Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer
Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homolo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sanguedolce, Francesca [verfasserIn] Cormio, Antonella [verfasserIn] Massenio, Paolo [verfasserIn] Pedicillo, Maria C. [verfasserIn] Cagiano, Simona [verfasserIn] Fortunato, Francesca [verfasserIn] Calò, Beppe [verfasserIn] Di Fino, Giuseppe [verfasserIn] Carrieri, Giuseppe [verfasserIn] Bufo, Pantaleo [verfasserIn] Cormio, Luigi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of cancer research and clinical oncology - Berlin : Springer, 1904, 144(2018), 4 vom: 23. Jan., Seite 637-644 |
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| Übergeordnetes Werk: |
volume:144 ; year:2018 ; number:4 ; day:23 ; month:01 ; pages:637-644 |
| Links: |
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| DOI / URN: |
10.1007/s00432-018-2593-9 |
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| Katalog-ID: |
SPR00586335X |
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| 100 | 1 | |a Sanguedolce, Francesca |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
| 264 | 1 | |c 2018 | |
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| 337 | |a Computermedien |b c |2 rdamedia | ||
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| 520 | |a Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. | ||
| 650 | 4 | |a Non-muscle-invasive bladder cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a HER-2 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MLH1 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MSH2 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Immunohistochemistry |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prognosis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cormio, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Massenio, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Pedicillo, Maria C. |e verfasserin |4 aut | |
| 700 | 1 | |a Cagiano, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Fortunato, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Calò, Beppe |e verfasserin |4 aut | |
| 700 | 1 | |a Di Fino, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Carrieri, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Bufo, Pantaleo |e verfasserin |4 aut | |
| 700 | 1 | |a Cormio, Luigi |e verfasserin |4 aut | |
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10.1007/s00432-018-2593-9 doi (DE-627)SPR00586335X (SPR)s00432-018-2593-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Sanguedolce, Francesca verfasserin aut Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cormio, Antonella verfasserin aut Massenio, Paolo verfasserin aut Pedicillo, Maria C. verfasserin aut Cagiano, Simona verfasserin aut Fortunato, Francesca verfasserin aut Calò, Beppe verfasserin aut Di Fino, Giuseppe verfasserin aut Carrieri, Giuseppe verfasserin aut Bufo, Pantaleo verfasserin aut Cormio, Luigi verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 144(2018), 4 vom: 23. Jan., Seite 637-644 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:144 year:2018 number:4 day:23 month:01 pages:637-644 https://dx.doi.org/10.1007/s00432-018-2593-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 144 2018 4 23 01 637-644 |
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10.1007/s00432-018-2593-9 doi (DE-627)SPR00586335X (SPR)s00432-018-2593-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Sanguedolce, Francesca verfasserin aut Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cormio, Antonella verfasserin aut Massenio, Paolo verfasserin aut Pedicillo, Maria C. verfasserin aut Cagiano, Simona verfasserin aut Fortunato, Francesca verfasserin aut Calò, Beppe verfasserin aut Di Fino, Giuseppe verfasserin aut Carrieri, Giuseppe verfasserin aut Bufo, Pantaleo verfasserin aut Cormio, Luigi verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 144(2018), 4 vom: 23. Jan., Seite 637-644 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:144 year:2018 number:4 day:23 month:01 pages:637-644 https://dx.doi.org/10.1007/s00432-018-2593-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 144 2018 4 23 01 637-644 |
| allfields_unstemmed |
10.1007/s00432-018-2593-9 doi (DE-627)SPR00586335X (SPR)s00432-018-2593-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Sanguedolce, Francesca verfasserin aut Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cormio, Antonella verfasserin aut Massenio, Paolo verfasserin aut Pedicillo, Maria C. verfasserin aut Cagiano, Simona verfasserin aut Fortunato, Francesca verfasserin aut Calò, Beppe verfasserin aut Di Fino, Giuseppe verfasserin aut Carrieri, Giuseppe verfasserin aut Bufo, Pantaleo verfasserin aut Cormio, Luigi verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 144(2018), 4 vom: 23. Jan., Seite 637-644 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:144 year:2018 number:4 day:23 month:01 pages:637-644 https://dx.doi.org/10.1007/s00432-018-2593-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 144 2018 4 23 01 637-644 |
| allfieldsGer |
10.1007/s00432-018-2593-9 doi (DE-627)SPR00586335X (SPR)s00432-018-2593-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Sanguedolce, Francesca verfasserin aut Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cormio, Antonella verfasserin aut Massenio, Paolo verfasserin aut Pedicillo, Maria C. verfasserin aut Cagiano, Simona verfasserin aut Fortunato, Francesca verfasserin aut Calò, Beppe verfasserin aut Di Fino, Giuseppe verfasserin aut Carrieri, Giuseppe verfasserin aut Bufo, Pantaleo verfasserin aut Cormio, Luigi verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 144(2018), 4 vom: 23. Jan., Seite 637-644 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:144 year:2018 number:4 day:23 month:01 pages:637-644 https://dx.doi.org/10.1007/s00432-018-2593-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 144 2018 4 23 01 637-644 |
| allfieldsSound |
10.1007/s00432-018-2593-9 doi (DE-627)SPR00586335X (SPR)s00432-018-2593-9-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Sanguedolce, Francesca verfasserin aut Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 Cormio, Antonella verfasserin aut Massenio, Paolo verfasserin aut Pedicillo, Maria C. verfasserin aut Cagiano, Simona verfasserin aut Fortunato, Francesca verfasserin aut Calò, Beppe verfasserin aut Di Fino, Giuseppe verfasserin aut Carrieri, Giuseppe verfasserin aut Bufo, Pantaleo verfasserin aut Cormio, Luigi verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 144(2018), 4 vom: 23. Jan., Seite 637-644 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:144 year:2018 number:4 day:23 month:01 pages:637-644 https://dx.doi.org/10.1007/s00432-018-2593-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 144 2018 4 23 01 637-644 |
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Enthalten in Journal of cancer research and clinical oncology 144(2018), 4 vom: 23. Jan., Seite 637-644 volume:144 year:2018 number:4 day:23 month:01 pages:637-644 |
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Non-muscle-invasive bladder cancer HER-2 MLH1 MSH2 Immunohistochemistry Prognosis |
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Sanguedolce, Francesca @@aut@@ Cormio, Antonella @@aut@@ Massenio, Paolo @@aut@@ Pedicillo, Maria C. @@aut@@ Cagiano, Simona @@aut@@ Fortunato, Francesca @@aut@@ Calò, Beppe @@aut@@ Di Fino, Giuseppe @@aut@@ Carrieri, Giuseppe @@aut@@ Bufo, Pantaleo @@aut@@ Cormio, Luigi @@aut@@ |
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| author |
Sanguedolce, Francesca |
| spellingShingle |
Sanguedolce, Francesca ddc 610 bkl 44.81 misc Non-muscle-invasive bladder cancer misc HER-2 misc MLH1 misc MSH2 misc Immunohistochemistry misc Prognosis Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
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Sanguedolce, Francesca |
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610 - Medicine & health |
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1432-1335 |
| topic_title |
610 ASE 44.81 bkl Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer Non-muscle-invasive bladder cancer (dpeaa)DE-He213 HER-2 (dpeaa)DE-He213 MLH1 (dpeaa)DE-He213 MSH2 (dpeaa)DE-He213 Immunohistochemistry (dpeaa)DE-He213 Prognosis (dpeaa)DE-He213 |
| topic |
ddc 610 bkl 44.81 misc Non-muscle-invasive bladder cancer misc HER-2 misc MLH1 misc MSH2 misc Immunohistochemistry misc Prognosis |
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ddc 610 bkl 44.81 misc Non-muscle-invasive bladder cancer misc HER-2 misc MLH1 misc MSH2 misc Immunohistochemistry misc Prognosis |
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ddc 610 bkl 44.81 misc Non-muscle-invasive bladder cancer misc HER-2 misc MLH1 misc MSH2 misc Immunohistochemistry misc Prognosis |
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Elektronische Aufsätze Aufsätze Elektronische Ressource |
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Journal of cancer research and clinical oncology |
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610 - Medicine & health |
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Journal of cancer research and clinical oncology |
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(DE-627)253769515 (DE-600)1459285-X |
| title |
Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
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(DE-627)SPR00586335X (SPR)s00432-018-2593-9-e |
| title_full |
Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
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Sanguedolce, Francesca |
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Journal of cancer research and clinical oncology |
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Journal of cancer research and clinical oncology |
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eng |
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600 - Technology |
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2018 |
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637 |
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Sanguedolce, Francesca Cormio, Antonella Massenio, Paolo Pedicillo, Maria C. Cagiano, Simona Fortunato, Francesca Calò, Beppe Di Fino, Giuseppe Carrieri, Giuseppe Bufo, Pantaleo Cormio, Luigi |
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610 ASE 44.81 bkl |
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Elektronische Aufsätze |
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Sanguedolce, Francesca |
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10.1007/s00432-018-2593-9 |
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610 |
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verfasserin |
| title_sort |
altered expression of her-2 and the mismatch repair genes mlh1 and msh2 predicts the outcome of t1 high-grade bladder cancer |
| title_auth |
Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
| abstract |
Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. |
| abstractGer |
Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. |
| abstract_unstemmed |
Purpose The identification of factors predicting the outcome of stage T1 high-grade bladder cancer (BC) is a major clinical issue. Methods We performed immunohistochemistry to assess the role of human epidermal growth factor receptor-2 (HER-2) and microsatellite instability (MSI) factors MutL homologue 1 (MLH1) and MutS homologue 2 (MSH2) in predicting recurrence and progression of T1 high-grade BCs having undergone transurethral resection of bladder tumor (TURBT) alone or TURBT + intravesical instillations of bacillus Calmette–Guerin (BCG). Results HER-2 overexpression was a significant predictor of disease-free survival (DFS) in the overall as well as in the two patients’ population; as for progression-free survival (PFS), it was significant in the overall but not in the two patients’ population. MLH1 was an independent predictor of PFS only in patients treated with BCG and MSH2 failed to predict DFS and PFS in all populations. Most importantly, the higher the number of altered markers the lowers the DFS and PFS. In multivariate Cox proportional-hazards regression analysis, the number of altered molecular markers and BCG treatment were significant predictors (p = 0.0004 and 0.0283, respectively) of DFS, whereas the number of altered molecular markers was the only significant predictor (p = 0.0054) of PFS. Conclusions Altered expression of the proto-oncogene HER-2 and the two molecular markers of genetic instability MLH1 and MSH2 predicted T1 high-grade BC outcome with the higher the number of altered markers the lower the DFS and PFS. These findings provide grounds for further testing them in predicting the outcome of this challenging disease. |
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| title_short |
Altered expression of HER-2 and the mismatch repair genes MLH1 and MSH2 predicts the outcome of T1 high-grade bladder cancer |
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https://dx.doi.org/10.1007/s00432-018-2593-9 |
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Cormio, Antonella Massenio, Paolo Pedicillo, Maria C. Cagiano, Simona Fortunato, Francesca Calò, Beppe Di Fino, Giuseppe Carrieri, Giuseppe Bufo, Pantaleo Cormio, Luigi |
| author2Str |
Cormio, Antonella Massenio, Paolo Pedicillo, Maria C. Cagiano, Simona Fortunato, Francesca Calò, Beppe Di Fino, Giuseppe Carrieri, Giuseppe Bufo, Pantaleo Cormio, Luigi |
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10.1007/s00432-018-2593-9 |
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2024-07-03T19:14:03.775Z |
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| score |
7.4021854 |