Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development

Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic str...
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Gespeichert in:

Autor*in:	Hosseiny, Salma [verfasserIn] Pietri, Mariel [verfasserIn] Petit-Paitel, Agnès [verfasserIn] Zarif, Hadi [verfasserIn] Heurteaux, Catherine [verfasserIn] Chabry, Joëlle [verfasserIn] Guyon, Alice [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Enriched environment Hippocampus neurogenesis and synaptogenesis Long-term potentiation Excitatory postsynaptic currents Postnatal development

Übergeordnetes Werk:	Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 220(2014), 6 vom: 06. Aug., Seite 3435-3448
Übergeordnetes Werk:	volume:220 ; year:2014 ; number:6 ; day:06 ; month:08 ; pages:3435-3448

Links:	Volltext

DOI / URN:	10.1007/s00429-014-0865-y

Katalog-ID:	SPR005724708

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author	Hosseiny, Salma
spellingShingle	Hosseiny, Salma ddc 610 bkl 44.34 misc Enriched environment misc Hippocampus neurogenesis and synaptogenesis misc Long-term potentiation misc Excitatory postsynaptic currents misc Postnatal development Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
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topic_title	610 ASE 44.34 bkl Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213
topic	ddc 610 bkl 44.34 misc Enriched environment misc Hippocampus neurogenesis and synaptogenesis misc Long-term potentiation misc Excitatory postsynaptic currents misc Postnatal development
topic_unstemmed	ddc 610 bkl 44.34 misc Enriched environment misc Hippocampus neurogenesis and synaptogenesis misc Long-term potentiation misc Excitatory postsynaptic currents misc Postnatal development
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title	Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
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title_full	Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
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title_sort	differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
title_auth	Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
abstract	Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity.
abstractGer	Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity.
abstract_unstemmed	Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity.
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title_short	Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
url	https://dx.doi.org/10.1007/s00429-014-0865-y
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author2	Pietri, Mariel Petit-Paitel, Agnès Zarif, Hadi Heurteaux, Catherine Chabry, Joëlle Guyon, Alice
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We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. 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Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development

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