Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla

Abstract Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging dat...
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Autor*in:	Rhindress, Kathryn [verfasserIn] Ikuta, Toshikazu [verfasserIn] Wellington, Robin [verfasserIn] Malhotra, Anil K. [verfasserIn] Szeszko, Philip R. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Magnetic resonance imaging Hippocampus Subregion 3 Tesla Delineation criteria

Übergeordnetes Werk:	Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 220(2014), 6 vom: 01. Aug., Seite 3259-3272
Übergeordnetes Werk:	volume:220 ; year:2014 ; number:6 ; day:01 ; month:08 ; pages:3259-3272

Links:	Volltext

DOI / URN:	10.1007/s00429-014-0854-1

Katalog-ID:	SPR005724597

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source	Enthalten in Anatomy and embryology 220(2014), 6 vom: 01. Aug., Seite 3259-3272 volume:220 year:2014 number:6 day:01 month:08 pages:3259-3272
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topic_facet	Magnetic resonance imaging Hippocampus Subregion 3 Tesla Delineation criteria
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author	Rhindress, Kathryn
spellingShingle	Rhindress, Kathryn ddc 610 bkl 44.34 misc Magnetic resonance imaging misc Hippocampus misc Subregion misc 3 Tesla misc Delineation criteria Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla
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topic_title	610 ASE 44.34 bkl Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla Magnetic resonance imaging (dpeaa)DE-He213 Hippocampus (dpeaa)DE-He213 Subregion (dpeaa)DE-He213 3 Tesla (dpeaa)DE-He213 Delineation criteria (dpeaa)DE-He213
topic	ddc 610 bkl 44.34 misc Magnetic resonance imaging misc Hippocampus misc Subregion misc 3 Tesla misc Delineation criteria
topic_unstemmed	ddc 610 bkl 44.34 misc Magnetic resonance imaging misc Hippocampus misc Subregion misc 3 Tesla misc Delineation criteria
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title	Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla
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title_full	Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla
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author_browse	Rhindress, Kathryn Ikuta, Toshikazu Wellington, Robin Malhotra, Anil K. Szeszko, Philip R.
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title_sort	delineation of hippocampal subregions using t1-weighted magnetic resonance images at 3 tesla
title_auth	Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla
abstract	Abstract Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1–3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10 min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71–0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66–0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70–0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82–0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1–3 and in the subiculum.
abstractGer	Abstract Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1–3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10 min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71–0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66–0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70–0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82–0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1–3 and in the subiculum.
abstract_unstemmed	Abstract Although several novel approaches for hippocampal subregion delineation have been developed, they need to be applied prospectively and may be limited by long scan times, the use of high field (>3T) imaging systems, and limited reliability metrics. Moreover, the majority of MR imaging data collected to date has employed a T1-weighted acquisition, creating a critical need for an approach that provides reliable hippocampal subregion segmentation using such a contrast. We present a highly reliable approach for the identification of six subregions comprising the hippocampal formation from MR images including the subiculum, dentate gyrus/cornu Ammonis 4 (DG/CA4), entorhinal cortex, fimbria, and anterior and posterior segments of cornu Ammonis 1-3 (CA1–3). MR images were obtained in the coronal plane using a standard 3D spoiled gradient sequence acquired on a GE 3T scanner through the whole head in approximately 10 min. The average ICC for inter-rater reliability across right and left volumetric regions-of-interest was 0.85 (range 0.71–0.98, median 0.86) and the average ICC for intra-rater reliability was 0.92 (range 0.66–0.99, median 0.97). The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70–0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82–0.90, median 0.85). An investigation of hippocampal asymmetry revealed significantly greater right compared to left hemisphere volumes in the anterior segment of CA1–3 and in the subiculum.
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title_short	Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla
url	https://dx.doi.org/10.1007/s00429-014-0854-1
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author2	Ikuta, Toshikazu Wellington, Robin Malhotra, Anil K. Szeszko, Philip R.
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The mean Dice index for inter-rater reliability across right and left hemisphere subregions was 0.75 (range 0.70–0.81, median 0.75) and the mean Dice index for intra-rater reliability was 0.85 (range 0.82–0.90, median 0.85). 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Delineation of hippocampal subregions using T1-weighted magnetic resonance images at 3 Tesla

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