserin aut Sebastian, A. verfasserin aut Belyaev, O. verfasserin aut Steinstraesser, L. verfasserin aut Steinau, H. U. verfasserin aut Kuhnen, C. verfasserin aut Enthalten in Langenbeck's archives of surgery Berlin : Springer, 1948 393(2007), 2 vom: 23. Jan., Seite 207-212 (DE-627)253770440 (DE-600)1459390-7 1435-2451 nnns volume:393 year:2007 number:2 day:23 month:01 pages:207-212 https://dx.doi.org/10.1007/s00423-006-0145-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 393 2007 2 23 01 207-212
allfields_unstemmed	10.1007/s00423-006-0145-2 doi (DE-627)SPR005574854 (SPR)s00423-006-0145-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Daigeler, A. verfasserin aut Metachronous bilateral soft tissue sarcoma of the extremities 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome. Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 Lehnhardt, M. verfasserin aut Sebastian, A. verfasserin aut Belyaev, O. verfasserin aut Steinstraesser, L. verfasserin aut Steinau, H. U. verfasserin aut Kuhnen, C. verfasserin aut Enthalten in Langenbeck's archives of surgery Berlin : Springer, 1948 393(2007), 2 vom: 23. Jan., Seite 207-212 (DE-627)253770440 (DE-600)1459390-7 1435-2451 nnns volume:393 year:2007 number:2 day:23 month:01 pages:207-212 https://dx.doi.org/10.1007/s00423-006-0145-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 393 2007 2 23 01 207-212
allfieldsGer	10.1007/s00423-006-0145-2 doi (DE-627)SPR005574854 (SPR)s00423-006-0145-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Daigeler, A. verfasserin aut Metachronous bilateral soft tissue sarcoma of the extremities 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome. Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 Lehnhardt, M. verfasserin aut Sebastian, A. verfasserin aut Belyaev, O. verfasserin aut Steinstraesser, L. verfasserin aut Steinau, H. U. verfasserin aut Kuhnen, C. verfasserin aut Enthalten in Langenbeck's archives of surgery Berlin : Springer, 1948 393(2007), 2 vom: 23. Jan., Seite 207-212 (DE-627)253770440 (DE-600)1459390-7 1435-2451 nnns volume:393 year:2007 number:2 day:23 month:01 pages:207-212 https://dx.doi.org/10.1007/s00423-006-0145-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 393 2007 2 23 01 207-212
allfieldsSound	10.1007/s00423-006-0145-2 doi (DE-627)SPR005574854 (SPR)s00423-006-0145-2-e DE-627 ger DE-627 rakwb eng 610 ASE 44.65 bkl Daigeler, A. verfasserin aut Metachronous bilateral soft tissue sarcoma of the extremities 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome. Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213 Lehnhardt, M. verfasserin aut Sebastian, A. verfasserin aut Belyaev, O. verfasserin aut Steinstraesser, L. verfasserin aut Steinau, H. U. verfasserin aut Kuhnen, C. verfasserin aut Enthalten in Langenbeck's archives of surgery Berlin : Springer, 1948 393(2007), 2 vom: 23. Jan., Seite 207-212 (DE-627)253770440 (DE-600)1459390-7 1435-2451 nnns volume:393 year:2007 number:2 day:23 month:01 pages:207-212 https://dx.doi.org/10.1007/s00423-006-0145-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2339 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.65 ASE AR 393 2007 2 23 01 207-212
language	English
source	Enthalten in Langenbeck's archives of surgery 393(2007), 2 vom: 23. Jan., Seite 207-212 volume:393 year:2007 number:2 day:23 month:01 pages:207-212
sourceStr	Enthalten in Langenbeck's archives of surgery 393(2007), 2 vom: 23. Jan., Seite 207-212 volume:393 year:2007 number:2 day:23 month:01 pages:207-212
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bilateral sarcoma Metachronous sarcoma Heterochronous sarcoma Symmetrical sarcoma Leiomyosarcoma
dewey-raw	610
isfreeaccess_bool	false
container_title	Langenbeck's archives of surgery
authorswithroles_txt_mv	Daigeler, A. @@aut@@ Lehnhardt, M. @@aut@@ Sebastian, A. @@aut@@ Belyaev, O. @@aut@@ Steinstraesser, L. @@aut@@ Steinau, H. U. @@aut@@ Kuhnen, C. @@aut@@
publishDateDaySort_date	2007-01-23T00:00:00Z
hierarchy_top_id	253770440
dewey-sort	3610
id	SPR005574854
language_de	englisch
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Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. 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author	Daigeler, A.
spellingShingle	Daigeler, A. ddc 610 bkl 44.65 misc Bilateral sarcoma misc Metachronous sarcoma misc Heterochronous sarcoma misc Symmetrical sarcoma misc Leiomyosarcoma Metachronous bilateral soft tissue sarcoma of the extremities
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topic_title	610 ASE 44.65 bkl Metachronous bilateral soft tissue sarcoma of the extremities Bilateral sarcoma (dpeaa)DE-He213 Metachronous sarcoma (dpeaa)DE-He213 Heterochronous sarcoma (dpeaa)DE-He213 Symmetrical sarcoma (dpeaa)DE-He213 Leiomyosarcoma (dpeaa)DE-He213
topic	ddc 610 bkl 44.65 misc Bilateral sarcoma misc Metachronous sarcoma misc Heterochronous sarcoma misc Symmetrical sarcoma misc Leiomyosarcoma
topic_unstemmed	ddc 610 bkl 44.65 misc Bilateral sarcoma misc Metachronous sarcoma misc Heterochronous sarcoma misc Symmetrical sarcoma misc Leiomyosarcoma
topic_browse	ddc 610 bkl 44.65 misc Bilateral sarcoma misc Metachronous sarcoma misc Heterochronous sarcoma misc Symmetrical sarcoma misc Leiomyosarcoma
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title	Metachronous bilateral soft tissue sarcoma of the extremities
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title_full	Metachronous bilateral soft tissue sarcoma of the extremities
author_sort	Daigeler, A.
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author_browse	Daigeler, A. Lehnhardt, M. Sebastian, A. Belyaev, O. Steinstraesser, L. Steinau, H. U. Kuhnen, C.
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title_sort	metachronous bilateral soft tissue sarcoma of the extremities
title_auth	Metachronous bilateral soft tissue sarcoma of the extremities
abstract	Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome.
abstractGer	Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome.
abstract_unstemmed	Background and aims Synchronous and heterochronous multiple soft tissue sarcoma of the extremities is very rare. Out of 1,201 of our patients, 4 patients presented with symmetrical bilateral soft tissue sarcoma of the extremities. The aim of this study was to identify possible reasons for this unusual manifestation of sarcomas. Materials and methods The patients’ data was acquired by review of the patients’ charts and follow-up information was gathered by phone calls to the patients or their relatives and their general practitioners. Results All tumours were located at the extremities and were diagnosed as leiomyosarcoma in two patients, malignant fibrous histiocytoma and clear cell sarcoma in one patient each. No other individual or family history of cumulation of neoplasms was known in the patients. The median interval between the diagnoses was 3 1/2 years (range: 4 months to 9 1/2 years). In two patients a second primary sarcoma of the same entity was considered the most likely diagnosis, whereas in one patient a contralateral lymph node metastasis and in one other patient an atypical soft tissue metastasis had to be taken into account. A positive family history with a father with malignant fibrous histiocytoma may indicate a hereditary predisposition in one patient. Aside from irradiation effects, exposition to other carcinogenic agents or genetic predisposition, the reasons for the clustering of soft tissue sarcoma in one same patient remain still unclear. Only one patient, although suffering from disseminated metastatic disease was living at follow-up time, the other three patients had already died. Conclusion The interpretation of the bilateral manifestation of soft tissue sarcoma remains open, but predicts an unfavourable outcome.
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container_issue	2
title_short	Metachronous bilateral soft tissue sarcoma of the extremities
url	https://dx.doi.org/10.1007/s00423-006-0145-2
remote_bool	true
author2	Lehnhardt, M. Sebastian, A. Belyaev, O. Steinstraesser, L. Steinau, H. U. Kuhnen, C.
author2Str	Lehnhardt, M. Sebastian, A. Belyaev, O. Steinstraesser, L. Steinau, H. U. Kuhnen, C.
ppnlink	253770440
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s00423-006-0145-2
up_date	2024-07-03T17:14:46.510Z
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Metachronous bilateral soft tissue sarcoma of the extremities

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Vorhandene Bände

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