Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model

Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum ve...
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Autor*in:	Amin, Anwar Tawfik [verfasserIn] Shiraishi, Norio [verfasserIn] Ninomiya, Shigeo [verfasserIn] Tajima, Masaaki [verfasserIn] Inomata, Masafumi [verfasserIn] Kitano, Seigo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	EGFR Laparoscopy Microscopic residual cancer Neoadjuvant chemotherapy Pneumoperitoneum Survivin

Übergeordnetes Werk:	Enthalten in: Surgical endoscopy and other interventional techniques - New York, NY : Springer, 1987, 24(2009), 6 vom: 30. Dez., Seite 1427-1433
Übergeordnetes Werk:	volume:24 ; year:2009 ; number:6 ; day:30 ; month:12 ; pages:1427-1433

Links:	Volltext

DOI / URN:	10.1007/s00464-009-0793-8

Katalog-ID:	SPR006283985

Internformat


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245	1	0	\|a Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
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520			\|a Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer.
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650		4	\|a Laparoscopy \|7 (dpeaa)DE-He213
650		4	\|a Microscopic residual cancer \|7 (dpeaa)DE-He213
650		4	\|a Neoadjuvant chemotherapy \|7 (dpeaa)DE-He213
650		4	\|a Pneumoperitoneum \|7 (dpeaa)DE-He213
650		4	\|a Survivin \|7 (dpeaa)DE-He213
700	1		\|a Shiraishi, Norio \|e verfasserin \|4 aut
700	1		\|a Ninomiya, Shigeo \|e verfasserin \|4 aut
700	1		\|a Tajima, Masaaki \|e verfasserin \|4 aut
700	1		\|a Inomata, Masafumi \|e verfasserin \|4 aut
700	1		\|a Kitano, Seigo \|e verfasserin \|4 aut
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912			\|a GBV_ILN_120
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912			\|a GBV_ILN_150
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912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_267
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
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912			\|a GBV_ILN_2108
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912			\|a GBV_ILN_4305
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912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
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Indexfelder

author_variant	a t a at ata n s ns s n sn m t mt m i mi s k sk
matchkey_str	article:14322218:2009----::nraemnepesooeiemlrwhatreetruaeiemleetrnsriiihmnaticneatrhsriasrsolprtm
hierarchy_sort_str	2009
bklnumber	44.87
publishDate	2009
allfields	10.1007/s00464-009-0793-8 doi (DE-627)SPR006283985 (SPR)s00464-009-0793-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Amin, Anwar Tawfik verfasserin aut Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer. EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213 Shiraishi, Norio verfasserin aut Ninomiya, Shigeo verfasserin aut Tajima, Masaaki verfasserin aut Inomata, Masafumi verfasserin aut Kitano, Seigo verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 24(2009), 6 vom: 30. Dez., Seite 1427-1433 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433 https://dx.doi.org/10.1007/s00464-009-0793-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 24 2009 6 30 12 1427-1433
spelling	10.1007/s00464-009-0793-8 doi (DE-627)SPR006283985 (SPR)s00464-009-0793-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Amin, Anwar Tawfik verfasserin aut Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer. EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213 Shiraishi, Norio verfasserin aut Ninomiya, Shigeo verfasserin aut Tajima, Masaaki verfasserin aut Inomata, Masafumi verfasserin aut Kitano, Seigo verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 24(2009), 6 vom: 30. Dez., Seite 1427-1433 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433 https://dx.doi.org/10.1007/s00464-009-0793-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 24 2009 6 30 12 1427-1433
allfields_unstemmed	10.1007/s00464-009-0793-8 doi (DE-627)SPR006283985 (SPR)s00464-009-0793-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Amin, Anwar Tawfik verfasserin aut Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer. EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213 Shiraishi, Norio verfasserin aut Ninomiya, Shigeo verfasserin aut Tajima, Masaaki verfasserin aut Inomata, Masafumi verfasserin aut Kitano, Seigo verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 24(2009), 6 vom: 30. Dez., Seite 1427-1433 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433 https://dx.doi.org/10.1007/s00464-009-0793-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 24 2009 6 30 12 1427-1433
allfieldsGer	10.1007/s00464-009-0793-8 doi (DE-627)SPR006283985 (SPR)s00464-009-0793-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Amin, Anwar Tawfik verfasserin aut Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer. EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213 Shiraishi, Norio verfasserin aut Ninomiya, Shigeo verfasserin aut Tajima, Masaaki verfasserin aut Inomata, Masafumi verfasserin aut Kitano, Seigo verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 24(2009), 6 vom: 30. Dez., Seite 1427-1433 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433 https://dx.doi.org/10.1007/s00464-009-0793-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 24 2009 6 30 12 1427-1433
allfieldsSound	10.1007/s00464-009-0793-8 doi (DE-627)SPR006283985 (SPR)s00464-009-0793-8-e DE-627 ger DE-627 rakwb eng 610 ASE 610 ASE 44.87 bkl Amin, Anwar Tawfik verfasserin aut Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer. EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213 Shiraishi, Norio verfasserin aut Ninomiya, Shigeo verfasserin aut Tajima, Masaaki verfasserin aut Inomata, Masafumi verfasserin aut Kitano, Seigo verfasserin aut Enthalten in Surgical endoscopy and other interventional techniques New York, NY : Springer, 1987 24(2009), 6 vom: 30. Dez., Seite 1427-1433 (DE-627)254909620 (DE-600)1463171-4 1432-2218 nnns volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433 https://dx.doi.org/10.1007/s00464-009-0793-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.87 ASE AR 24 2009 6 30 12 1427-1433
language	English
source	Enthalten in Surgical endoscopy and other interventional techniques 24(2009), 6 vom: 30. Dez., Seite 1427-1433 volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433
sourceStr	Enthalten in Surgical endoscopy and other interventional techniques 24(2009), 6 vom: 30. Dez., Seite 1427-1433 volume:24 year:2009 number:6 day:30 month:12 pages:1427-1433
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	EGFR Laparoscopy Microscopic residual cancer Neoadjuvant chemotherapy Pneumoperitoneum Survivin
dewey-raw	610
isfreeaccess_bool	false
container_title	Surgical endoscopy and other interventional techniques
authorswithroles_txt_mv	Amin, Anwar Tawfik @@aut@@ Shiraishi, Norio @@aut@@ Ninomiya, Shigeo @@aut@@ Tajima, Masaaki @@aut@@ Inomata, Masafumi @@aut@@ Kitano, Seigo @@aut@@
publishDateDaySort_date	2009-12-30T00:00:00Z
hierarchy_top_id	254909620
dewey-sort	3610
id	SPR006283985
language_de	englisch
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This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. 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author	Amin, Anwar Tawfik
spellingShingle	Amin, Anwar Tawfik ddc 610 bkl 44.87 misc EGFR misc Laparoscopy misc Microscopic residual cancer misc Neoadjuvant chemotherapy misc Pneumoperitoneum misc Survivin Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
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topic_title	610 ASE 44.87 bkl Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model EGFR (dpeaa)DE-He213 Laparoscopy (dpeaa)DE-He213 Microscopic residual cancer (dpeaa)DE-He213 Neoadjuvant chemotherapy (dpeaa)DE-He213 Pneumoperitoneum (dpeaa)DE-He213 Survivin (dpeaa)DE-He213
topic	ddc 610 bkl 44.87 misc EGFR misc Laparoscopy misc Microscopic residual cancer misc Neoadjuvant chemotherapy misc Pneumoperitoneum misc Survivin
topic_unstemmed	ddc 610 bkl 44.87 misc EGFR misc Laparoscopy misc Microscopic residual cancer misc Neoadjuvant chemotherapy misc Pneumoperitoneum misc Survivin
topic_browse	ddc 610 bkl 44.87 misc EGFR misc Laparoscopy misc Microscopic residual cancer misc Neoadjuvant chemotherapy misc Pneumoperitoneum misc Survivin
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hierarchy_parent_title	Surgical endoscopy and other interventional techniques
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title	Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
ctrlnum	(DE-627)SPR006283985 (SPR)s00464-009-0793-8-e
title_full	Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
author_sort	Amin, Anwar Tawfik
journal	Surgical endoscopy and other interventional techniques
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author_browse	Amin, Anwar Tawfik Shiraishi, Norio Ninomiya, Shigeo Tajima, Masaaki Inomata, Masafumi Kitano, Seigo
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class	610 ASE 44.87 bkl
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title_sort	increased mrna expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
title_auth	Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
abstract	Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer.
abstractGer	Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer.
abstract_unstemmed	Background Surgical impact may be associated with enhanced tumor growth and chemoresistance. This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. This might be associated with changes in the chemosensitivity of the remnant cancer cells after surgery, supporting the use of minimally invasive surgery for cancer.
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title_short	Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model
url	https://dx.doi.org/10.1007/s00464-009-0793-8
remote_bool	true
author2	Shiraishi, Norio Ninomiya, Shigeo Tajima, Masaaki Inomata, Masafumi Kitano, Seigo
author2Str	Shiraishi, Norio Ninomiya, Shigeo Tajima, Masaaki Inomata, Masafumi Kitano, Seigo
ppnlink	254909620
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doi_str	10.1007/s00464-009-0793-8
up_date	2024-07-03T22:01:32.226Z
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This study aimed to evaluate the effect of surgical impact on the mRNA expression of survivin, epidermal growth factor receptor (EGFR), and human epidermal receptor (HER2) in tumors after pneumoperitoneum versus laparotomy. Methods Nude mice were inoculated intraperitoneally with human gastric cancer cells (MKN45). Then laparotomy, carbon dioxide ($ CO_{2} $) pneumoperitoneum, and anesthesia alone were performed randomly, after which EGFR, HER2, and survivin mRNA expression using reverse transcription-polymerase chain reaction (RT-PCR) was evaluated. Results The expression of EGFR and HER2 mRNA increased significantly after the experiment. However, it was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum at almost all examined time points. Survivin mRNA expression increased significantly in the first 48 h, then returned to the control level. It was higher after laparotomy than after $ CO_{2} $ pneumoperitoneum 48 h after the surgical procedures. Conclusion The expression of EGFR, HER2, and survivin increased after each surgical procedure. However it was lower after $ CO_{2} $ pneumoperitoneum than after laparotomy. 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Increased mRNA expression of epidermal growth factor receptor, human epidermal receptor, and survivin in human gastric cancer after the surgical stress of laparotomy versus carbon dioxide pneumoperitoneum in a murine model

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