Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons
Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains s...
Ausführliche Beschreibung
Autor*in: |
Mongrédien, Raphaële [verfasserIn] Erdozain, Amaia M. [verfasserIn] Dumas, Sylvie [verfasserIn] Cutando, Laura [verfasserIn] del Moral, Amaia Nuñez [verfasserIn] Puighermanal, Emma [verfasserIn] Rezai Amin, Sara [verfasserIn] Giros, Bruno [verfasserIn] Valjent, Emmanuel [verfasserIn] Meana, J. Javier [verfasserIn] Gautron, Sophie [verfasserIn] Callado, Luis F. [verfasserIn] Fabre, Véronique [verfasserIn] Vialou, Vincent [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
Enthalten in: Anatomy and embryology - Berlin : Springer, 1891, 224(2019), 3 vom: 17. Jan., Seite 1219-1244 |
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Übergeordnetes Werk: |
volume:224 ; year:2019 ; number:3 ; day:17 ; month:01 ; pages:1219-1244 |
Links: |
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DOI / URN: |
10.1007/s00429-019-01831-x |
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Katalog-ID: |
SPR005735106 |
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520 | |a Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. | ||
650 | 4 | |a Hevin |7 (dpeaa)DE-He213 | |
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650 | 4 | |a Parvalbumin neurons |7 (dpeaa)DE-He213 | |
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650 | 4 | |a Glutamatergic neurons |7 (dpeaa)DE-He213 | |
650 | 4 | |a In situ hybridization |7 (dpeaa)DE-He213 | |
700 | 1 | |a Erdozain, Amaia M. |e verfasserin |4 aut | |
700 | 1 | |a Dumas, Sylvie |e verfasserin |4 aut | |
700 | 1 | |a Cutando, Laura |e verfasserin |4 aut | |
700 | 1 | |a del Moral, Amaia Nuñez |e verfasserin |4 aut | |
700 | 1 | |a Puighermanal, Emma |e verfasserin |4 aut | |
700 | 1 | |a Rezai Amin, Sara |e verfasserin |4 aut | |
700 | 1 | |a Giros, Bruno |e verfasserin |4 aut | |
700 | 1 | |a Valjent, Emmanuel |e verfasserin |4 aut | |
700 | 1 | |a Meana, J. Javier |e verfasserin |4 aut | |
700 | 1 | |a Gautron, Sophie |e verfasserin |4 aut | |
700 | 1 | |a Callado, Luis F. |e verfasserin |4 aut | |
700 | 1 | |a Fabre, Véronique |e verfasserin |4 aut | |
700 | 1 | |a Vialou, Vincent |e verfasserin |4 aut | |
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10.1007/s00429-019-01831-x doi (DE-627)SPR005735106 (SPR)s00429-019-01831-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Mongrédien, Raphaële verfasserin aut Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. Hevin (dpeaa)DE-He213 Matricellular protein (dpeaa)DE-He213 Parvalbumin neurons (dpeaa)DE-He213 Astrocytes (dpeaa)DE-He213 Glutamatergic neurons (dpeaa)DE-He213 In situ hybridization (dpeaa)DE-He213 Erdozain, Amaia M. verfasserin aut Dumas, Sylvie verfasserin aut Cutando, Laura verfasserin aut del Moral, Amaia Nuñez verfasserin aut Puighermanal, Emma verfasserin aut Rezai Amin, Sara verfasserin aut Giros, Bruno verfasserin aut Valjent, Emmanuel verfasserin aut Meana, J. Javier verfasserin aut Gautron, Sophie verfasserin aut Callado, Luis F. verfasserin aut Fabre, Véronique verfasserin aut Vialou, Vincent verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 224(2019), 3 vom: 17. Jan., Seite 1219-1244 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:224 year:2019 number:3 day:17 month:01 pages:1219-1244 https://dx.doi.org/10.1007/s00429-019-01831-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 224 2019 3 17 01 1219-1244 |
spelling |
10.1007/s00429-019-01831-x doi (DE-627)SPR005735106 (SPR)s00429-019-01831-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Mongrédien, Raphaële verfasserin aut Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. Hevin (dpeaa)DE-He213 Matricellular protein (dpeaa)DE-He213 Parvalbumin neurons (dpeaa)DE-He213 Astrocytes (dpeaa)DE-He213 Glutamatergic neurons (dpeaa)DE-He213 In situ hybridization (dpeaa)DE-He213 Erdozain, Amaia M. verfasserin aut Dumas, Sylvie verfasserin aut Cutando, Laura verfasserin aut del Moral, Amaia Nuñez verfasserin aut Puighermanal, Emma verfasserin aut Rezai Amin, Sara verfasserin aut Giros, Bruno verfasserin aut Valjent, Emmanuel verfasserin aut Meana, J. Javier verfasserin aut Gautron, Sophie verfasserin aut Callado, Luis F. verfasserin aut Fabre, Véronique verfasserin aut Vialou, Vincent verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 224(2019), 3 vom: 17. Jan., Seite 1219-1244 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:224 year:2019 number:3 day:17 month:01 pages:1219-1244 https://dx.doi.org/10.1007/s00429-019-01831-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 224 2019 3 17 01 1219-1244 |
allfields_unstemmed |
10.1007/s00429-019-01831-x doi (DE-627)SPR005735106 (SPR)s00429-019-01831-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Mongrédien, Raphaële verfasserin aut Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. Hevin (dpeaa)DE-He213 Matricellular protein (dpeaa)DE-He213 Parvalbumin neurons (dpeaa)DE-He213 Astrocytes (dpeaa)DE-He213 Glutamatergic neurons (dpeaa)DE-He213 In situ hybridization (dpeaa)DE-He213 Erdozain, Amaia M. verfasserin aut Dumas, Sylvie verfasserin aut Cutando, Laura verfasserin aut del Moral, Amaia Nuñez verfasserin aut Puighermanal, Emma verfasserin aut Rezai Amin, Sara verfasserin aut Giros, Bruno verfasserin aut Valjent, Emmanuel verfasserin aut Meana, J. Javier verfasserin aut Gautron, Sophie verfasserin aut Callado, Luis F. verfasserin aut Fabre, Véronique verfasserin aut Vialou, Vincent verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 224(2019), 3 vom: 17. Jan., Seite 1219-1244 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:224 year:2019 number:3 day:17 month:01 pages:1219-1244 https://dx.doi.org/10.1007/s00429-019-01831-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 224 2019 3 17 01 1219-1244 |
allfieldsGer |
10.1007/s00429-019-01831-x doi (DE-627)SPR005735106 (SPR)s00429-019-01831-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Mongrédien, Raphaële verfasserin aut Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. Hevin (dpeaa)DE-He213 Matricellular protein (dpeaa)DE-He213 Parvalbumin neurons (dpeaa)DE-He213 Astrocytes (dpeaa)DE-He213 Glutamatergic neurons (dpeaa)DE-He213 In situ hybridization (dpeaa)DE-He213 Erdozain, Amaia M. verfasserin aut Dumas, Sylvie verfasserin aut Cutando, Laura verfasserin aut del Moral, Amaia Nuñez verfasserin aut Puighermanal, Emma verfasserin aut Rezai Amin, Sara verfasserin aut Giros, Bruno verfasserin aut Valjent, Emmanuel verfasserin aut Meana, J. Javier verfasserin aut Gautron, Sophie verfasserin aut Callado, Luis F. verfasserin aut Fabre, Véronique verfasserin aut Vialou, Vincent verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 224(2019), 3 vom: 17. Jan., Seite 1219-1244 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:224 year:2019 number:3 day:17 month:01 pages:1219-1244 https://dx.doi.org/10.1007/s00429-019-01831-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 224 2019 3 17 01 1219-1244 |
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10.1007/s00429-019-01831-x doi (DE-627)SPR005735106 (SPR)s00429-019-01831-x-e DE-627 ger DE-627 rakwb eng 610 ASE 44.34 bkl Mongrédien, Raphaële verfasserin aut Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. Hevin (dpeaa)DE-He213 Matricellular protein (dpeaa)DE-He213 Parvalbumin neurons (dpeaa)DE-He213 Astrocytes (dpeaa)DE-He213 Glutamatergic neurons (dpeaa)DE-He213 In situ hybridization (dpeaa)DE-He213 Erdozain, Amaia M. verfasserin aut Dumas, Sylvie verfasserin aut Cutando, Laura verfasserin aut del Moral, Amaia Nuñez verfasserin aut Puighermanal, Emma verfasserin aut Rezai Amin, Sara verfasserin aut Giros, Bruno verfasserin aut Valjent, Emmanuel verfasserin aut Meana, J. Javier verfasserin aut Gautron, Sophie verfasserin aut Callado, Luis F. verfasserin aut Fabre, Véronique verfasserin aut Vialou, Vincent verfasserin aut Enthalten in Anatomy and embryology Berlin : Springer, 1891 224(2019), 3 vom: 17. Jan., Seite 1219-1244 (DE-627)253389798 (DE-600)1458423-2 1432-0568 nnns volume:224 year:2019 number:3 day:17 month:01 pages:1219-1244 https://dx.doi.org/10.1007/s00429-019-01831-x lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 44.34 ASE AR 224 2019 3 17 01 1219-1244 |
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cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons |
title_auth |
Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons |
abstract |
Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. |
abstractGer |
Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. |
abstract_unstemmed |
Abstract Hevin, also known as SPARC-like 1, is a member of the secreted protein acidic and rich in cysteine family of matricellular proteins, which has been implicated in neuronal migration and synaptogenesis during development. Unlike previously characterized matricellular proteins, hevin remains strongly expressed in the adult brain in both astrocytes and neurons, but its precise pattern of expression is unknown. The present study provides the first systematic description of hevin mRNA distribution in the adult mouse brain. Using isotopic in situ hybridization, we showed that hevin is strongly expressed in the cortex, hippocampus, basal ganglia complex, diverse thalamic nuclei and brainstem motor nuclei. To identify the cellular phenotype of hevin-expressing cells, we used double fluorescent in situ hybridization in mouse and human adult brains. In the mouse, hevin mRNA was found in the majority of astrocytes but also in specific neuronal populations. Hevin was expressed in almost all parvalbumin-positive projection neurons and local interneurons. In addition, hevin mRNA was found in: (1) subsets of other inhibitory GABAergic neuronal subtypes, including calbindin, cholecystokinin, neuropeptide Y, and somatostatin-positive neurons; (2) subsets of glutamatergic neurons, identified by the expression of the vesicular glutamate transporters VGLUT1 and VGLUT2; and (3) the majority of cholinergic neurons from motor nuclei. Hevin mRNA was absent from all monoaminergic neurons and cholinergic neurons of the ascending pathway. A similar cellular profile of expression was observed in human, with expression of hevin in parvalbumin interneurons and astrocytes in the cortex and caudate nucleus as well as in cortical glutamatergic neurons. Furthermore, hevin transcript was enriched in ribosomes of astrocytes and parvalbumin neurons providing a direct evidence of hevin mRNAs translation in these cell types. This study reveals the unique and complex expression profile of the matricellular protein hevin in the adult brain. This distribution is compatible with a role of hevin in astrocytic-mediated adult synaptic plasticity and in the regulation of network activity mediated by parvalbumin-expressing neurons. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_711 |
container_issue |
3 |
title_short |
Cartography of hevin-expressing cells in the adult brain reveals prominent expression in astrocytes and parvalbumin neurons |
url |
https://dx.doi.org/10.1007/s00429-019-01831-x |
remote_bool |
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author2 |
Erdozain, Amaia M. Dumas, Sylvie Cutando, Laura del Moral, Amaia Nuñez Puighermanal, Emma Rezai Amin, Sara Giros, Bruno Valjent, Emmanuel Meana, J. Javier Gautron, Sophie Callado, Luis F. Fabre, Véronique Vialou, Vincent |
author2Str |
Erdozain, Amaia M. Dumas, Sylvie Cutando, Laura del Moral, Amaia Nuñez Puighermanal, Emma Rezai Amin, Sara Giros, Bruno Valjent, Emmanuel Meana, J. Javier Gautron, Sophie Callado, Luis F. Fabre, Véronique Vialou, Vincent |
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doi_str |
10.1007/s00429-019-01831-x |
up_date |
2024-07-03T18:20:21.336Z |
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