Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials
Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Maringwa, John T. [verfasserIn] Quinten, Chantal [verfasserIn] King, Madeleine [verfasserIn] Ringash, Jolie [verfasserIn] Osoba, David [verfasserIn] Coens, Corneel [verfasserIn] Martinelli, Francesca [verfasserIn] Vercauteren, Jurgen [verfasserIn] Cleeland, Charles S. [verfasserIn] Flechtner, Henning [verfasserIn] Gotay, Carolyn [verfasserIn] Greimel, Eva [verfasserIn] Taphoorn, Martin J. [verfasserIn] Reeve, Bryce B. [verfasserIn] Koch, Joseph Schmucker-Von [verfasserIn] Weis, Joachim [verfasserIn] Smit, Egbert F. [verfasserIn] van Meerbeeck, Jan P. [verfasserIn] Bottomley, Andrew [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Übergeordnetes Werk: |
Enthalten in: Supportive care in cancer - Berlin : Springer, 1993, 19(2010), 11 vom: 01. Okt., Seite 1753-1760 |
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| Übergeordnetes Werk: |
volume:19 ; year:2010 ; number:11 ; day:01 ; month:10 ; pages:1753-1760 |
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| DOI / URN: |
10.1007/s00520-010-1016-5 |
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| Katalog-ID: |
SPR006584225 |
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| 245 | 1 | 0 | |a Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
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| 520 | |a Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. | ||
| 650 | 4 | |a Anchoring |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Health-related quality of life |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Minimal important difference |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Quinten, Chantal |e verfasserin |4 aut | |
| 700 | 1 | |a King, Madeleine |e verfasserin |4 aut | |
| 700 | 1 | |a Ringash, Jolie |e verfasserin |4 aut | |
| 700 | 1 | |a Osoba, David |e verfasserin |4 aut | |
| 700 | 1 | |a Coens, Corneel |e verfasserin |4 aut | |
| 700 | 1 | |a Martinelli, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Vercauteren, Jurgen |e verfasserin |4 aut | |
| 700 | 1 | |a Cleeland, Charles S. |e verfasserin |4 aut | |
| 700 | 1 | |a Flechtner, Henning |e verfasserin |4 aut | |
| 700 | 1 | |a Gotay, Carolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Greimel, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Taphoorn, Martin J. |e verfasserin |4 aut | |
| 700 | 1 | |a Reeve, Bryce B. |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Joseph Schmucker-Von |e verfasserin |4 aut | |
| 700 | 1 | |a Weis, Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Smit, Egbert F. |e verfasserin |4 aut | |
| 700 | 1 | |a van Meerbeeck, Jan P. |e verfasserin |4 aut | |
| 700 | 1 | |a Bottomley, Andrew |e verfasserin |4 aut | |
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10.1007/s00520-010-1016-5 doi (DE-627)SPR006584225 (SPR)s00520-010-1016-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Maringwa, John T. verfasserin aut Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 Quinten, Chantal verfasserin aut King, Madeleine verfasserin aut Ringash, Jolie verfasserin aut Osoba, David verfasserin aut Coens, Corneel verfasserin aut Martinelli, Francesca verfasserin aut Vercauteren, Jurgen verfasserin aut Cleeland, Charles S. verfasserin aut Flechtner, Henning verfasserin aut Gotay, Carolyn verfasserin aut Greimel, Eva verfasserin aut Taphoorn, Martin J. verfasserin aut Reeve, Bryce B. verfasserin aut Koch, Joseph Schmucker-Von verfasserin aut Weis, Joachim verfasserin aut Smit, Egbert F. verfasserin aut van Meerbeeck, Jan P. verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 19(2010), 11 vom: 01. Okt., Seite 1753-1760 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:19 year:2010 number:11 day:01 month:10 pages:1753-1760 https://dx.doi.org/10.1007/s00520-010-1016-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2010 11 01 10 1753-1760 |
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10.1007/s00520-010-1016-5 doi (DE-627)SPR006584225 (SPR)s00520-010-1016-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Maringwa, John T. verfasserin aut Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 Quinten, Chantal verfasserin aut King, Madeleine verfasserin aut Ringash, Jolie verfasserin aut Osoba, David verfasserin aut Coens, Corneel verfasserin aut Martinelli, Francesca verfasserin aut Vercauteren, Jurgen verfasserin aut Cleeland, Charles S. verfasserin aut Flechtner, Henning verfasserin aut Gotay, Carolyn verfasserin aut Greimel, Eva verfasserin aut Taphoorn, Martin J. verfasserin aut Reeve, Bryce B. verfasserin aut Koch, Joseph Schmucker-Von verfasserin aut Weis, Joachim verfasserin aut Smit, Egbert F. verfasserin aut van Meerbeeck, Jan P. verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 19(2010), 11 vom: 01. Okt., Seite 1753-1760 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:19 year:2010 number:11 day:01 month:10 pages:1753-1760 https://dx.doi.org/10.1007/s00520-010-1016-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2010 11 01 10 1753-1760 |
| allfields_unstemmed |
10.1007/s00520-010-1016-5 doi (DE-627)SPR006584225 (SPR)s00520-010-1016-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Maringwa, John T. verfasserin aut Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 Quinten, Chantal verfasserin aut King, Madeleine verfasserin aut Ringash, Jolie verfasserin aut Osoba, David verfasserin aut Coens, Corneel verfasserin aut Martinelli, Francesca verfasserin aut Vercauteren, Jurgen verfasserin aut Cleeland, Charles S. verfasserin aut Flechtner, Henning verfasserin aut Gotay, Carolyn verfasserin aut Greimel, Eva verfasserin aut Taphoorn, Martin J. verfasserin aut Reeve, Bryce B. verfasserin aut Koch, Joseph Schmucker-Von verfasserin aut Weis, Joachim verfasserin aut Smit, Egbert F. verfasserin aut van Meerbeeck, Jan P. verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 19(2010), 11 vom: 01. Okt., Seite 1753-1760 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:19 year:2010 number:11 day:01 month:10 pages:1753-1760 https://dx.doi.org/10.1007/s00520-010-1016-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2010 11 01 10 1753-1760 |
| allfieldsGer |
10.1007/s00520-010-1016-5 doi (DE-627)SPR006584225 (SPR)s00520-010-1016-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Maringwa, John T. verfasserin aut Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 Quinten, Chantal verfasserin aut King, Madeleine verfasserin aut Ringash, Jolie verfasserin aut Osoba, David verfasserin aut Coens, Corneel verfasserin aut Martinelli, Francesca verfasserin aut Vercauteren, Jurgen verfasserin aut Cleeland, Charles S. verfasserin aut Flechtner, Henning verfasserin aut Gotay, Carolyn verfasserin aut Greimel, Eva verfasserin aut Taphoorn, Martin J. verfasserin aut Reeve, Bryce B. verfasserin aut Koch, Joseph Schmucker-Von verfasserin aut Weis, Joachim verfasserin aut Smit, Egbert F. verfasserin aut van Meerbeeck, Jan P. verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 19(2010), 11 vom: 01. Okt., Seite 1753-1760 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:19 year:2010 number:11 day:01 month:10 pages:1753-1760 https://dx.doi.org/10.1007/s00520-010-1016-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2010 11 01 10 1753-1760 |
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10.1007/s00520-010-1016-5 doi (DE-627)SPR006584225 (SPR)s00520-010-1016-5-e DE-627 ger DE-627 rakwb eng 610 ASE 44.81 bkl Maringwa, John T. verfasserin aut Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 Quinten, Chantal verfasserin aut King, Madeleine verfasserin aut Ringash, Jolie verfasserin aut Osoba, David verfasserin aut Coens, Corneel verfasserin aut Martinelli, Francesca verfasserin aut Vercauteren, Jurgen verfasserin aut Cleeland, Charles S. verfasserin aut Flechtner, Henning verfasserin aut Gotay, Carolyn verfasserin aut Greimel, Eva verfasserin aut Taphoorn, Martin J. verfasserin aut Reeve, Bryce B. verfasserin aut Koch, Joseph Schmucker-Von verfasserin aut Weis, Joachim verfasserin aut Smit, Egbert F. verfasserin aut van Meerbeeck, Jan P. verfasserin aut Bottomley, Andrew verfasserin aut Enthalten in Supportive care in cancer Berlin : Springer, 1993 19(2010), 11 vom: 01. Okt., Seite 1753-1760 (DE-627)254909574 (DE-600)1463166-0 1433-7339 nnns volume:19 year:2010 number:11 day:01 month:10 pages:1753-1760 https://dx.doi.org/10.1007/s00520-010-1016-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.81 ASE AR 19 2010 11 01 10 1753-1760 |
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Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). 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Maringwa, John T. |
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Maringwa, John T. ddc 610 bkl 44.81 misc Anchoring misc EORTC QLQ-C30 misc Health-related quality of life misc Minimal important difference Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
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610 ASE 44.81 bkl Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials Anchoring (dpeaa)DE-He213 EORTC QLQ-C30 (dpeaa)DE-He213 Health-related quality of life (dpeaa)DE-He213 Minimal important difference (dpeaa)DE-He213 |
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ddc 610 bkl 44.81 misc Anchoring misc EORTC QLQ-C30 misc Health-related quality of life misc Minimal important difference |
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Supportive care in cancer |
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Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
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(DE-627)SPR006584225 (SPR)s00520-010-1016-5-e |
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Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
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Maringwa, John T. |
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Supportive care in cancer |
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Maringwa, John T. Quinten, Chantal King, Madeleine Ringash, Jolie Osoba, David Coens, Corneel Martinelli, Francesca Vercauteren, Jurgen Cleeland, Charles S. Flechtner, Henning Gotay, Carolyn Greimel, Eva Taphoorn, Martin J. Reeve, Bryce B. Koch, Joseph Schmucker-Von Weis, Joachim Smit, Egbert F. van Meerbeeck, Jan P. Bottomley, Andrew |
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10.1007/s00520-010-1016-5 |
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610 |
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verfasserin |
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minimal important differences for interpreting health-related quality of life scores from the eortc qlq-c30 in lung cancer patients participating in randomized controlled trials |
| title_auth |
Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
| abstract |
Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. |
| abstractGer |
Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. |
| abstract_unstemmed |
Background The aim of this study was to determine the smallest changes in health-related quality of life (HRQOL) scores in a subset of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scales, which could be considered as clinically meaningful in patients with non-small-cell lung cancer (NSCLC). Methods WHO performance status (PS) and weight change were used as clinical anchors to determine minimal important differences (MIDs) in HRQOL change scores (range, 0–100) in the EORTC QLQ-C30 scales. Selected distribution-based methods were used for comparison. Findings In a pooled dataset of 812 NSCLC patients undergoing treatment, the values determined to represent the MID depended on whether patients were improving or deteriorating. MID estimates for improvement (based on a one-category change in PS, 5 − <20% weight gain) were physical functioning (9, 5); role functioning (14, 7); social functioning (5, 7); global health status (9, 4); fatigue (14, 5); and pain (16, 2). The respective MID estimates for deterioration (based on PS, weight loss) were physical (4, 6); role (5, 5); social (7, 9); global health status (4, 4); fatigue (6, 11); and pain (3, 7). Interpretation Based on the selected QLQ-C30 scales, the MID may depend upon whether the patients’ PS is improving or worsening, but our results are not definitive. The MID estimates for the specified scales can help clinicians and researchers evaluate the significance of changes in HRQOL and assess the value of a health care intervention or compare treatments. The estimates also can be useful in determining sample sizes in the design of future clinical trials. |
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Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials |
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Quinten, Chantal King, Madeleine Ringash, Jolie Osoba, David Coens, Corneel Martinelli, Francesca Vercauteren, Jurgen Cleeland, Charles S. Flechtner, Henning Gotay, Carolyn Greimel, Eva Taphoorn, Martin J. Reeve, Bryce B. Koch, Joseph Schmucker-Von Weis, Joachim Smit, Egbert F. van Meerbeeck, Jan P. Bottomley, Andrew |
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Quinten, Chantal King, Madeleine Ringash, Jolie Osoba, David Coens, Corneel Martinelli, Francesca Vercauteren, Jurgen Cleeland, Charles S. Flechtner, Henning Gotay, Carolyn Greimel, Eva Taphoorn, Martin J. Reeve, Bryce B. Koch, Joseph Schmucker-Von Weis, Joachim Smit, Egbert F. van Meerbeeck, Jan P. Bottomley, Andrew |
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10.1007/s00520-010-1016-5 |
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2024-07-03T23:41:38.480Z |
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| score |
7.3998823 |