BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas
Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Soares, Paula [verfasserIn] Trovisco, Vítor [verfasserIn] Rocha, Ana Sofia [verfasserIn] Feijão, Tália [verfasserIn] Rebocho, Ana Paula [verfasserIn] Fonseca, Elsa [verfasserIn] Vieira de Castro, Inês [verfasserIn] Cameselle-Teijeiro, José [verfasserIn] Cardoso-Oliveira, Manuel [verfasserIn] Sobrinho-Simões, Manuel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2004 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Virchows Archiv - Berlin : Springer, 1847, 444(2004), 6 vom: 17. Apr., Seite 572-576 |
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| Übergeordnetes Werk: |
volume:444 ; year:2004 ; number:6 ; day:17 ; month:04 ; pages:572-576 |
| Links: |
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| DOI / URN: |
10.1007/s00428-004-1018-0 |
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| Katalog-ID: |
SPR005728797 |
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| 100 | 1 | |a Soares, Paula |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
| 264 | 1 | |c 2004 | |
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| 520 | |a Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. | ||
| 650 | 4 | |a Oncogene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mutation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Papillary thyroid carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Undifferentiated thyroid carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Poorly differentiated thyroid carcinoma |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Trovisco, Vítor |e verfasserin |4 aut | |
| 700 | 1 | |a Rocha, Ana Sofia |e verfasserin |4 aut | |
| 700 | 1 | |a Feijão, Tália |e verfasserin |4 aut | |
| 700 | 1 | |a Rebocho, Ana Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Fonseca, Elsa |e verfasserin |4 aut | |
| 700 | 1 | |a Vieira de Castro, Inês |e verfasserin |4 aut | |
| 700 | 1 | |a Cameselle-Teijeiro, José |e verfasserin |4 aut | |
| 700 | 1 | |a Cardoso-Oliveira, Manuel |e verfasserin |4 aut | |
| 700 | 1 | |a Sobrinho-Simões, Manuel |e verfasserin |4 aut | |
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10.1007/s00428-004-1018-0 doi (DE-627)SPR005728797 (SPR)s00428-004-1018-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Soares, Paula verfasserin aut BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 Trovisco, Vítor verfasserin aut Rocha, Ana Sofia verfasserin aut Feijão, Tália verfasserin aut Rebocho, Ana Paula verfasserin aut Fonseca, Elsa verfasserin aut Vieira de Castro, Inês verfasserin aut Cameselle-Teijeiro, José verfasserin aut Cardoso-Oliveira, Manuel verfasserin aut Sobrinho-Simões, Manuel verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 444(2004), 6 vom: 17. Apr., Seite 572-576 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:444 year:2004 number:6 day:17 month:04 pages:572-576 https://dx.doi.org/10.1007/s00428-004-1018-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 444 2004 6 17 04 572-576 |
| spelling |
10.1007/s00428-004-1018-0 doi (DE-627)SPR005728797 (SPR)s00428-004-1018-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Soares, Paula verfasserin aut BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 Trovisco, Vítor verfasserin aut Rocha, Ana Sofia verfasserin aut Feijão, Tália verfasserin aut Rebocho, Ana Paula verfasserin aut Fonseca, Elsa verfasserin aut Vieira de Castro, Inês verfasserin aut Cameselle-Teijeiro, José verfasserin aut Cardoso-Oliveira, Manuel verfasserin aut Sobrinho-Simões, Manuel verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 444(2004), 6 vom: 17. Apr., Seite 572-576 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:444 year:2004 number:6 day:17 month:04 pages:572-576 https://dx.doi.org/10.1007/s00428-004-1018-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 444 2004 6 17 04 572-576 |
| allfields_unstemmed |
10.1007/s00428-004-1018-0 doi (DE-627)SPR005728797 (SPR)s00428-004-1018-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Soares, Paula verfasserin aut BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 Trovisco, Vítor verfasserin aut Rocha, Ana Sofia verfasserin aut Feijão, Tália verfasserin aut Rebocho, Ana Paula verfasserin aut Fonseca, Elsa verfasserin aut Vieira de Castro, Inês verfasserin aut Cameselle-Teijeiro, José verfasserin aut Cardoso-Oliveira, Manuel verfasserin aut Sobrinho-Simões, Manuel verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 444(2004), 6 vom: 17. Apr., Seite 572-576 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:444 year:2004 number:6 day:17 month:04 pages:572-576 https://dx.doi.org/10.1007/s00428-004-1018-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 444 2004 6 17 04 572-576 |
| allfieldsGer |
10.1007/s00428-004-1018-0 doi (DE-627)SPR005728797 (SPR)s00428-004-1018-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Soares, Paula verfasserin aut BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 Trovisco, Vítor verfasserin aut Rocha, Ana Sofia verfasserin aut Feijão, Tália verfasserin aut Rebocho, Ana Paula verfasserin aut Fonseca, Elsa verfasserin aut Vieira de Castro, Inês verfasserin aut Cameselle-Teijeiro, José verfasserin aut Cardoso-Oliveira, Manuel verfasserin aut Sobrinho-Simões, Manuel verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 444(2004), 6 vom: 17. Apr., Seite 572-576 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:444 year:2004 number:6 day:17 month:04 pages:572-576 https://dx.doi.org/10.1007/s00428-004-1018-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 444 2004 6 17 04 572-576 |
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10.1007/s00428-004-1018-0 doi (DE-627)SPR005728797 (SPR)s00428-004-1018-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.47 bkl Soares, Paula verfasserin aut BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas 2004 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 Trovisco, Vítor verfasserin aut Rocha, Ana Sofia verfasserin aut Feijão, Tália verfasserin aut Rebocho, Ana Paula verfasserin aut Fonseca, Elsa verfasserin aut Vieira de Castro, Inês verfasserin aut Cameselle-Teijeiro, José verfasserin aut Cardoso-Oliveira, Manuel verfasserin aut Sobrinho-Simões, Manuel verfasserin aut Enthalten in Virchows Archiv Berlin : Springer, 1847 444(2004), 6 vom: 17. Apr., Seite 572-576 (DE-627)254910645 (DE-600)1463276-7 1432-2307 nnns volume:444 year:2004 number:6 day:17 month:04 pages:572-576 https://dx.doi.org/10.1007/s00428-004-1018-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.47 ASE AR 444 2004 6 17 04 572-576 |
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Enthalten in Virchows Archiv 444(2004), 6 vom: 17. Apr., Seite 572-576 volume:444 year:2004 number:6 day:17 month:04 pages:572-576 |
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Enthalten in Virchows Archiv 444(2004), 6 vom: 17. Apr., Seite 572-576 volume:444 year:2004 number:6 day:17 month:04 pages:572-576 |
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Oncogene Mutation Papillary thyroid carcinoma Undifferentiated thyroid carcinoma Poorly differentiated thyroid carcinoma |
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Soares, Paula @@aut@@ Trovisco, Vítor @@aut@@ Rocha, Ana Sofia @@aut@@ Feijão, Tália @@aut@@ Rebocho, Ana Paula @@aut@@ Fonseca, Elsa @@aut@@ Vieira de Castro, Inês @@aut@@ Cameselle-Teijeiro, José @@aut@@ Cardoso-Oliveira, Manuel @@aut@@ Sobrinho-Simões, Manuel @@aut@@ |
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2004-04-17T00:00:00Z |
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3610 |
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Soares, Paula |
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Soares, Paula ddc 610 bkl 44.47 misc Oncogene misc Mutation misc Papillary thyroid carcinoma misc Undifferentiated thyroid carcinoma misc Poorly differentiated thyroid carcinoma BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
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610 ASE 44.47 bkl BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas Oncogene (dpeaa)DE-He213 Mutation (dpeaa)DE-He213 Papillary thyroid carcinoma (dpeaa)DE-He213 Undifferentiated thyroid carcinoma (dpeaa)DE-He213 Poorly differentiated thyroid carcinoma (dpeaa)DE-He213 |
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ddc 610 bkl 44.47 misc Oncogene misc Mutation misc Papillary thyroid carcinoma misc Undifferentiated thyroid carcinoma misc Poorly differentiated thyroid carcinoma |
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ddc 610 bkl 44.47 misc Oncogene misc Mutation misc Papillary thyroid carcinoma misc Undifferentiated thyroid carcinoma misc Poorly differentiated thyroid carcinoma |
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ddc 610 bkl 44.47 misc Oncogene misc Mutation misc Papillary thyroid carcinoma misc Undifferentiated thyroid carcinoma misc Poorly differentiated thyroid carcinoma |
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BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
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BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
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Soares, Paula |
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Virchows Archiv |
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Soares, Paula Trovisco, Vítor Rocha, Ana Sofia Feijão, Tália Rebocho, Ana Paula Fonseca, Elsa Vieira de Castro, Inês Cameselle-Teijeiro, José Cardoso-Oliveira, Manuel Sobrinho-Simões, Manuel |
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braf mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
| title_auth |
BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
| abstract |
Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. |
| abstractGer |
Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. |
| abstract_unstemmed |
Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. The absence of BRAF mutations in our series of PDC supports the assumption that pure insular and insular-like PDCs are more closely related to follicular carcinoma than to PTC. |
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BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas |
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Trovisco, Vítor Rocha, Ana Sofia Feijão, Tália Rebocho, Ana Paula Fonseca, Elsa Vieira de Castro, Inês Cameselle-Teijeiro, José Cardoso-Oliveira, Manuel Sobrinho-Simões, Manuel |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR005728797</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519211720.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201002s2004 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00428-004-1018-0</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR005728797</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00428-004-1018-0-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.47</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Soares, Paula</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2004</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Somatic mutations of the BRAF gene ($ BRAF^{V599E} $ and $ BRAF^{K600E} $) were found to be closely associated with different histotypes of papillary thyroid carcinoma (PTC). The V599E mutation is highly prevalent in PTC with a papillary or mixed papillary follicular growth pattern, and the K600E mutation is apparently restricted to the follicular variant of PTC. It is usually accepted that thyroid malignancies may follow a progression path from well-differentiated to poorly differentiated (PDC) and undifferentiated (UC) carcinomas. One would expect that at least some of the less differentiated carcinomas would harbour the genetic alterations of pre-existing well-differentiated tumours. In order to find the prevalence of BRAF mutations in PDC and UC, we screened a series of 19 PDCs and 17 UCs, as well as 3 UC-derived cell lines, for both mutation types. The group of PDCs was restricted to the so-called insular and insular-like PDCs, thus excluding PTCs with solid, insular or trabecular foci of growth and PDCs displaying typical PTC nuclei. No BRAF mutations were detected in any of the 19 cases of PDC, whereas 6 of the UCs (35%) and one UC-derived cell line presented the $ BRAF^{V599E} $ mutation. The $ BRAF^{K600E} $ mutation was not detected in any case. We conclude that UC may progress from $ BRAF^{V599E} $-mutated PTC. 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