Alterations in hepatic function during laparoscopic surgery

Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum o...
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Autor*in:	Morino, M. [verfasserIn] Giraudo, G. [verfasserIn] Festa, V. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1998

Übergeordnetes Werk:	Enthalten in: Surgical endoscopy and other interventional techniques - New York, NY : Springer, 1987, 12(1998), 7 vom: Juli, Seite 968-972
Übergeordnetes Werk:	volume:12 ; year:1998 ; number:7 ; month:07 ; pages:968-972

Links:	Volltext

DOI / URN:	10.1007/s004649900758

Katalog-ID:	SPR006230296

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520			\|a Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures.
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allfields	10.1007/s004649900758 doi (DE-627)SPR006230296 (SPR)s004649900758-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Morino, M. verfasserin aut Alterations in hepatic function during laparoscopic surgery 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures. Giraudo, G. verfasserin aut Festa, V. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 7 vom: Juli, Seite 968-972 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:7 month:07 pages:968-972 https://dx.doi.org/10.1007/s004649900758 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 7 07 968-972
spelling	10.1007/s004649900758 doi (DE-627)SPR006230296 (SPR)s004649900758-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Morino, M. verfasserin aut Alterations in hepatic function during laparoscopic surgery 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures. Giraudo, G. verfasserin aut Festa, V. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 7 vom: Juli, Seite 968-972 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:7 month:07 pages:968-972 https://dx.doi.org/10.1007/s004649900758 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 7 07 968-972
allfields_unstemmed	10.1007/s004649900758 doi (DE-627)SPR006230296 (SPR)s004649900758-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Morino, M. verfasserin aut Alterations in hepatic function during laparoscopic surgery 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures. Giraudo, G. verfasserin aut Festa, V. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 7 vom: Juli, Seite 968-972 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:7 month:07 pages:968-972 https://dx.doi.org/10.1007/s004649900758 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 7 07 968-972
allfieldsGer	10.1007/s004649900758 doi (DE-627)SPR006230296 (SPR)s004649900758-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Morino, M. verfasserin aut Alterations in hepatic function during laparoscopic surgery 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures. Giraudo, G. verfasserin aut Festa, V. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 7 vom: Juli, Seite 968-972 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:7 month:07 pages:968-972 https://dx.doi.org/10.1007/s004649900758 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 7 07 968-972
allfieldsSound	10.1007/s004649900758 doi (DE-627)SPR006230296 (SPR)s004649900758-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Morino, M. verfasserin aut Alterations in hepatic function during laparoscopic surgery 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures. Giraudo, G. verfasserin aut Festa, V. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 12(1998), 7 vom: Juli, Seite 968-972 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:12 year:1998 number:7 month:07 pages:968-972 https://dx.doi.org/10.1007/s004649900758 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_120 GBV_ILN_121 GBV_ILN_150 GBV_ILN_267 GBV_ILN_374 GBV_ILN_711 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_2088 GBV_ILN_2118 GBV_ILN_2188 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2472 GBV_ILN_4125 GBV_ILN_4246 GBV_ILN_4305 GBV_ILN_4700 44.87 ASE AR 12 1998 7 07 968-972
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At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. 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title	Alterations in hepatic function during laparoscopic surgery
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title_sort	alterations in hepatic function during laparoscopic surgery
title_auth	Alterations in hepatic function during laparoscopic surgery
abstract	Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures.
abstractGer	Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures.
abstract_unstemmed	Abstract Background: Very few studies have been done on the consequences of pneumoperitoneum on hepatic function. At present, there is no consensus on the physiopathological hepatic implications of pneumoperitoneum. The purpose of this clinical study was to evaluate the effects of pneumoperitoneum on hepatic function in 52 patients treated with laparoscopic procedures. Methods: Thirty-two laparoscopic cholecystectomies and 20 nonhepatobiliary laparoscopic procedures were performed in 52 patients (12 men and 40 women) with a mean age of 44 years (range, 15–74). All patients had normal values on preoperative liver function tests. The anesthesiologic protocol was uniform, with drugs at low hepatic metabolism. The 32 cholecystectomies were randomized into 22 performed with pneumoperitoneum at 14 mmHg and 10 performed at 10 mmHg. All nonhepatobiliary laparoscopic procedures were performed with a pneumoperitoneum of 14 mmHg. The postoperative serologic levels of AST, ALT, bilirubin, and prothrombin time were measured at 6, 24, 48, and 72 h. The serologic changes were related to the procedure, the duration, and the level of pneumoperitoneum. Results: Mortality and morbidity were nil. All 52 patients had a postoperative increase in AST, ALT, bilirubin, and lengthening in prothrombin time. Slow return to normality occurred 48 or 72 h after operation. The increase of AST and ALT was statistically significant and correlated both to the level (10 versus 14 mmHg) and the duration of pneumoperitoneum. Conclusions: The duration and level of intraabdominal pressure are responsible for changes of hepatic function during laparoscopic procedures. Although no symptom appears in patients with normal hepatic function, patients with severe hepatic failure should probably not be subjected to prolonged laparoscopic procedures.
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title_short	Alterations in hepatic function during laparoscopic surgery
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