Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma
Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lazaridis, Lazaros [verfasserIn] Schäfer, Niklas [verfasserIn] Teuber-Hanselmann, Sarah [verfasserIn] Blau, Tobias [verfasserIn] Schmidt, Teresa [verfasserIn] Oster, Christoph [verfasserIn] Weller, Johannes [verfasserIn] Tzaridis, Theophilos [verfasserIn] Pierscianek, Daniela [verfasserIn] Keyvani, Kathy [verfasserIn] Kleinschnitz, Christoph [verfasserIn] Stuschke, Martin [verfasserIn] Scheffler, Björn [verfasserIn] Deuschl, Cornelius [verfasserIn] Sure, Ulrich [verfasserIn] Herrlinger, Ulrich [verfasserIn] Kebir, Sied [verfasserIn] Glas, Martin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of cancer research and clinical oncology - Berlin : Springer, 1904, 146(2019), 3 vom: 11. Dez., Seite 787-792 |
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| Übergeordnetes Werk: |
volume:146 ; year:2019 ; number:3 ; day:11 ; month:12 ; pages:787-792 |
| Links: |
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| DOI / URN: |
10.1007/s00432-019-03106-8 |
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| Katalog-ID: |
SPR005867967 |
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| 245 | 1 | 0 | |a Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
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| 520 | |a Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. | ||
| 650 | 4 | |a Glioblastoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TTfields |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a EF-14 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NOA-09 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Temozolomide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lomustine |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Schäfer, Niklas |e verfasserin |4 aut | |
| 700 | 1 | |a Teuber-Hanselmann, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Blau, Tobias |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Oster, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Weller, Johannes |e verfasserin |4 aut | |
| 700 | 1 | |a Tzaridis, Theophilos |e verfasserin |4 aut | |
| 700 | 1 | |a Pierscianek, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Keyvani, Kathy |e verfasserin |4 aut | |
| 700 | 1 | |a Kleinschnitz, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Stuschke, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Scheffler, Björn |e verfasserin |4 aut | |
| 700 | 1 | |a Deuschl, Cornelius |e verfasserin |4 aut | |
| 700 | 1 | |a Sure, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Herrlinger, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Kebir, Sied |e verfasserin |4 aut | |
| 700 | 1 | |a Glas, Martin |e verfasserin |4 aut | |
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10.1007/s00432-019-03106-8 doi (DE-627)SPR005867967 (SPR)s00432-019-03106-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lazaridis, Lazaros verfasserin aut Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 Schäfer, Niklas verfasserin aut Teuber-Hanselmann, Sarah verfasserin aut Blau, Tobias verfasserin aut Schmidt, Teresa verfasserin aut Oster, Christoph verfasserin aut Weller, Johannes verfasserin aut Tzaridis, Theophilos verfasserin aut Pierscianek, Daniela verfasserin aut Keyvani, Kathy verfasserin aut Kleinschnitz, Christoph verfasserin aut Stuschke, Martin verfasserin aut Scheffler, Björn verfasserin aut Deuschl, Cornelius verfasserin aut Sure, Ulrich verfasserin aut Herrlinger, Ulrich verfasserin aut Kebir, Sied verfasserin aut Glas, Martin verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 146(2019), 3 vom: 11. Dez., Seite 787-792 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:146 year:2019 number:3 day:11 month:12 pages:787-792 https://dx.doi.org/10.1007/s00432-019-03106-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 146 2019 3 11 12 787-792 |
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10.1007/s00432-019-03106-8 doi (DE-627)SPR005867967 (SPR)s00432-019-03106-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lazaridis, Lazaros verfasserin aut Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 Schäfer, Niklas verfasserin aut Teuber-Hanselmann, Sarah verfasserin aut Blau, Tobias verfasserin aut Schmidt, Teresa verfasserin aut Oster, Christoph verfasserin aut Weller, Johannes verfasserin aut Tzaridis, Theophilos verfasserin aut Pierscianek, Daniela verfasserin aut Keyvani, Kathy verfasserin aut Kleinschnitz, Christoph verfasserin aut Stuschke, Martin verfasserin aut Scheffler, Björn verfasserin aut Deuschl, Cornelius verfasserin aut Sure, Ulrich verfasserin aut Herrlinger, Ulrich verfasserin aut Kebir, Sied verfasserin aut Glas, Martin verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 146(2019), 3 vom: 11. Dez., Seite 787-792 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:146 year:2019 number:3 day:11 month:12 pages:787-792 https://dx.doi.org/10.1007/s00432-019-03106-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 146 2019 3 11 12 787-792 |
| allfields_unstemmed |
10.1007/s00432-019-03106-8 doi (DE-627)SPR005867967 (SPR)s00432-019-03106-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lazaridis, Lazaros verfasserin aut Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 Schäfer, Niklas verfasserin aut Teuber-Hanselmann, Sarah verfasserin aut Blau, Tobias verfasserin aut Schmidt, Teresa verfasserin aut Oster, Christoph verfasserin aut Weller, Johannes verfasserin aut Tzaridis, Theophilos verfasserin aut Pierscianek, Daniela verfasserin aut Keyvani, Kathy verfasserin aut Kleinschnitz, Christoph verfasserin aut Stuschke, Martin verfasserin aut Scheffler, Björn verfasserin aut Deuschl, Cornelius verfasserin aut Sure, Ulrich verfasserin aut Herrlinger, Ulrich verfasserin aut Kebir, Sied verfasserin aut Glas, Martin verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 146(2019), 3 vom: 11. Dez., Seite 787-792 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:146 year:2019 number:3 day:11 month:12 pages:787-792 https://dx.doi.org/10.1007/s00432-019-03106-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 146 2019 3 11 12 787-792 |
| allfieldsGer |
10.1007/s00432-019-03106-8 doi (DE-627)SPR005867967 (SPR)s00432-019-03106-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lazaridis, Lazaros verfasserin aut Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 Schäfer, Niklas verfasserin aut Teuber-Hanselmann, Sarah verfasserin aut Blau, Tobias verfasserin aut Schmidt, Teresa verfasserin aut Oster, Christoph verfasserin aut Weller, Johannes verfasserin aut Tzaridis, Theophilos verfasserin aut Pierscianek, Daniela verfasserin aut Keyvani, Kathy verfasserin aut Kleinschnitz, Christoph verfasserin aut Stuschke, Martin verfasserin aut Scheffler, Björn verfasserin aut Deuschl, Cornelius verfasserin aut Sure, Ulrich verfasserin aut Herrlinger, Ulrich verfasserin aut Kebir, Sied verfasserin aut Glas, Martin verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 146(2019), 3 vom: 11. Dez., Seite 787-792 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:146 year:2019 number:3 day:11 month:12 pages:787-792 https://dx.doi.org/10.1007/s00432-019-03106-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 146 2019 3 11 12 787-792 |
| allfieldsSound |
10.1007/s00432-019-03106-8 doi (DE-627)SPR005867967 (SPR)s00432-019-03106-8-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Lazaridis, Lazaros verfasserin aut Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 Schäfer, Niklas verfasserin aut Teuber-Hanselmann, Sarah verfasserin aut Blau, Tobias verfasserin aut Schmidt, Teresa verfasserin aut Oster, Christoph verfasserin aut Weller, Johannes verfasserin aut Tzaridis, Theophilos verfasserin aut Pierscianek, Daniela verfasserin aut Keyvani, Kathy verfasserin aut Kleinschnitz, Christoph verfasserin aut Stuschke, Martin verfasserin aut Scheffler, Björn verfasserin aut Deuschl, Cornelius verfasserin aut Sure, Ulrich verfasserin aut Herrlinger, Ulrich verfasserin aut Kebir, Sied verfasserin aut Glas, Martin verfasserin aut Enthalten in Journal of cancer research and clinical oncology Berlin : Springer, 1904 146(2019), 3 vom: 11. Dez., Seite 787-792 (DE-627)253769515 (DE-600)1459285-X 1432-1335 nnns volume:146 year:2019 number:3 day:11 month:12 pages:787-792 https://dx.doi.org/10.1007/s00432-019-03106-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 146 2019 3 11 12 787-792 |
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Enthalten in Journal of cancer research and clinical oncology 146(2019), 3 vom: 11. Dez., Seite 787-792 volume:146 year:2019 number:3 day:11 month:12 pages:787-792 |
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Lazaridis, Lazaros @@aut@@ Schäfer, Niklas @@aut@@ Teuber-Hanselmann, Sarah @@aut@@ Blau, Tobias @@aut@@ Schmidt, Teresa @@aut@@ Oster, Christoph @@aut@@ Weller, Johannes @@aut@@ Tzaridis, Theophilos @@aut@@ Pierscianek, Daniela @@aut@@ Keyvani, Kathy @@aut@@ Kleinschnitz, Christoph @@aut@@ Stuschke, Martin @@aut@@ Scheffler, Björn @@aut@@ Deuschl, Cornelius @@aut@@ Sure, Ulrich @@aut@@ Herrlinger, Ulrich @@aut@@ Kebir, Sied @@aut@@ Glas, Martin @@aut@@ |
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In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. 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| author |
Lazaridis, Lazaros |
| spellingShingle |
Lazaridis, Lazaros ddc 610 bkl 44.81 misc Glioblastoma misc TTfields misc EF-14 misc NOA-09 misc Temozolomide misc Lomustine Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
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1432-1335 |
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610 ASE 44.81 bkl Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma Glioblastoma (dpeaa)DE-He213 TTfields (dpeaa)DE-He213 EF-14 (dpeaa)DE-He213 NOA-09 (dpeaa)DE-He213 Temozolomide (dpeaa)DE-He213 Lomustine (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Glioblastoma misc TTfields misc EF-14 misc NOA-09 misc Temozolomide misc Lomustine |
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ddc 610 bkl 44.81 misc Glioblastoma misc TTfields misc EF-14 misc NOA-09 misc Temozolomide misc Lomustine |
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ddc 610 bkl 44.81 misc Glioblastoma misc TTfields misc EF-14 misc NOA-09 misc Temozolomide misc Lomustine |
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Journal of cancer research and clinical oncology |
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610 - Medicine & health |
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Journal of cancer research and clinical oncology |
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Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
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(DE-627)SPR005867967 (SPR)s00432-019-03106-8-e |
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Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
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Lazaridis, Lazaros |
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Journal of cancer research and clinical oncology |
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Journal of cancer research and clinical oncology |
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eng |
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600 - Technology |
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2019 |
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Lazaridis, Lazaros Schäfer, Niklas Teuber-Hanselmann, Sarah Blau, Tobias Schmidt, Teresa Oster, Christoph Weller, Johannes Tzaridis, Theophilos Pierscianek, Daniela Keyvani, Kathy Kleinschnitz, Christoph Stuschke, Martin Scheffler, Björn Deuschl, Cornelius Sure, Ulrich Herrlinger, Ulrich Kebir, Sied Glas, Martin |
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610 ASE 44.81 bkl |
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Lazaridis, Lazaros |
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10.1007/s00432-019-03106-8 |
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610 |
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verfasserin |
| title_sort |
tumour treating fields (ttfields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
| title_auth |
Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
| abstract |
Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. |
| abstractGer |
Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. |
| abstract_unstemmed |
Purpose In the EF-14 trial for newly diagnosed glioblastoma (ndGBM) patients addition of Tumour Treating Fields (TTFields) to temozolomide treatment resulted in a significantly improved overall survival (OS). In the NOA-09/CeTeG trial, combination of lomustine and temozolomide was superior to temozolomide monotherapy in patients with O6-methylguanine DNA methyltransferase (MGMT) promoter methylated (MGMTm) ndGBM. We evaluated combination of these two treatment modalities in patients with MGMTm ndGBM. There have been so far no data on the combination of these two efficient regimens. Methods This bicentric retrospective analysis investigated 16 patients. Parameters evaluated included safety outcome as measured by Common Toxicity Criteria for Adverse Events (CTCAE), clinical outcomes, and compliance to treatment. Results Hematologic adverse events CTCAE ≥ 3 were observed in seven, hepatotoxic adverse events of CTCAE ≥ 3 in four patients. Mild to moderate skin toxicity was detected in six patients. At data cutoff, patients demonstrated a median progression-free survival (PFS) of 20 months. The usage rate of TTFields showed a high median adherence (83%) to the therapy. Conclusions This analysis provides first indication that the combination of TTFields/lomustine/temozolomide is safe and feasible. The observed survival outcomes might suggest potential beneficial effects. |
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Tumour Treating Fields (TTFields) in combination with lomustine and temozolomide in patients with newly diagnosed glioblastoma |
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https://dx.doi.org/10.1007/s00432-019-03106-8 |
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Schäfer, Niklas Teuber-Hanselmann, Sarah Blau, Tobias Schmidt, Teresa Oster, Christoph Weller, Johannes Tzaridis, Theophilos Pierscianek, Daniela Keyvani, Kathy Kleinschnitz, Christoph Stuschke, Martin Scheffler, Björn Deuschl, Cornelius Sure, Ulrich Herrlinger, Ulrich Kebir, Sied Glas, Martin |
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Schäfer, Niklas Teuber-Hanselmann, Sarah Blau, Tobias Schmidt, Teresa Oster, Christoph Weller, Johannes Tzaridis, Theophilos Pierscianek, Daniela Keyvani, Kathy Kleinschnitz, Christoph Stuschke, Martin Scheffler, Björn Deuschl, Cornelius Sure, Ulrich Herrlinger, Ulrich Kebir, Sied Glas, Martin |
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| doi_str |
10.1007/s00432-019-03106-8 |
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2024-07-03T19:16:25.607Z |
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| score |
7.3984118 |