Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment
Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ardissino, Gianluigi [verfasserIn] Tel, Francesca [verfasserIn] Possenti, Ilaria [verfasserIn] Pavesi, Mariangela [verfasserIn] Perrone, Michela [verfasserIn] Forni, Giulia [verfasserIn] Salice, Patrizia [verfasserIn] Colombo, Lorenzo [verfasserIn] Ghirardello, Stefano [verfasserIn] Castiglione, Bianca [verfasserIn] Consonni, Dario [verfasserIn] Baca, Laura [verfasserIn] Vecchi, Daniela Li [verfasserIn] la Marca, Giancarlo [verfasserIn] Mosca, Fabio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: European journal of pediatrics - Berlin : Springer Science & Business Media B.V., 1975, 177(2018), 9 vom: 01. Feb., Seite 1383-1388 |
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| Übergeordnetes Werk: |
volume:177 ; year:2018 ; number:9 ; day:01 ; month:02 ; pages:1383-1388 |
| Links: |
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| DOI / URN: |
10.1007/s00431-018-3087-0 |
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| Katalog-ID: |
SPR005809908 |
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| 100 | 1 | |a Ardissino, Gianluigi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
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| 520 | |a Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. | ||
| 650 | 4 | |a Nephron endowment |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Newborn |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Arterial hypertension |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Blood Pressure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Perinatal serum creatinine |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Tel, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Possenti, Ilaria |e verfasserin |4 aut | |
| 700 | 1 | |a Pavesi, Mariangela |e verfasserin |4 aut | |
| 700 | 1 | |a Perrone, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Forni, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Salice, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Colombo, Lorenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Ghirardello, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Castiglione, Bianca |e verfasserin |4 aut | |
| 700 | 1 | |a Consonni, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Baca, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Vecchi, Daniela Li |e verfasserin |4 aut | |
| 700 | 1 | |a la Marca, Giancarlo |e verfasserin |4 aut | |
| 700 | 1 | |a Mosca, Fabio |e verfasserin |4 aut | |
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10.1007/s00431-018-3087-0 doi (DE-627)SPR005809908 (SPR)s00431-018-3087-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Ardissino, Gianluigi verfasserin aut Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 Tel, Francesca verfasserin aut Possenti, Ilaria verfasserin aut Pavesi, Mariangela verfasserin aut Perrone, Michela verfasserin aut Forni, Giulia verfasserin aut Salice, Patrizia verfasserin aut Colombo, Lorenzo verfasserin aut Ghirardello, Stefano verfasserin aut Castiglione, Bianca verfasserin aut Consonni, Dario verfasserin aut Baca, Laura verfasserin aut Vecchi, Daniela Li verfasserin aut la Marca, Giancarlo verfasserin aut Mosca, Fabio verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 177(2018), 9 vom: 01. Feb., Seite 1383-1388 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 https://dx.doi.org/10.1007/s00431-018-3087-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 177 2018 9 01 02 1383-1388 |
| spelling |
10.1007/s00431-018-3087-0 doi (DE-627)SPR005809908 (SPR)s00431-018-3087-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Ardissino, Gianluigi verfasserin aut Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 Tel, Francesca verfasserin aut Possenti, Ilaria verfasserin aut Pavesi, Mariangela verfasserin aut Perrone, Michela verfasserin aut Forni, Giulia verfasserin aut Salice, Patrizia verfasserin aut Colombo, Lorenzo verfasserin aut Ghirardello, Stefano verfasserin aut Castiglione, Bianca verfasserin aut Consonni, Dario verfasserin aut Baca, Laura verfasserin aut Vecchi, Daniela Li verfasserin aut la Marca, Giancarlo verfasserin aut Mosca, Fabio verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 177(2018), 9 vom: 01. Feb., Seite 1383-1388 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 https://dx.doi.org/10.1007/s00431-018-3087-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 177 2018 9 01 02 1383-1388 |
| allfields_unstemmed |
10.1007/s00431-018-3087-0 doi (DE-627)SPR005809908 (SPR)s00431-018-3087-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Ardissino, Gianluigi verfasserin aut Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 Tel, Francesca verfasserin aut Possenti, Ilaria verfasserin aut Pavesi, Mariangela verfasserin aut Perrone, Michela verfasserin aut Forni, Giulia verfasserin aut Salice, Patrizia verfasserin aut Colombo, Lorenzo verfasserin aut Ghirardello, Stefano verfasserin aut Castiglione, Bianca verfasserin aut Consonni, Dario verfasserin aut Baca, Laura verfasserin aut Vecchi, Daniela Li verfasserin aut la Marca, Giancarlo verfasserin aut Mosca, Fabio verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 177(2018), 9 vom: 01. Feb., Seite 1383-1388 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 https://dx.doi.org/10.1007/s00431-018-3087-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 177 2018 9 01 02 1383-1388 |
| allfieldsGer |
10.1007/s00431-018-3087-0 doi (DE-627)SPR005809908 (SPR)s00431-018-3087-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Ardissino, Gianluigi verfasserin aut Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 Tel, Francesca verfasserin aut Possenti, Ilaria verfasserin aut Pavesi, Mariangela verfasserin aut Perrone, Michela verfasserin aut Forni, Giulia verfasserin aut Salice, Patrizia verfasserin aut Colombo, Lorenzo verfasserin aut Ghirardello, Stefano verfasserin aut Castiglione, Bianca verfasserin aut Consonni, Dario verfasserin aut Baca, Laura verfasserin aut Vecchi, Daniela Li verfasserin aut la Marca, Giancarlo verfasserin aut Mosca, Fabio verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 177(2018), 9 vom: 01. Feb., Seite 1383-1388 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 https://dx.doi.org/10.1007/s00431-018-3087-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 177 2018 9 01 02 1383-1388 |
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10.1007/s00431-018-3087-0 doi (DE-627)SPR005809908 (SPR)s00431-018-3087-0-e DE-627 ger DE-627 rakwb eng 610 ASE 44.67 bkl Ardissino, Gianluigi verfasserin aut Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 Tel, Francesca verfasserin aut Possenti, Ilaria verfasserin aut Pavesi, Mariangela verfasserin aut Perrone, Michela verfasserin aut Forni, Giulia verfasserin aut Salice, Patrizia verfasserin aut Colombo, Lorenzo verfasserin aut Ghirardello, Stefano verfasserin aut Castiglione, Bianca verfasserin aut Consonni, Dario verfasserin aut Baca, Laura verfasserin aut Vecchi, Daniela Li verfasserin aut la Marca, Giancarlo verfasserin aut Mosca, Fabio verfasserin aut Enthalten in European journal of pediatrics Berlin : Springer Science & Business Media B.V., 1975 177(2018), 9 vom: 01. Feb., Seite 1383-1388 (DE-627)684135361 (DE-600)2647723-3 1432-1076 nnns volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 https://dx.doi.org/10.1007/s00431-018-3087-0 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.67 ASE AR 177 2018 9 01 02 1383-1388 |
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Enthalten in European journal of pediatrics 177(2018), 9 vom: 01. Feb., Seite 1383-1388 volume:177 year:2018 number:9 day:01 month:02 pages:1383-1388 |
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Nephron endowment Newborn Arterial hypertension Blood Pressure Perinatal serum creatinine |
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Ardissino, Gianluigi @@aut@@ Tel, Francesca @@aut@@ Possenti, Ilaria @@aut@@ Pavesi, Mariangela @@aut@@ Perrone, Michela @@aut@@ Forni, Giulia @@aut@@ Salice, Patrizia @@aut@@ Colombo, Lorenzo @@aut@@ Ghirardello, Stefano @@aut@@ Castiglione, Bianca @@aut@@ Consonni, Dario @@aut@@ Baca, Laura @@aut@@ Vecchi, Daniela Li @@aut@@ la Marca, Giancarlo @@aut@@ Mosca, Fabio @@aut@@ |
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2018-02-01T00:00:00Z |
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Ardissino, Gianluigi |
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Ardissino, Gianluigi ddc 610 bkl 44.67 misc Nephron endowment misc Newborn misc Arterial hypertension misc Blood Pressure misc Perinatal serum creatinine Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
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610 ASE 44.67 bkl Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment Nephron endowment (dpeaa)DE-He213 Newborn (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Blood Pressure (dpeaa)DE-He213 Perinatal serum creatinine (dpeaa)DE-He213 |
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ddc 610 bkl 44.67 misc Nephron endowment misc Newborn misc Arterial hypertension misc Blood Pressure misc Perinatal serum creatinine |
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ddc 610 bkl 44.67 misc Nephron endowment misc Newborn misc Arterial hypertension misc Blood Pressure misc Perinatal serum creatinine |
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ddc 610 bkl 44.67 misc Nephron endowment misc Newborn misc Arterial hypertension misc Blood Pressure misc Perinatal serum creatinine |
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Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
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Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
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Ardissino, Gianluigi |
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European journal of pediatrics |
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Ardissino, Gianluigi Tel, Francesca Possenti, Ilaria Pavesi, Mariangela Perrone, Michela Forni, Giulia Salice, Patrizia Colombo, Lorenzo Ghirardello, Stefano Castiglione, Bianca Consonni, Dario Baca, Laura Vecchi, Daniela Li la Marca, Giancarlo Mosca, Fabio |
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Ardissino, Gianluigi |
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10.1007/s00431-018-3087-0 |
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serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
| title_auth |
Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
| abstract |
Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. |
| abstractGer |
Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. |
| abstract_unstemmed |
Abstract It is well known that the nephron endowment of healthy subjects is highly variable and that individual nephron mass has potentially important implications both in health and disease. However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. Conclusion: The association between parental AH and high sCr during perinatal dehydration supports the hypothesis that the latter is a promising tool for identifying normal subjects with a reduced nephron mass with potential important implications in prevention and in understanding the individual outcome of renal and extrarenal diseases (including AH).What is Known:• Nephron endowment of healthy subjects is highly variable and individual nephron mass has potentially important implications both in health and disease however nephron count is not feasible in living subjects.What is New:• Serum creatinine during perinatal dehydration is a possible biomarker for identifying normal subjects with a reduced nephron mass. |
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Serum creatinine during physiological perinatal dehydration may estimate individual nephron endowment |
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Tel, Francesca Possenti, Ilaria Pavesi, Mariangela Perrone, Michela Forni, Giulia Salice, Patrizia Colombo, Lorenzo Ghirardello, Stefano Castiglione, Bianca Consonni, Dario Baca, Laura Vecchi, Daniela Li la Marca, Giancarlo Mosca, Fabio |
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Tel, Francesca Possenti, Ilaria Pavesi, Mariangela Perrone, Michela Forni, Giulia Salice, Patrizia Colombo, Lorenzo Ghirardello, Stefano Castiglione, Bianca Consonni, Dario Baca, Laura Vecchi, Daniela Li la Marca, Giancarlo Mosca, Fabio |
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10.1007/s00431-018-3087-0 |
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2024-07-03T18:51:20.203Z |
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However, nephron count is technically impossible in living subjects. Based on the observation of an increase in serum creatinine (sCr) in otherwise healthy newborns with solitary kidney during the physiological perinatal dehydration, we hypothesized that perinatal sCr might be helpful in identifying healthy subjects with a reduced nephron mass. In the framework of a study on blood pressure in babies (NeoNeph), sCr of normal Caucasian neonates was determined 48–96 h after birth and their association with a family history of arterial hypertension (AH) was analyzed. SCr was determined in 182 normal newborns (90 males) at a mean of 61 ± 8 h after birth (range 46–82). Newborns with paternal AH had a higher mean sCr (0.97 + 0.28 mg/dL) then newborns without paternal AH (0.73 + 0.28 mg/dL; p = 0.006). No differences in mean sCr were found in relation with mother or grandparent’s history of AH. 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