Laparoscopic vs conventional bowel resection in the rat

Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in ra...
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Autor*in:	Bouvy, N. D. [verfasserIn] Marquet, R. L. [verfasserIn] Tseng, L. N. L. [verfasserIn] Steyerberg, E. W. [verfasserIn] Lamberts, S. W. J. [verfasserIn] Jeekel, H. [verfasserIn] Bonjer, H. J. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1998

Übergeordnetes Werk:	Enthalten in: Surgical endoscopy and other interventional techniques - New York, NY : Springer, 1987, 12(1998), 5 vom: Mai, Seite 412-415
Übergeordnetes Werk:	volume:12 ; year:1998 ; number:5 ; month:05 ; pages:412-415

Links:	Volltext

DOI / URN:	10.1007/s004649900693

Katalog-ID:	SPR006229824

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245	1	0	\|a Laparoscopic vs conventional bowel resection in the rat
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520			\|a Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery.
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700	1		\|a Jeekel, H. \|e verfasserin \|4 aut
700	1		\|a Bonjer, H. J. \|e verfasserin \|4 aut
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allfields	10.1007/s004649900693 doi (DE-627)SPR006229824 (SPR)s004649900693-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bouvy, N. D. verfasserin aut Laparoscopic vs conventional bowel resection in the rat 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery. Marquet, R. L. verfasserin aut Tseng, L. N. L. verfasserin aut Steyerberg, E. W. verfasserin aut Lamberts, S. W. J. verfasserin aut Jeekel, H. verfasserin aut Bonjer, H. J. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 5 vom: Mai, Seite 412-415 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:5 month:05 pages:412-415 https://dx.doi.org/10.1007/s004649900693 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 5 05 412-415
spelling	10.1007/s004649900693 doi (DE-627)SPR006229824 (SPR)s004649900693-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bouvy, N. D. verfasserin aut Laparoscopic vs conventional bowel resection in the rat 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery. Marquet, R. L. verfasserin aut Tseng, L. N. L. verfasserin aut Steyerberg, E. W. verfasserin aut Lamberts, S. W. J. verfasserin aut Jeekel, H. verfasserin aut Bonjer, H. J. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 5 vom: Mai, Seite 412-415 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:5 month:05 pages:412-415 https://dx.doi.org/10.1007/s004649900693 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 5 05 412-415
allfields_unstemmed	10.1007/s004649900693 doi (DE-627)SPR006229824 (SPR)s004649900693-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bouvy, N. D. verfasserin aut Laparoscopic vs conventional bowel resection in the rat 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery. Marquet, R. L. verfasserin aut Tseng, L. N. L. verfasserin aut Steyerberg, E. W. verfasserin aut Lamberts, S. W. J. verfasserin aut Jeekel, H. verfasserin aut Bonjer, H. J. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 5 vom: Mai, Seite 412-415 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:5 month:05 pages:412-415 https://dx.doi.org/10.1007/s004649900693 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 5 05 412-415
allfieldsGer	10.1007/s004649900693 doi (DE-627)SPR006229824 (SPR)s004649900693-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bouvy, N. D. verfasserin aut Laparoscopic vs conventional bowel resection in the rat 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery. Marquet, R. L. verfasserin aut Tseng, L. N. L. verfasserin aut Steyerberg, E. W. verfasserin aut Lamberts, S. W. J. verfasserin aut Jeekel, H. verfasserin aut Bonjer, H. J. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 5 vom: Mai, Seite 412-415 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:5 month:05 pages:412-415 https://dx.doi.org/10.1007/s004649900693 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 5 05 412-415
allfieldsSound	10.1007/s004649900693 doi (DE-627)SPR006229824 (SPR)s004649900693-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bouvy, N. D. verfasserin aut Laparoscopic vs conventional bowel resection in the rat 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery. Marquet, R. L. verfasserin aut Tseng, L. N. L. verfasserin aut Steyerberg, E. W. verfasserin aut Lamberts, S. W. J. verfasserin aut Jeekel, H. verfasserin aut Bonjer, H. J. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 5 vom: Mai, Seite 412-415 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:5 month:05 pages:412-415 https://dx.doi.org/10.1007/s004649900693 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 5 05 412-415
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source	Enthalten in Surgical endoscopy and other interventional techniques 12(1998), 5 vom: Mai, Seite 412-415 volume:12 year:1998 number:5 month:05 pages:412-415
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authorswithroles_txt_mv	Bouvy, N. D. @@aut@@ Marquet, R. L. @@aut@@ Tseng, L. N. L. @@aut@@ Steyerberg, E. W. @@aut@@ Lamberts, S. W. J. @@aut@@ Jeekel, H. @@aut@@ Bonjer, H. J. @@aut@@
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D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Laparoscopic vs conventional bowel resection in the rat</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">1998</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). 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author	Bouvy, N. D.
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topic_title	610 ASE 44.87 bkl Laparoscopic vs conventional bowel resection in the rat
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title	Laparoscopic vs conventional bowel resection in the rat
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title_full	Laparoscopic vs conventional bowel resection in the rat
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title_sort	laparoscopic vs conventional bowel resection in the rat
title_auth	Laparoscopic vs conventional bowel resection in the rat
abstract	Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery.
abstractGer	Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery.
abstract_unstemmed	Abstract Background: The role of laparoscopic surgery in the treatment of colorectal disease is still controversial. To assess the metabolic consequences of laparoscopic and open bowel surgery, we studied serum levels of insulin-like growth factor 1 (IGF-1), an anabolic and mitogeneic peptide, in rats. Materials and methods: In experiment 1, the serum IGF-1 levels of 10 rats undergoing laparoscopic small bowel resections (group I) and 10 rats undergoing conventional small bowel resections (group II) were determined before surgery and on days 1, 2, and 7. Experiment 2 compared five rats that had $ CO_{2} $ pneumoperitoneum (group III), five rats that underwent laparotomy (group IV), and five rats that received anesthesia only (group V). Differences in IGF-1 levels were tested with analysis of covariance. Results: In experiment 1, preoperative IGF-1 levels were similar in groups I and II (87.9 ± 6.1 nmol/L versus 90.5 ± 8.1 nmol/L). One day after surgery IGF-1 was 54.6 ± 10.5 in group I versus 41.6 ± 8.3 in group II (p= 0.006). Two days after surgery, IGF-1 was 79.4 ± 9.2 in group I versus 59.0 ± 10.5 in group II (p < 0.001). Seven days after both types of surgery, IGF-1 levels had returned to almost normal levels. In experiment 2, no significant differences were found between the rats with $ CO_{2} $ pneumoperitoneum (group III) and those with laparotomy only (group IV). Rats that had anaesthesia only showed a significant decrease in IGF-1 levels between days 0 and 1 (p < 0.018). Conclusion: Our study indicates that laparoscopic bowel surgery is associated with a better postoperative anabolic state (i.e., less catabolism) than conventional surgery. This finding reflects a potential benefit of laparoscopy in bowel surgery.
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title_short	Laparoscopic vs conventional bowel resection in the rat
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