Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity
Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucos...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hahn, Andreas [verfasserIn] Gryglewski, Gregor [verfasserIn] Nics, Lukas [verfasserIn] Rischka, Lucas [verfasserIn] Ganger, Sebastian [verfasserIn] Sigurdardottir, Helen [verfasserIn] Vraka, Chrysoula [verfasserIn] Silberbauer, Leo [verfasserIn] Vanicek, Thomas [verfasserIn] Kautzky, Alexander [verfasserIn] Wadsak, Wolfgang [verfasserIn] Mitterhauser, Markus [verfasserIn] Hartenbach, Markus [verfasserIn] Hacker, Marcus [verfasserIn] Kasper, Siegfried [verfasserIn] Lanzenberger, Rupert [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 223(2017), 3 vom: 13. Nov., Seite 1369-1378 |
|---|---|
| Übergeordnetes Werk: |
volume:223 ; year:2017 ; number:3 ; day:13 ; month:11 ; pages:1369-1378 |
| Links: |
|---|
| DOI / URN: |
10.1007/s00429-017-1558-0 |
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| Katalog-ID: |
SPR005732239 |
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| 520 | |a Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. | ||
| 650 | 4 | |a Continuous task performance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Functional connectivity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Glucose metabolism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a White matter microstructure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Functional PET, fPET |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gryglewski, Gregor |e verfasserin |4 aut | |
| 700 | 1 | |a Nics, Lukas |e verfasserin |4 aut | |
| 700 | 1 | |a Rischka, Lucas |e verfasserin |4 aut | |
| 700 | 1 | |a Ganger, Sebastian |e verfasserin |4 aut | |
| 700 | 1 | |a Sigurdardottir, Helen |e verfasserin |4 aut | |
| 700 | 1 | |a Vraka, Chrysoula |e verfasserin |4 aut | |
| 700 | 1 | |a Silberbauer, Leo |e verfasserin |4 aut | |
| 700 | 1 | |a Vanicek, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Kautzky, Alexander |e verfasserin |4 aut | |
| 700 | 1 | |a Wadsak, Wolfgang |e verfasserin |4 aut | |
| 700 | 1 | |a Mitterhauser, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Hartenbach, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Hacker, Marcus |e verfasserin |4 aut | |
| 700 | 1 | |a Kasper, Siegfried |e verfasserin |4 aut | |
| 700 | 1 | |a Lanzenberger, Rupert |e verfasserin |4 aut | |
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10.1007/s00429-017-1558-0 doi (DE-627)SPR005732239 (SPR)s00429-017-1558-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hahn, Andreas verfasserin aut Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. Continuous task performance (dpeaa)DE-He213 Functional connectivity (dpeaa)DE-He213 Glucose metabolism (dpeaa)DE-He213 White matter microstructure (dpeaa)DE-He213 Functional PET, fPET (dpeaa)DE-He213 Gryglewski, Gregor verfasserin aut Nics, Lukas verfasserin aut Rischka, Lucas verfasserin aut Ganger, Sebastian verfasserin aut Sigurdardottir, Helen verfasserin aut Vraka, Chrysoula verfasserin aut Silberbauer, Leo verfasserin aut Vanicek, Thomas verfasserin aut Kautzky, Alexander verfasserin aut Wadsak, Wolfgang verfasserin aut Mitterhauser, Markus verfasserin aut Hartenbach, Markus verfasserin aut Hacker, Marcus verfasserin aut Kasper, Siegfried verfasserin aut Lanzenberger, Rupert verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 223(2017), 3 vom: 13. Nov., Seite 1369-1378 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 https://dx.doi.org/10.1007/s00429-017-1558-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 223 2017 3 13 11 1369-1378 |
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10.1007/s00429-017-1558-0 doi (DE-627)SPR005732239 (SPR)s00429-017-1558-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hahn, Andreas verfasserin aut Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. Continuous task performance (dpeaa)DE-He213 Functional connectivity (dpeaa)DE-He213 Glucose metabolism (dpeaa)DE-He213 White matter microstructure (dpeaa)DE-He213 Functional PET, fPET (dpeaa)DE-He213 Gryglewski, Gregor verfasserin aut Nics, Lukas verfasserin aut Rischka, Lucas verfasserin aut Ganger, Sebastian verfasserin aut Sigurdardottir, Helen verfasserin aut Vraka, Chrysoula verfasserin aut Silberbauer, Leo verfasserin aut Vanicek, Thomas verfasserin aut Kautzky, Alexander verfasserin aut Wadsak, Wolfgang verfasserin aut Mitterhauser, Markus verfasserin aut Hartenbach, Markus verfasserin aut Hacker, Marcus verfasserin aut Kasper, Siegfried verfasserin aut Lanzenberger, Rupert verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 223(2017), 3 vom: 13. Nov., Seite 1369-1378 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 https://dx.doi.org/10.1007/s00429-017-1558-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 223 2017 3 13 11 1369-1378 |
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10.1007/s00429-017-1558-0 doi (DE-627)SPR005732239 (SPR)s00429-017-1558-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hahn, Andreas verfasserin aut Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. Continuous task performance (dpeaa)DE-He213 Functional connectivity (dpeaa)DE-He213 Glucose metabolism (dpeaa)DE-He213 White matter microstructure (dpeaa)DE-He213 Functional PET, fPET (dpeaa)DE-He213 Gryglewski, Gregor verfasserin aut Nics, Lukas verfasserin aut Rischka, Lucas verfasserin aut Ganger, Sebastian verfasserin aut Sigurdardottir, Helen verfasserin aut Vraka, Chrysoula verfasserin aut Silberbauer, Leo verfasserin aut Vanicek, Thomas verfasserin aut Kautzky, Alexander verfasserin aut Wadsak, Wolfgang verfasserin aut Mitterhauser, Markus verfasserin aut Hartenbach, Markus verfasserin aut Hacker, Marcus verfasserin aut Kasper, Siegfried verfasserin aut Lanzenberger, Rupert verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 223(2017), 3 vom: 13. Nov., Seite 1369-1378 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 https://dx.doi.org/10.1007/s00429-017-1558-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 223 2017 3 13 11 1369-1378 |
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10.1007/s00429-017-1558-0 doi (DE-627)SPR005732239 (SPR)s00429-017-1558-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hahn, Andreas verfasserin aut Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. Continuous task performance (dpeaa)DE-He213 Functional connectivity (dpeaa)DE-He213 Glucose metabolism (dpeaa)DE-He213 White matter microstructure (dpeaa)DE-He213 Functional PET, fPET (dpeaa)DE-He213 Gryglewski, Gregor verfasserin aut Nics, Lukas verfasserin aut Rischka, Lucas verfasserin aut Ganger, Sebastian verfasserin aut Sigurdardottir, Helen verfasserin aut Vraka, Chrysoula verfasserin aut Silberbauer, Leo verfasserin aut Vanicek, Thomas verfasserin aut Kautzky, Alexander verfasserin aut Wadsak, Wolfgang verfasserin aut Mitterhauser, Markus verfasserin aut Hartenbach, Markus verfasserin aut Hacker, Marcus verfasserin aut Kasper, Siegfried verfasserin aut Lanzenberger, Rupert verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 223(2017), 3 vom: 13. Nov., Seite 1369-1378 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 https://dx.doi.org/10.1007/s00429-017-1558-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 223 2017 3 13 11 1369-1378 |
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10.1007/s00429-017-1558-0 doi (DE-627)SPR005732239 (SPR)s00429-017-1558-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Hahn, Andreas verfasserin aut Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. Continuous task performance (dpeaa)DE-He213 Functional connectivity (dpeaa)DE-He213 Glucose metabolism (dpeaa)DE-He213 White matter microstructure (dpeaa)DE-He213 Functional PET, fPET (dpeaa)DE-He213 Gryglewski, Gregor verfasserin aut Nics, Lukas verfasserin aut Rischka, Lucas verfasserin aut Ganger, Sebastian verfasserin aut Sigurdardottir, Helen verfasserin aut Vraka, Chrysoula verfasserin aut Silberbauer, Leo verfasserin aut Vanicek, Thomas verfasserin aut Kautzky, Alexander verfasserin aut Wadsak, Wolfgang verfasserin aut Mitterhauser, Markus verfasserin aut Hartenbach, Markus verfasserin aut Hacker, Marcus verfasserin aut Kasper, Siegfried verfasserin aut Lanzenberger, Rupert verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 223(2017), 3 vom: 13. Nov., Seite 1369-1378 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 https://dx.doi.org/10.1007/s00429-017-1558-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 223 2017 3 13 11 1369-1378 |
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Enthalten in Anatomy and embryology 223(2017), 3 vom: 13. Nov., Seite 1369-1378 volume:223 year:2017 number:3 day:13 month:11 pages:1369-1378 |
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Hahn, Andreas Gryglewski, Gregor Nics, Lukas Rischka, Lucas Ganger, Sebastian Sigurdardottir, Helen Vraka, Chrysoula Silberbauer, Leo Vanicek, Thomas Kautzky, Alexander Wadsak, Wolfgang Mitterhauser, Markus Hartenbach, Markus Hacker, Marcus Kasper, Siegfried Lanzenberger, Rupert |
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Task-relevant brain networks identified with simultaneous PET/MR imaging of metabolism and connectivity |
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Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. |
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Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. |
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Abstract Except for task-specific functional MRI, the vast majority of imaging studies assessed human brain function at resting conditions. However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. Exploiting the complementary nature of the different imaging modalities may reveal novel insights how the brain processes external stimuli and which networks are involved in certain tasks. |
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However, tracking task-specific neuronal activity yields important insight how the brain responds to stimulation. We specifically investigated changes in glucose metabolism, functional connectivity and white matter microstructure during task performance using several recent methodological advancements. Opening the eyes and right finger tapping had elicited an increased glucose metabolism in primary visual and motor cortices, respectively. Furthermore, a decreased metabolism was observed in the regions of the default mode network, which allowed absolute quantification of commonly described deactivations during cognitive tasks. These brain regions showed widespread task-specific changes in functional connectivity, which stretched beyond their primary resting-state networks and presumably reflected the level of recruitment of certain brain regions for each task. Finally, the corresponding white matter fiber pathways exhibited changes in axial and radial diffusivity during the tasks, which were regionally distinctive for certain tract groups. These results highlight that even simple task performance leads to substantial changes of entire brain networks. 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