Immunologic postoperative competence after laparoscopy versus laparotomy

Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From...
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Gespeichert in:

Autor*in:	Bolla, G. [verfasserIn] Tuzzato, G. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2003

Schlagwörter:	Immunological competence Laparoscopy Laparotomy

Übergeordnetes Werk:	Enthalten in: Surgical endoscopy and other interventional techniques - New York, NY : Springer, 1987, 17(2003), 8 vom: 13. Juni, Seite 1247-1250
Übergeordnetes Werk:	volume:17 ; year:2003 ; number:8 ; day:13 ; month:06 ; pages:1247-1250

Links:	Volltext

DOI / URN:	10.1007/s00464-002-9135-9

Katalog-ID:	SPR006248004

Internformat


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245	1	0	\|a Immunologic postoperative competence after laparoscopy versus laparotomy
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520			\|a Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy.
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773	0	8	\|i Enthalten in \|t Surgical endoscopy and other interventional techniques \|d New York, NY : Springer, 1987 \|g 17(2003), 8 vom: 13. Juni, Seite 1247-1250 \|w (DE-627)254909620 \|w (DE-600)1463171-4 \|x 1432-2218 \|7 nnns
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912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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Indexfelder

author_variant	g b gb g t gt
matchkey_str	article:14322218:2003----::muooipsoeaieoptnefelprso
hierarchy_sort_str	2003
bklnumber	44.87
publishDate	2003
allfields	10.1007/s00464-002-9135-9 doi (DE-627)SPR006248004 (SPR)s00464-002-9135-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bolla, G. verfasserin aut Immunologic postoperative competence after laparoscopy versus laparotomy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy. Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213 Tuzzato, G. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 17(2003), 8 vom: 13. Juni, Seite 1247-1250 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250 https://dx.doi.org/10.1007/s00464-002-9135-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 17 2003 8 13 06 1247-1250
spelling	10.1007/s00464-002-9135-9 doi (DE-627)SPR006248004 (SPR)s00464-002-9135-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bolla, G. verfasserin aut Immunologic postoperative competence after laparoscopy versus laparotomy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy. Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213 Tuzzato, G. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 17(2003), 8 vom: 13. Juni, Seite 1247-1250 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250 https://dx.doi.org/10.1007/s00464-002-9135-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 17 2003 8 13 06 1247-1250
allfields_unstemmed	10.1007/s00464-002-9135-9 doi (DE-627)SPR006248004 (SPR)s00464-002-9135-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bolla, G. verfasserin aut Immunologic postoperative competence after laparoscopy versus laparotomy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy. Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213 Tuzzato, G. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 17(2003), 8 vom: 13. Juni, Seite 1247-1250 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250 https://dx.doi.org/10.1007/s00464-002-9135-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 17 2003 8 13 06 1247-1250
allfieldsGer	10.1007/s00464-002-9135-9 doi (DE-627)SPR006248004 (SPR)s00464-002-9135-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bolla, G. verfasserin aut Immunologic postoperative competence after laparoscopy versus laparotomy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy. Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213 Tuzzato, G. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 17(2003), 8 vom: 13. Juni, Seite 1247-1250 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250 https://dx.doi.org/10.1007/s00464-002-9135-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 17 2003 8 13 06 1247-1250
allfieldsSound	10.1007/s00464-002-9135-9 doi (DE-627)SPR006248004 (SPR)s00464-002-9135-9-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Bolla, G. verfasserin aut Immunologic postoperative competence after laparoscopy versus laparotomy 2003 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy. Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213 Tuzzato, G. verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 17(2003), 8 vom: 13. Juni, Seite 1247-1250 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250 https://dx.doi.org/10.1007/s00464-002-9135-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 17 2003 8 13 06 1247-1250
language	English
source	Enthalten in Surgical endoscopy and other interventional techniques 17(2003), 8 vom: 13. Juni, Seite 1247-1250 volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250
sourceStr	Enthalten in Surgical endoscopy and other interventional techniques 17(2003), 8 vom: 13. Juni, Seite 1247-1250 volume:17 year:2003 number:8 day:13 month:06 pages:1247-1250
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immunological competence Laparoscopy Laparotomy
dewey-raw	610
isfreeaccess_bool	false
container_title	Surgical endoscopy and other interventional techniques
authorswithroles_txt_mv	Bolla, G. @@aut@@ Tuzzato, G. @@aut@@
publishDateDaySort_date	2003-06-13T00:00:00Z
hierarchy_top_id	254909620
dewey-sort	3610
id	SPR006248004
language_de	englisch
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Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. 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author	Bolla, G.
spellingShingle	Bolla, G. ddc 610 bkl 44.87 misc Immunological competence misc Laparoscopy misc Laparotomy Immunologic postoperative competence after laparoscopy versus laparotomy
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topic_title	610 ASE 44.87 bkl Immunologic postoperative competence after laparoscopy versus laparotomy Immunological competence (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Laparotomy (dpeaa)DE-He213
topic	ddc 610 bkl 44.87 misc Immunological competence misc Laparoscopy misc Laparotomy
topic_unstemmed	ddc 610 bkl 44.87 misc Immunological competence misc Laparoscopy misc Laparotomy
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title	Immunologic postoperative competence after laparoscopy versus laparotomy
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title_full	Immunologic postoperative competence after laparoscopy versus laparotomy
author_sort	Bolla, G.
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author_browse	Bolla, G. Tuzzato, G.
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title_sort	immunologic postoperative competence after laparoscopy versus laparotomy
title_auth	Immunologic postoperative competence after laparoscopy versus laparotomy
abstract	Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy.
abstractGer	Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy.
abstract_unstemmed	Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy.
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title_short	Immunologic postoperative competence after laparoscopy versus laparotomy
url	https://dx.doi.org/10.1007/s00464-002-9135-9
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up_date	2024-07-03T21:45:58.104Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR006248004</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519091716.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201002s2003 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00464-002-9135-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR006248004</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00464-002-9135-9-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">ASE</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.87</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bolla, G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Immunologic postoperative competence after laparoscopy versus laparotomy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2003</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background: Sepsis is a major complication associated with increased morbidity and mortality in patients treated surgically for hepatobiliary and colorectal diseases. Impairment of immune function after surgery may be one of the mechanisms causing increased susceptibility to infection. From November 1999 to October 2001, the perioperative and postoperative immune responses of 20 patients who underwent laparoscopy were compared with those of 20 patients who underwent laparotomy. All the patients were affected by benign pathologies. The current study aimed to elucidate the differences between the immune responses induced by the two different surgical approaches. Methods: Immunologic function was assessed by a count of lymphocyte subsets (CD3, CD4, CD8, CD3-HLA-DR, CD19, CD16, CD57) and monocytes expressing human leukocyte antigen DR (HLA-DR). Blood samples were obtained 1 day before the surgical therapy, then 2 and 8 days after therapy. For statistical analysis, the continuous variables were compared using Student’s t-test. Probability values less than 0.05 were considered significant. Results: With regard to T-lymphocyte function, a fall 2 days after surgery was assessed for both laparoscopy (p < 0.0005) and laprotomy (p < 0.00003) groups. At 8 days after surgery, these values had returned to the preoperative level on both groups. The activity of B-cells and natural killer cells was not significantly affected, whereas the number of monocytes expressing HLA-DR showed a long-lasting decrease after laparotomy (p < 0.011 2 days after surgery and p < 0.02 8 days after surgery), but not after laparoscopy. Conclusion: Impairment of cell-mediated immune function after surgery was demonstrated especially in patients treated by laparotomy, as compared with those treated by laparoscopy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunological competence</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Laparoscopy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Laparotomy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tuzzato, G.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Surgical endoscopy and other interventional techniques</subfield><subfield code="d">New York, NY : Springer, 1987</subfield><subfield code="g">17(2003), 8 vom: 13. Juni, Seite 1247-1250</subfield><subfield code="w">(DE-627)254909620</subfield><subfield code="w">(DE-600)1463171-4</subfield><subfield code="x">1432-2218</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:17</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:8</subfield><subfield code="g">day:13</subfield><subfield code="g">month:06</subfield><subfield code="g">pages:1247-1250</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1007/s00464-002-9135-9</subfield><subfield code="z">lizenzpflichtig</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield 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Immunologic postoperative competence after laparoscopy versus laparotomy

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