Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development
Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic str...
Ausführliche Beschreibung
Autor*in: |
Hosseiny, Salma [verfasserIn] Pietri, Mariel [verfasserIn] Petit-Paitel, Agnès [verfasserIn] Zarif, Hadi [verfasserIn] Heurteaux, Catherine [verfasserIn] Chabry, Joëlle [verfasserIn] Guyon, Alice [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Schlagwörter: |
Hippocampus neurogenesis and synaptogenesis |
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Übergeordnetes Werk: |
Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 220(2014), 6 vom: 06. Aug., Seite 3435-3448 |
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Übergeordnetes Werk: |
volume:220 ; year:2014 ; number:6 ; day:06 ; month:08 ; pages:3435-3448 |
Links: |
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DOI / URN: |
10.1007/s00429-014-0865-y |
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Katalog-ID: |
SPR005724708 |
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520 | |a Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. | ||
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650 | 4 | |a Excitatory postsynaptic currents |7 (dpeaa)DE-He213 | |
650 | 4 | |a Postnatal development |7 (dpeaa)DE-He213 | |
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10.1007/s00429-014-0865-y doi (DE-627)SPR005724708 (SPR)s00429-014-0865-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hosseiny, Salma verfasserin aut Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 Pietri, Mariel verfasserin aut Petit-Paitel, Agnès verfasserin aut Zarif, Hadi verfasserin aut Heurteaux, Catherine verfasserin aut Chabry, Joëlle verfasserin aut Guyon, Alice verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 220(2014), 6 vom: 06. Aug., Seite 3435-3448 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:220 year:2014 number:6 day:06 month:08 pages:3435-3448 https://dx.doi.org/10.1007/s00429-014-0865-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 220 2014 6 06 08 3435-3448 |
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10.1007/s00429-014-0865-y doi (DE-627)SPR005724708 (SPR)s00429-014-0865-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hosseiny, Salma verfasserin aut Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 Pietri, Mariel verfasserin aut Petit-Paitel, Agnès verfasserin aut Zarif, Hadi verfasserin aut Heurteaux, Catherine verfasserin aut Chabry, Joëlle verfasserin aut Guyon, Alice verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 220(2014), 6 vom: 06. Aug., Seite 3435-3448 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:220 year:2014 number:6 day:06 month:08 pages:3435-3448 https://dx.doi.org/10.1007/s00429-014-0865-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 220 2014 6 06 08 3435-3448 |
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10.1007/s00429-014-0865-y doi (DE-627)SPR005724708 (SPR)s00429-014-0865-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hosseiny, Salma verfasserin aut Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 Pietri, Mariel verfasserin aut Petit-Paitel, Agnès verfasserin aut Zarif, Hadi verfasserin aut Heurteaux, Catherine verfasserin aut Chabry, Joëlle verfasserin aut Guyon, Alice verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 220(2014), 6 vom: 06. Aug., Seite 3435-3448 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:220 year:2014 number:6 day:06 month:08 pages:3435-3448 https://dx.doi.org/10.1007/s00429-014-0865-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 220 2014 6 06 08 3435-3448 |
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10.1007/s00429-014-0865-y doi (DE-627)SPR005724708 (SPR)s00429-014-0865-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hosseiny, Salma verfasserin aut Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 Pietri, Mariel verfasserin aut Petit-Paitel, Agnès verfasserin aut Zarif, Hadi verfasserin aut Heurteaux, Catherine verfasserin aut Chabry, Joëlle verfasserin aut Guyon, Alice verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 220(2014), 6 vom: 06. Aug., Seite 3435-3448 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:220 year:2014 number:6 day:06 month:08 pages:3435-3448 https://dx.doi.org/10.1007/s00429-014-0865-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 220 2014 6 06 08 3435-3448 |
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10.1007/s00429-014-0865-y doi (DE-627)SPR005724708 (SPR)s00429-014-0865-y-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hosseiny, Salma verfasserin aut Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 Pietri, Mariel verfasserin aut Petit-Paitel, Agnès verfasserin aut Zarif, Hadi verfasserin aut Heurteaux, Catherine verfasserin aut Chabry, Joëlle verfasserin aut Guyon, Alice verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 220(2014), 6 vom: 06. Aug., Seite 3435-3448 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:220 year:2014 number:6 day:06 month:08 pages:3435-3448 https://dx.doi.org/10.1007/s00429-014-0865-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 220 2014 6 06 08 3435-3448 |
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610 ASE 44.34 bkl Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development Enriched environment (dpeaa)DE-He213 Hippocampus neurogenesis and synaptogenesis (dpeaa)DE-He213 Long-term potentiation (dpeaa)DE-He213 Excitatory postsynaptic currents (dpeaa)DE-He213 Postnatal development (dpeaa)DE-He213 |
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differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development |
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Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development |
abstract |
Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. |
abstractGer |
Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. |
abstract_unstemmed |
Abstract Enriched environment (EE) is characterized by improved conditions for enhanced exploration, cognitive activity, social interaction and physical exercise. It has been shown that EE positively regulates the remodeling of neural circuits, memory consolidation, long-term changes in synaptic strength and neurogenesis. However, the fine mechanisms by which environment shapes the brain at different postnatal developmental stages and the duration required to induce such changes are still a matter of debate. In EE, large groups of mice were housed in bigger cages and were given toys, nesting materials and other equipment that promote physical activity to provide a stimulating environment. Weaned mice were housed in EE for 4, 6 or 8 weeks and compared with matched control mice that were raised in a standard environment. To investigate the differential effects of EE on immature and mature brains, we also housed young adult mice (8 weeks old) for 4 weeks in EE. We studied the influence of onset and duration of EE housing on the structure and function of hippocampal neurons. We found that: (1) EE enhances neurogenesis in juvenile, but not young adult mice; (2) EE increases the number of synaptic contacts at every stage; (3) long-term potentiation (LTP) and spontaneous and miniature activity at the glutamatergic synapses are affected differently by EE depending on its onset and duration. Our study provides an integrative view of the role of EE during postnatal development in various mechanisms of plasticity in the hippocampus including neurogenesis, synaptic morphology and electrophysiological parameters of synaptic connectivity. This work provides an explanation for discrepancies found in the literature about the effects of EE on LTP and emphasizes the importance of environment on hippocampal plasticity. |
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Differential neuronal plasticity in mouse hippocampus associated with various periods of enriched environment during postnatal development |
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